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| 1 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 2 | Human mesenchymal stem cells from the umbilical cord matrix: Successful isolation and ex vivo expansion using serum‐/xeno‐free culture media显示文摘 | Irina N. Sim?es Joana S. Boura Francisco dos Santos Pedro Z. Andrade Carla M. P. Cardoso Jeffrey M. Gimble Cláudia L. da Silva Joaquim M. S. Cabral | 2013 | Biotechnology Journal2013，，4： | 1 |
| 3 | Rapid decontamination of gutta-percha cones with sodium hypochlorite显示文摘 | Cardoso CL Kotaka CR Redmerski R | 1999 | J Endod1999，25，7： | 1 |
| 4 | Clinical concepts of dry socket显示文摘 | Cardoso CL Rodrigues MT Ferreira Jfinior O | 2010 | J Oral Maxillofac Surg2010，68，8： | 1 |
| 5 | Effect of exercise performed during hemodialysis: strength versus aerobic 显示文摘 | de Lima MC Cicotoste CL Cardoso KS | 2013 | Ren Fail2013，35，5： | 1 |
| 6 | Clinicalconcepts of dry socket显示文摘 | Cardoso CL Rodrigues MT Ferreira Júnior O | 2010 | J Oral Maxillofac Surg2010，68，8： | 1 |
| 7 | White coat effect is not associated with additional increase of target organ damage in true resistant hypertension显示文摘 | Valéria Nasser Figueiredo Luiz Cláudio Martins Leandro Boer-Martins Ana Paula Cabral de Faria Carolina de Haro Moraes Rodrigo Cardoso Santos Armando R. Nogueira Heitor Moreno | 2012 | Medicina Clinica2012，，： | 1 |
| 8 | Real-time PCR versus conventional PCR for malaria parasite detection in low-grade parasitemia显示文摘 | Bianca E. Gama Felipe do E.S. Silva-Pires Mauro N’Kruman R. Lopes Maria Angélica B. Cardoso Constan?a Britto Kátia L. Torres Leila de Mendon?a Lima José Maria de Souza Cláudio T. Daniel-Ribeiro Maria de Fátima Ferreira-da-Cruz | 2007 | Experimental Parasitology2007，，4： | 1 |
| 9 | Rapid decontamination of gutta-percha cones with sodium hypochlorite 显示文摘 | Cardoso CL Kotaka CR Redmersik R | 1999 | Endod1999，25，7： | 1 |
| 10 | Nuclear 13- catenin in basal cell adenomas显示文摘 | do Prado RF Cardoso CL Consolaro A | 2007 | Intl J Surg Pathol2007，15，2： | 1 |
| 11 | Macroscopic and microscopic study of tissue response to oral antiseptics and its influence on carcinigenesis显示文摘 | Cardoso CL Prado RF Taveira LA | 2005 | J Appl Oral Sci2005，13，3： | 1 |
| 12 | Essential oil of Croton zehntneri and its major constituent anethole display gastroprotective effect by increasing the surface mucous layer显示文摘 | Andrelina N. Coelho‐de‐Souza Saad Lahlou Jo?o E.F. Barreto Maria E.M. Yum Ariclécio C. Oliveira Hermógenes D. Oliveira Nathalia R. Celed?nio Roney G.F. Feitosa Gloria P. Duarte Cláudia F. Santos Aline A.C. de Albuquerque José H. Leal‐Cardoso | 2012 | Fundamental & Clinical Pharmacology2012，，3： | 1 |
| 13 | Clinical concepts of dry socket显示文摘 | Cardoso CL Rodrigues MT Ferreira Junior O | 2010 | J Oral Maxillofac Surg2010，68，8： | 1 |
| 14 | Mitochondrial function is differentially affected upon oxidative stress显示文摘 | Sandra Morais Cardoso Cláudia Pereira Catarina Resende Oliveira | 1998 | Free Radical Biology and Medicine1998，，1： | 1 |
| 15 | Preliminary evaluation of adherence on abiotic and cellular surfaces of Acinetobacter baumannii strains isolated from catheter tips 显示文摘 | Costa GF Tognim MC Cardoso CL | 2006 | BrazJ Infect Dis2006，10，5： | 1 |
| 16 | Association Between Physical Activity Levels and Common Mental Disorder Among Physical Education Students of a Public University in the State of Bahia显示文摘 | Angelo Miguel Santos Maciel Elizandra Bezerra Almeida Edimara Bezerra Almeida Valmir Batista Neves Filho Cláudio Pinto Nunes Berta Leni Costa Cardoso | 2018 | US-China Education Review(B)2018，8，1： | 0 |
| 17 | Systemic mastocytosis: A rare cause of non-cirrhotic portal hypertension显示文摘Mastocytosis is a clonal neoplastic disorder of the mast cells(MC) that can be limited to the skin(cutaneous mastocytosis) or involve one or more extracutaneous organs(systemic mastocytosis). The clinical manifestations of mastocytosis are heterogeneous ranging from indolent disease with a long-term survival to a highly aggressive neoplasm with survival of about 6 mo. Although liver involvement in aggressive systemic mastocytosis(ASM) is relatively common, the development of portal hypertension with or without cirrhosis is rare. We report a case of ASM without skin involvement in a 72-year-old caucasian male who presented with non-cirrhotic portal hypertension based on clinical, analytical, imagiological and endoscopic findings. Given the hematological picture, the correct diagnosis was established based on ancillary tests for MC using bone marrow aspirates and biopsy. Extensive involvement of the liver and gastrointestinal tract was histologically documented. The disease progressed rapidly and severe pancytopenia and recurrent upper gastrointestinal bleeding became the dominant problem. This case illustrates the challenge in establishing a diagnosis of ASM especially when the clinical picture is atypical and without skin involvement. Gastroenterologists should consider infiltrative disease, particularly systemic mastocytosis, as a differential diagnosis in a clinical case of portal hypertension of unknown etiology. | Cláudio Martins Cristina Teixeira Suzane Ribeiro Daniel Trabulo Cláudia Cardoso Joao Mangualde Ricardo Freire élia Gamito Ana Luísa Alves Isabelle Cremers Cecília Alves Anabela Neves Ana Paula Oliveira | 2016 | World Journal of Gastroenterology2016，22，28： | 0 |
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