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| 1 | Osthole inhibits proliferation of human breast cancer cells by inducing cell cycle arrest and apoptosis显示文摘Recent studies have revealed that osthole,an active constituent isolated from the fruit of Cnidium monnieri(L.) Cusson,a traditional Chinese medicine,possesses anticancer activity.However,its effect on breast cancer cells so far has not been elucidated clearly.In the present study,we evaluated the effects of osthole on the proliferation,cell cycle and apoptosis of human breast cancer cells MDA-MB 435.We demonstrated that osthole is effective in inhibiting the proliferation of MDA-MB 435 cells,The mitochondrion-mediated apoptotic pathway was involved in apoptosis induced by osthole,as indicated by activation of caspase-9 and caspase-3 followed by PARP degradation.The mechanism underlying its effect on the induction of G1 phase arrest was due to the up-regulation of p53 and p21 and down-regulation of Cdk2 and cyclin D1 expression.Were observed taken together,these findings suggest that the anticancer efficacy of osthole is mediated via induction of cell cycle arrest and apoptosis in human breast cancer cells and osthole may be a potential chemotherapeutic agent against human breast cancer. | Lintao Wang Yanyan Peng Kaikai Shi Haixiao Wang Jianlei Lu Yanli Li Changyan Ma | 2015 | The Journal of Biomedical Research2015，29，2： | 12 |
| 2 | Root growth and spatio-temporal distribution of three common annual halophytes in a saline desert, northern Xinjiang显示文摘Root growth and spatial and temporal distribution in the 0-100 cm soil profiles of three common annual halophytes Salsola subcrassa, Suaeda acuminate and Petrosimonia sibirica distributed in a saline desert in northern Xinjiang, China were studied in 2009 and 2010. The results showed that the root systems of the three halophytes were of the taproot type, vertically distributed in the 90-cm soil profile, and were deepest in late July. Their taproots reached maximum depth rapidly, early in the growth period, but with rare lateral roots. They were then dug out in an orderly way, from bottom to top, exhibiting vertical development first and then horizontal development. The distribution of specific root length, which reflects the characteristics of the feeder root, was gradually increased from top to bottom, whereas root weight displayed an opposite distribution pattern. The root length distribution of the three halophytes was concentrated (62% to 76%) in the middle soil profile (20-60 cm), with less distribution in the surface (0-20 cm) and bottom (60-90 cm) soil profiles. The results indicated that the roots of the three annual halophytes grew rapidly into the deeper soil layer after germination, which ensured the plant survival and uptake of water and nutrition, and thus built up a strong tolerance to an arid, high-salt environment. | Ke ZHANG ChangYan TIAN ChunJian LI | 2012 | Journal of Arid Land2012，4，3： | 7 |
| 3 | Recombinant adenovirus-p53(Gendicine) sensitizes a pancreatic carcinoma cell line to radiation显示文摘Objective:In this study,we examine the effects of recombinant adenovirus-p53(rAd-p53)on the pancreatic carcinoma cell line SW1990.Specifically,we determine if expression of rAd-p53 sensitizes these cells to radiation.Methods:Following transfection of SW1990 cells with rAd-p53,we measured expression of P53,P21 and Bax by immunocytochemistry.Both transfected and control cell lines were irradiated with a range of doses,and the survival fractions(SF)were calculated.Dose survival curves were constructed and modeled for comparison.Results:Transfection of SW1990 cells with rAd-p53 resulted in increased expression of P53,P21 and Bax in a time-dependent