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| 1 | Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods显示文摘Neutralizing antibodies targeting the receptor-binding domain(RBD)of the SARS-CoV-2 spike(S)block severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)entry into cells via surface-expressed angiotensin-converting enzyme 2(ACE2).We used a surrogate virus neutralization test(sVNT)and SARS-CoV-2 S protein-pseudotyped vesicular stomatitis virus(VSV)vector-based neutralization assay(pVNT)to assess the degree to which serum antibodies from coronavirus disease 2019(COVID-19)convalescent patients interfere with the binding of SARS-CoV-2 S to ACE2.Both tests revealed neutralizing anti-SARS-CoV-2 S antibodies in the sera of ~90% of mildly and 100% of severely affected COVID-19 convalescent patients.Importantly,sVNT and pVNT results correlated strongly with each other and to the levels of anti-SARS-CoV-2 S1 IgG and IgA antibodies.Moreover,levels of neutralizing antibodies correlated with the duration and severity of clinical symptoms but not with patient age.Compared to pVNT,sVNT is less sophisticated and does not require any biosafety labs.Since this assay is also much faster and cheaper,sVNT will not only be important for evaluating the prevalence of neutralizing antibodies in a population but also for identifying promising plasma donors for successful passive antibody therapy. | Berislav Bosnjak Saskia Catherina Stein Stefanie Willenzon Anne Katrin Cordes Wolfram Puppe Gunter Bernhardt Inga Ravens Christiane Ritter Christian R.Schultze-Florey Nina Godecke Jorg Martens Hannah Kleine-Weber Markus Hoffmann Anne Cossmann Mustafa Yilmaz Isabelle Pink Marius M.Hoeper Georg M.N.Behrens Stefan Pohlm ann Rainer Blasczyk Thomas F.Schulz Reinhold Forster | 2021 | Cellular & Molecular Immunology2021，18，4： | 2 |
| 2 | A Systematic Correlation of Angiography and High-Resolution Optical Coherence Tomography in Diabetic Macular Edema显示文摘 | Matthias Bolz Markus Ritter Miklos Schneider Christian Simader Christoph Scholda Ursula Schmidt-Erfurth | 2009 | Ophthalmology2009，，1： | 1 |
| 3 | Differential expression of GHRH receptor and its splice variant 1 inhuman normal and malignant mucosa of the oesophagus and colon显示文摘 | Florian Hohla Angelika Moder Ursula Mayrhauser Cornelia Hauser-Kronberger Andrew Schally Jozsef Varga Marta Zarandi Stefan Buchholz Rudolf Huber Elmar Aigner Markus Ritter Christian Datz | 2008 | International Journal of Oncology2008，，1： | 1 |
| 4 | RFLP mapping on potato chromosomes of two genes controlling extreme resistance to potato virus X (PVX)显示文摘 | Enrique Ritter Thomas Debener Amalia Barone Francesco Salamini Christiane Gebhardt | 1991 | MGG Molecular & General Genetics1991，，1： | 1 |
| 5 | Emotmional labor, burnout, and lnauthenticity: does cender matter 显示文摘 | Rebecca J Erickson Christian Ritter | 2001 | Social Psychology Quarterly2001，64，2： | 1 |
| 6 | Family Influences on Absenteeism: Testing an Expanded Process Model显示文摘 | Rebecca J. Erickson Laura Nichols Christian Ritter | 2000 | Journal of Vocational Behavior2000，，2： | 1 |
| 7 | Immunoregulation of dendritic and T cells by alpha-fetoprotein in patients with hepatocellular carcinoma显示文摘 | Marcus Ritter Mona Y. Ali Christian F. Grimm Robert Weth Leonhard Mohr Wulf O. Bocher Katja Endrulat Heiner Wedemeyer Hubert E. Blum Michael Geissler | 2004 | Journal of Hepatology2004，，6： | 1 |
| 8 | The Role of Identity Salience and Commitment in the Stress Process显示文摘 | MARCUSSEN KRISTEN CHRISTIAN RITTER DEBORAH SAFRON | 2004 | Sociological Perspectives2004，，47： | 1 |
| 9 | Enhancing 3D Reconstruction Accuracy of FIB Tomography Data Using Multi‑voltage Images and Multimodal Machine Learning显示文摘FIB-SEM tomography is a powerful technique that integrates a focused ion beam(FIB)and a scanning electron microscope(SEM)to capture high-resolution imaging data of nanostructures.This approach involves collecting in-plane SEM imagesand using FIB to remove material layers for imaging subsequent planes,thereby producing image stacks.However,theseimage stacks in FIB-SEM tomography are subject to the shine-through effect,which makes structures visible from theposterior regions of the current plane.This artifact introduces an ambiguity between image intensity and structures in thecurrent plane,making conventional segmentation methods such as thresholding or the k-means algorithm insufficient.Inthis study,we propose a multimodal machine learning approach that combines intensity information obtained at differentelectron beam accelerating voltages to improve the three-dimensional(3D)reconstruction of nanostructures.By treatingthe increased shine-through effect at higher accelerating voltages as a form of additional information,the proposed methodsignificantly improves segmentation accuracy and leads to more precise 3D reconstructions for real FIB tomography data. | Trushal Sardhara Alexander Shkurmanov Yong Li Lukas Riedel Shan Shi Christian J.Cyron Roland C.Aydin Martin Ritter | 2024 | Nanomanufacturing and Metrology2024，7，1： | 0 |
| 10 | Biliary tract cancer stem cells-translational options and challenges显示文摘Management of biliary tract cancer remains challenging. Tumors show high recurrence rates and therapeutic resistance, leading to dismal prognosis and short survival. The cancer stem cell model states that a tumor is a heterogeneous conglomerate of cells, in which a certain subpopulation of cells-the cancer stem cells-possesses stem cell properties. Cancer stem cells have high clinical relevance due to their potential contributions to development, progression and aggressiveness as well as recurrence and metastasis of malignant tumors. Consequently, reliable identification of as well as pharmacological intervention with cancer stem cells is an intensively investigated and promising research field. The involvement of cancer stem cells in biliary tract cancer is likely as a number of studies demonstrated their existence and the obvious clinical relevance of several established cancer stem cell markers in biliary tract cancer models and tissues. In the present article, we review and discuss the currently available literature addressing the role of putative cancer stem cells in biliary tract cancer as well as the connection between known contributors of biliary tract tumorigenesis such as oncogenic signaling pathways, micro-RNAs and the tumor microenvironment with cancer stem cells. | Christian Mayr Matthias Ocker Markus Ritter Martin Pichler Daniel Neureiter Tobias Kiesslich | 2017 | World Journal of Gastroenterology2017，23，14： | 0 |
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