|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Functional exhaustion of antiviral lymphocytes in COVID-19 patients显示文摘In December 2019,a novel coronavirus was first reported in Wuhan,China.1 It was named by the World Health Organization as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and is responsible for coronavirus disease 2019(COVID-19).Up to 28 February 2020,79,394 cases have been confirmed according to China’s National Health Commission.Outside China,the virus has spread rapidly to over 36 countries and territories. | Yuanhong Xuand Zhigang Tian Meijuan Zheng Yong Gao Gang Wang Guobin Song Siyu Liu Dandan Sun Yuanhong Xu Zhigang Tian | 2020 | Cellular & Molecular Immunology2020，17，5： | 54 |
| 2 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 3 | Fast and interpretable classification of small X-ray diffraction datasets using data augmentation and deep neural networks显示文摘X-ray diffraction(XRD)data acquisition and analysis is among the most time-consuming steps in the development cycle of novel thin-film materials.We propose a machine learning-enabled approach to predict crystallographic dimensionality and space group from a limited number of thin-film XRD patterns.We overcome the scarce data problem intrinsic to novel materials development by coupling a supervised machine learning approach with a model-agnostic,physics-informed data augmentation strategy using simulated data from the Inorganic Crystal Structure Database(ICSD)and experimental data.As a test case,115 thin-film metalhalides spanning three dimensionalities and seven space groups are synthesized and classified.After testing various algorithms,we develop and implement an all convolutional neural network,with cross-validated accuracies for dimensionality and space group classification of 93 and 89%,respectively.We propose average class activation maps,computed from a global average pooling layer,to allow high model interpretability by human experimentalists,elucidating the root causes of misclassification.Finally,we systematically evaluate the maximum XRD pattern step size(data acquisition rate)before loss of predictive accuracy occurs,and determine it to be 0.16°2θ,which enables an XRD pattern to be obtained and classified in 5.5 min or less. | Felipe Oviedo Zekun Ren Shijing Sun Charles Settens Zhe Liu Noor Titan Putri Hartono Savitha Ramasamy Brian L.DeCost Siyu I.P.Tian Giuseppe Romano Aaron Gilad Kusne Tonio Buonassisi | 2019 | npj Computational Materials2019，，1： | 15 |
| 4 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 5 | Recent Progress in the Fabrication, Properties, and Devices of Heterostructures Based on 2D Materials显示文摘With a large number of researches being conducted on two?dimen?sional(2D) materials, their unique properties in optics, electrics, mechanics, and magnetics have attracted increasing attention. Accordingly, the idea of combining distinct functional 2D materials into heterostructures naturally emerged that pro?vides unprecedented platforms for exploring new physics that are not accessible in a single 2D material or 3D heterostructures. Along with the rapid development of controllable, scalable, and programmed synthesis techniques of high?quality 2D heterostructures, various heterostructure devices with extraordinary performance have been designed and fabricated, including tunneling transistors, photodetectors, and spintronic devices. In this review, we present a summary of the latest progresses in fabrications, properties, and applications of di erent types of 2D heterostruc?tures, followed by the discussions on present challenges and perspectives of further investigations. | Yanping Liu Siyu Zhang Jun He Zhiming M.Wang Zongwen Liu | 2019 | Nano-Micro Letters2019，11，1： | 13 |
| 6 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 7 | S and Pb Isotopic Constraints on the Relationship between the Linong Granodiorite and the Yangla Copper Deposit,Yunnan,China显示文摘The Yangla copper deposit, located in western Yunnan Province, China, is a typical giant, newly started mining copper deposit with an estimated Cu reserves of about 1,200,000 tons. The deposit is spatially and temporally associated with the Linong granodiorite, which is rich in SiO2 (SiO2=58.25 wt%-69.84 wt%) and alkalis (Na2O+K2O=5.98 wt%-8.34 wt%), indicating an association with shoshonitic series to high-K calc-alkaline series granites, and shows low contents of TiO2 (0.35 wt%-0.48 wt%), MgO (1.51 wt%-1.72 wt%), and Al2O3 (13.38 wt%-19.75 wt%). The δ34S values of sulfides of the main ore stage from copper ores vary range from ?4.2‰ to ?0.9‰, indicating a much greater contribution from the mantle to the ore-forming fluids. The δ34S values of the late ore stage is 9.8‰, indicating enrichment of biogenic sulfur which may derive from the crustal hydrothermal fluid. The 208Pb/204Pb, 207Pb/204Pb and 206Pb/204Pb of sulfides of the main ore stage from copper ores range within 38.66-38.73, 15.71-15.74 and 18.35-19.04, respectively, implying that the Pb was derived from the mantle, with the crustal component, probably representing mixtures of mantle lead and crustal lead. Sulfide of the late ore stage in their Pb isotopic composition, 208Pb/204Pb= 38.69, 207Pb/204Pb=15.70, 206Pb/204Pb=18.35, implying that the Pb was derived from the crust. The Linong granodiorite is syn-collisional, produced by partial melting of thickened lower crust, which was triggered by the westward subduction of the Jinshajiang Oceanic plate. During a transition in geodynamic setting from collision-related compression to extension, gently dipping ductile shear zones (related to subduction) were transformed to brittle shear zones, consisting of a series of thrust faults in the Jinshajiang tectonic belt. The tensional thrust faults would have been a favorable environment for ore-forming fluids. The ascending magma provided a channel for the ore-forming fluid from the mantle wedge. After the magma arrived at the base of the early-stage Linong granodiorite, the platy granodiorite at the base of the body would have shielded the late-stage magma from the fluid. The magma would have cooled slowly, and some of the ore-forming fluid in the magma would have entered the gently dipping thrust faults near the Linong granodiorite, resulting in mineralization. | YANG Xi'an LIU Jiajun HAN Siyu WANG Huan CHEN Siyao | 2012 | Acta Geologica Sinica(English Edition)2012，86，6： | 9 |
| 8 | A New Perspective for Parkinson's Disease:Circadian Rhythm显示文摘Circadian rhythm is manifested by the behavioral and physiological changes from day to night,which is controlled by the pacemaker and its regulator. The former is located at the suprachiasmatic nuclei(SCN) in the anterior hypothalamus,while the latter is composed of clock genes present in all tissues. Circadian desynchronization influences normal patterns of day-night rhythms such as sleep and alertness cycles,rest and activity cycles.Parkinson's disease(PD) exhibits diurnal fluctuations.Circadian dysfunction has been observed in PD patients and animal models,which may result in negative consequences to the homeostasis and even exacerbate the disease progression. Therefore,circadian therapies,including light stimulation,physical activity,dietary and social schedules,may be helpful for PD patients. However,the cellular and molecular mechanisms that underlie the circadian dysfunction in PD remain elusive. Further research on circadian patterns is needed. This article summarizes the existing research on the circadian rhythms in PD,focusing on the clinical symptom variations,molecular changes,as well as the available treatment options. | Siyue Li Yali Wang Fen Wang Li-Fang Hu Chun-Feng Liu | 2017 | Neuroscience Bulletin2017，33，1： | 9 |
| 9 | Iron-group electrocatalysts for ambient nitrogen reduction reaction in aqueous media显示文摘Electrochemical nitrogen reduction reaction(NRR)is considered as an alternative to the industrial Haber-Bosch process for NH3 production due to both low energy consumption and environment friendliness.However,the major problem of electrochemical NRR is the unsatisfied efficiency and selectivity of electrocatalyst.As one group of the cheapest and most abundant transition metals,iron-group(Fe,Co,Ni and Cu)electrocatalysts show promising potential on cost and performance advantages as ideal substitute for traditional noble-metal catalysts.In this minireview,we summarize recent advances of iron-group-based materials(including their oxides,hydroxides,nitrides,sulfides and phosphides,etc.)as non-noble metal electrocatalysts towards ambient N2-to-NH3 conversion in aqueous media.Strategies to boost NRR performances and perspectives for future developments are discussed to provide guidance for the field of NRR studies. | Benyuan Ma Haitao Zhao Tingshuai Li Qian Liu Yongsong Luo Chengbo Li Siyu Lu Abdullah M.Asiri Dongwei Ma Xuping Sun | 2021 | Nano Research2021，14，3： | 8 |
