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| 1 | Risk factors for cervical lymph node metastasis in papillary thyroid microcarcinoma: a study of 1,587 patients显示文摘Objective: The purposes of this study were to identify risk factors for cervical lymph node metastasis and to examine the association between BRAF^(V600E) status and clinical features in papillary thyroid microcarcinoma(PTMC).Methods: A total of 1,587 patients with PTMC, treated in Tianjin Medical University Cancer Institute and Hospital from January2011 to March 2013, underwent retrospective analysis. We reviewed and analyzed factors including clinical results, pathology records, ultrasound results, and BRAF^(V600E) status.Results: Multivariate logistic regression analyses demonstrated that gender(male) [odds ratio(OR) = 1.845, P = 0.000], age(< 45 years)(OR = 1.606, P = 0.000), tumor size(> 6 mm)(OR = 2.137, P = 0.000), bilateralism(OR = 2.011, P = 0.000) and extrathyroidal extension(OR = 1.555, P = 0.001) served as independent predictors of central lymph node metastasis(CLNM).Moreover, CLNM(OR = 29.354, P = 0.000) served as an independent predictor of lateral lymph node metastasis(LLNM). Among patients with a solitary primary tumor, those with tumor location in the lower third of the thyroid lobe or the isthmus were more likely to experience CLNM(P < 0.05). Univariate analyses indicated that CLNM, LLNM, extrathyroidal extension, and multifocality were not significantly associated with BRAF^(V600E) mutation.Conclusions: The present study suggested that prophylactic neck dissection of the central compartment should be considered in patients with PTMC, particularly in men with tumor size greater than 6 mm, age less than 45 years, extrathyroidal extension, and tumor bilaterality. Among patients with PTMC, BRAF^(V600E) mutation is not significantly associated with prognostic factors. For a better understanding of surgical management of PTMC and the risk factors, we recommend multicenter research and long-term follow-up. | Xiangqian Zheng Chen Peng Ming Gao Jingtai Zhi Xiukun Hou Jingzhu Zhao Xi Wei Jiadong Chi Dapeng Li Biyun Qian | 2019 | Cancer Biology & Medicine2019，16，1： | 54 |
| 2 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 3 | Polymer-based EMI shielding composites with 3D conductive networks:A mini-review显示文摘High-frequency electromagnetic waves and electronic products can bring great convenience to people’s life,but lead to a series of electromagnetic interference(EMI)problems,such as great potential dangers to the normal operation of elec-tronic components and human safety.Therefore,the research of EMI shield-ing materials has attracted extensive attention by the scholars.Among them,polymer-based EMI shielding materials with light weight,high specific strength,and stable properties have become the current mainstream.The construction of 3D conductive networks has proved to be an effective method for the prepara-tion of polymer-based EMI shielding materials with excellent shielding effective-ness(SE).In this paper,the shielding mechanism of polymer-based EMI shield-ing materials with 3D conductive networks is briefly introduced,with emphasis on the preparation methods and latest research progress of polymer-based EMI shielding materials with different 3D conductive networks.The key scientific and technical problems to be solved in the field of polymer-based EMI shielding materials are also put forward.Finally,the development trend and application prospects of polymer-based EMI shielding materials are prospected. | Lei Wang Zhonglei Ma Yali Zhang Lixin Chen Dapeng Cao Junwei Gu | 2021 | SusMat2021，1，3： | 22 |
| 4 | 青藏高原吉隆-鲁谷(Hi-Climb)层析成像与印藏碰撞的消减作用显示文摘利用中美合作Hi-Climb项目北段吉隆-鲁谷剖面的天然地震探测数据,拾取2004-2005年期间5级以上地震事件的P波与4级以上地震的Pn波震相的走时,通过多震相层析成像反演获得青藏高原腹地的地下500 km以上的P波速度扰动结构.结果表明雅江地区为北向倾斜的低速扰动,班公-怒江断裂下方存在向南俯冲并被印度板块俯冲挤压而回折的高速体,建立了印度板块在冈底斯地块下方拆沉并被雅江低速体穿越的构造样式.说明印度板块俯冲在到达班公-怒江缝合带之前已经开始消减,与拆沉位置对比发现,印度板块的前锋深部呈现多期多级次特征,并受到地幔热循环作用的影响. | 钱辉 姜枚 Chen Wangping John Nabelek Zhao Dapeng 赵磊 王亚军 | 2007 | 地球物理学报2007，50，5： | 15 |
