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| 1 | Organochlorine pesticides and polycyclic aromatic hydrocarbons in water and sediment of the Bosten Lake,Northwest China显示文摘We evaluated organic pollution in Bosten Lake, Xinjiang, China, by measuring the concentrations and distributions of organochlorine pesticides(OCPs) and polycyclic aromatic hydrocarbons(PAHs). Water and sediment samples were collected from 19 sites(B1–B19) in the lake for analysis. Our analytical results show that the concentrations of total OCPs in water ranges from 30.3 to 91.6 ng/L and the concentrations of PAHs ranges from undetectable(ND) to 368.7 ng/L. The concentrations of total OCPs in surface(i.e., lake bottom) sediment ranges from 6.9 to 16.7 ng/g and the concentrations of PAHs ranges from 25.2 to 491.0 ng/g. Hexachlorocyclohexanes(HCHs) and dichlorodiphenyltrichloroethanes(DDTs) account for large proportions of the OCPs. Low α- to γ-HCH ratios in both water and sediment samples indicate possible contributions from both industrial products and lindane. DDTs in water are probably from historical input, whereas DDTs in sediments are from both historical and recent inputs. Moreover, DDT products in both water and sediments were from multiple sources in the northwestern part of the lake(B11, B12, B13, and B14). Fugacity ratios for DDT isomers(p,p′-DDE and p,p′-DDT) at these sites were generally higher than equilibrium values. These results suggest that the input from the Kaidu River and diffusion of DDTs from the sediment to the water are responsible for DDT pollution in the water. Lower-molecular-weight PAHs, which originate primarily from wood and coal combustion and petroleum sources, represent the major fraction of the PAHs in both water and sediment samples. Our findings indicate that OCPs and PAHs in Bosten Lake can be attributed primarily to human activities. A risk assessment of OCPs and PAHs in water and sediment from Bosten Lake, however, suggests that concentrations are not yet high enough to cause adverse biological effects on the aquatic ecosystem. | SHEN Beibei WU Jinglu ZHAO Zhonghua | 2017 | Journal of Arid Land2017，9，2： | 12 |
| 2 | Synthesis of bifunctional Pt/MgAPO-5 catalysts and their catalytic performance in the hydrogenation of nitrobenzene to p-aminophenol显示文摘MgAPO-5 molecular sieves have been synthesized using diethylaminoethanol as the templating agent in a wide range of the MgO/Al2O3 ratio.The samples were characterized by XRD,SEM,solid state NMR,FT-IR and NH3-TPD.Using MgAPO-5 as acidic supports,bifunctional Pt/MgAPO-5 catalysts were prepared for hydrogenation of nitrobenzene to p-aminophenol (PAP).The results showed that the MgO/Al2O3 ratios influenced the Mg content and the acidity of MgAPO-5 samples,thereby greatly affecting the catalytic performance of Pt/MgAPO-5 catalysts.The selectivity to PAP over Pt/MgAPO-5 was dependent on the amount of strong acid sites of MgAPO-5.When the MgO/Al2O3 molar ratio was 0.5,the synthesized MgAPO-5 sample exhibited the largest amount of strong acid and a highest PAP yield of 41.1% was achieved over Pt/MgAPO-5 catalyst. | ShuFang Wang YaDan Jin BeiBei He YanJi Wang XinQiang Zhao | 2010 | Science China Chemistry2010，53，7： | 9 |
| 3 | Graphitic carbon nitride/biochar composite synthesized by a facile ball-milling method for the adsorption and photocatalytic degradation of enrofloxacin显示文摘In order to enhance the removal performance of graphitic carbon nitride(g-C_(3)N_(4)) on organic pollutant, a simultaneous process of adsorption and photocatalysis was achieved via the compounding of biochar and g-C_(3)N_(4). In this study, g-C_(3)N_(4) was obtained by a condensation reaction of melamine at 550 °C. Then the g-C_(3)N_(4)/biochar composites were synthesized by ball milling biochar and g-C_(3)N_(4) together, which was considered as a simple, economical, and green strategy. The characterization of resulting g-C_(3)N_(4)/biochar suggested that biochar and g-C_(3)N_(4) achieved effective linkage. The adsorption and photocatalytic performance of the composites were evaluated with enrofloxacin(EFA) as a model pollutant. The result showed that all the g-C_(3)N_(4)/biochar composites displayed higher adsorption and photocatalytic performance to EFA than that of pure g-C_(3)N_(4). The 