| 10 | Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation显示文摘The lack of capability to quantify oxygen metabolism noninvasively impedes both fundamental investigation and clinical diagnosis of a wide spectrum of diseases including all the major blinding diseases such as age-related macular degeneration,diabetic retinopathy,and glaucoma.Using visible light optical coherence tomography(vis-OCT),we demonstrated accurate and robust measurement of retinal oxygen metabolic rate(rMRO2)noninvasively in rat eyes.We continuously monitored the regulatory response of oxygen consumption to a progressive hypoxic challenge.We found that both oxygen delivery,and rMRO2 increased from the highly regulated retinal circulation(RC)under hypoxia,by 0.2860.08 μL min(^-1)(p,0.001),and 0.2060.04 μL min(^-1)(p,0.001)per 100 mmHg systemic pO2 reduction,respectively.The increased oxygen extraction compensated for the deficient oxygen supply from the poorly regulated choroidal circulation.Results from an oxygen diffusion model based on previous oxygen electrode measurements corroborated our in vivo observations.We believe that vis-OCT has the potential to reveal the fundamental role of oxygen metabolism in various retinal diseases. | Ji Yi Wenzhong Liu Siyu Chen Vadim Backman Nader Sheibani Christine M.Sorenson Amani A.Fawzi Robert A.Linsenmeier Hao F.Zhang | 2015 | Light(Science & Applications)2015，4，1： | 8 |
| 11 | Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication,metabolite traits,and antiinflammatory effects显示文摘Foxtail millet(Setaria italica),which was domesticatedfromthewild speciesgreenfoxtail(Setaria viridis),isa richsource of phytonutrientsfor humans.To evaluate how breeding changed themetabolome offoxtail millet grains,we generated and analyzed the datasets encompassing the genomes,transcriptomes,metabolomes,and anti-inflammatory indices from 398 foxtail millet accessions.We identified hundreds of common variants that influence numerous secondary metabolites.We observed tremendous differences in natural variations of the metabolites and their underlying genetic architectures between distinct sub-groups of foxtail millet.Furthermore,we found that the selection of the gene alleles associated with yellow grains led to altered profiles of metabolites such as carotenoids and endogenous phytohormones.Using CRiSPR-mediated genome editing wevalidated the function of PHYTOENE SYNTHASE1(PSY1)gene in affecting milletgrain colorand quality.Interestingly,our in vitro cell inflammation assays showed that 83 metabolites in millet grains have anti-inflammatory effects.Taken together,ourmulti-omics study illustrates how the breeding history of foxtail millet has shaped its metabolite profile.The datasets we generated in this study also provide important resources for further understanding how millet grain quality is affected by different metabolites,laying the foundations for future millet genetic research and metabolome-assisted improvement. | Xukai Li Jianhua Gao Jingyi Song Kai Guo Siyu Hou Xingchun Wang Qiang He Yanyan Zhang Yakun Zhang Yulu Yang Jiaoyan Tang Hailang Wang Staffan Persson Mingquan Huang Lishuai Xu Linlin Zhong Dongqin Li Yongming Liu Hua Wu Xianmin Diao Peng Chen Xiaowen Wang Yuanhuai Han | 2022 | Molecular Plant2022，15，8： | 8 |
| 12 | Kilogram-scale synthesis of carbon quantum dots for hydrogen evolution, sensing and bioimaging显示文摘The development of large-scale synthetic methods for high quality carbon quantum dots(CQDs) is fundamental to their applications.However,the macroscopic preparation and scale up synthetic of CQDs is still in its infancy.Here,we report a facile,green,kilogram-scale synthesis of high quality fluorescent CQDs derived from poplar leaves via a one-step hydrothermal method.Notably,the throughput of CQDs can reach a level up to as high as 1.4975 kg in one pot.The structure and properties of the as-prepared CQDs were assessed through TEM,XRD,XPS and various spectroscopic methods.The obtained high quality CQD s with a photoluminescent quantum yield of 10.64% showed remarkable stability in aqueous media,rich functional groups,high photostability,consistent photoluminescence within biological pH range and low cytotoxicity.On account of these good properties,we demonstrated the multifunctional application to electrocatalytic water splitting,Fe^3+ sensing and bioimaging.It showed remarkable electrocatalytic activity,Fe^3+ sensitivity and good biocompatibility.This study provides a green,facile,inexpensive and large-scale method for producing high quality CQDs,which provides application value for large-scale production of CQDs. | Weidong Li Yuan Liu Boyang Wang Haoqiang Song Zhongyi Liu Siyu Lu Bai Yang | 2019 | Chinese Chemical Letters2019，30，12： | 7 |