| 5 | Paleozoic sedimentary record of the Xing-Meng Orogenic Belt, Inner Mongolia: Implications for the provenances and tectonic evolution of the Central Asian Orogenic Belt显示文摘The Xing-Meng Orogenic Belt is the eastern extension of the Central Asian Orogenic Belt, which marks the boundary between the North China and Siberian blocks. Key information on the collision between these two blocks and the evolution of this orogenic belt at the end of the Paleozoic are preserved in the widely distributed Paleozoic sedimentary sequences. Petrographic studies of the clastic sedimentary rocks from the Ordovician to the Permian in this region have shown that the rocks are mainly greywackes and arkosic sandstones characterized by low maturity, poor sorting and a large number of lithic fragments. Provenances of Paleozoic sandstones are mainly newly accreted crustal materials. Nd model ages range from the Neoproterozoic to the Late Mesoproterozoic. These ages are very different from those of the North China Block, but the change of εNd(t) (from the initial εNd value) is similar to that of igneous rocks in the Xing-Meng Orogen. This result indicates that provenances of these Paleozoic sedimentary rocks mainly arise from the Xing-Meng Orogen itself. These clastic sedimentary rocks mainly consist of inputs of juvenile accreted crustal materials and limited recycled old crusts. Their provenance is controlled by the following three end members: a felsic basement, a partially melted mafic, and a mafic end member. From the point view of lithology, these three end members must have mixed in a ratio of 53:41:5 to form the average composition of the clastic sedimentary rocks. The depositional environment began to change from an arc to an orogen during the Permian, and therefore the collision was complete before the Triassic. This interpretation is consistent with the argument that the final collision time was at the end of the Permian or beginning of the Triassic. | LI DaPeng CHEN YueLong WANG Zhong LIN Yu ZHOU Jian | 2012 | Chinese Science Bulletin2012，57，7： | 15 |
| 6 | Initial study of biexponential model of intravoxel incoherent motion magnetic resonance imaging in evaluation of the liver fibrosis显示文摘 | Chen Cuiyun Wang Bin Shi Dapeng Fu Fangfang Zhang Jiliang Wen Zejun Zhu Shaocheng Xu Junling Lin Qing Li Jing Dou Shewei | 2014 | Chinese Medical Journal2014，，17： | 15 |
| 7 | Recognition on the forming-vanishing process and underlying mechanisms of the hypoxia off the Yangtze River estuary显示文摘On the basis of compiled multidisciplinary historical data in 2006–2007 and incorporation of relevant simulation results and remote sensing data, we performed an in-depth study of the generation and dissipation process of the hypoxic zone and its distribution morphology and structure off the Yangtze River estuary. Based on the hydrological circulation dynamics, reproduction of phytoplankton(leading to the decomposition of organic matter), and other factors, we comprehensively and systematically investigated the generation and dissipation of the hypoxic zone and underlying mechanisms for the seasonal variation in its position, explored the multi-factorial synergistic reactions during the generation and dissipation process of the hypoxic zone, and revealed the controlled mechanism for the morphology and structure of the hypoxic zone's distribution. Our studies indicate that in the winter and spring seasons, the hydrological environment off the Yangtze River estuary provides a water body with relatively low contents of dissolved oxygen(DO), which is the background for the formation of a hypoxic zone. After entering into the summer season, the hypoxic zone gradually develops