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| 1 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 2 | Helicobacter pylori and gastrointestinal adenocarcinomas显示文摘 | Peek R M Jr blaser M J | 2002 | Nat Res Cancer2002，2，1： | 1 |
| 3 | Genetic organization and heterogeneity of the iceA locus of Helicobacter pylori显示文摘 | Céu Figueiredo Wim G.V Quint Ricardo Sanna Erwin Sablon John P Donahue Qing Xu Geraldine G Miller Richard M Peek Martin J Blaser Leen-Jan van Doorn | 2000 | Gene2000，，1： | 1 |
| 4 | Proteases and their inhibitors are indicative in gestational disease 显示文摘 | KOLBEN M LOPENS A BLASER J | 1996 | Eur J Obstet Gyneeol Reprod Biol1996，68，12： | 1 |
| 5 | Helicobacter pylori and overweight status in the United States: data from the Third National Health and Nutrition Examination Survey显示文摘 | Cho I Blaser M J Francois F | 2005 | Am J Epidemiol2005，162，6： | 1 |
| 6 | Helicobacter pylori and gastrointestinal adenocarcinomas显示文摘 | Peek R M Jr Blaser M J | 2002 | Nat Rev Cancer2002，2，1： | 1 |
| 7 | Helicobacter pylori and the pathogenesis of gastroduodenal inflammation 显示文摘 | Blaser M J | 1990 | Journal of Infectious Diseases1990，161，4： | 1 |
| 8 | STEP(satellite test of the equivalence principle)显示文摘 | Sumner T J Anderson J Blaser J P Cruise A M Damour T Dittus D Everitt C W F Fou-lon B Jafry Y Kent B J Lockerbie N Loeffler F Mann G Mester J Pegrum C ReinhardtR Sandford M Scheicher A Speake C C Torii R Theil S Touboul P Vitale S Vodel W Worden P W | 2007 | Advance in Space Re-search2007，39，2： | 1 |
| 9 | Combating antimicrobial resistance: policy recommendations to save lives 显示文摘 | Infectious Diseases Society of America (IDSA) Spellberg B Blaser M Guidos RJ Boucher HW Bradley JS Eisenstein BI Gerding D Lynfield R Relier LB Rex J Schwartz D Septimus E Tenover FC Gilbert DN | 2011 | Clin Infect Dis2011，52，5： | 1 |
| 10 | Helicobacter pylori:A bacterial cause of gastritis,peptic ulcer disease,and gastric cancer 显示文摘 | Cover T L Blaser M J | 1995 | American Society for Microbiology News1995，61，： | 1 |
| 11 | Susceptibility of Campylobacter isolates to the bactericidal activity of human serum 显示文摘 | Blaser M J Smith P F Kohler P F | 1985 | J Infect Dis1985，151，2： | 1 |
| 12 | Helicobacter pylori 显示文摘 | Dunn BE Cohen H Blaser M J | 1997 | Ctin Microbiol Rev1997，10，4： | 1 |
| 13 | Protease and their inhibitors are indicative in gestational disease显示文摘 | Kolben M Lopens A Blaser J | 1996 | Eur J Obstet Gynecol Reprod Biol1996，68，12： | 1 |
| 14 | Detection and characterization of autoagglutination activity by Campylobacter jejuni 显示文摘 | Misawa N Blaser M J | 2000 | Infect Immun2000，68，11： | 1 |
| 15 | Activation of IL- 8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-кB in gastric epithelial cells显示文摘 | Sharma SA Tummuru MK Blaser M J | 1998 | J Immunol1998，160，5： | 1 |
| 16 | Ezrin/moesin in motile Walker 256 carcinosarcoma cells: signal-dependent relocalization and role in migration显示文摘 | ROSSY J GUTJAHR M C BLASER N | 2007 | Exp Cell Res2007，313，6： | 1 |
| 17 | Role of helicobacter pylori virulence factors vacuolaling cytotoxin, Cag A and urease in a mouse model of disease显示文摘 | Ghiare P Marchetti M Blaser M J | 1995 | Infect Immun1995，63，12： | 1 |
| 18 | Cloning and expression of a high molecular 2 mass major antigen of helicobacter pylori evidence of linkage to cytotoxin production显示文摘 | COVER T L BLASER M J | 1993 | Infect Immune1993，6，15： | 1 |
| 19 | Experimental campylohacter jejuni infection of adult mice显示文摘 | Blaser M J D J Duncan G H Warren | 1983 | Infec Immun1983，39，： | 1 |
| 20 | The human mierobiome :at the interface of health and disease 显示文摘 | Cho I Blaser M J | 2012 | Nature Reviews Genetics2012，13，4： | 1 |
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