| 13 | Interface electron collaborative migration of Co–Co3O4/carbon dots:Boosting the hydrolytic dehydrogenation of ammonia borane显示文摘Ammonia borane(AB)is an excellent candidate for the chemical storage of hydrogen.However,its practical utilization for hydrogen production is hindered by the need for expensive noble-metal-based catalysts.Herein,we report Co-Co3O4 nanoparticles(NPs)facilely deposited on carbon dots(CDs)as a highly efficient,robust,and noble-metal-free catalyst for the hydrolysis of AB.The incorporation of the multiinterfaces between Co,Co3O4 NPs,and CDs endows this hybrid material with excellent catalytic activity(rB=6816 mLH2 min^-1 gCo^-1)exceeding that of previous non-noble-metal NP systems and even that of some noble-metal NP systems.A further mechanistic study suggests that these interfacial interactions can affect the electronic structures of interfacial atoms and provide abundant adsorption sites for AB and water molecules,resulting in a low energy barrier for the activation of reactive molecules and thus substantial improvement of the catalytic rate. | Han Wu Min Wu Boyang Wang Xue Yong Yushan Liu Baojun Li Baozhong Liu Siyu Lu | 2020 | Journal of Energy Chemistry2020，29，9： | 7 |
| 14 | An Overview of Mineral Dust Modeling over East Asia显示文摘East Asian dust(EAD) exerts considerable impacts on the energy balance and climate/climate change of the earth system through its influence on solar and terrestrial radiation, cloud properties, and precipitation efficiency. Providing an accurate description of the life cycle and climate effects of EAD is therefore critical to better understanding of climate change and socioeconomic development in East Asia and even worldwide. Dust modeling has undergone substantial development since the late 1990 s, associated with improved understanding of the role of EAD in the earth system. Here, we review the achievements and progress made in recent decades in terms of dust modeling research,including dust emissions, long-range transport, radiative forcing(RF), and climate effects of dust particles over East Asia. Numerous efforts in dust/EAD modeling have been directed towards furnishing more sophisticated physical and chemical processes into the models on higher spatial resolutions. Meanwhile, more systematic observations and more advanced retrieval methods for instruments that address EAD related science issues have made it possible to evaluate model results and quantify the role of EAD in the earth system, and to further reduce the uncertainties in EAD simulations. Though much progress has been made, large discrepancies and knowledge gaps still exist among EAD simulations. The deficiencies and limitations that pertain to the performance of the EAD simulations referred to in the present study are also discussed. | Siyu CHEN Jianping HUANG Yun QIAN Chun ZHAO Litai KANG Ben YANG Yong WANG Yuzhi LIU Tiangang YUAN Tianhe WANG Xiaojun MA Guolong ZHANG | 2017 | Journal of Meteorological Research2017，31，4： | 7 |
| 15 | Repair of abnormal perfusion foci in idiopathic epilepsy patients under long-term antiepileptic treatment显示文摘Epileptic seizure control and the disappearance of epileptiform discharge are not indicative of the absence of abnormal perfusion foci.Perfusion abnormalities are a major cause of epileptic discharge,and the existence of abnormal perfusion foci implies possible relapse.Very little is known about perfusion abnormality repair in epilepsy.The present study selected 43 cases of idiopathic epilepsy under antiepileptic drug control for an average of 24 months.Comparisons between interictal single-photon emission CT(SPECT)images and long-term electroencephalogram(EEG)pre-and post-treatment showed that cases of normal SPECT increased by 48%(12/25)following treatment,with a total number of 15 reduced foci(36%,15/41).Perfusion foci,i.e.,region of interest,were altered following treatment.These changes included:normal to abnormal in 3 cases(7%,3/43;2 hyperperfusion and 1 hypoperfusion);abnormal to normal in 14 cases(32%,14/43;10 pre-treatment hypoperfusion and 4 hyperperfusion);abnormal to abnormal in 7 cases(16%,7/43;hyperperfusion to hypoperfusion in 5 cases,hypoperfusion to hyperperfusion in 2 cases).Long-term EEG revealed in an increase in the number of normal cases by 20(40%,20/39),and there were 25 fewer cases with epileptiform discharges(66%,25/38).These findings demonstrate that long-term control of anti-epileptic drugs partially repaired cerebral perfusion abnormalities and reduced epileptiform discharges in idiopathic epilepsy. | Weimin Wang Siyu Zhao Yaqing Liu | 2011 | Neural Regeneration Research2011，6，2： | 7 |