towards the north and becomes mature. Because of the impact of the terrain, local decomposition of organic matter, and upwelling of the Kuroshio subsurface water in July–August, the hypoxic zone off the Yangtze River estuary exhibits the characteristics of discontinuous distribution in space and has a south and north 'dual-core' structure in the inner continental shelf. In addition, there is a hypoxic core in the eastern outer continental shelf. The degrees of hypoxia vary for different areas; they are strongest overall in the north, next strongest in the south; they are weakest on the outer continental shelf. In summer, the hypoxic zone in the north is related to the northward differentiation of the southern hypoxic zone and results from local development and intensification. In August, the hypoxic zone in the north reaches its peak, and after September, it rapidly retreats southward and disappears because of weakening stratification. In the fall, there is hypoxic zone along the coast of Zhejiang in the south, and there is also a low-DO area to the southwest of Jeju Island, with both zones disappearing rapidly. In addition, the change of dynamic environment also causes the low-DO area of the outer continental shelf to move outward in the fall. The variation in the intensity of the stratification and its cumulative effects as a barrier of vertical DO transportation over long periods of time have a significant impact on the degree of hypoxia in the hypoxic zone. In addition, the seasonal variations in the size of the stratified region, intensity of each current system/water mass, upwelling, front, and high-value area of phytoplankton biomass jointly restrict the extension of the hypoxic zone in the inner continental shelf and latitudinal(south-north direction) movement of its location off the Yangtze River estuary. The combined effect of dynamic factors, such as that of the Kuroshio subsurface water, causes a low-DO core in the outer continental shelf. The bottom cold water to the north of the East China Sea is the dynamic basis for the formation of the low-DO area to the southwest of Jeju Island during the fall season. The special seabed topography and mud area distribution off the Yangtze River estuary have a certain degree of influence on the development of the hypoxic zone. The generation and dissipation of the hypoxic zone and its distribution morphology off the Yangtze River estuary, and seasonal variation of its structure and position are a result of the synergistic effects of various factors. | WEI QinSheng WANG BaoDong CHEN JianFang XIA ChangShui QU DaPeng XIE LinPing | 2015 | Science China Earth Sciences2015，58，4： | 15 |
| 8 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of cerebral venous sinus thrombosis显示文摘Aim Cerebral venous sinus thrombosis(CVST)is a less common cerebrovascular disease that predominantly affects young patients.The incidence of CVST is 2-5/10000000/year,accounting for 0.5%-1%of all stroke.To reduce mortality and morbidity associated with CVST,Chinese Stroke Association commissioned the authors to write the current guideline on the management of CVST.Methods PubMed(MEDLINE),CNKI and Wanfang database were searched for studies related to CVST from 1 January 1990 to 31 July 2019.Data were synthesised by evidence tables.Each recommendation was fully discussed by the writing group members and reviewed by Chinese Stroke Association Stroke Fellow Committees.Levels of evidence grading algorithm of Chinese Stroke Association was used to grade each recommendation.results This guideline mainly focuses on the diagnostic evaluation,therapeutic strategies and secondary prevention of CVST.CT/CTV and MRI/MRV are recommended in the initial imaging evaluation of patients with suspected CVST.Anticoagulation therapy with low-molecular weight heparin should be initiated in patients with CVST immediately.After the acute stage,warfarin is recommended for 3-6 months to prevent the recurrence of CVST and other venous thromboembolic events.Conclusions The guideline summarises the current evidence regarding the management of CVST,and provides references for diagnosis,treatment and secondary prevention of CVST in China. | Yuhua Fan Jian Yu Hongbing Chen Jian Zhang Jiangang Duan Dapeng Mo Wenhao Zhu Bo Wang Fubing Ouyang Yicong Chen Linfang Lan Jinsheng Zeng Chinese Stroke Association Stroke Council CVST Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，2： | 14 |
