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| 1 | Cancer risk in primary sclerosing cholangitis: Epidemiology,prevention, and surveillance strategies显示文摘Primary sclerosing cholangitis(PSC) is a rare cholestatic liver disease characterized by progressive fibroinflammatory destruction of the intra-and/or extrahepatic biliary ducts. While its features and disease course can be variable,most patients with PSC have concurrent inflammatory bowel disease and will eventually develop liver cirrhosis and end-stage liver disease, with liver transplantation representing the only potentially curative option. Importantly,PSC is associated with a significantly increased risk of malignancy compared to the general population, mainly cholangiocarcinoma, gallbladder carcinoma,hepatocellular carcinoma, and colorectal cancer, with nearly 50% of deaths in patients with PSC being due to cancer. Therefore, robust surveillance strategies are needed, though uncertainty remains regarding how to best do so. In this review, we discuss the epidemiology, prevention, and surveillance of cancers in patients with PSC. Where evidence is limited, we present pragmatic approaches based on currently available data and expert opinion. | Brian M Fung Keith D Lindor James H Tabibian | 2019 | World Journal of Gastroenterology2019，25，6： | 15 |
| 2 | Foreign object ingestion and esophageal food impaction:An update and review on endoscopic management显示文摘Foreign body ingestion encompasses both foreign object ingestion(FOI) and esophageal food impaction(EFI) and represents a common and clinically significant scenario among patients of all ages. The immediate risk to the patient ranges from negligible to life-threatening, depending on the ingested substance,its location, patient fitness, and time to appropriate therapy. This article reviews the FOI and EFI literature and highlights important considerations and implications for pediatric and adult patients as well as their providers. Where published literature is insufficient to provide evidence-based guidance, expert opinion is included to supplement the content of this comprehensive review. | Brian M Fung Seth Sweetser Louis M Wong Kee Song James H Tabibian | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，3： | 15 |
| 3 | 加拿大Ⅰ级创伤中心10年间创伤结构变化分析显示文摘创伤不仅在发达国家,而且在中低收入国家也已成为最主要的公共健康问题之一。WHO的报告显示,在全球15~44岁的人口中十大致死原因中的第五位是创伤;道路交通事故已成为全球与创伤有关死亡的主要原因。了解和认识一定区域内创伤的变化情况和趋势,有助于制订社区疾病预防措施,也是医院制订医疗服务和发展计划的基本依据。笔者旨在探讨1995,2000和2004年加拿大安大略省汉密尔顿地区Ⅰ级创伤中心收治严重创伤患者的相关情况。 | 李建林 Brian Yang Mohit Bhandari Wayne Fung | 2007 | 中华创伤杂志2007，23，11： | 3 |
| 4 | Large polyps:Pearls for the referring and receiving endoscopist显示文摘Polyps are precursors to colorectal cancer,the third most common cancer in the United States.Large polyps,i.e.,,those with a size≥20 mm,are more likely to harbor cancer.Colonic polyps can be removed through various techniques,with the goal to completely resect and prevent colorectal cancer;however,the management of large polyps can be relatively complex and challenging.Such polyps are generally more difficult to remove en bloc with conventional methods,and depending on level of expertise,may consequently be resected piecemeal,leading to an increased rate of incomplete removal and thus polyp recurrence.To effectively manage large polyps,endoscopists should be able to:(1)Evaluate the polyp for characteristics which predict high difficulty of resection or incomplete removal;(2)Determine the optimal resection technique(e.g.,snare polypectomy,endoscopic mucosal resection,endoscopic submucosal dissection,etc.);and(3)Recognize when to refer to colleagues with greater expertise.This review covers important considerations in this regard for referring and receiving endoscopists and methods to best manage large colonic polyps. | Eric Markarian Brian M Fung Mohit Girotra James H Tabibian | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，12： | 1 |