| 16 | Analysis of the Oldest Carbonate Gas Reservoir in China——New Geological Significance of the Dengying Gas Reservoir in the Weiyuan Structure, Sichuan Basin显示文摘The Weiyuan Structure is the largest surface structure in the Sichuan Basin. However, the abundance of the Dengying Formation gas reservoir in the Weiyuan Structure is low. The height of the gas column is 244 m, but the integrated abundance is only 26.4%. After nearly 40 years of exploration, the Gaoshi1 Well and Moxi8 Well yielded gas flows that marked an important exploration success after the discovery of the Sinian Dengying Formation gas reservoir in the Weiyuan Structure, Sichuan Basin, Lower-Paleozoic in 1964. Combined with research examples of oil and gas migration and gas chimneys around the world, the authors used comprehensive geological-geophysical-geochemical research methods to provide a reasonable explanation of the low abundance of the gas reservoir in the Weiyuan Structure based on the surface and subsurface data. The latest research results show that(1) currently, the Weiyuan Structure is the apex of the Dengying Formation in the Mid-Sichuan Basin. The Guang'an, Longnüsi, Gaoshiti-Moxi, and Weiyuan structures are a series of traps in the Dengying Formation with gradual uplifting spill and closure points during the regional uplift of the Himalayan period. The natural gas of the Dengying Formation accumulated in different ways over a wide range and long distance in the Sichuan Basin.(2) At approximately 40 Ma, the Weiyuan area started to uplift and form the present structure, and it is the only outcropped area with the Triassic Jialingjiang Formation and Leikoupo Formation in the surface of the Sichuan Basin(except the steep structural belt in East Sichuan). Caused by the uplift and denudation, the core of the Weiyuan Structure has formed an escaping 'skylight' for natural gas. The evidence of a gas chimney includes(1) the component percentage of non-hydrocarbon gas, which decreased from the bottom to the top,(2) the pressure coefficient is normal because the gas reservoir from the Upper Sinian to the Lower Permian commonly have a normal pressure coefficient(an average of 1.0), and(3) the isotope geochemistry of the argon mostly represents abiogenic characteristics of a deep source, and the 40 Ar/36 Ar ratio is as high as 2 855–5 222 in the Upper Permian. All of these characteristics provide sufficient evidence for a gas chimney effect. The characteristics of low abundance in the Weiyuan Structure can be a reference example for studying the late reconstruction of deep oil and gas reservoirs in the superimposed basins of western China. | Xiao Liang Shugen Liu Shubei Wang Bin Deng Siyu Zhou Wenxin Ma | 2019 | Journal of Earth Science2019，30，2： | 7 |
| 17 | Effect of organic amine alkali and inorganic alkali on benzotriazole removal during post Cu-CMP cleaning显示文摘Benzotriazole(BTA), an anticorrosion agent of slurry, is the main organic pollutant remaining after CMP of multilayer copper wiring, and also the main removal object of post CMP cleaning. The adsorption of BTA onto the copper could form a dense Cu-BTA film, which makes the copper surface strongly passivated. According to this characteristic, quantitative analysis of BTA residue after cleaning is carried out by contact angle measurement and electrochemical measurement in this paper. A scanning electron microscope(SEM) with EDX was used to observe and analyze the BTA shape and elements. The efficiencies of organic alkali and inorganic alkali on the removal of BTA were studied. The corresponding reaction mechanism was also analyzed. The results show that the adsorption structure of Cu(I)-BTA cannot be destroyed in an alkaline environment with a pH less than 10; the effect of BTA removal by inorganic alkali is worse than that of the organic amine alkali with the coordination structure under the same pH environment; the FA/O Ⅱ chelating agent with the fraction of 200 ppm can effectively remove BTA residue on the surface of copper wafer. | Liu Yang Baimei Tan Yuling Liu Baohong Gao Yilin Liu Chunyu Han Qi Wang Siyu Tian | 2018 | Journal of Semiconductors2018，39，12： | 6 |
