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| 1 | MiR-9 reduces human acyl-coenzyme A:cholesterol acyltransferase-1 to decrease THP-1 macrophage-derived foam cell formation显示文摘MicroRNAs (miRNAs ) post-transcriptionally 由指向 mRNAs 调整基因表示并且控制大量生物函数。最近的研究显示了 miRNAs 能在哺乳动物调整类脂化合物和胆固醇新陈代谢。酰辅酶 A:cholesterol acyltransferase (ACAT ) 是在细胞的胆固醇新陈代谢的关键酶。积累的 cholesteryl 酉旨被 ACAT1 主要在泡沫房间的形成期间综合,早动脉粥样硬化患者损害的一个特点。这里,我们表明 miR-9 能指向人的 ACAT1 mRNA 的 3-untranslated 区域,明确地在不同人的房间线减少人的 ACAT1 或记者萤火虫酶(Fluc ) 蛋白质然而并非他们的 mRNAs,并且机能上地减少从 THP-1-derived 巨噬细胞的泡沫房间的形成。我们的调查结果建议 miR-9 可能是在细胞的胆固醇动态平衡和减少的一个重要管理者在由减少 ACAT1 蛋白质的 vivo 的泡沫房间的形成。 | Jiajia Xu Guangjing Hu Ming Lu Ying Xiong Qin Li Catherine C.Y. Chang Baoliang Song Tayuan Chang Boliang Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 17 |
| 2 | Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins显示文摘Most mammalian cells take up cholesterol from low-density lipoproteins(LDLs) via receptor-mediated endocytosis.After reaching lysosomes,LDL-derived cholesterol continues to transport to downstream organelles including the ER for specific structural and functional needs.Peroxisomes are recently found to receive cholesterol from lysosomes through lysosomeperoxisome membrane contacts.However,whether and how cholesterol is conveyed from peroxisomes to the ER remain unknown.Here,by combining high-resolution microscopic analyses and in vitro reconstitution of highly purified organelles or artificial liposomes,we demonstrate that peroxisomes form membrane contacts with the ER through the interaction between peroxisomal PI(4,5)P2 and ER-resident extended synaptotagmin-1,2 and 3(E-Syts).Depletion of peroxisomal PI(4,5)P2 or ESyts markedly decreases peroxisome-ER membrane contacts and induces cholesterol accumulation in lysosomes.Furthermore,we show that cholesterol is delivered from 3H-labeled peroxisomes or PI(4,5)P2-containing liposomes to the ER in vitro,and that the presence of peroxisomes augments cholesterol transfer from lysosomes to the ER.Together,our study reveals a new cholesterol transport pathway along the lysosome-peroxisome-ER membrane contacts in the cell. | Jian Xiao Jie Luo Ao Hu Ting Xiao Meixin Li Zekai Kong Luyi Jiang Zimu Zhou Yacheng Liao Chang Xie Beibei Chu Honghua Miao Boliang Li Xiongjie Shi Bao-Liang Song | 2019 | Science China(Life Sciences)2019，62，9： | 8 |
| 3 | ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-a-processing alteration显示文摘 | Ming Zhu Xiaonan Zhao Jia Chen Jiajia Xu Guangjing Hu Dongqing Guo Qin Li Xiaowei Zhang Catherine C.Y. Chang Baoliang Song Ying Xiong Tayuan Chang Boliang Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 7 |
| 4 | The optional long 5'-untranslated region of human ACAT1 mRNAs impairs the production of ACAT1 protein by promoting its mRNA decay显示文摘我们以前报导了人的 ACAT1 mRNAs 用 AUG13971399 开始 codon 生产 50 kDa 蛋白质,并且另外一个未成年者用在上游的在里面框架 GGC12741276 开始 codon 的 56 kDa isoform。GGC12741276 codon 在可选的长 5-untranslated 区域被定位(5-UTR, nt 11396 ) mRNAs。相应于这 5-UTR 的 DNA 序列位于二个不同染色体, 7 和 1。在当前的工作,我们报导可选的长 5-UTR 显著地损害从 AUG13971399 codon 开始的人的 ACAT1 蛋白质的生产,主要由支持它的 mRNA 腐烂。西方的污点分析显示可选的长 5-UTR potently 损害了从 AUG13971399 codon 开始的不同蛋白质的生产,意味着这损害效果没被 3-UTR 或 ACAT1 mRNA 的编码顺序影响。反向的抄写量的聚合酶链反应的结果证明这 5-UTR 戏剧性地减少了它的连接 mRNAs 的内容。到 mRNA 比率的蛋白质的分析证明这 5-UTR 主要减少了它的 mRNA 稳定性而非改变它的翻译效率。我们下次执行了 plasmid transfection 实验并且使用了放线菌素 D 禁止抄写。结果证明这 5-UTR 支持了它的 mRNA 腐烂。用在 vitro 准备的 RNA 的另外的 transfection 和 nucleofection 实验说明了那,在细胞质和房间的原子核,没有连接,可选的长 5-UTR-linked mRNAs 比那些快腐烂了。总的来说,我们的学习在抄写以后的水平把新卓见带到人的 ACAT1 基因表示的规定。 | Xiaonan Zhao Jia Chen Lei Lei Guangjing Hu Ying Xiong Jiajia Xu Qin Li Xinying Yang Catherine C.Y. Chang Baoliang Song Tayuan Chang Boliang Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 6 |