50% g-C_(3)N_(4)/biochar performed best and removed 45.2% and 81.1% of EFA(10 mg/L) under darkness and light with a dosage of 1 mg/mL, while g-C_(3)N_(4) were 19.0% and 27.3%, respectively. Besides, 50% g-C_(3)N_(4)/biochar showed the highest total organic carbon(TOC) removal efficiency(65.9%). Radical trapping experiments suggested that superoxide radical( ·O_(2)^(-)) and hole(h~+) were the main active species in the photocatalytic process. After 4 cycles, the composite still exhibited activity for catalytic removal of EFA. | Yao Xiao Honghong Lyu Chengliang Yang Beibei Zhao Lan Wang Jingchun Tang | 2021 | Journal of Environmental Sciences2021，33，5： | 8 |
| 4 | 小鼠骨骼肌挫伤后基因表达的时间进程(英文)显示文摘Background:Though the mechanisms of skeletal muscle regeneration are deeply understood,those involved in muscle contusion,one of the most common muscle injuries in sports medicine clinics,are not.The objective of this study is to explore the mechanisms involved in muscle regeneration after contusion injury.Methods:In this study,a total of 72 mice were used.Eight of them were randomly chosen for the control group,while the rest were subjected to muscle contusion.Subsequently,their gastrocnemius muscles were harvested at different time points.The changes in muscle morphology were assessed by hematoxylin and eosin(HE) stain.In addition,the gene expression was analyzed by real-time polymerase chain reaction.Results:The data showed that the expression of many genes,i.e.,specific markers of immune cells and satellite cells,regulatory factors for muscle regeneration,cytokines,and chemokines,increased in the early stages of recovery,especially in the first 3 days.Furthermore,there were strict rules in the expression of these genes.However,almost all the genes returned to normal at 14 days post-injury.Conclusion:The sequence of immune cells invaded after muscle contusion was neutrophils,M1 macrophages and M2 macrophages.Some CC(CCL2,CCL3,and CCL4) and CXC(CXCL10) chemokines may be involved in the chemotaxis of these immune cells.HGF may be the primary factor to activate the satellite cells after muscle contusion.Moreover,2 weeks are needed to recover when acute contusion happens as used in this study. | Weihua Xiao Yu Liu Beibei Luo Linlin Zhao Xiaoguang Liu Zhigang Zeng Peijie Chen | 2016 | Journal of Sport and Health Science2016，5，1： | 8 |
| 5 | Size control of monodisperse nonporous silica particles by seed particle growth显示文摘Monodisperse nonporous silica particles were prepared by sol-precipitation via seed particle growth method,and the particle size,which varied from 1.0 to 4.7 m,was strictly controlled in our experiment. The formation of secondary particles,which resulted in a multimodal distribution of particle size,was suppressed by changing tetraethoxysilane(TEOS) concentration and reaction temperature. Furthermore,the effect of adding small amounts of electrolyte to the hydrolysis mixture was examined. | Beibei Zhao Caihua Tian Yan Zhang Tao Tang Fengyun Wang | 2011 | Particuology2011，9，3： | 7 |
| 6 | Preparation of high-purity monodisperse silica microspheres by the sol-gel method coupled with polymerization-induced colloid aggregation显示文摘Ultra-pure mesoporous silica microspheres with good monodispersity were synthesized in two steps:nanometer-sized silica sol was produced by the sol-gel process,then micrometer-sized silica microspheres were synthesized by polymerization-induced colloid aggregation of the silica sol.The total metal content of the microspheres was extremely low,which eliminated the tailing of chromatographic peaks by chelating reagents.The pore structure of the silica microspheres could be controlled by altering the sol-gel conditions.The silica microsphere particle size could be adjusted by using different polymerizationinduced colloid aggregation conditions. | Beibei Zhao Yan Zhang Tao Tang Fengyun Wang Tong Li Qiyu Lu | 2015 | Particuology2015，13，5： | 7 |
