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| 1 | Graphitic carbon nitride/biochar composite synthesized by a facile ball-milling method for the adsorption and photocatalytic degradation of enrofloxacin显示文摘In order to enhance the removal performance of graphitic carbon nitride(g-C_(3)N_(4)) on organic pollutant, a simultaneous process of adsorption and photocatalysis was achieved via the compounding of biochar and g-C_(3)N_(4). In this study, g-C_(3)N_(4) was obtained by a condensation reaction of melamine at 550 °C. Then the g-C_(3)N_(4)/biochar composites were synthesized by ball milling biochar and g-C_(3)N_(4) together, which was considered as a simple, economical, and green strategy. The characterization of resulting g-C_(3)N_(4)/biochar suggested that biochar and g-C_(3)N_(4) achieved effective linkage. The adsorption and photocatalytic performance of the composites were evaluated with enrofloxacin(EFA) as a model pollutant. The result showed that all the g-C_(3)N_(4)/biochar composites displayed higher adsorption and photocatalytic performance to EFA than that of pure g-C_(3)N_(4). The 50% g-C_(3)N_(4)/biochar performed best and removed 45.2% and 81.1% of EFA(10 mg/L) under darkness and light with a dosage of 1 mg/mL, while g-C_(3)N_(4) were 19.0% and 27.3%, respectively. Besides, 50% g-C_(3)N_(4)/biochar showed the highest total organic carbon(TOC) removal efficiency(65.9%). Radical trapping experiments suggested that superoxide radical( ·O_(2)^(-)) and hole(h~+) were the main active species in the photocatalytic process. After 4 cycles, the composite still exhibited activity for catalytic removal of EFA. | Yao Xiao Honghong Lyu Chengliang Yang Beibei Zhao Lan Wang Jingchun Tang | 2021 | Journal of Environmental Sciences2021，33，5： | 8 |
| 2 | Study on the structure characterization and moisturizing effect of Tremella polysaccharide fermented from GCMCC5.39显示文摘The structure and moisture retention of Tremella polysaccharide fermented from GCMCC5.39(FTP)were evaluated.After UV,infrared spectrum analysis,HPAEC-PAD,HPSEC and 1 D NMR analysis,the composition of the purifi ed FTP was determined.Purifi ed components of fermented Tremella polysaccharide(FTPS)was made of galactose,mannose,glucose,galactosmine,glucosamine,and contain a large amount of hydroxyl,carbonyl and amino groups.FTPS wasα-neutral pyranose without uronic acid.FTPS-1 and FTPS-2 were obtained after purifi cation by DEAE-Sepharose Fast Flow Column.The molecular weights of FTPS-1 and FTPS-2 were 25722 and 177263 Da.FTPS-2 had a better ability to prevent moisture loss,and the optimal moisture retention period was 0–4 h.FTPS-2 could signifi cantly increase the moisture content of the skin epidermis and showed a dose-concentration relationship.The effect of FTPS-2 on the expression of different moisturizing genes was evaluated in a human skin keratinocyte model.The results showed that FTPS-2 has no cytotoxicity,and could signifi cantly promote AQP3,TGM1,CASP14,HYAL2,FLG gene expression level in HaCaT cells.It has the most signifi cant infl uence at HYAL2 protein expression on 50μg/mL. | Meng Yang Zilong Zhang Yan He Chengliang Li Jinmei Wang Xia Ma | 2021 | Food Science and Human Wellness2021，10，4： | 6 |
| 3 | Comparison of labeling methods and time course of traumatic brain injury-induced cell death in mice显示文摘BACKGROUND:Various molecular mechanisms of cell death following traumatic brain injury have been previously described.However,the time course of cell death remains unclear.TUNEL and Fluoro-Jade B labeling have been widely used to label apoptotic cells and neuronal degeneration.Propidium iodide (PI) functions as a biomarker of cell death in vivo.OBJECTIVE:To explore the role of PI labeling compared to TUNEL and Fluoro-Jade B staining for detecting neural cell death,and to observe time course of traumatic brain injury-induced cell death in mice.DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at the Laboratory of Aging and Nervous Diseases,Soochow University from September 2007 to December 2008.MATERIALS:PI (B1221) was purchased from Sigma,USA.TUNEL kit was purchased from Roche Molecular Biochemicals,USA.Fluoro-Jade B was purchased from Chemicon,USA.METHODS:A total of 70 healthy,male,Kunming mice were randomly assigned to sham-surgery (n=5) and model (n=65) groups.Traumatic brain injury was established using the controlled cortical impact method.PI was intraperitoneally injected at 1 hour prior to animal sacrifice.MAIN OUTCOME MEASURES:TUNEL,Fluoro-Jade B,and PI-positive cells were quantified using a double-labeling method to determine the time course of traumatic brain injury-induced cell death.RESULTS:PI labeled cells in an earlier phase of cell death than