| 5 | Excess TNF-α in the blood activates monocytes with the potential to directly form cholesteryl ester-laden cells显示文摘肿瘤坏死因素 --(TNF-) 并且 monocytic 房间在动脉粥样硬化的发展起一个关键作用,它是冠的心疾病(CHD ) 的主要原因。在这个工作,我们在血在单核白血球上调查了过量 TNF- 的效果并且发现从 CHD 病人的血单核白血球有潜力直接形成 cholesteryl 酉旨(CE ) 沉重的房间在下面在里面有 oxLDL 的 vitro 孵化。proinflammatory cytokines 的血浆层次例如 TNF- , interleukin 6 (IL-6 ) ,并且 C 反应蛋白质(CRP ) ,在 CHD,病人们是比在控制的那些显著地高级的健康志愿者。然而, TNF- ,然而并非 IL-6 或 CRP 的仅仅血浆水平,断然与血单核白血球的潜力被相关直接形成 CE 沉重的房间。由使用人的血单核白血球和 monocytic THP-1 房间, CE 沉重的房间的形成上的 TNF- 的激活的效果被表明,它能被 anti-TNF- 抗体明确地堵住。而且, TNF- 能由分别地提高功能的粘附分子和 scavenger 受体的表示增加粘附和单核白血球的 oxLDL 举起,这也被揭示。最后,结果在 vivo 并且在 vitro,与一个老鼠模型一起的实验证实在血的过量 TNF- 与潜力激活单核白血球直接形成 CE 沉重的房间。这些数据证明在血的过量 TNF- 是为动脉粥样硬化和 CHD 的开发的主要扳机。 | Ming Zhu Lei Lei Zhenhua Zhu Qin Li Dongqing Guo Jiajia Xu Jia Chen Huifang Sha Xiaowei Zhang Xinying Yang Baoliang Song Boliang Li Yan Yan Ying Xiong | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 4 |
| 6 | Low-level expression of human ACA T2 gene in monocytic cells is regulated by the C/EBP transcription factors显示文摘 | Dongqing Guo Ming Lu Xihan Hu Jiaiia Xu Guangjing Hu Ming Zhu Xiaowei Zhang Qin Li Catherine C. Y. Chang Tayuan Chang Baoliang Song Ying Xiong Boliang Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 3 |
| 7 | Factors Influencing Diurnal Variations of Cloud and Precipitation in the Yushu Area of the Tibetan Plateau显示文摘Using the cloud radar,ground observations,and ECMWF Reanalysis v5(ERA5)data,we investigate the factors influencing nighttime precipitation during summer in the Yushu area of the Tibetan Plateau(TP).The cloud top height(CTH),cloud base height(CBH),and liquid water content(LWC)are compared between non-precipitation and precipitation days.The results show that the average CTH on precipitation days in Yushu is below 10 km above ground level(AGL)in the daytime,whereas it exceeds 10 km AGL at night,with the maximum at 2300 BT(Beijing Time).The CBH is in-phase with the dewpoint spread.The precipitation intensity and CTH are in-phase with the LWC.The hourly averaged precipitation intensity and convective available potential energy in ERA5 reach their maximums at2100 BT,which is 3 h ahead of their observed counterparts.There is descending motion in the mid day on non-precipitation days,whereas there is ascending motion at night on precipitation days.In addition,the horizontal wind direction in the lower level(below 5000 m)shows clockwise rotation from morning to night.Wind shear occurs in the mid level of the atmosphere,accompanied by a subtropical westerly jet in the upper level.The difference in horizontal wind speed between 200 and 500 hPa is positively related to the LWC,thereby contributing to the formation of upper-level cloud. | Bangjun CAO Shihua LYU Yu ZHANG Xianyu YANG Boliang LI Liang YUAN Meilin LI | 2022 | Journal of Meteorological Research2022，36，2： | 2 |
| 8 | Modulatory effects of one polysaccharide from Acanthopanax senticosus in alloxan-induced diabetic mice显示文摘 | Jianfang Fu Jufang Fu Yang Liu Ruiyu Li Bin Gao Nanyan Zhang Boliang Wang Yizhan Cao Kaoshan Guo Yanyang Tu | 2011 | Carbohydrate Polymers2011，，3： | 1 |
| 9 | Financial distress prediction based on OR-CBR in the principle of k-nearest neigh- bors显示文摘 | Li Hui Sun Jie Sun Boliang | 2009 | Expert System with Applications2009，36，： | 1 |
| 10 | Influence of snow cover on the lower limit of permafrost in Altai Mountains显示文摘 | Zhang Tingjun Tong Boliang Li Shude | 1985 | Journal o Glaciology and Geocryology1985，7，1： | 1 |
| 11 | Tetra-glutamic acid residues adjacent to for the ubiquitination mediated by gp78 Lys248 in HMG-CoA reductase are critical and UBE2G2显示文摘3-hydroxy-3-methylglutaryl 辅酶的调整甾醇的降级 reductase (HMGCR ) 是快速的反馈房间由采用控制胆固醇生合成的规章的机制。这个过程被在 HMGCR 和 Insig-1/gp78 之间的导致甾醇的相互作用开始,膜界限 ubiquitin ligase 建筑群。有二 Lys 残余(Lys89 和 Lys248 ) ,在 HMGCR 的膜领域面对 cytosol,并且 Lys248 是主要 ubiquitination 地点。在这研究,我们在 HMGCR 调查了 ubiquitination 地点选择的机制。我们发现到膜的 Lys248 的距离为它的 ubiquitination 是非必需的。然而,邻近在 HMGCR 的 Lys248 的保存 tetra-glutamic 酸残余是必要的。有 tetra 精氨酸的这些否定地控告的残余的代替引起 HMGCR 的抵抗到导致甾醇的 ubiquitination 和降级,这个变异的 HMGCR 罐头仍然绑在 Insig-1 的虽然。我们进一步发现 tetra-glutamic 酸残余为他们的邻近的 Lys 上的修正必要然而并非足够,自从他们不在 HMGCR 或在 SCAP 的 Lys89 上是功能的。UBE2G2, gp78 的以前已知的 E2,被表明涉及 HMGCR 的调整甾醇的 ubiquitination 和降级。在摘要,当在为 ubiquitination 反应的 HMGCR 的一个批评主题由 gp78 和 UBE2G2 调停了,这些结果识别 tetra-glutamic 酸残余。 | Honghua Miao Wei Jiang Liang Ge Boliang Li Baoliang Song | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 1 |