| 5 | Experience With Liver And Kidney Allografts From Non-Heart-Beating Donors显示文摘 | Adrian Casavilla Carlo Ramirez Ron Shapiro Dai Nghiem Kevin Miracle Oscar Bronsther Parmjeet Randhawa Brian Broznick John J. Fung Thomas Starzl | 1995 | Transplantation1995，，2： | 1 |
| 6 | Nationwide retrospective study of hepatitis B virological response and liver stiffness improvement in 465 patients on nucleos(t)ide analogue显示文摘BACKGROUND Hepatitis B virus(HBV)nucleos(t)ide analog(NA)therapy reduces liver disease but requires prolonged therapy to achieve hepatitis B surface antigen(HBsAg)loss.There is limited North American real-world data using non-invasive tools for fibrosis assessment and few have compared 1st generation NA or lamivudine(LAM)to tenofovir disoproxil fumarate(TDF).AIM To assess impact of NA on virological response and fibrosis regression using liver stiffness measurement(LSM)(i.e.,FibroScan®).METHODS Retrospective,observational cohort study from the Canadian HBV Network.Data collected included demographics,NA,HBV DNA,alanine aminotransferase(ALT),and LSM.Patients were HBV monoinfected patients,treatment naïve,and received 1 NA with minimum 1 year follow-up.RESULTS In 465(median 49 years,37%female,35%hepatitis B e antigen+at baseline,84%Asian,6%White,and 9%Black).Percentage of 64(n=299)received TDF and 166 were LAM-treated with similar median duration of 3.9 and 3.7 years,respectively.The mean baseline LSM was 11.2 kPa(TDF)vs 8.3 kPa(LAM)(P=0.003).At 5-year follow-up,the mean LSM was 7.0 kPa in TDF vs 6.7 kPa in LAM(P=0.83).There was a significant difference in fibrosis regression between groups(i.e.,mean-4.2 kPa change in TDF and-1.6 kPa in LAM,P<0.05).The last available data on treatment showed that all had normal ALT,but more TDF patients were virologically suppressed(<10 IU/mL)(n=170/190,89%)vs LAM-treated(n=35/58,60%)(P<0.05).None cleared HBsAg.CONCLUSION In this real-world North American study,approximately 5 years of NA achieves liver fibrosis regression rarely leads to HBsAg loss. | Alnoor Ramji Karen Doucette Curtis Cooper Gerald Yosel Minuk Mang Ma Alexander Wong David Wong Edward Tam Brian Conway David Truong Philip Wong Lisa Barrett Hin Hin Ko Sarah Haylock-Jacobs Nishi Patel Gilaad G Kaplan Scott Fung Carla S Coffin | 2022 | World Journal of Gastroenterology2022，28，31： | 1 |
| 7 | Prognostic Value of Abdominal CT Scanning and Hepatic Histopathology in Patients with Acute Liver Failure显示文摘 | A. Obaid Shakil Brian C. Jones Randall G. Lee Michael P. Federle John J. Fung Jorge Rakela | 2000 | Digestive Diseases and Sciences2000，，2： | 1 |
| 8 | Cultural Variation in Affect Valuation 显示文摘 | Tsai Jeanne L Knutson Brian Fung Helene H | 2006 | Journal of Personality and Social Psychology2006，90，2： | 1 |
| 9 | Common chronic health problems and life satisfaction among Macao elderly people显示文摘Aim:Most elderly people live with one or more health problems and their quality of life is affected.This study aimed to compare life satisfaction of elderly people living with common chronic medical illness compared with those without these health conditions in order to identify conditions that most affect life satisfaction of elderly people living in the community.Method:The data was collected by a questionnaire survey of 529 elderly living in community dwellings of Macao using a single measure of life satisfaction and self-reported common chronic medical illness diagnosed by a physician.A purposeful stratified random sampling method was used.Independent sample t-tests were conducted to compare participants who had a health condition to those without a health condition.Results:Respondents who indicated the lowest life satisfaction were those with fracture after the age of 60,eye illness,chronic bronchitis/emphysema,and metabolic arthritis/arthritis.For men,prostate problems was also significantly related to low life satisfaction.Conclusion:Lowest life satisfaction was reported among Macao elderly people living with mobility related chronic medical illness.Policies and practices should pay more attention to mobility related health problems or issues of elderly people,such as eye health and neuromuscular weaknesses. | Sydney X.X.Hu Wai In Lei Ka Kei Chao Brian J.Hall Siu Fung Chung | 2016 | International Journal of Nursing Sciences2016，3，4： | 1 |
