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| 1 | Successful photodynamic therapy for biliary papillomatosis:A case report显示文摘Papillomatosis of the bile duct is a rare disease with a high risk of malignant transformation. Therapeutical options include partial hepatectomy and liver transplantation. A previously healthy 65-years old male developed jaundice and right upper abdominal quadrant pain in 1996. A villous adenoma of the distal bile duct was diagnosed. A Whipple procedure was performed. In 2002 the patient turned symptomatic again. Another adenoma was found in the right hepatic duct resulting in a right hepatectomy. Two years later the patient again developed cholestasis. After drainage of the left hepatic duct with a percutaneous transhepatic cholangial drainage (PTCD) catheter, a recurrent biliary adenomatosis was diagnosed by cholangioscopy. As there was no surgical option left, the patient received photodynamic therapy (PDT) for the recurrent biliary papillomatosis. Three mo after he received further photodynamic therapies, the bile duct epithelium appeared normal and the patient had no signs of adenomatosis, both macroscopically and histologically. The follow-up cholangioscopy in late 2005 revealed only a small papilloma without the need for intervention. In early 2006, the patient died of multi organ failure without signs of extrahepatic cholestasis or cholangitis at the age of 75, 10 years after the diagnosis of biliary papillomatosis was established. The patient exceeded the average life expectancy of patients with biliary papillomatosis by far. Thus, PDT might be a sufficient therapeutic option for recurrent papillomatosis patients with no significant side effects. | Lars P Bechmann Philip Hilgard Andrea Frilling Brigitte Schumacher Hideo A Baba Guido Gerken Thomas Zoepf | 2008 | World Journal of Gastroenterology2008，14，26： | 7 |
| 2 | Decline of semen quality during IVF is not associated with subjective male stress显示文摘如果精液质量衰退在期间,现在的学习的目的是估计在 vitro 授精(IVF ) 并且这现象是否被长期的男应力触发。以便测试这个假设,我们首先调查了 155 个男 IVF 病人(严峻的队) 的一个回顾的队。随后,我们在经历他们的第一 IVF 的人开始了未来的队研究并且用一个验证工具估计了精液质量和主观男长期的应力,即富饶问题库存(FPI ) 问询表。在应力和精子质量衰落之间的协会在 IVF (T1 ) 的开始前是 4-6 星期,在卵母细胞的日子,检索(T2 ) 是主要结果。实时出生率,第一三个月流产和差的应答者的率是第二等的结果。在严峻的队,吝啬的进步活动性,然而并非吝啬的精子密度显著地衰退了。有 78/154 (51%) 人和在进步活动性显示出衰落的 50/154 (32%) 人,在精液密度看了衰落。在确认队,进步活动性衰退了,而,从 T1 增加到 T2 的精子密度。78 个人, 27 个人增加了应力(FPI 分数 >146 ) 。精子密度和进步活动性不在有或没有应力的人是显著地不同的。面对男应力,然而,夫妇们有差的应答者,流产和实时出生的更低的率的更高的率。主观应力没在在 IVF 期间观察的精液质量与衰落被联系,但是可以与不利怀孕结果被联系。 | Kazem Nouri Brigitte Litschauer Michael Sator Denise Tiringer Johannes Ott Katherina Walch Lukas A Hefler Clemens B Tempfer | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 3 | Liver Fibrosis: Noninvasive Assessment with Acoustic Radiation Force Impulse Elastography—Comparison with FibroScan M and XL Probes and FibroTest in Patients with Chronic Liver Disease显示文摘 | Christophe Cassinotto Bruno Lapuyade Ania A?t-Ali Julien Vergniol Delphine Gaye Juliette Foucher Claire Bailacq-Auder Faiza Chermak Brigitte Le Bail Victor de Lédinghen | 2013 | Radiology2013，，1： | 3 |
| 4 | 【原创论文】德国东西部睾丸癌后发生第二原发癌的风险关注对侧睾丸癌显示文摘上世纪70年代起以顺铂为基础的化疗使睾丸癌的存活率显著提高。然而,化疗和放疗具有潜在的致癌性。本研究的目的是评估德国睾丸癌存活者患第二原发癌(包括原发组织学类型精原细胞瘤和非精原细胞瘤)的风险。我们确认了德国东部地区(1961-1989年和1996-2008年)癌症登记的16990例睾丸癌和德国西部地区萨尔州(1970.2008年)癌症登记的1401例睾丸癌。我们用标准化发病率(SIRs)和95%N信区间(95%CI)估计第二原发癌的风险。我们将估计的年标准化发病率绘制成图以显示趋势。德国东部1961.1989年观察到301例第二原发癌(SIR:1.9;95%CI:1.7-2.1),1996—2008年观察到159例第二原发癌(SIR:1.7:95%CI:1.4~2.0)。两地癌症登记的对侧睾丸癌增加(SIR:萨尔6.0,德国东部13.9)。与其它地区相比,德国东部精原细胞瘤的SIR增加更为显著。数据分析显示对侧睾丸癌的SIR有稳定的趋势。大多数其它癌症(包括组织学特异性肿瘤)的SIRs的估计精度低,可能与样本量较小有关。睾丸癌患者患第二原发癌尤其是对侧睾丸癌的风险增加,因此应进行严密随访。 | Carsten Rusner Brigitte Streller Christa Stegmaier Pietro Trocchi Oliver Kuss Katherine A McGlynn Britton Traberts Andreas Stang | 2014 | Asian Journal of Andrology2014，16，2： | 2 |
