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| 1 | hsa-miR-29c and hsa-miR-135b differential expression aspotential biomarker of gastric carcinogenesis显示文摘AIM: To investigate the expression profiles of hsa-mi R-29 c and hsa-mi R-135 b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS: The expression levels of hsa-mi R-29 c and hsa-mi R-135 b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinaltype gastric adenocarcinoma were analysed using quantitative real-time PCR. The difference between hsa-mi R-29 c and hsa-mi R-135 b expression profiles in the grouped samples was evaluated by ANOVA and Student's t-test tests. The results were adjusted for multiple testing by using Bonferroni's correction. P values ≤ 0.05 were considered statistically significant. To evaluate hsa-mi R-29 c and hsa-mi R-135 b expressions as potential biomarkers of gastric carcinogenesis, we performed a receiver operating characteristic curve analysis and the derived area under the curve, and a Categorical Principal Components Analysis. In silico identification of the genetic targets of hsa-mi R-29 c and hsa-mi R-135 b was performed using different prediction tools, in order to identify possible genes involved in gastric carcinogenesis.RESULTS: The expression levels of hsa-mi R-29 c were higher in normal gastric mucosal samples, and decreased progressively in non-atrophic chronic gastritis samples, intestinal metaplasia samples and intestinal-type gastric adenocarcinoma samples. The expression of hsa-mi R-29 c in the gastric lesions showed that non-atrophic gastritis have an intermediate profile to gastric normal mucosa and intestinal-type gastric adenocarcinoma, and that intestinal metaplasia samples presented an expression pattern similar to that in intestinal-type gastric adenocarcinoma. This micro RNA(mi RNA) has a good discriminatory accuracy between normal gastric samples and(1) intestinal-type gastric adenocarcinoma; and(2) intestinal metaplasia, and regulates the DMNT3 A oncogene. hsa-mi R-135 b is up-regulated in non-atrophic chronic gastritis and intestinal metaplasia samples and down-regulated in normal gastric mucosa and intestinal-type gastric adenocarcinoma samples. Non-atrophic chronic gastritis and intestinal metaplasia are significantly different from normal gastric mucosa samples. hsa-mi R-135 b expression presented a greater discriminatory accuracy between normal samples and gastric lesions. This mi RNA was associated with Helicobacter pylori presence in non-atrophic chronic gastritis samples and regulates the APC and KLF4 tumour suppressor genes.CONCLUSION: Our results provide evidence of epigenetic alterations in non-atrophic chronic gastritis and intestinal metaplasia and suggest that hsa-mi R-29 c and hsa-mi R-135 b are promising biomarkers of gastric carcinogenesis. | Amanda Ferreira Vidal Aline MP Cruz Leandro Magalhães Adenilson L Pereira Ana KM Anaissi Nélisson CF Alves Paulo JBS Albuquerque Rommel MR Burbano Samia Demachki Ândrea Ribeiro-dos-Santos | 2016 | World Journal of Gastroenterology2016，22，6： | 7 |
| 2 | Packaging Waste Recycling in Europe: Is the Industry Paying for It?显示文摘 | Cruz N F 'Ferreira S Cabral M | 2014 | Waste Manarement2014，34，： | 1 |
| 3 | Antithrombotic treatment in chronic heart failure and sinus rhythm: Systematic review显示文摘AIM: To assess the efficacy and safety of antithrombotic drugs(antiplatelet or anticoagulant drugs) compared to no antithrombotic treatment or placebo in patients with heart failure(HF) and sinus rhythm. METHODS: We searched Medline and Cochrane Library for randomized controlled trials evaluating antithrombotic treatment and no antithrombotic treatment in patients with HF and sinus rhythm. Risk ratio(RR) and 95%CIs were estimated performing meta-analysis with random effects method. RESULTS: Two studies met the inclusion criteria: Heart failure Long-term Antithrombotic Study and Warfarin/Aspirin