manner.At 96 h after transfection,89.92%of cells expressed P53,56.8%expressed P21,and 76.50%expressed Bax.The SF following radiation was lower in the rAd-p53 transfected cells compared to the control cells,suggesting that rAd-p53 sensitizes SW1990 cells to radiation(D0for the experimental and control groups was 2.199 and 2.462,respectively).Conclusions:Use of the adenoviral vector is an effective means of transfecting SW1990 cells with wild-type P53,and this sensitizes the cell line to irradiation.This work suggests that combining rAd-p53with radiation therapy in pancreatic cancer may be therapeutically beneficial. | Jinluan Li Jianji Pan Xianggao Zhu Ying Su Lingling Bao Sufang Qiu Changyan Zou Yong Cai Junxin Wu Ivan W.K.Tham | 2013 | Chinese Journal of Cancer Research2013，25，6： | 6 |
| 4 | Localized salt accumulation: the main reason for cotton root length decrease during advanced growth stages under drip irrigation with mulch film in a saline soil显示文摘High salinity in soil can prevent root growth of most plants. To investigate soil salinity dynamics under drip irrigation with mulch film(DI) and its effects on cotton root length, we conducted field experiments in saline soil based on a monolith method using flooding irrigation with mulch film(FI) as a control at the Korla Experimental Station of the Xinjiang Academy of Agricultural Sciences, China in 2009 and 2010. The results showed that the total root length decreased 120 days after sowing(DAS) under DI, and was mainly centered in the 0–30 cm soil layer and at distances of 30–70 cm from the drip-lines. There was almost complete overlap in the area of root length decline and salt accumulation. In the soil depth of 0–30 cm and at distances of 30–70 cm from the drip-lines at 110 to 160 DAS in 2009 and 171 DAS in 2010, the electrical conductivity(EC) in all soil samples was at least 3 mS/cm and in some cases exceeded 5 mS/cm under DI treatment. However, EC barely exceeded 3 mS/cm and no reduc- tion in root length was observed under FI treatment. Correlation analysis of soil EC and root length density indicated that the root length declined when the soil EC exceeded 2.8 mS/cm. The main reason for the decrease of root length in cotton under DI was localized accumulation of salinity. | WenXuan MAI ChangYan TIAN Li LI | 2014 | Journal of Arid Land2014，6，3： | 6 |
| 5 | Diversity of arbuscular mycorrhizal fungi associated with desert ephemerals growing under and beyond the canopies of Tamarisk shrubs显示文摘arbuscular mycorrhizal (AM ) 四很普通的短暂植物种的真菌的地位, Chorispora tenella (棺罩) DC, Cerato-cephalus testiculatus (Crantz ) 贝丝, Eremopyrum 面向(L) Jaub et Spash 和在树柳属植物灌木(Tamarix spp ) 统治的一个区域成长的维朗妮卡 campy-lopoda Boiss 被调查。四 ephemerals 和他们的根围土壤的样品从在下面并且在 Tamariskshrubs 的华盖以外被收集。植物 mycorrhizal 地位和土壤 AM 真菌的孢子密度和社区结构被分析并且比较在下面并且在灌木华盖以外。在他们的相应根围土壤的 ephemerals 和孢子密度的 mycorrhizal 殖民率在灌木华盖下面是显著地更低的比在远处。在灌木(12 ) 下面的 AM 真菌的种类的数字也比在华盖(19 ) 以外低。什么时候在四 ephemerals 的根围玷污性质,被检验的、可得到的 N 和 P 和全部的 P,有机物内容,全部的盐内容和电的电导率(EC ) 都在华盖下面是更高的比在远处。相反,玷污显示出的可得到的 K 和酸碱值没有如此的趋势。上午 21 点的一个总数真菌的种类从四 ephemerals 的根围土壤被孤立。五属于 Acaulospora,到 Archaeo-spora, 13 到血管球并且二到 Paraglomus。我们得出结论 Tamarix spp 的华盖。对 ephemerals 的 AM 地位并且在 AM 真菌的社区和一些他们的根围土壤的性质上施加了一些影响。 | SHI Zhaoyong ZHANG Liyun FENG Gu Chr stie Peter TIAN Changyan LI Xiaolin | 2006 | Chinese Science Bulletin2006，51，A01： | 6 |