| 12 | In situ printing of liquid superlenses for subdiffraction-limited color imaging of nanobiostructures in nature显示文摘The nanostructures and patterns that exist in nature have inspired researchers to develop revolutionary components for use in modern technologies and our daily lives.The nanoscale imaging of biological samples with sophisticated analytical tools,such as scanning electron microscopy(SEM)and transmission electron microscopy(TEM),has afforded a precise understanding of structures and has helped reveal the mechanisms contributing to the behaviors of the samples but has done so with the loss of photonic properties.Here,we present a new method for printing biocompatible“superlenses”directly on biological objects to observe subdiffraction-limited features under an optical microscope in color.We demonstrate the nanoscale imaging of butterfly wing scales with a super-resolution and larger field-of-view(FOV)than those of previous dielectric microsphere techniques.Our approach creates a fast and flexible path for the direct color observation of nanoscale biological features in the visible range and enables potential optical measurements at the subdiffraction-limited scale. | Boliang Jia Feifei Wang Hoyin Chan Guanglie Zhang Wen Jung Li | 2019 | Microsystems & Nanoengineering2019，5，1： | 1 |
| 13 | An estimation model of time-varying origin-destination flows in expressway corridors based on unscented Kalman filter显示文摘On the basis of measurable time series of mainline and ramp flows from traffic counts and the assumption of travel time distributions, this research presents a dynamic system model and its on-line estimation algorithm for recursive estimation of time-varying origin-destination (OD) matrices in expressway corridors. The proposed model employs a macro-traffic flow model to estimate travel times of OD flows and uses parameters of the traffic model as state variables, which are added to the constrained function of the system. To improve the model efficiency, we revise the travel time distribution based on the feature of normal distribution. The research employs a newly developed filtering technique, called unscented Kalman filter. The proposed model is evaluated with simulation experiments. Numerical analyses with respect to the sensitivity of the selection of initial parameters on the estimation results indicate that the proposed model is sufficiently reasonable and stable for real-world appli-cations. | LI JunWei LIN BoLiang SUN ZhiHui GENG XueFei | 2009 | Science China(Technological Sciences)2009，52，7： | 0 |
| 14 | Plasma exchange therapy for acute necrotizing encephalopathy of childhood显示文摘Importance Acute necrotizing encephalopathy(ANE)is a rare disease with high mortality.Plasma exchange(PLEX)has recently been reported to treat ANE of childhood(ANEC),but its efficacy is uncertain.Objective This study aimed to investigate the effectiveness of PLEX on ANEC.Methods A retrospective study was conducted in four pediatric intensive care units from December 2014 to December 2020.All patients who were diagnosed with ANEC were included;however,these patients were excluded if their length of stay was less than 24 h.Participants were classified into PLEX and non-PLEX groups.Results Twenty-nine patients with ANEC were identified,10 in the PLEX group and 19 in the non-PLEX group.In the PLEX group,C-reactive protein,procalcitonin,alanine aminotransferase,and aspartate aminotransaminase levels were significantly lower after 3 days of treatment than before treatment(13.1 vs.8.0,P=0.043;9.8 