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| 1 | Expression of perforin and granzyme B mRNA in judgement of immunosuppressive effect in rat liver transplantation显示文摘AIM To explore the expression of perform andgranzyme B genes mRNA to judge the effect ofimmunosuppression in acute rejection of livertransplantation.METHODS The expression of perform andgranzyme B genes mRNA was examined byreverse transcriptase-polymerase chain reaction(RT--PCR) in hamster to rat liver grafts under theimmunosuppression of cyclosporine or/andsplenectomy. Histological findings were studiedcomparatively.RESULTS Cyclosporine could obviouslydecrease the cellular infiltration, and completelyrepress the expression of mRNA for perform andgranzyme B, but could not change severehepatocyte necrosis and hemorrhage.SPlenectomy could significantly lightenhepatocyte necrosis, and completely eliminatehemorrhage, but not atfect the cellularinfiltration and the expression of perform andgranzyme B genes mRNA. Cyclosporine orsplenectomy alone could not prolong theSurvival time, however, their combination couldcompletely repress the rejection of liver grafts.The survival time of animals were significantlyprolonged (37.1 days ). The architecture ofhepatic lobules was preserved. There was slightcellular infiltration in the portal tracts and noexpression of perform and granzyme B genesmRNA could be seen in three weeks aftertransplantation.CONCLUSION Perform and granzyme B genesare valuable in judging the effect ofimmunosuppression in liver transplantation. | Zhang SG Wu MC Tan JW Chen H Yang JM Qian QJ | 1999 | World Journal of Gastroenterology1999，5，3： | 15 |
| 2 | Recovery of novel bacterial diversity from mangrove sediment显示文摘 | Liang JB Chen YQ Lan CY Tan NFY Zan QJ Huang LN | 2007 | 中国生物学文摘2007，21，7： | 7 |
| 3 | Effects of hydrosalpinx onpinopodes,leukaemia inhibitory factor,integrin beta3 and MUC1expression in the peri-implantation endometrium显示文摘 | Li L Xu BF Chen QJ | 2010 | Eur J ObstetGynecol Reprod Biol2010，151，2： | 1 |
| 4 | NANOG changes in mouse kidneys with age显示文摘 | Yan QJ Chen XM Zhang YM | 2005 | Rejuvenation Res2005，8，4： | 1 |
| 5 | Effects of ovarian high response on implantation and pregnancy outcome during controlled ovarian hyperstimulation(with GnRH agonist and rFSH)显示文摘 | Chen QJ Sun XX Li L | 2007 | Acta Obstet Gynecol Scand2007，86，7： | 1 |
| 6 | Endotheliumspecific overexpression of class Ⅲ deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E deficient mice显示文摘 | Zhang QJ Wang Z Chen HZ | 2008 | Cardiovasc Res2008，80，2： | 1 |
| 7 | arginineasopressin,fever and temperture regulation显示文摘 | Chen X Mouihate A | 1998 | ProgBrain Res1998，119，： | 1 |
| 8 | Arginine vasopressin, fever and temperature regulation显示文摘 | Chen X Mouihate A | 1998 | Prog Brain Res1998，119，： | 1 |
| 9 | Surface texture on friction of a microtextured poly(dimethylsiloxane)(PDMS)显示文摘 | He B Chen W Wang QJ | 2008 | Tribology Letters2008，，31： | 1 |
| 10 | Propionibacterium acnes-induced IL-8 production may be mediated by NF-KB activation in human monocytes显示文摘 | Chen QJ Koga T Uchi H | 2002 | J Dermatol Sci2002，29，： | 1 |
| 11 | Contents and antioxidant capacity of limonin and nomilin in different tissues of citrus fruit of four cultivars during fruit growth and maturation显示文摘 | Sun CD Chen KS Chen Y Chen QJ | 2005 | Food Chem2005，93，： | 1 |
| 12 | Comparing the a- bility of a series of viral protein-expressing plasmid DNAs to pro- tect against H5N1 influenza virus显示文摘 | CHEN QJ KUANG HM WANG HD | 2009 | Virus Genes2009，38，1： | 1 |
| 13 | Effects of hydrosalpinxon pinopodes, leukaemia inhibitory factor, integrinbeta3 and MUC1 expression in the peri-implantationendometrium显示文摘 | Li L Xu BF Chen QJ | 2010 | Eur J Obstet Gynecol Reprod Biol2010，151，2： | 1 |
| 14 | Matrix metalloprotein-ase 9 and vascular endothelial growth factor are essential for osteoclasts recruitment into developing long bones显示文摘 | Engsig MT Chen QJ VU TH | 2000 | J Cell Biol2000，151，4： | 1 |
| 15 | Endothelium-specific overex- pression of class Ⅲ deacetylase SIRT1 decreases atheroselerosis in apolipoprotein E-deficient mice显示文摘 | Zhang QJ Wang Z Chen HZ | 2008 | Cardiovasc Res2008，80，2： | 1 |
| 16 | Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteo- elast recruitment into developing long bones显示文摘 | Engsig MT Chen QJ Vu TH | 2000 | J Cell Biol2000，151，4： | 1 |
| 17 | NANOG changes in mouse kidneys with age显示文摘 | Yah QJ Chen XM Zhang YM | 2005 | Rejuvenation Res2005，8，4： | 1 |
| 18 | Gensenoside Rg3 inhibits hy- poxia-induced VEGF expression in human cancer cells 显示文摘 | Chen QJ Zhang MZ Wang LX | 2010 | Cell Physiol Biochem2010，26，6： | 1 |
| 19 | Effects of pulsed electromagnetic fields on the mRNA expression of CAII and RANK in ovariectomized rats显示文摘 | Chen J Huang LQ Xia QJ | | 0，，： | 1 |
| 20 | Effeets of ovarian high response on implantation and pregnancy outcome during controlled ovarian hyperstimulation (with GnRH agonist and rFSH) 显示文摘 | Chen QJ Sun XX Li L | 2007 | Acta Obstet Gynecol Scand2007，86，7： | 1 |
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