| 6 | Improving the electrochemical performance of Fe3O4 nanoparticles via a double protection strategy through carbon nanotube decoration and graphene networks显示文摘氧化铁是为锂离子电池的有希望的阳极材料,但是因为它的差的传导性和大体积变化,它通常在锂举起和版本过程期间展出差的电气化学的性质。在这个工作,为改进 Fe 的电气化学的性能的双保护策略 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 通过有多围的碳 nanotubes 和减少的 graphene 氧化物网络的装饰的使用的 4 nanoparticles 被开发了。产生 MWCNTs-Fe <潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”> 4 -rGO nanocomposites 与 MWCNTs-Fe 比较展出了优秀骑车的性能和率能力<潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”> 4 , MWCNTs-Fe <潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”>身体上与 rGO 混合的 4 ,和 Fe <潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class= a-plus-plus > 4 -rGO 。680 | Shuliang Yang Changyan Cao Gen Li Yongbin Sun Peipei Huang Fangfang Wei Weiguo Song | 2015 | Nano Research2015，8，4： | 4 |
| 7 | Oxygen vacancy enhanced biomimetic superoxide dismutase activity of CeO_(2)-Gd nanozymes显示文摘Cerium oxide-based nanozymes have recently drawn much attention in the field of biomedical and antioxidant applications,because of their unique regenerative or autocatalytic properties.Herein,we studied the biomimetic superoxide dismutase(SOD)nanozymes CeO_(2)-Gd that combines the fluorescence properties of rare earth Gd with the antioxidant properties of CeO_(2)nanoparticles,which was prepared via facile route.The structure and composition of the CeO_(2)-Gd were measured and verified by X-ray powder diffraction(XRD),Raman spectroscopy,transmission electron microscopy(TEM),energydispersive X-ray spectroscopy(EDX),and X-ray electron spectroscopy(XPS).Confocal microscopy was used to image cells.Antioxidant performance and cell viability of these nanozymes were measured in vitro using BGC-803 cell.CeO_(2)-Gd nanozymes with a higher Ce^(3+)/Ce^(4+)ratio show higher superoxide dismutase(SOD)mimetic activity.Their antioxidant activity and fluorescence properties of CeO_(2)-Gd in BGC-803 cancer cells are enhanced by oxygen vacancies generated by doping rare-earth elements Gd.This work may guide the future design of CeO_(2)-Gd-based biomimetic nanozymes for anticancer and antioxidant applications. | Xiangcheng Shi Jingjie Yang Xintong Wen Fuii Tian Changyan Li | 2021 | Journal of Rare Earths2021，39，9： | 4 |
| 8 | Differential mRNA expression profiling of oral squamous cell carcinoma by high-throughput RNA sequencing显示文摘Differentially expressed genes are thought to regulate the development and progression of oral squamous cell carcinomas(OSCC).The purpose of this study was to screen differentially expressed mRNAs in OSCC and matched paraneoplastic normal tissues,and to explore the intrinsic mechanism of OSCC development and progression.We obtained the differentially expressed mRNA expression profiles in 10 pairs of fresh-frozen OSCC tissue specimens and matched paraneoplastic normal tissue specimens by high-throughput RNA sequencing.By using Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analyses,the functional significance of the differentially expressed genes were analyzed.We identified 1,120 significantly up-regulated mRNAs and 178 significantly down-regulated mRNAs in OSCC,compared to normal tissue.The differentially expressed mRNAs were involved in 20 biological processes and 68 signal pathways.Compared to adjacent normal tissue,the expression of MAGEA11 was up-regulated;TCHH was down-regulated.These findings were verified by real-time PCR.These differentially expressed mRNAs may function as oncogenes or tumor suppressors in the development and progression of OSCC.This study provides novel insights into OSCC.However,further work is needed to determine if these differentially expressed mRNAs have potential roles as diagnostic biomarkers and candidate therapeutic targets for OSCC. | Liangyu Ge Siyu Liu Long Xie Lei Sang Changyan Ma Hongwei Li | 2015 | The Journal of Biomedical Research2015，29，5： | 4 |