TUNEL and Fluoro-Jade B labeling.PI-positive cells were observed immediately following injury,and the numbers rapidly increased in injured brain areas at 1 hour,peaked at 24-48 hours,and subsequently decreased at 3-21 days post-injury.TUNEL-labeled cells were significantly increased at 12 hours,while Fluoro-Jade B-labeled cells were increased at 6 hours after injury,with cells still visible at 6-48 hours post-injury.Moreover,a greater number of PI-positive cells were observed compared to TUNEL-and Fluoro-Jade B-labeled cells.CONCLUSION:PI labeling is more sensitive and reliable than TUNEL and Fluoro-Jade B staining for detecting cell death following traumatic brain injury.Moreover,PI labeling can function as a reliable marker to estimate the entire time course of cell death. | Chengliang Luo Xiping Chen Hong Ni Qianqian Li Rui Yang Yuxia Sun Guangyou Zhu Luyang Tao | 2010 | Neural Regeneration Research2010，5，9： | 6 |
| 4 | Observation and research of deep underground multi-physical fields—Huainan–848 m deep experiment显示文摘Compared with the surface,the deep environment has the advantages of allowing“super-quiet and ultra-clean”-geophysical field observation with low vibration noise and little electromagnetic interference,which are conducive to the realization of long-term and high-precision observation of multi-physical fields,thus enabling the solution of a series of geoscience problems.In the Panyidong Coal Mine,where there are extensive underground tunnels at the depth of 848 m below sea level,we carried out the first deep-underground geophysical observations,including radioactivity,gravity,magnetic,magnetotelluric,background vibration and six-component seismic observations.We concluded from these measurements that(1)the background of deep subsurface gravity noise in the long-period frequency band less than 2 Hz is nearly two orders of magnitude weaker than that in the surface observation environment;(2)the underground electric field is obviously weaker than the surface electric field,and the relatively high frequency of the underground field,greater than 1 Hz,is more than two orders of magnitude weaker than that of the surface electric field;the east-west magnetic field underground is approximately the same as that at the surface;the relatively high-frequency north-south magnetic field underground,below 10 Hz,is at least one order of magnitude lower than that at the surface,showing that the underground has a clean electromagnetic environment;(3)in addition to the highfrequency and single-frequency noises introduced by underground human activities,the deep underground space has a significantly lower background vibration noise than the surface,which is very beneficial to the detection of weak earthquake and gravity signals;and(4)the underground roadway support system built with ferromagnetic material interferes the geomagnetic field.We also found that for deep observation in the“ultra-quiet and ultra-clean”environment,the existing geophysical equipment and observation technology have problems of poor adaptability and insufficient precision as well as data cleaning problems,such as the effective separation of the signal and noise of deep observation data.It is also urgent to interpret and comprehensively utilize these high-precision multi-physics observation data. | Yun WANG Yaxin YANG Heping SUN Chengliang XIE Qisheng ZHANG Xiaoming CUI Chang CHEN Yongsheng HE Qiangqiang MIAO Chaomin MU Lianghui GUO Jiwen TENG | 2023 | Science China Earth Sciences2023，66，1： | 3 |
| 5 | EFFECTS OF POLYTROPIC EXPONENT ON DATA PROCESSING METHODS USED IN CONSTANT VOLUME DISCHARGE显示文摘In order to obtain the accurate sonic conductance of solenoid valves,the polytropic exponent is used in the data processing of the discharge method for measuring the flow rate characteristics of pneumatic components. Three data processing principles are first introduced,and then the discharge pressure data obtained from the measured solenoid valve are processed to obtain the sonic conductance with three methods: the partial polytropic exponent method,the complete polytropic exponent method and the adiabatic method. By comparison of the obtained results it indicates that the complete polytropic exponent method is the most accurate. However,the partial polytropic exponent method is of a high applicable value,because it is easy and simple to measure and the obtained results are relatively accurate. | YANG Lihong LIU Chengliang ZHA Xuanfang | 2008 | Chinese Journal of Mechanical Engineering2008，21，1： | 2 |
