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| 1 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 2 | Hyperhomocysteinemia induces cardiac injury by up-regulation of p53-dependent Noxa and Bax expression through the p53 DNA methylation in ApoE-/- mice显示文摘Hyperhomocysteinemia (HHcy ) 是为心血管的疾病的一个风险因素并且与心失败有强壮的关联。然而,心脏的织物上的 HHcy 的效果仍然保持不太好理解。阐明在导致 HHcy 的心脏的损害的 p53 依赖的 apoptosis 的角色,我们用高蛋氨酸饮食喂了 ApoE/ 老鼠建立 HHcy 模型。浆液 Hcy,心脏的酶,和类脂化合物被测量。Noxa, DNMT1, caspases-3/9,和 p53 的蛋白质层次被连接酶的 immunosorbent 试金决定。Bcl-2 和 Bax 蛋白质被染色的 immunohistochemistry 检测。S-adenosyl 蛋氨酸和 S-adenosyl homocysteine 集中被高效的液体层析决定。p53 和 DNMT1 的 mRNA 层次被即时聚合酶链反应(PCR ) 分析, p53 的 methylation 层次被嵌套的 methylation-specific-PCR 分析。我们的数据证明浆液 Hcy 和类脂化合物的集中与 N 控制组相比在 Meth 组被增加,它显示模型成功地被建立。p53 和 Noxa 的表示层次在 Meth 组被增加,当 p53 的 methylation 地位是 hypomethylation 时。caspase-3/9 的活动与 N 控制组相比在 Meth 组被增加。另外,染色的 immunohistochemistry 证明 Bax 的表示显著地与 N 控制组相比在 Meth 和 Meth-F 组被增加。在摘要, HHcy 由 p53 依赖的 pro-apoptotic 的起来规定导致心脏的损害联系了基因 Noxa 和 Bax,当 p53 DNA hypomethylation 是在 HHcy 导致的病理学的过程的关键分子的机制时。 | ShengchaoMa Huiping Zhang Weiwei Sun HuiHui Gong YanhuaWang Changjian Ma Ju Wang Chengjian Cao Xiaoling Yang Jue Tian Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 12 |
| 3 | In vitro and in vivo biodegradation and biocompatibility of an MMT/BSA composite coating upon magnesium alloy AZ31显示文摘The performance of biodegradable magnesium alloy requires special attention to rapid degradation and poor biocompatibility, which can cause the implant to fail. Here, a sodium montmorillonite(MMT)/bovine serum albumin(BSA) composite coating was prepared upon magnesium alloy AZ31 via hydrothermal synthesis, followed by dip coating. We evaluated the surface characterization and corrosion behavior in vitro, and the biocompatibility in vitro and in vivo. Biodegradation progress of the MMT-BSA coated Mg pieces was examined through hydrogen evolution, immersion tests, and electrochemical measurements in Hank’s solution. In vitro biocompatibility studies were evaluated via hemolysis tests, dynamic cruor time tests, platelet adhesion, MTT testing and live-dead stain of osteoblast cells(MC3 T3-E1). It was found that the MMT-BSA coating had good corrosion resistance and a marked improvement in biocompatibility in comparison to bare Mg alloy AZ31. in vivo studies were carried out in rat model and the degradation was characterized by computed tomography scans. Results revealed that the MMT-BSA coated Mg alloy AZ31 implants maintained their structural integrity and slight degradation after 120 d of post-implantation. A100% survival rate for the rats was observed with no obvious toxic damages on the organs and tissues.Additionally, we proposed a sound coating formation mechanism. Considering the good corrosion protection and biocompatibility, the MMT-BSA coated Mg alloy AZ31 is a promising candidate material for biomedical implants. | Jian Wang Lanyue Cui Yande Ren Yuhong Zou Jinlong Ma Chengjian Wang Zhongyin Zheng Xiaobo Chen Rongchang Zeng Yufeng Zheng | 2020 | Journal of Materials Science & Technology2020，47，12： | 7 |
| 4 | Simultaneous elution of polycyclic aromatic hydrocarbons and heavy metals from contaminated soil by two amino acids derived from β-cyclodextrins显示文摘Two highly water-soluble amino acids,which derived from β-CDs,i.e.,glutamic acid-β-cyclodextrin (GluCD) and ethylene-diamineβ-cyclodextrin (EDCD),were synthesized and were examined for their effect on solubilization of anthracene (ANT),complexation of cadmium (Cd2+),and elution removal of ANT and Cd2+ in soil.The results showed that GluCD and EDCD were powerful complexant for ANT and Cd2+.In the presence of 10 g/L GluCD and EDCD,the solubilization of ANT increased by 47.04 and 23.85 times compared to the control,respectively.GluCD resulted in approximately 90% complexation of Cd2+ while 70% complexation was observed for EDCD.Simultaneously,GluCD and EDCD could greatly enhance the elution removal of ANT and Cd 2+ from soil.GluCD resulted in the highest elution efficiency of ANT and Cd2+.With the addition of 10 g/L GluCD,53.5% of ANT and 85.6% of Cd2+ were eluted,respectively.The ANT had a negligible effect on the Cd2+ removal due to different complexing sites of ANT and Cd2+,while Cd2+ enhanced the ANT removal under the addition of GluCD because Cd2+ neutralized the-COOH group of GluCD.Adversely,the removal of ANT was decreased with Cd2+ under the addition of EDCD,this was due to the fact that Cd2+ enhanced the polarity of EDCD molecule and inhibited the complexation between ANT and EDCD.The study suggested that GluCD could be preferred and be successfully applied to remediation of heavy metals or organic compounds in contaminated soil. | Chengjian Yang Qingru Zeng Yunzhong Wang Bohan Liao Jian Sun Hui Shi Xingdou Chen | 2010 | Journal of Environmental Sciences2010，22，12： | 7 |
