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| 1 | Learning deep representations for semantic image parsing: a comprehensive overview显示文摘 | Lili HUANG Jiefeng PENG Ruimao ZHANG Guanbin LI Liang LIN | 2018 | Frontiers of Computer Science2018，12，5： | 2 |
| 2 | Migration behavior and separation of active components in Glycyrrhiza uralensis Fisch and its commercial extract by micellar electrokinetic pillary chromatography 显示文摘 | Hongyi Zhang Yuquan Fan | 1999 | J Chromatogra A1999，863，： | 1 |
| 3 | Chemical signals based on multi-channel wavelet denoising method 显示文摘 | ZHONG Hongbin ZHOU Changli LI Guanbin | 2006 | Computer and Applied Chemistry2006，23，10： | 1 |
| 4 | Wavelet coefficients research area related threshold denoising method 显示文摘 | LI Guanbin ZHONG Hongbo LIU Hui | 2004 | Analysis of Laboratory2004，21，1： | 1 |
| 5 | Determination of Micro Amounts of Palladium(Ⅱ) by Extraction Method without Usual Organic Solvents显示文摘 | Chen Xingguo Li Guanbin Hu Zhide | 1996 | Microchimica Acta1996，122，： | 1 |
| 6 | Migration be havior and separation of active componenls in Glycyrrhiza ura lensis Fisch and its commercial extract by micellar electroki netic capillary chromalography显示文摘 | Guanbin Li Hongyi Zhang Yuquan Fan | 1999 | journal of Chromatography A1999，863，： | 1 |
| 7 | Determination of micro amounts of palladium(Ⅱ) by extraction method without usual organic solvents显示文摘 | Guanbin Li Zhide Hu | 1996 | Microchimica Acta1996，，122： | 1 |
| 8 | Novel Approach for the Decoration of Magnetic Carbon Nanospheres with Platinum Nanoparticles and Their Enhanced Peroxidase Activity for the Colorimetric Detection of H2O2显示文摘Pt/Fe3O4-DIB-DETA-CNS(PFDDC)nanocomposite(DIB=2,4-dihydroxybenzaldehyde;DETA=diethylenetfiamine;CNS=carbon nanosphere)was synthesized by dispersing Pt nanoparticles on magnetic carbon nanospheres. The structure,morphology and composition of the nanocomposite were studied by X-ray diffraction(XRD),transmission electron microscopy(TEM),energy-dispersive X-ray spectroscopy(EDX)and X-ray photoelectron spectroscopy(XPS). In addition,the nanocomposite showed superior peroxidase-like activity towards 3,3',5,5'-tetramethylbenzidine(TMB) with a visual color change in the presence of hydrogen peroxide(H2O2).Therefore,the PFDDC nanocomposite provides a sensing platform for the colorimetric detection of H2O2 with high sensitivity and selectivity.Furthermore,the nanocomposite can be conveniently preserved and separated.These features enable the nanocomposite to colorimetrically detect H2O2 for potential pharmaceutical,environmental and industrial applications. | SU Ce BAI Lingling ZHANG Hongbo CHANG Kaishan LI Guanbin LI Siliang | 2019 | Chemical Research in Chinese Universities2019，35，1： | 0 |
| 9 | Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin显示文摘Therapeutic targeting FOxO3A(a forkhead transcription factor)represents a prom-ising strategy to suppress acute myeloid leukemia(AML).However,the effective inhibitors that target FOXO3A are lacking and the adaptive response signaling weakens the cytotoxic effect of FOxO3A depletion on AML cells.Here,we show that FOxO3A deficiency induces a compensa-tory response involved in the reactive activation of mTOR that leads to signaling rebound and adaptive resistance.Mitochondrial metabolism acts downstream of mTOR to provoke activa-tion of JNK/c-JUN via reactive oxygen species(ROS).At the molecular level,FOXO3A directly binds to the promoter of G protein gamma subunit 7(GNG7)and preserves its expression,while GNG7 interacts with mTOR and restricts phosphorylated activation of mTOR.Consequently,combinatorial inhibition of FOXO3A and mTOR show a synergistic cytotoxic effect on AML cells and prolongs survival in a mouse model of AML.Through a structure-based virtual screening,we report one potent small-molecule FOxO3A inhibitor(Gardenoside)that exhibits a strong effect of anti-FOXO3A DNA binding.Gardenoside synergizes with rapamycin to substantially reduce tumor burden and extend survival in AML patient-derived xenograft model.These results demonstrate that mTOR can mediate adaptive resistance to FOxO3A inhibition and validate a combinatorial approach for treating AML. | Zhe Chen Qian Guo Shichen Huang Lei Li Feng Wu Zhilong Liu Zhigang Li Tao Chen Guanbin Song Shuangnian Xu Jieping Chen Yu Hou | 2024 | Genes & Diseases2024，11，1： | 0 |
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