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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | POEMS syndrome (or Crow-Fukase syndrome)显示文摘 | Lagueny A Bouillot S Vital C | 2004 | Rev Neurol (Paris)2004，160，3： | 1 |
| 3 | Comparison of three tonometers for measuring intraocular pressure in rabbits显示文摘 | Abrams LS Vitale S Jampel HD | | 0，，05： | 1 |
| 4 | Large dinurnal fluctuations in intraocular pressure are an in- dependent risk factor in patients with glaucoma显示文摘 | Asrani S Zeimer R Wilensky J Gieser D Vitale S IAndenmuth K | 2000 | J Glauco- ma2000，9，2： | 1 |
| 5 | Clinical evaluation of a lumbar interspinous dynamic stabilization device(the Wallis system)with a 13-year mean follow-up显示文摘 | Sénégas J Vital JM Pointillart V | 2009 | Neurosurg Rev2009，32，3： | 1 |
| 6 | Endoplasmic Retieulum Quality Control and theUnfolded Protein Response: Insights from Plants 显示文摘 | VITALE A BOSTON R S | 2008 | Blackwell Munks- gaard2008，9，： | 1 |
| 7 | Treatment of acute respiratory failure secondaryto pulmonary edema with bilevel positive airway pressure by nasal mask 显示文摘 | Lo Coco A Vitale G Marchese S | 2001 | Monaldi Arch Chest Dia2001，63，： | 1 |
| 8 | Consumer Trust in an Internet Store显示文摘 | JARVENPAA S TRACTINSKY N VITALE M | 2000 | Information Technology and Management2000，1，12： | 1 |
| 9 | Pancreatic cancer among workers processing synthetic resins显示文摘 | Teta MJ Vitale JN | 1995 | Am J Ind Med1995，28，3： | 1 |
| 10 | POEMS syndrome(or Crow-Fukase syndrome)显示文摘 | Lagueny A Bouillot S Vital C | 2004 | Rev Neurol(Paris)2004，160，3： | 1 |
| 11 | Anterior tension-free repair of recurrent inguinal hernia under local anesthesia: a 7-year experience in a teaching hospital显示文摘 | Ginanetta E Cuneo S Vitale B | 2000 | Ann surg2000，23，1： | 1 |
| 12 | Astigmatism outcomes of horizontal temporal versus nasal clear corneal incision cataract surgery显示文摘 | Barequet IS Yu E Vitale S | | 0，，02： | 1 |
| 13 | Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves显示文摘 | VITALE N DE FEO M DE SANTO L S | 1999 | J Am Coll Cardiol1999，33，6： | 1 |
| 14 | Effects of pulsed electric fields on microorganisms in orange juice using electric strengths of 30 and 50 kV/cm 显示文摘 | MCDONALD C J LLOYD S W VITALE M A | 2000 | J Food Sci2000，65，6： | 1 |
| 15 | Existence of both inhibitory (P58) and activatory (P50) receptors for HLA-C molecules in human natural killer cells 显示文摘 | Sirori S Vitale M | 1995 | J Exp Med1995，182，3： | 1 |
| 16 | The LISA Pathfinder drift mode: implementation solutions for a robust algorithm 显示文摘 | Grynagier A Fichter W Vitale S | 2009 | Classical and Quantum Gravity2009，26，9： | 1 |
| 17 | Familial prion disease with a novel 144-bp insertion in the prion protein gene in a Basque family显示文摘 | Capellari S Vital C Parchi P | 1997 | Neurology1997，49，： | 1 |
| 18 | Eight - year clinical and ra- diological follow- up of the Bryan cervical disc arthroplasty 显示文摘 | Quan GM Vital JM Hansen S | 2011 | Spine2011，8，： | 1 |
| 19 | Clinico-biological features of 5202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stralified in age cohorts显示文摘 | Chiaretti S Vitale A Cazzaniga G | 2013 | Haematologica2013，98，11： | 1 |
| 20 | Serum levels of IL-lbeta, IL-6and TNF-alpha in infertile patients with o- varian dysfunction 显示文摘 | Vital Reyes VS Tellez Velasco S Hinojosa Cruz JC | 2005 | Ginecol Obstet Mex2005，73，60： | 1 |
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