| 6 | Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication显示文摘HepatitisBvirus(HBV)infection causes acuteand chronic liver diseases,but is not directly cytopathic.Liver injury results fromrepeated attempts of the cellular immune response system to control the viral infection.Here,we investigate the roles of cellular factors and signaling pathways involved in the regulation of HBV replication to reveal the mechanism underlying HBV infection and pathogenesis.Weshowthat collagen triple helix repeat containing 1(CTHRC1)expression is elevated in HBV-infected patients andin HBV-transfected cells through epigenetic modification and transcriptional regulation.CTHRC1 facilitates HBV replication in cultured cells and BALB/c mice by activating the PKCa/ERK/JNK/c-Jun cascade to repress the IFN/JAK/STAT pathway.HBV-activated CTHRC1 downregulates the activityof typeI interferon(IFN),theproductionof IFN-stimulatedgenes(ISGs),andthephosphorylationofsignal transducerandactivator of transcription 1/2(STAT1/2),whereas it upregulates the phosphorylation and ubiquitination of type I IFN receptors(IFNARa/b).Thus,our results showthat HBV uses a novelmechanismto hijack cellular factors and signal cascades in order to evade host antiviral immunity and maintain persistent infection.We also demonstrate that CTHRC1 has a novel role in viral infection. | Lan Bai Wei Zhang Li Tan Hongchuan Yang Maolin Ge Chengliang Zhu Rui Zhang Yanhua Cao Junbo Chen Zhen Luo Wenzhe Ho Fang Liu Kailang Wu Jianguo Wu | 2015 | Journal of Molecular Cell Biology2015，7，6： | 2 |
| 7 | Identification and functional annotation of lncRNA genes with hypermethylation in colorectal cancer显示文摘 | Qi Liao Weiling He Jianfa Liu Yi Cen Liang Luo Chengliang Yu Yang Li Sitong Chen Shiwei Duan | 2015 | Gene2015，，： | 1 |
| 8 | Structural basis for a homodimeric ATPase subunit of an ECF transporter显示文摘The transition metal cobalt,an essential cofactor for many enzymes in prokaryotes,is taken up by several specifi c transport systems.The CbiMNQO protein complex be-longs to type-1 energy-coupling factor(ECF)transporters and is a widespread group of microbial cobalt transport-ers.CbiO is the ATPase subunit(A-component)of the cobalt transporting system in the gram-negative thermo-philic bacterium Thermoanaerobacter tengcongensis.Here we report the crystal structure of a nucleotide-free CbiO at a resolution of 2.3Å.CbiO contains an N-terminal canonical nucleotide-binding domain(NBD)and C-termi-nal helical domain.Structural and biochemical data show that CbiO forms a homodimer mediated by the NBD and the C-terminal domain.Interactions mainly via conserved hydrophobic amino acids between the two C-terminal do-mains result in formation of a four-helix bundle.Structural comparison with other ECF transporters suggests that non-conserved residues outside the T-component bind-ing groove in the A component likely act as a specifi city determinant for T components.Together,our data provide information on understanding of the structural organiza-tion and interaction of the CbiMNQO system. | Chengliang Chai You Yu Wei Zhuo Haifeng Zhao Xiaolu Li Na Wang Jijie Chai Maojun Yang | 2013 | Protein & Cell2013，4，10： | 1 |
| 9 | Partially coherent vortex beams:Fundamentals and applications显示文摘It has been over 30 years since the concept of optical vortices was first proposed by Coullet et al.in 1989,and the field of structured beams has grown extremely.In the last two decades,partially coherent vortex beams(PCVBs)have received increasing interest in the fields of optical manipulation,optical communication,optical imaging,etc.,and great progress has been made in the area of the coherence singularities,generation methods,topological charge measurements,and promising applications of PCVBs.In this review,we firstly outline the basic concepts of PCVBs.We explicate the relationship between the coherence vortices and optical vortices,and the evolution behavior of optical vortices to coherence vortices is summarized in detail.We discuss a special form of coherence singularity,ring dislocation,mathematically and physically.The ring dislocation in the correlation functions under low coherence is dependent on the mode indices,which provide a feasible approach to measure mode indices of PCVBs.Subsequently,we summarize the various methods for measuring the topological charge of PCVBs,highlight the measurement method based on the cross-correlation function,and a physical explanation on the relation between ring dislocation and topological charge is given.After that,we review the recent advances on experimental generation of several kinds of PCVBs.Lastly,we give an overview on the potential applications of PCVBs. | Miao Dong ChengLiang Zhao YangJian Cai YuanJie Yang | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，2： | 1 |