| 7 | Health risk assessment of dietary exposure to polycyclic aromatic hydrocarbons in Taiyuan, China显示文摘Sixteen polycyclic aromatic hydrocarbons(PAHs) were determined in 24 duplicate-diet samples from people in Taiyuan during summer and winter in 2009. Dietary intake of PAHs for 2862 participants was subsequently estimated by a survey in Taiyuan. Results from these 24 samples were compared with a raw food study in Taiyuan in 2008. Three main sources of dietary PAHs are vegetables, wheat flour and fruits, the sum of which contributes 75.95% of PAHs in dietary food. Compared to the estimated value in raw food, much more B[a]Peq(benzo[a]pyrene equivalents) were detected in food samples collected in the duplicate-diet study in Taiyuan(60.75 ng/day). The cooking process may introduce more B[a]Peq into food, and the relative contribution of 16 PAHs in the diet would be changed during the cooking procedure. | Jing Nie Jing Shi Xiaoli Duan Beibei Wang Nan Huang Xiuge Zhao | 2014 | Journal of Environmental Sciences2014，26，2： | 6 |
| 8 | Bacillus cereus AR156 primes induced systemic resistance by suppressing miR825/825 and activating defense-related genes in Arabidopsis显示文摘Small RNAs play an important role in plant immune responses. However, their regulatory function in induced systemic resistance(ISR) is nascent. Bacillus cereus AR156 is a plant growth-promoting rhizobacterium that induces ISR in Arabidopsis against bacterial infection. Here,by comparing small RNA profiles of Pseudomonas syringae pv. tomato(Pst) DC3000-infected Arabidopsis with and without AR156 pretreatment, we identified a group of Arabidopsis micro RNAs(mi RNAs) that are differentially regulated by AR156 pretreatment. mi R825 and mi R825 are two mi RNA generated from a single mi RNA gene.Northern blot analysis indicated that they were significantly downregulated in Pst DC3000-infected plants pretreated with AR156, in contrast to the plants without AR156 pretreatment. mi R825 targets two ubiquitin-protein ligases,while mi R825 targets toll-interleukin-like receptor(TIR)-nucleotide binding site(NBS) and leucine-rich repeat(LRR)type resistance(R) genes. The expression of these target genes negatively correlated with the expression of mi R825 and mi R825. Moreover, transgenic plants showing reduced expression of mi R825 and mi R825 displayed enhanced resistance to Pst DC3000 infection, whereas transgenic plants overexpressing mi R825 and mi R825 were more susceptible. Taken together, our data indicates that Bacillus cereus AR156 pretreatment primes ISR to Pst infection by suppressing mi R825 and mi R825 and activating the defense related genes they targeted. | Dongdong Niu Jing Xia Chunhao Jiang Beibei Qi Xiaoyu Ling Siyuan Lin Weixiong Zhang Jianhua Guo Hailing Jin Hongwei Zhao | 2016 | Journal of Integrative Plant Biology2016，58，4： | 6 |
| 9 | FGF1^(△HBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression显示文摘As a classically known mitogen,fibroblast growth factor 1(FGF1)has been found to exert other pleiotropic functions such as metabolic regulation and myocardial protection.Here,we show that serum levels of FGF1 were decreased and positively correlated with fraction shortening in diabetic cardiomyopathy(DCM)patients,indicating that FGF1 is a potential therapeutic target for DCM.We found that treatment with a FGF1 variant(FGF1^(△HBS))with reduced proliferative potency prevented diabetes-induced cardiac injury and remodeling and restored cardiac function.RNA-Seq results obtained from the cardiac tissues of db/db mice showed significant increase in the expression levels of anti-oxidative genes and decrease of Nur77 by FGF1AHBS treatment.Both in vivo and in vitro studies indicate that FGF1^(△HBS) exerted these beneficial effects by markedly reducing mitochondrial fragmentation,reactive oxygen species(ROS)generation and cytochrome c leakage and enhancing mitochondrial respiration rate and β-oxidation in a 5;AMP-activated protein kinase(AMPK)/Nur77-dependent manner,all of which were not observed in the AMPK null mice.The favorable metabolic activity and reduced proliferative properties of FGF1^(△HBS) testify to its promising potential for use in the treatment of DCM and other metabolic disorders. | Dezhong Wang Yuan Yin Shuyi Wang Tianyang Zhao Fanghua Gong Yushuo Zhao Beibei Wang Yuli Huang Zizhao Cheng Guanghui Zhu Zengshou Wang Yang Wang Jun Ren Guang Liang Xiaokun Li Zhifeng Huang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 6 |
