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| 1 | Tribenuron-Methyl Induces Male Sterility through Anther-Specific Inhibition of Acetolactate Synthase Leading to Autophagic Cell Death显示文摘Tribenuron 甲基(TM ) 是禁止分支链的强大的 sulfonylurea 除草剂由指向 acetolactate synthase (ALS ) 的催化子单元(CSR1 ) 的氨基酸(BCAA ) 生合成。由在低剂量的 TM 的叶的喷洒的男绝育的选择正式就职广泛地在油菜籽(Brassica 马来麝) 为混合种子生产被使用了;然而,内在的机制仍然保持未知。这里,我们 reportgreater TM 累积和在花药的 BCAA 饥饿比在在 TM 申请以后的叶子和茎。csr1-1D (aCSR1 异种) 的组成或花药特定的表示消除了花药选择的 ALS 抑制并且在油菜籽和 Arabidopsis 颠倒了导致 TM 的男无菌的显型。TM 涂抹茎实验的结果,在叶肉或韧皮部由 TM 新陈代谢基因 Bel 的指向的表示在导致 TM 的男绝育的花药和回复与很少 TM 累积的观察结合了,建议叶水花的 TM 通过叶肉和韧皮部主要对花药极运输。显微镜学和 immunoblotting 揭示了那 autophagy,在房间死亡期间导致的一个体积降级过程,在导致 TM 的男无菌的花药并且由被提高花药特定 ALS 击倒。而且,导致 TM 的花粉流产被 autophagy 禁止者 3 麻省显著地禁止。这些数据最终建议 TM 对花药极运输,导致经由花药特定的 ALS 抑制的 BCAA 饥饿并且,,在花药的 autophagic 房间死亡。 | Lun Zhao Xue Jing Li Chen Yingjun Liu Yanan Su Tingting Liu Changbin Gao Bin Yi Jing Wen Chaozhi Ma Jinxing Tu Jitao Zou Tingdong Fu Jinxiong Shen | 2015 | Molecular Plant2015，8，12： | 7 |
| 2 | Studies on pathogen of explosive epidemic disease of shrimp Ⅱ. Purification of pathogen显示文摘 | Wang Jinxing, Liu Changbin, Zhang Hongwei, Zhao Shuangyi, Zhang Yanjun and Zhao Jing (College of Life Sciences, Shandong University, Jinan 250100, China) | 1998 | Acta Oceanologica Sinica1998，17，4： | 3 |
| 3 | Wheat speciation and adaptation:perspectives from reticulate evolution显示文摘Reticulate evolution through the interchanging of genetic components across organisms can impact significantly on the fitness and adaptation of species.Bread wheat(Triticum aestivum subsp.aestivum)is one of the most important crops in the world.Allopolyploid speci ation,frequent hybridization,extensive introgression,and occasional horizontal gene transfer(HGT)have been shaping a typical paradigm of reticulate evolution in bread wheat and its wild relatives,which is likely to have a sub-stantial influence on phenotypic traits and environmental adaptability of bread wheat.In this review,we outlined the evolutionary history of bread wheat and its wild relatives with a highlight on the interspecific hybridization events,demonstrating the reticulate relationship between species/sub-species in the genera Triticum and Aegilops.Furthermore,we discussed the genetic mechanisms and evolutionary significance underlying the introgression of bread wheat and its wild relatives.An in-depth understanding of the evolutionary process of Triticum species should be beneficial to future genetic study and breeding of bread wheat. | Xuebo Zhao Xiangdong Fu Changbin Yin Fei Lu | 2021 | aBIOTECH2021，2，4： | 2 |
| 4 | Microarray Analysis of Gene Expression Involved in Anther Development in rice (Oryza sativa L.)显示文摘 | Zhen Wang Yu Liang Chijun Li Yunyuan Xu Lefu Lan Dazhong Zhao Changbin Chen Zhihong Xu Yongbiao Xue Kang Chong | 2005 | Plant Molecular Biology2005，，5： | 1 |
| 5 | Microarray Analysis of Gene Expression Involved in Anther Development in rice (Oryza sativa L.)显示文摘 | Zhen Wang Yu Liang Chijun Li Yunyuan Xu Lefu Lan Dazhong Zhao Changbin Chen Zhihong Xu Yongbiao Xue Kang Chong | 2005 | Plant Molecular Biology2005，，5： | 1 |
| 6 | Nano-sized Ag rather than single-atom Ag determines CO oxidation activity and stability显示文摘Single-atom catalysis recently attracts great attentions,however,whether single atom or their nanoparticle(NP)has the advantage in its intrinsic activity remains under heated debate.Ag/Al_(2)O_(3) is a widely used catalyst for many catalytic reactions,while the effect of Ag particle size on the actity is seldom investigated due to the great difficulty in synthesizing single atom Ag and Ag clusters/particles with different sizes.Herein,we firstly prepared an atomically dispersed Ag/Al_(2)O_(3) catalyst using a