Study in Heart failure, with 336 patients and mean follow-up 1.8-2.25 years. Stroke risk was not reduced by acetylsalicylic acid(RR = 1.18, 95%CI: 0.17-8.15), oral anticoagulation(RR = 0.30, 95%CI: 0.03-2.65) or overall antithrombotic drugs(RR = 0.52, 95%CI: 0.10-2.74). Acetylsalicylic acid showed a significant increased risk of worsening HF(RR = 1.78, 95%CI: 1.08-2.92), while oral anticoagulation had no impact in this outcome(RR = 1.03, 95%CI: 0.61-1.75). Overall antithrombotic drugs showed a significant risk increase of major bleeding(RR = 6.99, 95%CI: 0.89-54.64). CONCLUSION: Best available evidence does not support the routine use of antithrombotic drugs in patients with HF and sinus rhythm. These drugs, particularly oral anti-coagulation has the hazard of increase significantly major bleeding risk. | Daniel Caldeira Inês Cruz Rita Calé Cristina Martins Helder Pereira Joaquim J Ferreira Fausto J Pinto Joo Costa | 2015 | World Journal of Meta-Analysis2015，3，1： | 1 |
| 4 | Metabolic response to different glucose and glutamine levels in baby hamster kidney cell culture 显示文摘 | Cruz HJ Ferreira AS Freitas CM | 1999 | Appl Microbiol Biotechnol1999，51，5： | 1 |
| 5 | Valorisation of natural extracts from marine source focused on marine by-products: A review显示文摘 | Vincenza Ferraro Isabel B. Cruz Ruben Ferreira Jorge F. Xavier Malcata Manuela E. Pintado Paula M.L. Castro | 2010 | Food Research International2010，，9： | 1 |
| 6 | Controlled crystallization and ionic conductivity of a nanostructured Li Al Ge PO4glass-ceramic显示文摘 | Cruz A M Ferreira E B Rodrigues A C M | 2009 | Journal of Non-Crystalline Solids2009，355，4547： | 1 |
| 7 | Microstructural and optical properties of CSS and CBD-CdS thin films for photovoltaic solar cells显示文摘 | CRUZ L R FERNANDES J A S FERREIRA C L | 2014 | Matéria (Rio de Janeiro)2014，19，3： | 1 |
| 8 | Impacto da idade no tratamento e resultados após enfarte agudo do miocárdio em particular nos muito idosos显示文摘 | Ana Teresa Timóteo Ruben Ramos Alexandra Toste Ana Lousinha José Alberto Oliveira Maria Lurdes Ferreira Rui Cruz Ferreira | 2011 | Revista Portuguesa de Cardiologia2011，，12： | 1 |
| 9 | Analysis and diagnosis of open-circuit faults in matrix converters显示文摘 | CRUZ S M A FERREIRA M MENDES AMS CARDOSO A J M | 2011 | IEEE Trans on Ind Electron2011，58，5： | 1 |
| 10 | The activation of the ERK pathway contributes to the spinal c-los expression observed after noxious bladder stimulation 显示文摘 | Cruz C D Ferreira D McMahon S B | 2007 | Somatosens Mot Res2007，24，12： | 1 |
| 11 | Analysis and diagnosis of open-circuit faults in matrix converters显示文摘 | Cruz S M A Ferreira M Cardoso A J M | 2011 | IEEE Trans on Industrial Electronics2011，58，5： | 1 |
| 12 | Multiple sclerosis, europsy- chiatric lupus and antiphospholipid syndrome: where do we stand?显示文摘 | Ferreira S D'Cruz DP Hughes GR | 2005 | Rheumatology (Oxford)2005，44，： | 1 |
| 13 | Carbon-carbon double bond cleavage using solid-supported potassium permanaganate on silica-gel显示文摘 | J Tercio B Ferreira W O Cruz | 1987 | J Organic Chemistry1987，52，16： | 1 |
| 14 | Evaluation of overload effects on fatigue crack growth and closure 显示文摘 | Borrego L P Ferreira J M Cruz J M P D | 2003 | Engineering Fracture Mechanics2003，70，11： | 1 |
| 15 | Metabolic responses to different glucose and glutamine levels in baby hamster kidney cell eulture显示文摘 | Cruz H J Ferreira A S Freitas C M M | 1999 | Appl Microbiol Biotechnol1999，51，： | 1 |
| 16 | Thrombus Formation on a Left Atrial Appendage Closure Device显示文摘 | Lorette Cardona Galrinho Ana Branco Luísa Ana Leal Fiarresga António Sousa Lídia Ferreira Rui Cruz | 2011 | Circulation2011，，14： | 1 |