| 9 | COVID-19 Super Spreading Event Amongst Elderly Individuals—Jilin Province,China,January 2021显示文摘Summary What is already known on this topic?Clusters of COVID-19 cases often happened in small settings(e.g.,families,offices,school,or workplaces)that facilitate person-to-person virus transmission,especially from a common exposure.What is added by this report?On January 10 and 11,2021,an individual gave three product promotional lectures in Tonghua City. | Laishun Yao Mingyu Luo Tiewu Jia Xingang Zhang Zhulin Hou Feng Gao Xin Wang Xiaogang Wu Weihua Cheng Guoqian Li Jing Lu Bing Zhao Tao Li Enfu Chen Dapeng Yin Biao Huang | 2021 | China CDC weekly2021，3，10： | 13 |
| 10 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 11 | Zircon LA-ICPMS study and petrogenesis simulation of Dahuabei pluton in the Wulashan area,Inner Mongolia显示文摘Dahuabei pluton in the Wulashan area,Inner Mongolia,is an alkaline and peraluminous granitic pluton.LA-ICPMS U-Pb dating of zircons indicates that this pluton crystallized at 330±10 Myr.The pluton did not experience apparent zircon fractionation.The consistent temperatures between Zr saturation(765℃) and the average zircon-rutile Ti equilibrium(780℃),together with zircon ages and their CL images,indicated that there were no inherited zircons in this pluton.Through the simulation of the dry-system crystallization process of magma cooling at 200 MPa and 1100-709℃,the phase diagram and composition evolution tendency of different phases were obtained.The magma reached its liquidus at 1069℃.Sanidine was the first crystallized phase;at 709℃the residual magma was less than 4%,and the range of 1069-719℃should be the most suitable approach to the real condition.It is shown that at least some part of the pluton underwent such isobaric equilibrium crystallization processes during its crystallization. | Dapeng Li Yuelong Chen Liemeng Chen Zhong Wang Jinbao Liu | 2009 | Progress in Natural Science:Materials International2009，19，12： | 11 |
| 12 | A LysM Receptor Heteromer Mediates Perception of Arbuscular Mycorrhizal Symbiotic Signal in Rice显示文摘Symbiotic microorganisms improve nutrient uptake by plants.To initiate mutualistic symbiosis with arbus-cular mycorrhizal(AM)fungi,plants perceive Myc factors,including lipochitooligosaccharides(LCOs)and short-chain chitooligosaccharides(CO4/CO5),secreted by AM fungi.However,the molecular mechanism of Myc factor perception remains elusive.In this study,we identified a heteromer of LysM receptor-like kinases consisting of OsMYR1/OsLYK2 and OsCERK1 that mediates the perception of AM fungi in rice.CO4 directly binds to OsMYR1,promoting the dimerization and phosphorylation of this receptor complex.Compared with control plants,Osmyr1 and Oscerk1 mutant rice plants are less sensitive to Myc factors and show decreased AM colonization.We engineered transgenic rice by expressing chimeric receptors that respectively replaced the ectodomains of OsMYR1 and OsCERK1 with those from the homologous Nod factor receptors MtNFP and MtL YK3 of Medicago truncatula.Transgenic plants displayed increased cal-cium oscillations in response to Nod factors compared with control rice.Our study provides significant mechanistic insights into AM symbiotic signal perception in rice.Expression of chimeric Nod/Myc recep-tors achieves a potentially important step toward generating cereals that host nitrogen-fixing bacteria. | Jiangman He Chi Zhang Huiling Dai Huan Liu Xiaowei Zhang Jun Yang Xi Chen Yayun Zhu Dapeng Wang Xiaofeng Qi Weichao Li Zhihui Wang Guoyong An Nan YU Zuhua He Yong-Fei Wang Youli Xiao Peng Zhang Ertao Wang | 2019 | Molecular Plant2019，12，12： | 9 |