| 5 | New insights into the management of acne: An update from the Global Alliance to Improve Outcomes in Acne Group显示文摘 | Diane Thiboutot Harald Gollnick Vincenzo Bettoli Brigitte Dréno Sewon Kang James J. Leyden Alan R. Shalita Vicente Torres Lozada Diane Berson Andrew Finlay Chee Leok Goh María Isabel Herane Ana Kaminsky Raj Kubba Alison Layton Yoshiki Miyachi Montserrat P | 2009 | Journal of the American Academy of Dermatology2009，，5： | 2 |
| 6 | Facile isolation and the characterization of human retinal stem cells显示文摘 | Brenda LKC Brigitte A Tomoyuki I | 2004 | Proc Natl Acad Sci USA2004，101，15： | 1 |
| 7 | Analysis of K- ras mutation in pancreatic tissue after fine needle aspirates 显示文摘 | Brigitte P Sonke A Ken B | 1999 | Anticancer Res1999，19，10： | 1 |
| 8 | Muscle resident macrophages control the immune cell reaction in a mouse model of notexin- induced myoinjury 显示文摘 | Brigitte M Schihe C Plonquet A | 2010 | Arthritis Rheum2010，62，1： | 1 |
| 9 | Concomitant changes in viscoelastic properties and amorphous polymers during the hydro- thermal treatment of hardwood and softwood 显示文摘 | Carole A Vincent P Brigitte C | 2009 | Journal of Agri- culture Food Chemistry2009，57，15： | 1 |
| 10 | Comparison of taqman real-time PCR and p24 ELISA for quantification of in vitro HIV-1 replication显示文摘 | Stefan A K Susanne K Brigitte R | 2002 | Journal of virological methods2002，107，2003： | 1 |
| 11 | Synthesis and in Vitro Antioxidant Activity of Glyeyrrhetinic Acid Derivatives Tested with the Cytochrome P450/NADPH System显示文摘 | Mourboul A Brigitte L Choi D W | 2004 | Chemical Pharmacetical Bulletin2004，52，12： | 1 |
| 12 | Synthesis and in vitro antioxidant activity of glycyrrhetinic acid derivatives tested with the cytochrome P450/NADPH system显示文摘 | Mourboul A Brigitte L Choi D W | 2004 | Chem Pharm Bull2004，52，12： | 1 |
| 13 | Disposition and metabolism of quercetin-4'-glucoside in rats 显示文摘 | BRIGITTE A G WILLIAM M STUART T C | 2005 | Drug Metab Dispos2005，33，7： | 1 |
| 14 | Expression of nine tumour antigens in a series of human Glioblastoma multiforme:Interest of EGFRvI- Ⅱ, IL-13Ra2, gp100, And TRP-2 for immunotherapy 显示文摘 | Stephan S Tony A Brigitte C | 2007 | J Neuroonco12007，81，2： | 1 |
| 15 | Down-regulation of cinnamyl alcohol dehydrogenase in transgenic alfalfa and the effect on lignin compositon and digestibility 显示文摘 | BAUCHER M MARIE A B BRIGITTE C | 1999 | Plant Molecular Biology1999，39，： | 1 |
| 16 | Muscle resident macrophages control the immune cell reaction in a mouse model of notexin-induced myoinjury显示文摘 | Brigitte M Schilte C Plonquet A | 2010 | Arthritis Rheum2010，62，1： | 1 |
| 17 | Muscle resident macrophages control the immune cell reaction in a mouse model of notexin-induced myoinjury显示文摘 | Brigitte M Schilte C Plonquet A | 2010 | Arthritis and Rheumatism2010，62，1： | 1 |
| 18 | A coumaroylester-3-hydroxylase insertion mutant reveals the existence of nonredundant meta-hydroxylation pathways and essential roles for phenolic precursors in cell expansion and plant growth显示文摘 | Nawroz A Brigitte P Jtirgen E | 2006 | Plant Physiology2006，140，： | 1 |
| 19 | Treatment of congestive heart failure interfering the aldosterone-cardiac extracellular matrix relationship显示文摘 | Faiez Z Brigitte D Francois A | 2001 | Hypertension2001，38，： | 1 |
| 20 | Muscle resident macropha-ges control the immune cell reaction in a mouse model of notexin-induced myoinjury显示文摘 | Brigitte M Schilte C Plonquet A | 2010 | Arthritis Rheum2010，62，1： | 1 |
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