| 18 | Valleytronics in transition metal dichalcogenides materials显示文摘Valley degree of freedom in the first Brillouin zone of Bloch electrons offers an innovative approach to information storage and quantum computation.Broken inversion symmetry together with the presence of time-reversal symmetry endows Bloch electrons non-zero Berry curvature and orbital magnetic moment,which contribute to the valley Hall effect and optical selection rules in valleytronics.Furthermore,the emerging transition metal dichalcogenides(TMDs)materials naturally become the ideal candidates for valleytronics research attributable to their novel structural,photonic and electronic properties,especially the direct bandgap and broken inversion symmetry in the monolayer.However,the mechanism of inter-valley relaxation remains ambiguous and the complicated manipulation of valley predominantly incumbers the realization of valleytronic devices.In this review,we systematically demonstrate the fundamental properties and tuning strategies(optical,electrical,magnetic and mechanical tuning)of valley degree of freedom,summarize the recent progress of TMD-based valleytronic devices.We also highlight the conclusion of present challenges as well as the perspective on the further investigations in valleytronics. | Yanping Liu Yuanji Gao Siyu Zhang Jun He Juan Yu Zongwen Liu | 2019 | Nano Research2019，12，11： | 6 |
| 19 | Porous LaFeO3 nanofiber with oxygen vacancies as an efficient electrocatalyst for N2 conversion to NH3 under ambient conditions显示文摘Electrocatalytic N2 reduction to NH3 under ambient conditions is an eco-friendly and sustainable alternative to the traditional Haber-Bosch process. However, inhibited by the high activation barrier of N2, this process needs efficient electrocatalysts to adsorb and activate the N2, enabling the N2 reduction reaction(NRR). Herein, we report that porous LaFeO3 nanofiber with oxygen vacancies acts as an efficient NRR electrocatalyst with abundant active sites to enhance the adsorption and activation of N2. When tested in 0.1 M HCl, such electrocatalyst achieves a high Faradaic efficiency of 8.77% and a large NH3 yield rate of 18.59 μg h–1 mgcat–1.at-0.55 V versus reversible hydrogen electrode. This catalyst also shows high long-term electrochemical stability and excellent selectivity for NH3 formation. Density functional theory calculations reveal that, by introducing oxygen vacancy on LaFeO3, the subsurface metallic ions are exposed with newly localized electronic states near the Fermi level, which facilitates the adsorption and activation of N2 molecules as well as the subsequent hydrogenation reactions. | Chengbo Li Dongwei Ma Shiyong Mou Yongsong Luo Benyuan Ma Siyu Lu Guanwei Cui Quan Li Qian Liu Xuping Sun | 2020 | Journal of Energy Chemistry2020，29，11： | 6 |
| 20 | Room temperature ferromagnetism in ultra-thin van der Waals crystals of 1T-CrTe2显示文摘Although many emerging new phenomena have been unraveled in two dimensional(2D)materials with long-range spin orderings,the usually low critical temperature in van der Waals(vdW)magnetic material has thus far hindered the related practical applications.Here,we show that ferromagnetism can hold above 300 K in a metallic phase of 1T-CrTe2 down to the ultra-thin limit.It thus makes CrTe2 so far the only known exfoliated ultra-thin vdW magnets with intrinsic long-range magnetic ordering above room temperature.An in-plane room-temperature negative anisotropic magnetoresistance(AMR)was obtained in ultra-thin CrTe2 devices,with a sign change in the AMR at lower temperature,with−0.6%and+5%at 300 and 10 K,respectively.Our findings provide insights into magnetism in ultra-thin CrTe2,expanding the vdW crystals toolbox for future room-temperature spintronic applications. | Xingdan Sun Wanying Li Xiao Wang Qi Sui Tongyao Zhang Zhi Wang Long Liu Da Li Shun Feng Siyu Zhong Hanwen Wang Vincent Bouchiat Manuel Nunez Regueiro Nicolas Rougemaille Johann Coraux Anike Purbawati Abdellali Hadj-Azzem Zhenhua Wang Baojuan Dong Xing Wu Teng Yang Guoqiang Yu Bingwu Wang Zheng Han Xiufeng Han Zhidong Zhang | 2020 | Nano Research2020，13，12： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员