| 13 | Embedding variable micro-capacitors polydimethylsiloxane for enhancing output of triboelectric nanogenerator in power显示文摘 | Xiaona Xia Jie Chen Hengyu Guo Guanlin Liu Dapeng Wei Yi Xi Xue Wang Chenguo Hu | 2017 | Nano Research2017，10，1： | 7 |
| 14 | Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy显示文摘 | Li Zhuo Nianrong Zhang Guming Zou Dapeng Chen Wenge Li | 2017 | Frontiers of Medicine2017，11，3： | 7 |
| 15 | Numerical investigation on freeze-drying of aqueous material frozen with pre-built pores显示文摘Freeze-drying of the initially porous frozen material with pre-built pores from liquid material was found experimentally to save drying time by over 30% with an initial saturation being 0.28 compared with the conventional operation with the initial saturation being 1, using mannitol as the solid material. In order to understand the mass and heat transfer phenomena of this novel process, a two-dimensional mathematical model of coupled mass and heat transfer was derived with reference to the cylindrical coordinate system. Three adsorption–desorption equilibrium relationships between the vapour pressure and saturation value namely, power-law, Redhead's style and Kelvin's style equation, were tested. Kelvin's style in exponential form of adsorption equilibrium relation gave an excellent agreement between the model prediction and experimental measurement when the equation parameter, γ, of 5000 was applied. Analyses of temperature and ice saturation profiles show that additional heat needs to be supplied to increase the sample temperature in order to promote the desorption process. Simulation also shows that there is a threshold initial porosity after which the drying time decreased with the increase in the initial porosity. Enhanced freeze-drying is expected to be achieved by simultaneously enhancing mass and heat transfer of the process. | Wei Wang Dapeng Hu Yanqiu Pan Guohua Chen | 2016 | Chinese Journal of Chemical Engineering2016，24，1： | 7 |
| 16 | Magma Origin and Evolution of Tengchong Cenozoic Volcanic Rocks from West Yunnan,China:Evidence from Whole Rock Geochemistry and Nd-Sr-Pb Isotopes显示文摘Tengchong 新生代 volcanics 穿上记录钥匙信息因为它跨越全部第四级的时期的唯一的爆发历史,西藏的高原的东南边缘的构造进化和披风特征是很重要的。Tengchong 新生代暴烈的岩石的岩浆起源和进化在 Ma'anshan 区域从不同爆发根据 Nd-Sr-Pb 同位素和专业和踪迹元素数据被学习。在一爆发以内的不同样品显示出相对相同岩性学,化学药品和同位素的作文。然而,为五爆发的 geochemical 特征来自对方是不同的。这些暴烈的岩石显示出低 Mg# 价值(< 45 ) ,对高分别中等 LREE 和 HREE,和 Nb 的 Pb 和 Ba 和弄空的丰富。Tengchong 新生代暴烈的岩石基于 Nd-Sr-Pb 同位素的研究从一个充实的披风被导出。并且证据的线证明外壳的污染应该在 Tengchong 新生代暴烈的岩石的不同时期的爆发前被包含。更旧的 subducted 部件可能为在进化的各种各样的阶段再循环的 adakite 负责,它为 Tengchong 新生代暴烈的岩石的同位素的特征导致充实的披风来源岩浆财务的起源。分离原始岩浆搏动注入了岩浆房间,部分与外壳部件结晶并且污染。最后,有为每爆发的不同化学、同位素的作文的岩浆形成了。Yingjiang 构造的带的东北片断的延期在 Tengchong 区域触发了新生代 volcanics 的搏动的爆发。 | LI Dapeng LUO Zhaohua LIU Jiaqi CHEN Yuelong JIN Ye | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 6 |
| 17 | Elevated 8-oxo-7,8-dihydro-2'-deoxyguanosine in genome of T24 bladder cancer cells induced by halobenzoquinones显示文摘Halobenzoquinones(HBQs) are an emerging class of halogenated disinfection byproducts(DBPs) in drinking water, which raised public concerns due to potential carcinogenic effects to human bladder. Our previous work demonstrated that HBQs and hydrogen peroxide(H_2O_2)together generated oxidative DNA damage via a metal-independent and intercalationenhanced oxidation mechanism in vitro. This study further investigated the efficiency of various HBQs to induce oxidative DNA damage in T24 bladder cancer cells. Compared with T24 cells without treatment(3.1 lesions