| 10 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 11 | Progress of Fabrication and Applications of Electrospun Hierarchically Porous Nanofibers显示文摘In recent years,electrospun nanofibers have attracted great attention for their facile adjustable structure,morphology feature and chemical composition.Especially,significant interest has been devoted to the development of electrospun nanofibers with multiscale pores from micropores and mesopores to macropores,owing to their large specific surface area,hierarchical pore structures,abundant active sites and many other unique properties and applications.This review presents an overview on the design strategies,preparation methods,physical properties and applications of electrospun hierarchical porous nanofibers.At first,electrospinning fabrication of nanofibers with different types of pores including micropores,mesopores,macropores and hierarchical pores are introduced.Then the structures,properties of electrospun porous nanofibers and their applications in several important areas,such as catalysis,energy storage,adsorption and separation,heat insulation and flame retardant,sound absorption and wave absorption,sensor and biomedical are summarized.At last,challenges and potential opportunities of electrospun porous nanofibers in the future are highlighted. | Ranran Liu Lanlan Hou Guichu Yue Huaike Li Jiesan Zhang Jing Liu Beibei Miao Nü Wang Jie Bai Zhimin Cui Tianxi Liu Yong Zhao | 2022 | Advanced Fiber Materials2022，4，4： | 3 |
| 12 | Light weight, mechanically strong and biocompatible α-chitin aerogels from different aqueous alkali hydroxide/urea solutions显示文摘Light weight and mechanically strong α-chitin aerogels were fabricated using the sol-gel/self-assembly method from α-chitin in different aqueous alkali hydroxide(KOH, Na OH and Li OH)/urea solutions. All of the α-chitin solutions exhibited temperature-induced rapid gelation behavior. 13 C nuclear magnetic resonance(NMR) spectra revealed that the aqueous alkali hydroxide/urea solutions are non-derivatizing solvents for α-chitin. Fourier transform infrared(FT-IR), X-ray diffraction(XRD) and cross-polarization magic angle spinning(CP/MAS) 13 C NMR confirmed that α-chitin has a stable aggregate structure after undergoing dissolution and regeneration. Subsequently, nanostructured α-chitin aerogels were fabricated by regeneration from the chitin solutions in ethanol and then freeze-drying from t-Bu OH. These α-chitin aerogels exhibited high porosity(87% to 94%), low density(0.09 to 0.19 g/cm^3), high specific surface area(419 to 535 m^2/g) and large pore volume(2.7 to 3.8 cm^3/g). Moreover, the α-chitin aerogels exhibited good mechanical properties under compression and tension models. In vitro studies showed that m BMSCs cultured on chitin hydrogels have good biocompatibility. These nanostructured α-chitin aerogels may be useful for various applications, such as catalyst supports, carbon aerogel precursors and biomedical materials. | Beibei Ding Dan Zhao Jianhui Song Huichang Gao Duoduo Xu Min Xu Xiaodong Cao Lina Zhang Jie Cai | 2016 | Science China Chemistry2016，59，11： | 2 |
| 13 | Development and Application of an Extraction and Quantitative HPLC Method for Sulforaphene in Radish显示文摘Sulforaphene, an isothiocyanate generated by the conversion of glucoraphenin in radish(Raphanus sativus L.), plays an important role in plants as a defensive compound and has been shown to have anti-cancer properties. However, a reliable method for the determination of sulforaphene in radish has not yet been established. In the present study, the enzymolysis conditions, extraction solvent and extraction conditions employed to obtain sulforaphene from radish were all optimized using single factor experiments and orthogonal testing. During these trials, sulforaphene was separated and quantified using reverse phase C18 high performance liquid chromatography(HPLC), employing methanol︰water(3︰7 ν/ν) as the mobile phase at a flow rate of 0.3 mL · min-1 together with a detection wavelength of 245 nm. Evaluation of this newly established method showed good linearity between the sulforaphene concentration and the characteristic peak area over the range of 5 to 200 μg· m L-1(R2 = 0.9996). This method was thus found to be precise. It was established that sulforaphene was extracted from radish with 95.48% efficiency(RSD = 0.94%) using the optimized conditions. This same technique was successfully applied to the quantification of sulforaphene in the fleshy roots of different radish germplasms as a means of selecting the germplasms with the highest sulforaphene levels. | HUA Beibei WANG Haiping ZHAO Wen QIU Yang LIU Su LI Xixiang | 2015 | Horticultural Plant Journal2015，1，2： | 2 |
