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| 1 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 2 | Coadaptation of Helicobacter pylori and humans: ancient history, modern implications显示文摘 | Atherton John C Blaser Martin J | 2009 | Journal of Clinical Investigation2009，，9： | 2 |
| 3 | Helicobacter pylori and gastrointestinal adenocarcinomas显示文摘 | Peek R M Jr blaser M J | 2002 | Nat Res Cancer2002，2，1： | 1 |
| 4 | 查看详情显示文摘 | Blaser H.U Jalett H.P Wiehl J | | 0，，： | 1 |
| 5 | Critical Examination of Trace Element Enrichments and Depletions in Soils: As, Cr, Cu, Ni, Pb and Zn in Swiss Forest Soils显示文摘 | Blaser P Zimmermann S Luster J | 2000 | The Science of the Total Environment2000，249，： | 1 |
| 6 | Genetic organization and heterogeneity of the iceA locus of Helicobacter pylori显示文摘 | Céu Figueiredo Wim G.V Quint Ricardo Sanna Erwin Sablon John P Donahue Qing Xu Geraldine G Miller Richard M Peek Martin J Blaser Leen-Jan van Doorn | 2000 | Gene2000，，1： | 1 |
| 7 | Critical examination of trace element enrichments and depletions in soils:As,Cr,Cu,Ni,Pb,and Zn in Swiss forest soils显示文摘 | Blaser P Zimmermann S Luster J | 2000 | The Science of the Total Environment2000，249，： | 1 |
| 8 | Simulation of amoxicillin pharmacokinetics in humans for the prevention of streptococcal endocarditis in rats显示文摘 | Fluckiger U Moreillon P Blaser J | 1994 | Antimicrob Agents Chemother1994，38，： | 1 |
| 9 | Proteases and their inhibitors are indicative in gestational disease 显示文摘 | KOLBEN M LOPENS A BLASER J | 1996 | Eur J Obstet Gyneeol Reprod Biol1996，68，12： | 1 |
| 10 | Helicobacter pylori and overweight status in the United States: data from the Third National Health and Nutrition Examination Survey显示文摘 | Cho I Blaser M J Francois F | 2005 | Am J Epidemiol2005，162，6： | 1 |
| 11 | Critical examination of trace element enrichments and depletions in soils: As, Cr, Cu, Ni, Pb, and Zn in Swiss forest soils显示文摘 | BLASER P ZIMMERMANN S LUSTER J | 2000 | Science of the Total Environment2000，249，13： | 1 |
| 12 | Mechanisms of allergen-specific munotherapy: T-regulatory cells and more显示文摘 | VERHAGEN J BLASER K AKDIS C A | 2006 | Immunol Allergy Clin North Am2006，26，： | 1 |
| 13 | Winter cereal canopy effect on cereal and interseeded legume productivity 显示文摘 | Blaser B C Singer J W Gibson L R | 2011 | Agronomy Journal2011，103，4： | 1 |
| 14 | Helicobacter pylori and gastrointestinal adenocarcinomas显示文摘 | Peek R M Jr Blaser M J | 2002 | Nat Rev Cancer2002，2，1： | 1 |
| 15 | Fluoride-induced mobilization and leaching of organic matter,iron and aluminium显示文摘 | Polomski J Fluhier H Blaser P | | 0，，01： | 1 |
| 16 | Transfer Function Method of Measuring Induct Acoustic Properties显示文摘 | Chung J Y Blaser D A | 1980 | Acoustical Society of America1980，68，3： | 1 |
| 17 | Radiation use effi- ciency in dual winter cereal forage production systems 显示文摘 | Singer J W Sauer T J Blaser B C | 2007 | Agronomy Journal2007，99，4： | 1 |
| 18 | Helicobacter pylori and the pathogenesis of gastroduodenal inflammation 显示文摘 | Blaser M J | 1990 | Journal of Infectious Diseases1990，161，4： | 1 |
| 19 | Disappearing microiota Helicobacter pylori protection against esophageal adenocarcinoma显示文摘 | Blaser Martin J | | 0，，： | 1 |
| 20 | STEP(satellite test of the equivalence principle)显示文摘 | Sumner T J Anderson J Blaser J P Cruise A M Damour T Dittus D Everitt C W F Fou-lon B Jafry Y Kent B J Lockerbie N Loeffler F Mann G Mester J Pegrum C ReinhardtR Sandford M Scheicher A Speake C C Torii R Theil S Touboul P Vitale S Vodel W Worden P W | 2007 | Advance in Space Re-search2007，39，2： | 1 |
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