| 10 | Multiwavelength generation based on a mode-locked fiber laser using carbon nanotube and fiber Fabry-Perot filter显示文摘 | Wang Yuanwu Xia Li Yang Chengliang | 2013 | Applied Optics2013，52，26： | 1 |
| 11 | New donor acceptor random copolymers with pendent triphenyl- amine and 1,3,4 oxadiazole for high performance memory device applications显示文摘 | Fang Yikai Liu Chengliang Yang Guei-Yu | 2011 | Macromolecules2011，44，8： | 1 |
| 12 | Experimental Investigation on Pouch Lithium-ion Battery Thermal Management with Mini-Channels Cooling Plate Based on Heat Generation Characteristic显示文摘An electrochemical thermal coupling model of lithium battery was established to study the heat generation characteristic in this study.The simulation results showed that the heat generation density of the battery increased with the discharge rate.With the discharge process,the heat generation density of the battery increased continuously.With 2.5C discharge rate,the heat generation density at the end of discharge was 1.82 times of that at the beginning of discharge.The heat generation density at different areas of the battery was not uniform and 46%of the total ohmic heat was generated near the electrode tabs.A cooling plate with variable mini-channels was designed to improve the temperature non-uniformity caused by the heat generation characteristic.A cooling plate with uniform mini-channels was designed for compared experiment.The experiments were conducted with deionized water and refrigerant R141b and carried out with 1.5C,2C and 2.5C discharge rates.Experimental results showed that the cooling plate with variable mini-channels had a better cooling performance in both single-phase and two-phase cooling conditions. | REN Honglei JIA Li DANG Chao YANG Chengliang JIA Hongyang LIU Junjie | 2022 | Journal of Thermal Science2022，31，3： | 1 |
| 13 | Nonlin- ear spectrum broadening of femtosecond laser pulses in photorefractive waveguide arrays 显示文摘 | Wang Zhe Wu Qiang Yang Chengliang | 2010 | Optical Express2010，18，10： | 1 |
| 14 | An Effi?cient Secure Proxy Verifiably Encrypted Signature Scherre 显示文摘 | ZHANG Jianhong UU Chengliang YANG Yixian | 2010 | Journal of Network and Computer Applications2010，33，1： | 1 |
| 15 | Aluminum scandium nitride thin-film bulk acoustic resonators for 5G wideband applications显示文摘Bulk acoustic wave(BAW)filters have been extensively used in consumer products for mobile communication systems due to their high performance and standard complementary metal-oxide-semiconductor(CMOS)compatible integration process.However,it is challenging for a traditional aluminum nitride(AlN)-based BAW filter to meet several allocated 5G bands with more than a 5%fractional bandwidth via an acoustic-only approach.In this work,we propose an Al_(0.8)Sc_(0.2)N-based film bulk acoustic wave resonator(FBAR)for the design of radio frequency(RF)filters.By taking advantage of a high-quality Al_(0.8)Sc_(0.2)N thin film,the fabricated resonators demonstrate a large K_(eff)^(2) of 14.5%and an excellent figure of merit(FOM)up to 62.The temperature coefficient of frequency(TCF)of the proposed resonator is measured to be−19.2 ppm/℃,indicating excellent temperature stability.The fabricated filter has a center frequency of 4.24 GHz,a−3 dB bandwidth of 215 MHz,a small insertion loss(IL)of 1.881 dB,and a rejection>32 dB.This work paves the way for the realization of wideband acoustic filters operating in the 5G band. | Yang Zou Chao Gao Jie Zhou Yan Liu Qinwen Xu Yuanhang Qu WenJuan Liu Jeffrey Bo Woon Soon Yao Cai Chengliang Sun | 2022 | Microsystems & Nanoengineering2022，8，6： | 0 |
| 16 | Hierarchical Sb-Ni nanoarrays as robust binder-free anodes for high-performance sodium-ion half and full cells显示文摘A novel hierarchical electrode material for Na-ion batteries composed of Sbnanoplates on Ni nanorod arrays is developed to tackle the issues of the rapidcapacity fading and poor rate capability of Sb-based materials. The three-dimensional (3D) Sb-Ni nanoarrays as anodes exhibit the synergistic effects ofthe two-dimensional nanoplates and the open and conductive array structureas well as strong structural integrity. Further, their capacitive behavior isconfirmed through a kinetics analysis, which shows that their excellent Na-storageperformance is attributable to their unique nanostructure. When used asbinder-free sodium-ion battery (SIB) anodes, the nanoarrays exhibit a highcapacity retention rate (more than 80% over 200 cycles) at a current density of0.5 A.g-1 and excellent rate capacity (up to 20 A·g^-1), with their capacity being580 mAh-g-1. Moreover, a P2-Na2/3Nil/3Mn2/302//3D Sb-Ni nanoarrays full celldelivers a highly reversible capacity of 579.8 mAh.g-1 over 200 cycles and an energydensity as high as 100 Wh-kg^-1 This design strategy for ensuring fast and stableNa storage may work with other electrode materials as well. | Liying Liang Yang Xu Liaoyong Wen Yueliang Li Min Zhou Chengliang Wang Huaping Zhao Ute Kaiser Yong Lei | 2017 | Nano Research2017，10，9： | 0 |