vs.1.5,P=0.028;133.4 vs.31.9,P=0.028;282.4 vs.50.5,P=0.046,respectively).Nine patients(31.0%,9/29)died at discharge,and a significantly difference was found between the PLEX group and non-PLEX group[0 vs.47.4%(9/19),P=0.011].The median follow-up period was 27 months,and three patients were lost to follow-up.Thirteen patients(50.0%,13/26)died at the last follow-up,comprising three(33.3%,3/9)in the PLEX group and ten(58.8%,10/17)in the non-PLEX group,but there was no significant difference between the two groups(P=0.411).Three patients(10.3%,3/29)fully recovered.Interpretation PLEX may reduce serum C-reactive protein and procalcitonin levels and improve liver function in the short term.PLEX may improve the prognosis of ANEC,and further studies are needed. | Kechun Li Tao Zhang Gang Liu Ping Jin Yeqing Wang Lijie Wang Meixian Xu Chunyi Liu Yingchao Liu Tao Zhou Yan Xu Ying Yang Boliang Fang Xin Yang Chunfeng Liu Suyun Qian | 2021 | Pediatric Investigation2021，5，2： | 0 |
| 15 | Phylogenetically diverse,acetaldehyde-degrading bacterial community in the deep sea water of the West Pacific Ocean显示文摘As a major aldehyde pollutant widely existing in industry and our daily life, acetaldehyde is more and more harmful to human health. As characteristic habitat niche, bacteria from deep sea environments are abundant and distinctive in heredity, physiology and ecological functions. Thus, the development of acetaldehyde-degrading bacteria from deep sea provides a new method to harness acetaldehyde pollutant. Firstly, in this study,acetaldehyde-degrading bacteria in the deep sea water of the West Pacific Ocean were enriched in situ and in the laboratory respectively, and then the diversity of uncultured bacteria was studied by using 16 S r RNA genes. Then acetaldehyde-degrading strains were isolated from two samples, including enrichment in situ and enrichment in laboratory samples of deep sea water from the West Pacific Ocean using acetaldehyde as the sole carbon source,and then the ability of acetaldehyde degradation was detected. Our results showed that the main uncultured bacteria of two samples with different enrichment approaches were similar, including Proteobacteria,Actinobacteria, Firmicutes, Cyanobacteria, but the structure of bacterial community were significant different.Four subgroups, α, γ, δ and ε, were found in Proteobacteria group. The γ-Proteobacteria was dominant(63.5%clones in laboratory enriched sample, 75% clones in situ enriched sample). The species belonged to γ-Proteobacteria and their proportion was nearly identical between the two enrichment samples, and Vibrio was the predominant genus(45% in laboratory enriched sample, 48.5% in situ enriched sample), followed by Halomonas(9% in situ enriched sample) and Streptococcus(6% in laboratory enriched sample). A total of 12 acetaldehyde-degrading strains were isolated from the two samples, which belonged to Vibrio, Halomonas,Pseudoalteromonas, Pseudomonas and Bacillus of γ-Proteobacteria. Strains ACH-L-5, ACH-L-8 and ACH-S-12,belonging to Vibrio and Halomonas, have strong ability of acetaldehyde degradation, which could tolerate 1.5 g/L acetaldehyde and degrade 350 mg/L acetaldehyde within 24 hours. Our results indicated that bacteria of γ-Proteobacteria may play an important role in carbon cycle of deep sea environments, especial the bacteria belonging to Vibrio and Halomonas and these strains was suggested for their potentials in government of aldehyde pollutants. | GAO Boliang SHANG Xiexie LI Li DI Wenjie ZENG Runying | 2018 | Acta Oceanologica Sinica2018，37，8： | 0 |
| 16 | The ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters显示文摘 | Dongqing Guo Xiaowei Zhang Qin Li Lei Qian Jiajia Xu Ming Lu Xihan Hu Ming Zhu Catherine C. Y. Chang Baoliang Song Tayuan Chang Ying Xiong and Boliang Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 0 |
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