| 9 | Synthesis and biological evaluation of 8-substituted and deglucuronidated scutellarin and baicalin analogues as antioxidant responsive element activators显示文摘Flavonoids are important bioactive dietary compounds, which are proved to be antioxidant responsive element (ARE) activators to defend against electrophilic toxicants and oxidative stress. The activators induce ARE gene transcription through Nrf2 factor, a major transcriptional stimulator of cytoprotective genes, relieved from a Keap1 complex. In this report, based on the structures of two flavonoids, scutellarin and baicalin, which are extracted from two common Chinese plants Dengzhanhua (Erigeron breviscapus (vant) Hand-Mazz) and Huangqin (Scutellaria baicalensis Georigi), respectively, we synthesized several 8-substituted and deglucuronidated analogues and identified the ARE activation effects of these flavonoids. We found that the Baicalin, deglucurnonidated Baicalin and diaza cyclopenta derivative were more active. Their dose-dependent upregulation activities of ARE and NQO1 and induction effects of Nrf2 were testified. The results presented that these three analogues had good upregulation effects on ARE, and they could be potentially utilized in relieving oxidative stress, upon further neuroprotective tests. | YANG Ping KONG XiangZhen CHENG ChangMei LI ChangYan YANG XiaoMing ZHAO Xing'E | 2011 | Science China Chemistry2011，54，10： | 3 |
| 10 | Models for calculating phreatic water evaporation on bare and Tamarix-vegetated lands显示文摘地下水是在干旱区域的自然植被的水消费的主要来源。由井的蒸发学习自然植被的生态的水需求是一条有效途径。为了学习生态的水, Tarim 河盆要求,基于以 Aksu 水平衡的赤裸的陆地上的井的蒸发的观察数据从 1989~1996 的试验性的车站由分析井的蒸发的关系,井的表面的深度和水的蒸发,拿限制井的蒸发的率作为控制条件,并且基于在水的井的蒸发和蒸发之间的关系是非线性的客观法律,我们建立当 pheratic 水平衰落就被土壤水分蒸发蒸腾损失总量从 2003 ~ 2004 在生长 Tamarix 的土地上引起时,根据井的表面和土壤潮湿的深度的数据,我们计算井的蒸发的数量并且在生长 Tamarix 的土地上为精明的井的蒸发建立模型。赤裸的土地和生长 Tamarix 的土地上的井的蒸发能被一个 Tamarix 植被变换系数互相转变。测试结果证明模型的计算精确性高,模型对 Tarim 河盆合适。 | HU Shunjun TIAN Changyan SONG Yudong CHEN Xiaobing LI Yuetan | 2006 | Chinese Science Bulletin2006，51，A01： | 3 |
| 11 | Characteristics of mineral elements in shoots of three annual halophytes in a saline desert, Northern Xinjiang显示文摘Halophytes are valuable salt-, alkali-and drought-resistant germplasm resources. However, the characteristics of mineral elements in halophytes have not been investigated as intensively as those in crops. This study attempted to investigate the characteristics of mineral elements for annual halophytes during their growth period to reveal their possible physiological mechanisms of salt resistance. By using three native annual halophytes (Salsola subcrassa, Suaeda acuminate and Petrosimonia sibirica) distributed in the desert in Northern Xinjiang of China, the dynamic changes in the mineral element contents of annual halophytes were analyzed through field sampling and laboratory analyses. The results demonstrated that the annual halophytes were able to absorb water and mineral nutrients selectively. In the interaction between the annual halophytes and saline soil, the adaptability of the annual halophytes was manifested as the accumulation of S, Na and Cl during the growth period and maintenance of water and salt balance in the plant, thus ensuring their selective absorption of N, P, K, Ca, Mg and other mineral nutrients according to their growth demand. By utilizing this property, halophyte planting and mowing (before the wilting and death periods) could bioremediate heavy saline-alkali soil. | Ke ZHANG ChunJian LI ZhongShao LI FuHai ZHANG ZhenYong ZHAO ChangYan TIAN | 2013 | Journal of Arid Land2013，5，2： | 3 |