| 17 | Chromate separation by selective crystallization显示文摘A new paradigm to remove toxic chromate anions from aqueous solution by crystallization of chromatewater clusters with imine-linked guanidinium cationic ligands is introduced.The guanidium-based cationic ligand was easily prepared through the imine condensation of an alde hyde and aminoguanidine hydrochloride.The cationic imine-linked guanidinium liga nd(BBIG-CI)showed a high re moval capacity(292.5 mg/g)in the solutions.Rapid decontamination of chromate anions from the wastewater by this cationic ligand was resulted from an instantaneous crystallization.The produced guanidium chromate salts have an extremely low solubility(Ksp,BBIG=8.19×10^9).Such superior removal performance of these mate rials was attributed to the cha rge-assisted hydrogen bonding between the cationic ligand and chromate-water hydrate anions,which was revealed by the single-crystal X-ray diffraction analysis and density functional theory(DFT)calculations.In addition,the succes s ful recove ry of the guanidium-based ligand makes it more attractive for real-world applications. | Xijian Chen Xing Dai Rongzhen Xie Jie Li Afshin Khayambashi Lei Xu Chuang Yang Nannan Shen Yaxing Wang Linwei He Yugang Zhang Chengliang Xiao Zhifang Chai Shuao Wanga | 2020 | Chinese Chemical Letters2020，31，7： | 0 |
| 18 | Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell显示文摘Hematopoietic stem cell(HSC) transplantation is the only curative therapy for many diseases.HSCs from umbilical cord blood(UCB) source have many advantages over from bone marrow.However,limited HSC dose in a single CB unit restrict its widespread use.Over the past two decades,ex vivo HSC expansion with small molecules has been an effective approach for obtaining adequate HSCs.Till now,several small-molecule compounds have entered the phase Ⅰ/Ⅱ trials,showing safe and favorable pharmacological profiles.As HSC expansion has become a hot topic over recent years,many newly identified small molecules along with novel biological mechanisms for HSC expansion would help solve this challenging issue.Here,we will give an overview of HSC biology,discovery and medicinal chemistry development of small molecules,natural products targeting for HSC expansion,and their recent clinical progresses,as well as potential protein targets for HSC expansion. | Jiaxing Li Xiao Wang Jiayu Ding Yasheng Zhu Wenjian Min Wenbing Kuang Kai Yuan Chengliang Sun Peng Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 0 |
| 19 | Bispecific antibodies in cancer therapy:Target selection and regulatory requirements显示文摘In recent years,the development of bispecific antibodies(bsAbs)has been rapid,with many new structures and target combinations being created.The boom in bsAbs has led to the successive issuance of industry guidance for their development in the US and China.However,there is a high degree of similarity in target selection,which could affect the development of diversity in bsAbs.This review presents a classification of various bsAbs for cancer therapy based on structure and target selection and examines the advantages of bsAbs over monoclonal antibodies(mAbs).Through database research,we have identified the preferences of available bsAbs combinations,suggesting rational target selection options and warning of potential wastage of medical resources.We have also compared the US and Chinese guidelines for bsAbs in order to provide a reference for their development. | Yanze Sun Xinmiao Yu Xiao Wang Kai Yuan Gefei Wang Lingrong Hu Guoyu Zhang Wenli Pei Liping Wang Chengliang Sun Peng Yang | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 20 | Bacterial coinfections contribute to severe COVID-19 in winter显示文摘Dear Editor,Although most cases of COVID-19 caused by SARS-CoV-2 Omicron variants are mild or asymptomatic worldwide,coinfection with SARS-CoV-2 and other respiratory pathogens may still aggravate the severity of the illness.1,2 The current literature indicates that coinfection with COVID-19 could occur in 3.70%–9.7%of patients.1,3,4 The proportion of bacterial,and other respiratory viral coinfections may range from 3.02%to 9.7%and 5.41%to 6.61%,respectively.However,these studies demonstrated that coinfections with respiratory pathogens are not common. | Hui Fan Li Zhou Jingjun Lv Shimin Yang Guozhong Chen Xinjin Liu Chunyan Han Xue Tan Shengnan Qian Zegang Wu Shan Yu Ming Guo Chengliang Zhu Yu Chen Ke Lan | 2023 | Cell Research2023，33，7： | 0 |
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