| 10 | Endoscopic ultrasound in chronic liver disease显示文摘Endoscopic ultrasound(EUS)is a minimally invasive diagnostic and therapeutic modality with a number of established as well as evolving uses in patients with chronic liver disease.Compared to other diagnostic tools such as cross-sectional imaging or conventional endoscopy,EUS has been shown to increase diagnostic sensitivity and therapeutic success for many clinical scenarios and applications with a low rate of adverse events.In this review,we discuss and focus on the current and growing role of EUS in the evaluation and/or treatment of hepatobiliary masses,hepatic parenchymal disease,portal hypertension,esophageal and other varices,and indeterminate biliary strictures. | Brian M Fung Alexander P Abadir Armen Eskandari Michael J Levy James H Tabibian | 2020 | World Journal of Hepatology2020，12，6： | 0 |
| 11 | Anterior perineal hernia after anterior exenteration显示文摘Perineal hernia is a rare complication of anterior exenteration.We reported this complication after an anterior exenteration for bladder cancer with bleeding complication requiring packing and second-look laparotomy.Perineal approach is a simple and effective method for repair of perineal hernia. | Ka Wing Wong Terence Chun-ting Lai Ada Tsui-lin Ng Brian Sze-ho Ho James Hok-leung Tsu Chiu Fung Tsang W.K.Ma Ming Kwong Yiu | 2017 | Asian Journal of Urology2017，4，4： | 0 |
| 12 | 拍卖行化身多元艺术空间——嘉德艺术中心显示文摘嘉德艺术中心紧邻紫禁城,作为一座全新的综合文化机构,将北京的古城韵味与现代大都会的蓬勃生机以及多元艺术融为一体.嘉德艺术中心是世界上第一个量身定制的拍卖行总部,在北京的中心创建了一个全新的多元艺术机构类型.建筑提供博物馆硬件质量的展示空间和最先进的艺术品保护设施,同时也是一个灵活丰富的文化空间,与餐馆、酒店、公共交通基础设施结合在一起. | Marcel Holmberg Sun Ke Emily Liang Cecilia Lei Yingda Ahrens Mark Biemans Kim Bjarke Catarina Canas Alicia Casals Michael Cavander Jeffrey Cheng Patrick Conway Dyno Du Nicolaz Frez Brian Fung Daniel Hawkins Xinran Ji Philipp Kramer Emeline Laurencon Yuyang Lin Mavis Liu Wymen Lo Max Ma Rafael Merino John Murphey Marcin Olszowski Kevin Ou Kevin Park Yanyadech Phornphong Aaron Powers Klementina Savickaite Jim Shi Chiara Storino Joseph Tang Yang Tao Elena Yang Quentin Yiu Francis Young Lei Yu Danny Zhang Bruno Zhao Weiwei Zhang Yi Zhu Catarina Canas Brian Fung Paloma Hernaiz Marcel Holmberg Tait Kaplan Jaime Oliver Joseph Tang | 2018 | 设计家2018，，1： | 0 |
| 13 | Geoepidemiologic variation in outcomes of primary sclerosing cholangitis显示文摘Primary sclerosing cholangitis(PSC)is a chronic,progressive,hepatobiliary disease characterized by inflammation and fibrosis of the intra-and extra-hepatic bile ducts.Its natural history is one that generally progresses towards cirrhosis,liver failure,cholangiocarcinoma,and ultimately disease-related death,with a median liver transplantation-free survival time of approximately 15-20 years.However,despite its lethal nature,PSC remains a heterogenous disease with significant variability in outcomes amongst different regions of the world.There are also many regions where the outcomes of PSC have not been studied,limiting the overall understanding of this disease worldwide.In this review,we present the geoepidemiologic variations in outcomes of PSC,with a focus on survival pre-and post-liver transplantation as well as the concurrence of inflammatory bowel disease and hepatobiliary neoplasia. | Tej I Mehta Simcha Weissman Brian M Fung James H Tabibian | 2020 | World Journal of Hepatology2020，12，4： | 0 |
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