per 10~6 d G), the level of 8-oxo-7,8-dihydro-2′-deoxyguanosine(8-oxod G) significantly increased by 1.4, 3.2, 8.8, and 9.2 times after treatment with tetrabromo-1,4-benzoquinone(TBBQ), terachloro-1,4-benzoquinone(TCBQ),2,6-dichloro-1,4-benzoquinone(2,6-DCBQ) and 2,5-dichloro-1,4-benzoquinone(2,5-DCBQ) for24 hr, respectively. Interestingly, we found that the oxidative potency of HBQs in T24 cells(2,5-DCBQ ≈ 2,6-DCBQ > TCBQ > TBBQ) is inconsistent with that of in vitro ds DNA oxidation(TCBQ > TBBQ > 2,5-DCBQ > 2,6-DCBQ), suggesting HBQs induce oxidative lesions in cellular genomic DNA probably involved with a complex mechanism. | Tian Xu Junfa Yin Shaokun Chen Dapeng Zhang Hailin Wang | 2018 | Journal of Environmental Sciences2018，30，1： | 5 |
| 18 | Modeling and optimal design of multilayer thermal cantilever microactuators显示文摘A model of curvature and tip deflection of multilayer thermal cantilever actuators is derived.The sim-plified expression received from the model avoids inverting complex matrices enhances understanding and makes it easier to optimize the structure parameters.Experiment is performed,the modeled and experimental results demonstrate the validity of the model,and it also indicates that Young's module makes great contribution to the deflection;therefore,thin layers cannot be ignored arbitrarily. | FU JianYu CHEN DaPeng YE TianChun JIAO BinBin OU Yi | 2009 | Science China(Technological Sciences)2009，52，5： | 5 |
| 19 | Structural basis of immunosuppression by the therapeutic antibody daclizumab显示文摘发信号的 Interleukin-2 (IL )-2 在小径被显示出为在有机关移植的病人的免疫力的抑制有效减轻 / 消除 allograft 拒绝的堵住这的有免疫力的回答,和药的激活起一个枢轴的作用。首先人性化的 monoclonal 抗体(mAb ) daclizumab 掉进这个范畴并且对 IL-2 受体建筑群的一个关键部件显示出高特性和亲密关系,也就是 IL-2R 伪。揭示由 daclizumab 表明小径的 IL-2 的抑制的分子的机制,我们在 2.6 和 2.8 点与 IL-2R 伪 ectodomain 在免费形式并且在建筑群决定了 daclizumab Fab 的水晶结构?分辨率分别地。daclizumab Fab 当面采用类似的符合构造或 IL-2R 伪 ectodomain 的缺席。daclizumab 的抗原绑定地点主要由决定形成大断然控告的表面消沉和通常是恐水病的二个 flanking 补丁的区域(CDR ) 的五补充组成。 conformational epitope 由 IL-2R 伪 ectodomain 的几个不连续的片断组成,哪个与与 IL-2 交往的区域重叠的大部分,建议到 IL-2R 伪 的 daclizumab 的绑定将阻止 IL-2 绑定到 IL-2R 伪 和 IL-2/IL-2R 伪尾纬c 建筑群的随后的形成,因此堵住表明小径的 IL-2 。这些结果也为指向 IL-2R 伪的改进 mAb 药的设计和发展有含意。 | Hui Yang Jianchuan Wang Jiamu Du Chen Zhong Dapeng Zhang Huaizu Guo Yajun Guo Jianping Ding | 2010 | Cell Research2010，20，12： | 5 |
| 20 | Mechanics of flexible and stretchable piezoelectrics for energy harvesting显示文摘As rapid development in wearable/implantable electronic devices benefit human life in daily health monitoring and disease treatment medically, all kinds of flexible and/or stretchable electronic devices are booming, together with which is the demanding of energy supply with similar mechanical property. Due to its ability in converting mechanical energy lying in human body into electric energy, energy harvesters based on piezoelectric materials are promising for applications in wearable/implantable device's energy supply in a renewable, clean and life-long way. Here the mechanics of traditional piezoelectrics in energy harvesting is reviewed, including why piezoelectricity is the choice for minor energy harvesting to power the implantable/wearable electronics and how. Different kinds of up to date flexible piezoelectric devices for energy harvesting are introduced, such as nanogenerators based on Zn O and thin and conformal energy harvester based on PZT. A detailed theoretical model of the flexible thin film energy harvester based on PZT nanoribbons is summarized, together with the in vivo demonstration of energy harvesting by integrating it with swine heart. Then the initial researches on stretchable energy harvesters based on piezoelectric material in wavy or serpentine configuration are introduced as well. | CHEN Ying LU BingWei OU DaPeng FENG Xue | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，9： | 5 |
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