| 12 | Uniform single atomic Cu_(1)-C_(4)sites anchored in graphdiyne for hydroxylation of benzene to phenol显示文摘For single-atom catalysts(SACs),the catalyst supports are not only anchors for single atoms,but also modulators for geometric and electronic structures,which determine their catalytic performance.Selecting an appropriate support to prepare SACs with uniform coordination environments is critical for achieving optimal performance and clarifying the relationship between the structure and the property of SACs.Approaching such a goal is still a significant challenge.Taking advantage of the strong d-πinteraction between Cu atoms and diacetylenic in a graphdiyne(GDY)support,we present an efficient and simple strategy for fabricating Cu single atoms anchored on GDY(Cu_(1)/GDY)with uniform Cu_(1)-C_(4)single sites under mild conditions.The Cu atomic structure was confirmed by combining synchrotron radiation X-ray absorption spectroscopy,X-ray photoele ctron spectroscopy and density functional theory(DFT)calculations.The as-prepared Cu1/GDY exhibits much higher activity than state-of-the-art SACs in direct benzene oxidation to phenol with H_(2)O_(2)reaction,with turnover frequency values of 251 h^(-1)at room temperature and 1889 h^(-1)at 60℃,respectively.Furthermore,even with a high benzene conversion of86%,high phenol sele ctivity(96%)is maintaine d,which can be ascribed to the hydrophobic and oleophyllic surface nature of Cu1/GDY for benzene adsorption and phenol desorption.Both experiments and DFT calculations indicate that Cu_(1)-C_(4)single sites are more effective at activating H_(2)O_(2)to form Cu=O bonds,which are important active intermediates for benzene oxidation to phenol. | Jia Yu Changyan Cao Hongqiang Jin Weiming Chen Qikai Shen Peipei Li Lirong Zheng Feng He Weiguo Song Yuliang Li | 2022 | National Science Review2022，9，9： | 3 |
| 13 | Theoretical analysis of the limiting rate of phreatic evaporation for aeolian sandy soil in Taklimakan Desert显示文摘Phreatic evaporation is a great lose for shallow groundwater in the Taklimakan Desert. Given soil type and groundwater table, the limiting rate of phreatic evaporation is defined as the maximum of water transferred from groundwater to soil surface per unit time, which is a key parameter and control condition for phreatic evaporation model developing. The soil water characteristic curve for the aeolian sandy soil in the Taklimakan Desert was fitted with the least square method based on the formula of soil moisture characteristics curve proposed by Van Genuchten, using observed soil moisture and soil water suction data. The unsaturated hydraulic conductivity was determined by the instantaneous profile method in situ and the calculation formula for unsaturated hydraulic conductivity was established. According to the steady flow theory, the quasi-analytical solution of limiting rate of phreatic evaporation was derived on the basis of generalization of the formula of unsaturated hydraulic conductivity. The results show that the soil moisture characteristics in the Taklimakan Desert can be well described by Van Genuchten’s formula, and the limiting rate of phreatic evaporation declines by power function with the descending of groundwater table. | HU ShunJun LEI JiaQiang XU XinWen SONG YuDong TIAN ChangYan CHEN XiaoBin LI XiuChang | 2008 | Chinese Science Bulletin2008，53，S2： | 2 |
| 14 | 3-epi-bufotalin suppresses the proliferation in colorectal cancer cells through the inhibition of the JAK1/STAT3 signaling pathway显示文摘Traditional Chinese medicine(TCM)has been increasingly employed in the last decades in China for both preventing and treating a variety of cancers.3-epi-bufotalin is an active ingredient of TCM“Chanpi”with anti-tumor potential.However,the effect and mechanism of 3-epi-bufotalin on colorectal cancers were not well disclosed.The present study demonstrated that 3-epi-bufotalin could reduce viability,trigger apoptosis,and block the cell cycle at the G2/M stage in colorectal cancer cell lines HT29,RKO,and COLO205 in vitro.Moreover,3-epi-bufotalin inhibited the JAK1/STAT3 signaling pathway.These results indicated the anti-proliferation ability of 3-epi-bufotalin in colorectal cancer cells. | SANHUA LI QINGHONG KONG XIAOKE ZHANG XINTING ZHU CHUNBO YU CHANGYAN YU NIAN JIANG JING HUI LINGJIE MENG YUN LIU | 2022 | BIOCELL2022，46，11： | 2 |