| 5 | Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis显示文摘 | Lin He Xinhua Liu Jianguo Yang Wanjin Li Shumeng Liu Xujun Liu Ziran Yang Jie Ren Yue Wang Lin Shan Chengjian Guan Fei Pei Liandi Lei Yu Zhang Xia Yi Xiaohan Yang Jing Liang Rong Liu Luyang Sun Yongfeng Shang | 2018 | Cell Research2018，28，9： | 5 |
| 6 | Biodegradation of N,N-dimethylacetamide by Rhodococcus sp.strain B83 isolated from the rhizosphere of pagoda tree显示文摘The biodegradation characteristic and potential metabolic pathway for removal of environmental N,N-dimethylacetamide(DMAC) by Rhodococcus sp. strain B83 was studied.Rhodococcus sp. strain B83 was isolated from the rhizosphere of a pagoda tree and proved capable of utilizing DMAC as sole source of carbon and nitrogen. Batch culture studies showed that strain B83 could tolerate up to 25 g/L DMAC and showed distinct growth on possible catabolic intermediates except for acetate. The nitrogen balance analysis revealed that approximately 71% of the initial nitrogen was converted to organic nitrogen. DMAC degradation has led to accumulation of acetate and organic nitrogen, meanwhile traces of nitrate and ammonia was build-up but without nitrite. The growth of strain B83 could be inhibited by adding exogenous acetate. By means of the assay of enzymatic degradation of DMAC, several catabolic intermediates at different intervals were observed and identified.Based on the results obtained from culture solution and enzymatic degradation assay, a detailed pathway is proposed for DMAC biodegradation. | Xingdu Chen Chengjian Yang Weiwei Wang Bizhou Ge Jun Zhang Yucan Liu Yaping Nan | 2017 | Journal of Environmental Sciences2017，29，3： | 3 |
| 7 | In situ FTIR investigation on phase transformations in BN nanoparticles显示文摘Fourier transformation infrared spectrum (FTIR) was employed to investigate phase transformation of nanoparticle BN, containing eBN, rBN, wBN and cBN, in which eBN and rBN are the main components. We found that part of eBN was converted into rBN at 200―350℃. At and above 400℃, eBN transformed into wBN, and some of wBN were converted into cBN simultaneously. This conclusion is supported by the results from high- resolution transmission electron microscopic (HRTEM) and Raman spectroscopic measurements. In this work, the converting processes be- tween different BN phases were continuously monitored by in situ FTIR spectroscopy. The results will be helpful for synthesis of cBN at moderate conditions. | YU Lili GAO Bin CHEN Zhi SUN Chuantao CUI Deliang WANG Chengjian WANG Qilong JIANG Minhua | 2005 | Chinese Science Bulletin2005，50，24： | 2 |
| 8 | An Analysis of Stability of Milstein Method for Stochastic Differential Equations with Delay显示文摘 | WANG Zhiyong ZHANG Chengjian | 2006 | Computers and Mathematics with Applications2006，51，： | 1 |
| 9 | Applying Fuzzy Method to Vision-Based Lane Detectionand Departure Warning System显示文摘 | Jyungguo Wang Chengjian Lin ShyJming Chen | 2010 | Expert Systems with Applications2010，37，： | 1 |
| 10 | An analysis of stability of Milstein method for stochastic differential equations with delay显示文摘 | Wang Zhiyong Zhang Chengjian | 2006 | Computers and Mathematics with Applications2006，51，： | 1 |
| 11 | An analysis of stability of Milstein method for stochastic differential equations with delay显示文摘 | Wang Zhiyong Zhang Chengjian | 2006 | Computers and Mathematics with Applications2006，51，： | 1 |