| 17 | Literature review on earthen vernacular heritage: contributions to a referential framework显示文摘The state of the art of earthen architecture and vernacular built heritage comprises a complex set of issues that range from fundamental problematic recognition to anthropological and cultural studies and,more recently,to technological and experimental analyses.This paper addresses the development of the feld,following the milestones of the international literature and pursuing a refective-theory approach within a historical framework.It aims to explore the main contributions that have enhanced vernacular heritage and earthen architecture as specifc domains,from pioneering public awareness essays to institutional expertise guidelines.Finally,in addition to the literature review process,this paper considers the recent corpus of recommendations from conservation management reference institutions,the updating of the operative problematic of earthen vernacular built heritage,and the relevance of local community involvement in facing increasing challenges. | Gilberto Carlos Telma Ribeiro Maddalena Achenza Cristina Cruz Ferreira de Oliveira Humberto Varum | 2022 | Built Heritage2022，6，2： | 1 |
| 18 | Metabolic respon- ses to different glucose and glutamine levels in baby ham- ster kidney cell culture显示文摘 | Cruz H j Ferreira A S Freitas C M M | 1999 | Appl Microbiol Biotechnol1999，51，： | 1 |
| 19 | Changes in cellular proliferation and plasma products are associated with liver failure显示文摘AIM To study the differences in immune response and cytokine profile between acute liver failure and selflimited acute hepatitis.METHODS Forty-six patients with self-limited acute hepatitis(AH), sixteen patients with acute liver failure(ALF), and twenty-two healthy subjects were involved in this study. The inflammatory and anti-inflammatory products in plasma samples were quantified using commercial enzyme-linked immunoassays and quantitative real-time PCR. The cellular immune responses were measured by proliferation assay using flow cytometry. The groups were divided into viral- and non-viral-induced selflimited AH and ALF. Thus, we worked with five groups: Hepatitis A virus(HAV)-induced self-limited acute hepatitis(HAV-AH), HAV-induced ALF(HAV-ALF), nonviral-induced self-limited acute hepatitis(non-viral AH), non-viral-induced acute liver failure(non-viral ALF), and healthy subjects(HC). Comparisons among HAV and non-viral-induced AH and ALF were performed.RESULTS The levels of mitochondrial DNA(mt DNA) and the cytokines investigated [interleukin(IL)-6, IL-8, IL-10, interferon gamma, and tumor necrosis factor] were significantly increased in ALF patients, independently of etiology(P < 0.05). High plasma mt DNA and IL-10 were the best markers associated with ALF [mt DNA: OR = 320.5(95%CI: 14.42-7123.33), P < 0.0001; and IL-10: OR = 18.8(95%CI: 1.38-257.94), P = 0.028] and death [mt DNA: OR = 12.1(95%CI: 2.57-57.07), P = 0.002; and IL-10: OR = 8.01(95%CI: 1.26-50.97), P = 0.027]. In the cellular proliferation assay, NK^(bright), NKT and regulatory T cells(TReg) predominated in virusspecific stimulation in HAV-induced ALF patients with an anergic behavior in the cellular response to mitotic stimulation. Therefore, in non-viral-induced ALF, anergic behavior of activated T cells was not observed after mitotic stimulation, as expected and as described by the literature. CONCLUSION mt DNA and IL-10 may be predictors of ALF and death. TReg cells are involved in immunological disturbance in HAV-induced ALF. | Juliana Gil Melgaco Frederico Marianetti Soriani Pedro Henrique Ferreira Sucupira Leonardo Assaf Pinheiro Yasmine Rangel Vieira Jaqueline Mendes de Oliveira Lia Laura Lewis-Ximenez Cristina Carvalho Vianna Araújo Lúcio Filgueiras Pacheco-Moreira Gustavo Batista Menezes Oswaldo Goncalves Cruz Claudia Lamarca Vitral Marcelo Alves Pinto | 2016 | World Journal of Hepatology2016，8，32： | 1 |
| 20 | Does metabolic syndrome predict significant angiographic cor- onary artery disease? 显示文摘 | Timoteo A T Mota Carmo M Cruz Ferreira R | 2012 | Revista Portuguesa De Cardiologia2012，31，12： | 1 |
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