nano-sized y-Al_(2)O_(3) as the support,subsequently obtained a series of Ag/Al_(2)O_(3) catalysts with different Ag particle sizes by H_(2) reducing single-atom Ag/Al_(2)O_(3) catalyst at various temperatures.The Ag/Al_(2)O_(3) treated at 600℃demonstrated superior CO oxidation performance over single-atom Ag/Al_(2)O_(3) and the Ag/Al_(2)O_(3) treated at 400 and 800℃.Based on experimental data and dpnsity functional theory(DFT)calculation results,we reveal that the larger Ag°particle is beneficial to oxygen activation and improves the valence stability during oxidation reaction,while the aggregation of Ag°particle also accordingly decreases the concentration of surface active sites,hence,there is an optimum Ag0 particle size.Our findings clearly confirm that Ag0nanoparticle has the advantage over single-atom Ag species in its intrinsic activity for CO oxidation. | Fei Wang Zhao Li Honghong Wang Min Chen Changbin Zhang Ping Ning Hong He | 2022 | Nano Research2022，15，1： | 1 |
| 7 | Arsenic trioxide depletes cancer stem-like cells and inhibits repopulation of neurosphere derived from glioblastoma by downregulation of Notch pathway显示文摘 | Jianing Wu Zhiyong Ji Huailei Liu Yaohua Liu Dayong Han Chen Shi Changbin Shi Chunlei Wang Guang Yang Xiaofeng Chen Chen Shen Huadong Li Yunke Bi Dongzhi Zhang Shiguang Zhao | 2013 | Toxicology Letters2013，，1： | 1 |
| 8 | Role of nuclear factor-κB, reactive oxygen species and cellular signaling in the early phase of acute pancreatitis显示文摘 | Changbin Shi Xia Zhao Xiangdong Wang Roland Andersson | 2005 | Scandinavian Journal of Gastroenterology2005，，1： | 1 |
| 9 | Alterations of Adhesion Molecule Expression and Inflammatory Mediators in Acute Lung Injury Induced by Septic and Non-septic Challenges显示文摘 | Xia Zhao Marwan Dib Ellen Andersson Changbin Shi Bengt Widegren Xiangdong Wang Roland Andersson | 2005 | Lung2005，，2： | 1 |
| 10 | Genetic dissection of top three leaf traits in rice using progenies from a japonica × indica cross显示文摘The size of the top three leaves of rice plants is strongly associated with yield; thus, it is important to consider quantitative traits representing leaf size(e.g.,length and width) when breeding novel rice varieties.It is challenging to measure such traits on a large scale in the field, and little is known about the genetic factors that determine the size of the top three leaves. In the present study, a population of recombinant inbred lines(RILs) and reciprocal single chromosomal segment substitution lines(SSSLs) derived from the progeny of a japonica Asominori ? indica IR24 cross were grown under four diverse environmental conditions. Six morphological traits associated with leaf size were measured,namely length and width of the flag, second and third leaves. In the RIL population, 49 QTLs were identified that clustered in 30 genomic region. Twenty-three of these QTLs were confirmed in the SSSL population. A comparison with previously reported genes/QTLs revealed eight novel genomic regions that contained uncharacterized ORFs associated with leaf size. The QTLs identified in this study can be used for markerassisted breeding and for fine mapping of novel genetic elements controlling leaf size in rice. | Changbin Yin Huihui Li Zhigang Zhao Zhiquan Wang Shijia Liu Liangming Chen Xi Liu Yunlu Tian Juan Ma Lidong Xu Dashuang Zhang Susong Zhu Danting Li Jianmin Wan Jiankang Wang | 2017 | Journal of Integrative Plant Biology2017，59，12： | 1 |
| 11 | Alterations of Adhesion Molecule Expression and Inflammatory Mediators in Acute Lung Injury Induced by Septic and Non-septic Challenges显示文摘 | Xia Zhao Marwan Dib Ellen Andersson Changbin Shi Bengt Widegren Xiangdong Wang Roland Andersson | 2005 | Lung2005，，2： | 1 |