| 14 | Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis显示文摘环境暗示和细胞内部的 bioenergetic 状态深刻地影响细胞内部的 pH (pHi ) 。一个房间怎么对 pHi 变化作出回应维持 bioenergetic 动态平衡,留下逃犯。这里,我们显示出那 Smad5,发信号的形态基因的蛋白质(BMP ) 回答到 pHi 的骨头的一个描绘得好的下游的部件变化。冷、基本或张力亢进的条件增加 pHi,它接着在 Smad5 的 MH1 域以内声言不赞成控告的氨基酸簇,推动它到细胞质的从原子核的重定位。在另一方面,加热,酸或张力减退的条件减少 pHi,堵住 Smad5 的原子出口,并且因此引起它的原子累积。环境变化和 pHi 变化导致的 Smad5 的活跃 nucleocytoplasmic shuttling 独立于 BMP 发信号, carboxyl 终点 phosphorylation 和 Smad4。另外, Smad5 的脱离引起在区别识别了的神经发展过程人的 pluripotent 干细胞建模的细胞的 bioenergetic 动态平衡和破坏正常的长期、不可逆的 dysregulation。重要地,在 Smad5 缺乏的房间的这些新陈代谢、发展的赤字能仅仅由细胞质的 Smad5 被救。细胞质的 Smad5 身体上与 hexokinase 交往 1 并且加速 glycolysis。一起,我们的调查结果显示 Smad5 充当一个 pHi 送信人并且由调整细胞质的新陈代谢的机械维持房间的 bioenergetic 动态平衡。 | Yujiang Fang Zhongliang Liu Zhenyu Chen Xiangjie Xu Mengtao Xiao Yanyan Yu Yuanyuan Zhang Xiaobai Zhang Yanhua Du Cizhong Jiang Yuzheng Zhao Yiran Wang Beibei Fan Daniel Terheyden-Keighley Yang Liu Lei Shi Yi Hui Xin Zhang Bowen Zhang Hexi Feng Lin Ma Quanbin Zhang Guohua Jin Yi Yang Bin Xiang Ling Liu Xiaoqing Zhang | 2017 | Cell Research2017，27，9： | 2 |
| 15 | Convergence analysis of the formal energies of symplectic methods for Hamiltonian systems显示文摘Based on Feng's theory of formal vector fields and formal flows, we study the convergence problem of the formal energies of symplectic methods for Hamiltonian systems and give the clear growth of the coefficients in the formal energies. With the help of B-series and Bernoulli functions, we prove that in the formal energy of the mid-point rule, the coefficient sequence of the merging products of an arbitrarily given rooted tree and the bushy trees of height 1(whose subtrees are vertices), approaches 0 as the number of branches goes to ∞; in the opposite direction, the coefficient sequence of the bushy trees of height m(m ≥ 2), whose subtrees are all tall trees, approaches ∞ at large speed as the number of branches goes to +∞. The conclusion extends successfully to the modified differential equations of other Runge-Kutta methods. This disproves a conjecture given by Tang et al.(2002), and implies:(1) in the inequality of estimate given by Benettin and Giorgilli(1994) for the terms of the modified formal vector fields, the high order of the upper bound is reached in numerous cases;(2) the formal energies/formal vector fields are nonconvergent in general case. | ZHANG RuiLi TANG YiFa ZHU BeiBei TU XiongBiao ZHAO Yue | 2016 | Science China Mathematics2016，59，2： | 2 |
| 16 | Ultrathin Ti_(3)C_(2) nanowires derived from multi-layered bulks for high-performance hydrogen evolution reaction显示文摘One-dimensional ultrathin nanowires(NWs)offer a great deal of promising properties for electrochemical energy storage and conversion due to their nanoscale confinement effect and high surface-to-volume ratios.It is highly desirable to precisely design and synthesize ultrathin Ti_(3)C_(2)NWs in the aspect of size,crystalline structure and composition.Here,we report a simple alkalization strategy to design the ultrathin Ti_(3)C_(2)NWs for hydrogen evolution reaction(HER)by modulating the surface-active sites.The design principle can well improve the amount of the defect sites and ion accessibility to increase the interactions between Ti_(3)C_(2)NWs and H^(*).The optimized Ti_(3)C_(2)NWs achieve an overpotential of 476 mV at the current density of 10 mA/cm^(2)and a Tafel slope of 129 mV/dec for HER catalysis,which are superior to that of Ti_(3)C_(2)nanosheets and m-Ti_(3)C_(2).It paves an avenue for the rational transformation of MXene bulks to one-dimensional NWs catalysts for HER. | Weiwei Zhao Beibei Jin Longlu Wang Chengbo Ding Mengyue Jiang Tiantian Chen Shuaihang Bi Shujuan Liu Qiang Zhao | 2022 | Chinese Chemical Letters2022，33，1： | 2 |
| 17 | Cobalt-free oxide Ba 0.5 Sr 0.5 Fe 0.8 Cu 0.2 O 3? δ for proton-conducting solid oxide fuel cell cathode显示文摘 | Ling Zhao Beibei He Yihan ling Zhiqing Xun Ranran Peng Guangyao Meng Xingqin Liu | 2010 | International Journal of Hydrogen Energy2010，，8： | 1 |
