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| 1 | A laser light scattering study of the interaction between human serum albumin and ampicillin sodium显示文摘The complexes formed by the interaction of human serum albumin and ampicillin sodium in aqueous solutions were investigated at 25 ± 0.1℃, ionic strength I = 0.085 mol·kg-1, pH 4.9, 5.8 and 7.4. The results of static light scattering have suggested that at pH 7.4, 5.8, 4.9, the molecular weight of the protein/drug complexes is 210,000 g·mol-1, 418,000 g·mol-1, 448,000 g·mol-1, re- spectively. The z-average root-mean-square radius of gyration and the second virial coefficients de- crease with pH decreasing. Dynamic light scattering provides information on diffusion coefficient and particle distributions of protein/drug complexes under different conditions, which suggests a broad hydrodynamic diameter range of scatters. The diffusion coefficients of the systems change with am- picillin sodium concentration and pH changing. | WANG Weiping TANG Jianghong PENG Xuhong HU Zhide CHEN Xingguo | 2006 | Science China Chemistry2006，49，4： | 3 |
| 2 | Preparation and application of iron oxide/persimmon tannin/graphene oxide nanocomposites for efficient adsorption of erbium from aqueous solution显示文摘Rare earth elements(REEs)are used for the developme nt of new energy materials owing to their intrinsic physicochemical property.However,excess REEs in water threaten the safety of animals,plants and humans.An efficient way to separate REEs from the water is therefore needed.In this study,a biosorbent consisting of iron oxide(Fe3 O4),persimmon tannin(PT),and graphene oxide(GO)as Fe3 O4/PT/GO was prepared,and the adsorption of trivalent erbium(Er3+)ions from aqueous solution was investigated.The adsorption process for Er3+ions conforms to pseudo-second order kinetic and the Langmuir isotherm model behavior.Thermodynamic studies indicate that the adsorption process is spontaneous and endothermic.Scanning electron microscopy(SEM),X-ray photoelectron spectroscopy(XPS),X-ray diffraction(XRD),thermogravimetric analysis(TGA).Fourier-transform infrared(FT-IR)spectroscopy;Brunauer-Emmett-Teller(BET)analysis,and vibrating sample magnetometer(VSM)were used to assess the adsorption mechanism of Er3+ions onto the Fe3 O4/PT/GO biosorbent.A combination of electrostatic interactions,redox reactivity and chelation are responsible for adsorption of Er3+ions on the Fe3 O4/PT/GO biosorbent,The magnetic Fe3 O4/PT/GO biosorbent can be easily separated under the magnetic field for effective recycle of Er3+ions from aqueous solution.Therefore,this new biomass composite holds great promise for wastewater treatment. | Lin Gao Zhongmin Wang Chaoke Qin Zhenming Chen Mingmin Gao Na He Xi Qian Zhide Zhou Guiyin Li | 2020 | Journal of Rare Earths2020，38，12： | 3 |
| 3 | Molecular imaging of advanced atherosclerotic plaques with folate receptor-targeted 2D nanoprobes显示文摘Vulnerable atherosclerotic plaques are responsible for most cardiovascular diseases(CVDs).Folate receptor(FR)positive activated macrophages were thought to be a prominent component in the development of vulnerable plaque.The objective of this study is to develop folate conjugated two-dimensional(2D)Pd@Au nanomaterials(Pd@Au-PEG-FA)for targeted multimodal imaging of the FRs in advanced atherosclerotic plaques.Pharmacokinetic and imaging studies(single photon emission computed tomography(SPECT),computed tomography(CT)and photoacoustic(PA)imaging)were performed to confirm the prolonged blood half-life and enrichment of radioactivity in atherosclerotic plaques.Strong signals were detected in vivo with SPECT,CT and PA imaging in heavy atherosclerotic plaques,which were significantly higher than those of the normal aortas after injection of Pd@Au-PEG-FA.Blocking studies with preinjection of excess FA could effectively reduce the targeting ability of Pd@Au-PEG-FA in atherosclerotic plaques,further demonstrating the specific binding of Pd@Au-PEG-FA for plaque lesions.Histopathological characterization revealed that the signal of probe was in accordance with the high-risk plaques.In summary,the Pd@Au-PEG-FA has favorable pharmacokinetic properties and provides a valuable approach for detecting high-risk plaques in the presence of FRs in atherosclerotic plaques. | Zhide Guo Liu Yang Mei Chen Xuejun Wen Huanhuan Liu Jingchao Li Duo Xu Yuanyuan An Changrong Shi Jindian Li Xinhui Su Zijing Li Ting Liu Rongqiang Zhuang Nanfeng Zheng Haibo Zhu Xianzhong Zhang | 2020 | Nano Research2020，13，1： | 2 |
| 4 | Separation and simultaneous determination of tutin,puerarin,daidzein,esculin and esculetin in medicinal preparations by non-aqueous capillary显示文摘 | Cunhong Li Anjia Chen Xiaofeng Chen Xingguo Chen Zhide Hu | | 0，，： | 1 |
| 5 | Non-aqueous capillary electrophoresis for simultaneous separation and determination of three major active components in traditional medicinal preparations显示文摘 | Cunhong Li Jiyou Zhang Anjia Chen Jianping Xie Xingguo Chen Zhide Hu | | 0，，： | 1 |