| 12 | Microarray Analysis of Gene Expression Involved in Anther Development in rice (Oryza sativa L.)显示文摘 | Zhen Wang Yu Liang Chijun Li Yunyuan Xu Lefu Lan Dazhong Zhao Changbin Chen Zhihong Xu Yongbiao Xue Kang Chong | 2005 | Plant Molecular Biology2005，，5： | 1 |
| 13 | Effect of As2O3 on cell cycle progression and cyclins D1 and B1 expressionin two glioblastoma cell lines differing in p53 status显示文摘 | Shiguang Zhao Takahiro Tsuchida Katsuhiro Kawakami Changbin Shi Keiji Kawamoto | 2002 | International Journal of Oncology2002，，1： | 1 |
| 14 | Spatiotemporal variations in surface albedo during the ablation season and linkages with the annual mass balance on Muz Taw Glacier,Altai Mountains显示文摘Melt-albedo feedback on glaciers is recognized as important processes for understanding glacier behavior and its sensitivity to climate change.This study selected the Muz Taw Glacier in the Altai Mountains to investigate the spatiotemporal variations in albedo and their linkages with mass balance,which will improve our knowledge of the recent acceleration of regional glacier shrinkage.Based on the Landsat-derived albedo,the spatial distribution of ablation-period albedo was characterized by a general increase with elevation,and significant east–west differences at the same elevation.The gap-filling MODIS values captured a nonsignificant negative trend of mean ablation-period albedo since 2000,with a total decrease of approximately 4.2%.From May to September,glacier-wide albedo exhibited pronounced V-shaped seasonal variability.A significant decrease in annual minimum albedo was found from 2000 to 2021,with the rate of approximately−0.30%yr−1 at the 99%confidence level.The bivariate relationship demonstrated that the change of ablation-period albedo explained 82%of the annual mass-balance variability.We applied the albedo method to estimate annual mass balance over the period 2000–2015.Combined with observed values,the average mass balance was−0.82±0.32 m w.e.yr−1 between 2000 and 2020,with accelerated mass loss. | Xiaoying Yue Zhongqin Li Feiteng Wang Jun Zhao Huilin Li Changbin Bai | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
| 15 | Scientific objectives and payload configuration of the Chang’E-7 mission显示文摘As the cornerstone mission of the fourth phase of the Chinese Lunar Exploration Program,Chang’E-7(CE-7)was officially approved,and implementation started in 2022,including a main probe and a communication relay satellite.The main probe,consisting of an orbiter,a lander,a rover and a mini-flying probe,is scheduled to be launched in 2026.The lander will land on Shackleton crater’s illuminated rim near the lunar south pole,along with the rover and mini-flying probe.The relay satellite(named Queqiao-2)will be launched in February 2024 as an independent mission to support relay communication during scientific exploration undertaken by Chang’E-4,the upcoming Chang’E-6 in 2024 and subsequent lunar missions.The CE-7 mission is mainly aimed at scientific and resource exploration of the lunar south pole.We present CE-7’s scientific objectives,the scientific payloads configuration and the main functions for each scientific payload with its key technical specifications. | Chi Wang Yingzhuo Jia Changbin Xue Yangting Lin Jianzhong Liu Xiaohui Fu Lin Xu Yun Huang Yufen Zhao Yigang Xu Rui Gao Yong Wei Yuhua Tang Dengyun Yu Yongliao Zou | 2024 | National Science Review2024，11，2： | 0 |