| 15 | A novel antibacterial biomaterial mesh coated by chitosan and tigecycline for pelvic floor repair and its biological performance显示文摘The biomaterials composed of mammalian extracellular matrix(ECM)have a great potential in pelvic floor tissue repair and functional reconstruction.However,bacterial infection does cause great damage to the repair function of biomaterials which is the major problem in clinical utilization.Therefore,the development of biological materials with antimicrobial effect is of great clinical significance for pelvic floor repair.Chitosan/tigecycline(CS/TGC)antibacterial biofilm was prepared by coating CS/TGC nanoparticles on mammalian-derived ECM.Infrared spectroscopy,scanning electron microscopy,bacteriostasis circle assay and static dialysis methods were used to characterize the membrane.MTS assay kit and DAPI fluorescence staining were used to evaluate cytotoxicity and cell adhesion.The biocompatibility was assessed by subabdominal implantation model in goats.Subcutaneous antimicrobial test in rabbit back was used to evaluate the antimicrobial and repairing effects on the infected wounds in vivo.Infrared spectroscopy showed that the composite coating had been successfully modified.The antibacterial membrane retained the main structure of ECM multilayer fibers.In vitro release of biomaterials showed sustained release and stability.In vivo studies showed that the antibacterial biological membrane had low cytotoxicity,fast degradation,good compatibility,anti-infection and excellent repair ability. | Changyan Liang You Ling Feng Wei Lijie Huang Xiaomao Li | 2020 | Regenerative Biomaterials2020，7，5： | 1 |
| 16 | Effect of Supports on the Gold Catalyst Activity for Catalytic Combustion of CO and HCHO显示文摘 | Meilin Jia Yuenian Shen Changyan Li Zhaorigetu Bao Shishan Sheng | 2005 | Catalysis Letters (-)2005，，3： | 1 |
| 17 | Effect of supports on the gold catalyst activity for catalytic combustion of CO and HCHO显示文摘 | Jia Meilin Shen Yuenian Li Changyan | 2005 | Catalysis Letters2005，99，34： | 1 |
| 18 | Na_(2)SO_(4)-NaCl binary eutectic salt roasting to enhance extraction of lithium from pyrometallurgical slag of spent lithium-ion batteries显示文摘Effectively extracting lithium at a relatively low temperature from the slag produced by the pyrometallurgical treatment of spent lithium-ion batteries remains a great challenge,which limits the acquirement of lithium.Herein,we proposed a eutectic system to roast slag at a lower temperature based on sodium sulfate-sodium chloride(Na_(2)SO_(4)-NaCl)binary eutectic salts.The optimal roasting conditions are as follows:the slag was roasted at 750℃with a(SO_(4)^(2-)+Cl^(-))/Li+molar ratio of 5:1 for 120 min.Followed by aqueous leaching 5 min at room temperature with a water/roasted samples mass ratio of 30:1,it can get 97.07%lithium extraction efficiency. | Hui Dang Zhidong Chang Xue Wu Sihang Ma Yifei Zhan Na Li Wenbo Liu Wenjun Li Hualei Zhou Changyan Sun | 2022 | Chinese Journal of Chemical Engineering2022，35，1： | 1 |
| 19 | Catalytic Combustion of Formaldehyde on Gold/Iron-Oxide Catalysts显示文摘 | Li Changyan Shen Yuenian Jia Meiling | 2008 | Catal Commun2008，9，3： | 1 |
| 20 | High-quality conductive polypyrrole within a secondary crosslinked interpenetrating polymer network显示文摘 | Yin Wusheng Liu Changyan Li Jun | 1997 | J Appl Polym Sci1997，65，1： | 1 |
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