| 18 | Imitation of Fabric Flagging in the Wind with 1/F~β Noise显示文摘This paper presents a dynamic simulation model,based on noise,to simulate fabric flagging in the wind.The wind noise is generated by two sine functions defined in advance.The frequencies and amplitudes of these sine functions are change- able to presenting the basic model of the fabric.In order to obtain more fabric fluctuant effect,we adopt a cosine function to achieve the fabric dynamic display effect.In the actual process,the traditional Phong illumination model is improved.Therefore, the model of simulating fabric flagging in the wind can be built successfully.Comparison with the physical model shows that it is a fast arithmetic because of adopting a new model in stead of the time consuming iteration arithmetic.It can achieve a friendly de- sign interface and an ideal simulation effect.Designers can select wind force and fabric material by controlling different parame- ters.The basic characteristics of fabric swaying in the wind are simulated efficiently and displayed vividly. | LI Beibei ZHAO Zhihong GENG Zhaofeng (Information Institute,DongHua University,Shanghai 200051,China, | 2006 | 武汉理工大学学报2006，28，S2： | 1 |
| 19 | Orchestrating antigen delivery and presentation efficiency in lymph node by nanoparticle shape for immune response显示文摘Activating humoral and cellular immunity in lymph nodes(LNs)of nanoparticle-based vaccines is critical to controlling tumors.However,how the physical properties of nanovaccine carriers orchestrate antigen capture,lymphatic delivery,antigen presentation and immune response in LNs is largely unclear.Here,we manufactured gold nanoparticles(AuNPs)with the same size but different shapes(cages,rods,and stars),and loaded tumor antigen as nanovaccines to explore their disparate characters on above four areas.Results revealed that star-shaped AuNPs captured and retained more repetitive antigen epitopes.On lymphatic delivery,both rods and star-shaped nanovaccines mainly drain into the LN follicles region while cage-shaped showed stronger paracortex retention.A surprising finding is that the star-shaped nanovaccines elicited potent humoral immunity,which is mediated by CD4^(+)T helper cell and follicle B cell cooperation significantly preventing tumor growth in the prophylactic study.Interestingly,cage-shaped nanovaccines preferentially presented peptide-MHC I complexes to evoke robust CD8^(+)T cell immunity and showed the strongest therapeutic efficacy when combined with the PD-1 checkpoint inhibitor in established tumor study.These results highlight the importance of nanoparticle shape on antigen delivery and presentation for immune response in LNs,and our findings support the notion that different design strategies are required for prophylactic and therapeutic vaccines. | Hongjuan Zhao Yatong Li Beibei Zhao Cuixia Zheng Mengya Niu Qingling Song Xinxin Liu Qianhua Feng Zhenzhong Zhang Lei Wang | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 1 |
| 20 | Genome-wide signatures of the geographic expansion and breeding of soybean显示文摘Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We analyzed the genome sequences of 2,214 soybeans and proposed a soybean evolutionary route, i.e., the expansion of annual wild soybean(Glycine soja Sieb. & Zucc.) from southern China and its domestication in central China, followed by the expansion and local breeding selection of its landraces(G. max(L.) Merr.). We observed that the genetic introgression in soybean landraces was mostly derived from sympatric rather than allopatric wild populations during the geographic expansion. Soybean expansion and breeding were accompanied by the positive selection of flowering time genes, including GmSPA3c. Our study sheds light on the evolutionary history of soybean and provides valuable genetic resources for its future breeding. | Ying-Hui Li Chao Qin Li Wang Chengzhi Jiao Huilong Hong Yu Tian Yanfei Li Guangnan Xing Jun Wang Yongzhe Gu Xingpeng Gao Delin Li Hongyu Li Zhangxiong Liu Xin Jing Beibei Feng Tao Zhao Rongxia Guan Yong Guo Jun Liu Zhe Yan Lijuan Zhang Tianli Ge Xiangkong Li Xiaobo Wang Hongmei Qiu Wanhai Zhang Xiaoyan Luan Yingpeng Han Dezhi Han Ruzhen Chang Yalong Guo Jochen C.Reif Scott A.Jackson Bin Liu Shilin Tian Li-juan Qiu | 2023 | Science China(Life Sciences)2023，66，2： | 1 |
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