| 16 | Organic single crystal phototransistors:Recent approaches and achievements显示文摘Organic phototransistors(OPTs),compared to traditional inorganic counterparts,have attracted a great deal of interest because of their inherent flexibility,light-weight,easy and low-cost fabrication,and are considered as potential candidates for next-generation wearable electronics.Currently,significant advances have been made in OPTs with the development of new organic semiconductors and optimization of device fabrication protocols.Among various types of OPTs,small molecule organic single crystal phototransistors(OSCPTs)standout because of their exciting features,such as long exciton diffusion length and high charge carrier mobility relative to organic thinfilm phototransistors.In this review,a brief introduction to device architectures,working mechanisms and figure of merits for OPTs is presented.We then overview recent approaches employed and achievements made for the development of OSCPTs.Finally,we spotlight potential future directions to tackle the existing challenges in this field and accelerate the advancement of OSCPTs towards practical applications. | Changbin Zhao Muhammad Umair Ali Jiaoyi Ning Hong Meng | 2021 | Frontiers of physics2021，16，4： | 0 |
| 17 | Retrospective case-analysis of the magnetic resonance imaging characteristics in the brain of patients with Wilson disease显示文摘BACKGROUND: Wilson disease (WD) damages liver, brain, kidney, cornea and nervous system severely. It is manifested in four ways: brain, liver, kidney and bone muscle. Whether or not magnetic resonance imaging (MRI) can clearly display the diseased region and range in brain of patient with WD, which provides imageological evidence for clinical practice, is unclear. OBJECTIVE: To observe the characteristics of MRI of brain in patient with SD, and analyze the correlation of diseased region with clinical symptoms. DESIGN: Retrospective case-analysis. SETTING: Department of Radiology, Second Hospital Affiliated to the General Hospital of Chinese PLA. PARTICIPANTS: Thirty-one patients, including 18 males and 13 females, with WD admitted to the Department of Neurology, Second Hospital Affiliated to the General Hospital of Chinese PLA between January 1999 and December 2005 were retrieved. The involved patients presented serum copper oxidase(sCP) activity decreasing and/or ceruloplasmin level decreasing and /or urinary copper content increasing; typical extrapyramidal symptoms and/or physical sign; abnormality showed by slit-lamp examination, Kayser-Fleischer ring positive. METHODS: ① All the involved patients underwent MRI examination. A GE 1.5T imaging equipment was used. Spin-echo sequence was adopted to perform T2 and T1 -weighed image at transverse axis level. Partial cases subjected to head scanning at coronal and/or sagittal level. Gd-DTPA with dosage of 0.1 mmol/kg was the strongest in 4 cases. ② MRI characteristics of patients with different clinical symptoms were observed. MAIN OUTCOME MEASURES: MRI detection results of patients with WD and MRI characteristics of patients with different clinical symptoms. RESULTS: Thirty-one patients with WD participated in the result analysis. ① Imageological examination results: WD involved many regions in the brain: dorsal caudate putamen (n =28), thalamencephalon(n =25), mesencephalon (n =25), globus pallidus (n =23), pons(n =21), posterior limb of internal capsule (n =16), dentate nucleus(n =16), caudate nucleus(n =15) and cerebral cortex (n =11). MRI presented hypo-intensity signal on T2 - weighted image and T1 -weighted image or isointensity signal on T1 -weighted image in 24 patients, characteristic hypo-intensity signal of globus pallidus in 4 patients, mixed signal of hyper- and hypo-intensity in 2 patients, hypo-intensity signal of globus pallidus, pars anterior pedunculi cerebri and pontine tegmentum on T1 - weighted image in 1 patient. Pathological changes distributed in symmetry and focus of infection mostly presented mottling, lamellar or strip. Different degrees of