| 6 | Non-aqueous capillary electrophoresis for separation and simultaneous determination of fraxin,esculin and esculetin in Cortex fraxini and its medicinal preparations显示文摘 | Cunhong Li Anjia Chen Xiaofeng Chen Xiao Ma Xingguo Chen Zhide Hu | | 0，，： | 1 |
| 7 | Quantification of noradrenaline and dopamine in Portulace oleracea L by capillary electrophoresis with laser-induced fluorescence detection显示文摘 | Jiyou Zhang Xingguo Chen Zhide Hu | 2002 | Analytica Chimica Acta2002，471，： | 1 |
| 8 | Binding study of diprophylline with lysozyme by spectroscopic methods显示文摘 | Weiping Wang Wenao Min Jianrong Chen Xiaohua Wu Zhide Hu | 2010 | Journal of Luminescence2010，，4： | 1 |
| 9 | Application of artificial neural network for determination of proteins with CPA - pl by Raleigh light scattering teachnique显示文摘 | DONG Lijun CHEN Xingguo HU Zhide | 2006 | Journal of Luminescence2006，124，1： | 1 |
| 10 | A Microcomputer Fitted Method for Determination of the True ODF of Hexagonal Materials according to the Maximum-Entropy Estimate显示文摘A method which is especially suitable for microcomputer calculation of the true orientation distribution function(ODF) according to the maximum-entropy estimate is proposed for hexagonal system polycrystalline materialswith physical symmetry.The resultant computational software system has been also designed and first carried outin a microcomputer PANAFACOM-U1200 being on line with the X-ray diffractometer D/max-3A.The simu-lated calculation shows that the method is concisely pragmatic and easily popularized,while the results obtainedare trust worthy. | Liqing CHEN Fu WANG Zhide LIANG Dept.of Materials Science and Engineering,Northeast University of Technology.Shenyang,110006,China | 1993 | Journal of Materials Science & Technology1993，9，1： | 1 |
| 11 | Interaction of isofraxidin with human serum albumin显示文摘 | Jiaqin Liu Jianniao Tian Xuan Tian Zhide Hu Xingguo Chen | 2003 | Bioorganic & Medicinal Chemistry2003，，2： | 1 |
| 12 | Study on the relation- ship between intake of trace elements and breast cancer mortality with chemometric methods 显示文摘 | Honglin Zhai Xingguo Chen Zhide Hu | 2003 | Computational Biology and Chemistry2003，27，6： | 1 |
| 13 | Network service incen- tive mechanism based on competitive game 显示文摘 | CHEN Zhide ZHENG Jinhua XU Li | 2009 | Communica-tions in Computer and Information Science2009，60，1： | 1 |
| 14 | Binding of wogonin to human serum albumin: a common binding site of wogonin in subdomain IIA显示文摘 | Jianniao Tian Jiaqin Liu Jianping Xie Xiaojun Yao Zhide Hu Xinguo Chen | 2004 | Journal of Photochemistry & Photobiology, B: Biology2004，，1： | 1 |
| 15 | Determination of Micro Amounts of Palladium(Ⅱ) by Extraction Method without Usual Organic Solvents显示文摘 | Chen Xingguo Li Guanbin Hu Zhide | 1996 | Microchimica Acta1996，122，： | 1 |
| 16 | 显示文摘 | ZHANG Jiyou HU Zhide CHEN Xingguo | 2005 | Talanta2005，65，4： | 1 |
| 17 | High-performance liquid chromatographic method for simultaneous determination of honokiol and magnolol in rat plasma 显示文摘 | Wu Xinan Chen Xingguo Hu Zhide | 2003 | Talanta2003，59，1： | 1 |
| 18 | Determination of micro amounts of palladium(Ⅱ) by extraction method without usual organic solvents显示文摘 | Guanbin Li Zhide Hu | 1996 | Microchimica Acta1996，，122： | 1 |
| 19 | Interaction of magnolol with bovine serum albumin: a fluorescence-quenching study显示文摘 | Jiaqin Liu Jian-niao Tian Jiyou Zhang Zhide Hu Xingguo Chen | 2003 | Analytical and Bioanalytical Chemistry2003，，6： | 1 |
| 20 | Pd@Ir-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy显示文摘Lactic acid(LA)plays a major role in the occurrence,development,and spread of cancer.Enlightened by its high accumulation in tumor site,a novel lactate oxidase(LOD)conjugated two-dimensional Pd@Ir nanoplatform(Pd@Ir-LOD,PIL)was fabricated to combine cascade reaction with photothermal for tumor therapy.In detail,the overexpressed LA in tumor microenvironment(TME)was a key factor to activate the PIL-based cascade reaction:(1)Plenty of H_(2)O_(2)could be generated from LA by the catalysis of LOD with O_(2);(2)potent·OH was produced from H_(2)O_(2)due to the peroxidase(POD)-like activity of PIL;(3)meantime,PIL’s catalase(CAT)-like activity could decompose part H_(2)O_(2)into O_(2)to achieve the purpose of LA cyclic oxidization.Moreover,the reduced glutathione(GSH)scavenging capability of PIL might protect the produced reactive oxygen species(ROS)from being cleared to further improve the cascade therapeutic effect.More importantly,PIL had excellent photothermal conversion efficiency(37.35%)and manifested a surprising temperature rising effect in tumor.Taken together,the decreasing LA concentration,accumulation of high-toxic ROS,the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor therapy.Therefore,a promising therapeutic tactic based on PIL integrating endogenous LA consumption,chemodynamic therapy(CDT),and photothermal therapy(PTT)has been put forward. | Zichen Ye Yun Li Jingchao Li Xinyan Hu Jinyang Zheng Gongxin Zhang Sijin Xiang Tianbao Zhu Zhide Guo Xiaolan Chen | 2024 | Nano Research2024，17，1： | 0 |
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