| 12 | Brocaeloid D,a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049显示文摘Microbes serve as the most important resource for drug discovery.During our screening for bioactive compounds from our natural products library,a pathogenic fungus,Microdochium majus strain 99049,from wheat was selected for further investigation.A new alkaloid named brocaeloid D(1),together with six previously characterized compounds(2–7)were identified.Compound 1 belongs to 4-oxoquinoline with C-2 reversed prenylation and a succinimide substructure.All the structures of these newly isolated compounds were determined by different means in spectroscopic experiments.The absolute configurations of 1 was further deduced from comparison of its CD spectrum with that of known compound 2.The bioactivities of these identified compounds were evaluated against several pathogenic microorganisms and cancer cell lines.Compounds 1–5 showed activity against HUH-7 human hepatoma cells with IC50 values of 80μg/mL.Compound 6 showed mild activity against HeLa cells(IC50=51.9μg/mL),weak anti-MTB activity(MIC=80μg/mL),and moderate anti-MRSA activity(MIC=25μg/mL),and compound 7 showed weak anti-MRSA activity(MIC=100μg/mL). | Jingyu Zhang Zhenzhen Wang Zhijun Song Loganathan Karthik Chengjian Hou Guoliang Zhu Lan Jiang Jianying Han Rong Ma Li Li Lixin Zhang Xueting Liu Tom Hsiang | 2019 | Synthetic and Systems Biotechnology2019，4，4： | 1 |
| 13 | Excitation Current and Vibration Characteristics of DC Biased Transformer显示文摘In practical engineering,DC disturbance will lead to excitation saturation and vibration intensification on transformer core,as well as affecting the normal operation of equipment and power grid.According to the problem,a new idea is proposed in this paper.Based on the electromagnetic characteristics of DC biased transformer,excitation saturation and core vibration are studied by using excitation-vibration harmonic response analysis method.Excitation current is identified through electromagnetic coupling to characterize the excitation saturation degree.Then,vibration harmonic response model is established to analyze core vibration.Electromagnetic characteristics of DC biased Y/△transformer are simulated.The variation of excitation current and core vibration at different DC levels are studied.Excitation-vibration characteristics of three-phase group transformer and three-phase three-limb transformer are compared and sum-marized.With experimental platform built,the correctness of simulation results is verified by experimental data,and the effectiveness of the proposed method can be proved. | Chao Pan Chengjian Wang Hao Su | 2021 | CSEE Journal of Power and Energy Systems2021，7，3： | 1 |
| 14 | An analysis of stability of Milstein method for stochastic differenti- al equations with delay显示文摘 | WANG Zhiyong ZHANG Chengjian | 2006 | Computers and Mathematics with Applications2006，51，： | 1 |
| 15 | An analysis of stability of Milstein method for stochastic differential equations with delay显示文摘 | Wang Zhiyong Zhang Chengjian | 2006 | Computers and Mathematics with Applications2006，51，： | 1 |
| 16 | An analysis of stability of Milstein method for stochastic dif- ferential equations with delay显示文摘 | Zhiyong Wang Chengjian Zhang | 2006 | Computers and Mathematics with Applications2006，51，： | 1 |
| 17 | Immunotherapy of tumor with vaccine based on basic fibroblast growth factor-activated fibroblasts显示文摘 | Xiuying Li Yongsheng Wang Yuwei Zhao Hengxiu Yang Aiping Tong Chengjian Zhao Huashan Shi Yang Li Zhenlin Wang Yuquan Wei | 2014 | Journal of Cancer Research and Clinical Oncology2014，，2： | 1 |
| 18 | An analysis of stability of Milstein method for stochastic differential equations with delay显示文摘 | Zhiyong Wang Chengjian Zhang | 2006 | Computers and Mathematics with Applications2006，51，： | 1 |
| 19 | Protein extraction methods compatible with proteomic analysis for the cotton seedling显示文摘 | CHENGJIAN XIE DE WANG XINGYONG YANG | 2009 | Crop Science2009，，49： | 1 |
| 20 | Measurement of One Proton Transfer Reaction 208Pb(7Li,6He)209Bi in Deep Sub-barrier Region显示文摘Due to the limit of the intensity and quality of the radioactive ion beam(RIB),it is a difficult task to extract the optical model potentials(OMPs)of halo nuclear systems directly from the elastic scattering measurement.In view of this fact,the transfer reaction was tried to be used as an alternative method to extract and stud- | LIN Chengjian YANG Lei JIA Huiming MA Nanru SUN Lijie WANG Dongxi XU Xinxing YANG Feng ZHANG Huanqiao LIU Zuhua | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
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