cerebral cortex atrophy, especially subtentorial cerebellar atrophy, were found in 20 patients. Four patients subjected to enhancement scanning, but no clear imaging was found. ③MRI characteristics of patients with different symptoms: Abnormal signal of dorsal caudate putamen was found in 28 patients with dystonia, 21 patients with dysarthria and 16 patients with bradykinesia; Abnormal signal of mesencephalon was found in 22 patients with trepidation, among which, 18 presented abnormal signal of pons; Abnormal signal of caudate nucleus and lenticular nucleus was found in 15 patients with dysphagia; Abnormal signal of dentate nucleus was found in 16 patients with cerebellar ataxia; Different degrees of changes in cerebral atrophy were found in 14 patients with deteriorating memory and dementia. CONCLUSION: MRI can clearly display the characteristics of diseased regions in brain of patient with WD. Diseased regions reflected by MRI have obvious differences in patients with different clinical neurosigns. | Hong Li Kun You Baoming He Jiagui Su Jian Hong Changbin Quan Min Zhao | 2006 | Neural Regeneration Research2006，1，6： | 0 |
| 18 | Hysteresis-Free, High-Performance Polymer-Dielectric Organic Field-Effect Transistors Enabled by Supercritical Fluid显示文摘Organic field-effect transistors(OFETs)are of the core units in organic electronic circuits,and the performance of OFETs replies critically on the properties of their dielectric layers.Owing to the intrinsic flexibility and natural compatibility with other organic components,organic polymers,such as poly(vinyl alcohol)(PVA),have emerged as highly interesting dielectric materials for OFETs.However,unsatisfactory issues,such as hysteresis,high subthreshold swing,and low effective carrier mobility,still considerably limit the practical applications of the polymer-dielectric OFETs for high-speed,low-voltage flexible organic circuits.This work develops a new approach of using supercritical CO_(2) fluid(SCCO_(2))treatment on PVA dielectrics to achieve remarkably high-performance polymer-dielectric OFETs.The SCCO_(2) treatment is able to completely eliminate the hysteresis in the transfer characteristics of OFETs,and it can also significantly reduce the device subthreshold slope to 0._(2)5 V/dec and enhance the saturation regime carrier mobility to 30.2 cm^(2) V^(-1) s^(-1),of which both the numbers are remarkable for flexible polymer-dielectric OFETs.It is further demonstrated that,coupling with an organic light-emitting diode(OLED),the SCCO_(2)-treated OFET is able to function very well under fast switching speed,which indicates that an excellent switching behavior of polymer-dielectric OFETs can be enabled by this SCCO_(2) approach.Considering the broad and essential applications of OFETs,we envision that this SCCO_(2) technology will have a very broad spectrum of applications for organic electronics,especially for high refresh rate and low-voltage flexible display devices. | Yuhao Shi Yingkai Zheng Jialiang Wang Ran Zhao Tao Wang Changbin Zhao Kuan-Chang Chang Hong Meng Xinwei Wang | 2020 | Research2020，，1： | 0 |
| 19 | Isothianaphthene diimide: an air-stable n-type semiconductor显示文摘Herein,we propose a new strategy to develop air-stable n-type organic semiconductors with non-classical thiophene aromatic diimide derivatives by replacing aromatic naphthalene with a heteroaromatic isothianaphthene core.We designed and successfully synthesized the isothianaphthene core based diimide material,N,N′-bis(n-hexyl)isothianaphthene-2,3,6,7-tetracarboxylic acid diimide(BTDI-C6)as an n-type semiconductor.Compared to N,N′-bis(n-hexyl)naphthalene-1,4,5,8-tetracarboxylic acid diimide(NDI-C6),BTDI-C6 possesses a deeper LUMO energy level of-4.21 eV,which is 0.32 eV lower than that of NDI-C6.Both molecular modelling and experimental results elucidated that organic thin film transistors(OTFTs)based on both of these materials exhibit comparable mobilities;however,the threshold voltage of BTDI-C6 based device(+7.5 V)is significantly lower than that of NDI-C6 based counterpart(+34V).Moreover,the low-lying LUMO energy level of BTDI-C6 ensures excellent air-stability which is further validated by the device performance.In addition,BTDI-C6 shows high luminescence while NDI-C6 is not luminescent at all in solution,which reveals the potential application of our newly synthesized material in n-type light-emitting transistors. | Xiaolong Chen Yaowu He Muhammad Umair Ali Yu He Yanan Zhu Aiyuan Li Changbin Zhao Igor FPerepichka Hong Meng | 2019 | Science China Chemistry2019，62，10： | 0 |
| 20 | High expression of BCL6 inhibits the differentiation and development of hematopoietic stem cells and affects the growth and development of chickens显示文摘Background:B-cell CLL/lymphoma 6(BCL6)is a transcriptional master regulator that represses more than 1200 potential target genes.Our previous study showed that a decline in blood production in runting and stunting syndrome(RSS)affected sex-linked dwarf(SLD)chickens compared to SLD chickens.However,the association between BCL6 gene and hematopoietic function remains unknown in chickens.Methods:In this study,we used RSS affected SLD(RSS-SLD)chickens,SLD chickens and normal chickens as research object and overexpression of BCL6 in hematopoietic stem cells(HSCs),to investigate the effect of the BCL6 on differentiation and development of HSCs.Results:The results showed that comparison of RSS-SLD chickens with SLD chickens,the BCL6 was highly expressed in RSS-SLD chickens bone marrow.The bone marrow of RSS-SLD chickens was exhausted and red bone marrow was largely replaced by yellow bone marrow,bone density was reduced,and the levels of immature erythrocytes in peripheral blood were increased.At the same time,the hematopoietic function of HSCs decreased in RSS-SLD chickens,which was manifested by a decrease in the hematopoietic growth factors(HGFs)EPO,SCF,TPO,and IL-3,as well as hemoglobinα1 and hemoglobinβexpression.Moreover,mitochondrial function in the HSCs of RSS-SLD chickens was damaged,including an increase in ROS production,decrease in ATP concentration,and decrease in mitochondrial membrane potential(ΔΨm).The same results were also observed in SLD chickens compared with normal chickens;however,the symptoms were more serious in RSS-SLD chickens.Additionally,after overexpression of the BCL6 in primary HSCs,the secretion of HGFs(EPO,SCF,TPO and IL-3)was inhibited and the expression of hemoglobinα1 and hemoglobinβwas decreased.However,cell proliferation was accelerated,apoptosis was inhibited,and the HSCs entered a cancerous state.The function of mitochondria was also abnormal,ROS production was decreased,and ATP concentration andΔΨm were increased,which was related to the inhibition of apoptosis of stem cells.Conclusions:Taken together,we conclude that the high expression of BCL6 inhibits the differentiation and development of HSCs by affecting mitochondrial function,resulting in impaired growth and development of chickens.Moreover,the abnormal expression of BCL6 might be a cause of the clinical manifestations of chicken comb,pale skin,stunted growth and development,and the tendency to appear RSS in SLD chickens. | Hongmei Li Bowen Hu Shang Hu Wen Luo Donglei Sun Minmin Yang Zhiying Liao Haohui Wei Changbin Zhao Dajian Li Meiqing Shi Qingbin Luo Dexiang Zhang Qinghua Nie Xiquan Zhang | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 0 |
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