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| 1 | Microvascular protective role of pericytes in melatonin-treated spinal cord injury in the C57BL/6 mice显示文摘 | Jing Yingli Wu Qingbin Yuan Xiaochen Li Bingwei Liu Mingming Zhang Xiaoyan Liu Shuying Li Hongwei Xiu Ruijuan | 2014 | Chinese Medical Journal2014，，15： | 9 |
| 2 | Wearable skin-like optoelectronic systems with suppression of motion artifacts for cuff-less continuous blood pressure monitor显示文摘According to the statistics of the World Health Organization,an estimated 17.9 million people die from cardiovascular diseases each year,representing 31%of all global deaths.Continuous non-invasive arterial pressure(CNAP)is essential for the management of cardiovascular diseases.However,it is difficult to achieve long-term CNAP monitoring with the daily use of current devices due to irritation of the skin as well as the lack of motion artifacts suppression.Here,we report a high-performance skin-like optoelectronic system integrated with ultra-thin flexible circuits to monitor CNAP.We introduce a theoretical model via the virtual work principle for predicting the precise blood pressure and suppressing motion artifacts,and propose optical difference in the frequency domain for stable optical measurements in terms of skin-like devices.We compare the results with the blood pressure acquired by invasive(intra-arterial)blood pressure monitoring for>1500 min in total on 44 subjects in an intensive care unit.The maximum absolute errors of diastolic and systolic blood pressure were±7/±10 mm Hg,respectively,in immobilized,and±10/±14 mm Hg,respectively,in walking scenarios.These strategies provide advanced blood pressure monitoring techniques,which would directly address an unmet clinical need or daily use for a highly vulnerable population. | Haicheng Li Yinji Ma Ziwei Liang Zhouheng Wang Yu Cao Yuan Xu Hua Zhou Bingwei Lu Ying Chen Zhiyuan Han Shisheng Cai Xue Feng | 2020 | National Science Review2020，7，5： | 7 |
| 3 | Synergistic Effects of Chiral Morphology and Reconfiguration in Cattail Leaves显示文摘 | Zilong Zhao Weixi Huang Bingwei Li Kexing Chen Kuifu Chen Hongping Zhao Xiqiao Feng | 2015 | Journal of Bionic Engineering2015，12，4： | 3 |
| 4 | Analysis of Vitamin P Content and Inheritance Models in Eggplant显示文摘The eggplant(Solanum melongena L.)is rich in vitamin P(also known as rutin),which is beneficial for humans.In this study,the vitamin P contents of 53 eggplant lines were measured via UV spectrophotometry.The results showed that the vitamin P content differed significantly among the eggplant lines and the actual contents of vitamin P in fresh fruit pulp and fresh peel were 0.18–0.82mg·g^−1 and 0.42–2.32mg·g^−1,respectively.Furthermore,themixed major gene and polygene inheritance modelmethod was used for the inheritance analysis of the vitamin P content in F2 populations of three hybridization combinations.Inheritance analysis demonstrated that the vitamin P content of these eggplant lines was a quantitative trait.One or two major genes were the contributor,and the genetic effect was an additive-dominance effect.The high vitamin P content trait was regulated by the main gene and followed an additive effect.The heritability of the major genes controlling the high vitamin P content was low,while the heritability of the major gene that controls the low vitamin P content trait was high.These results provide a theoretical basis for the breeding of eggplants with high vitamin P content. | Riyue Dong Bingwei Yu Shuangshuang Yan Zhengkun Qiu Jianjun Lei Changming Chen Ye Li Bihao Cao | 2020 | Horticultural Plant Journal2020，6，4： | 3 |
| 5 | A brief review on anterior urethral strictures显示文摘The treatment of urethral strictures remains a challenging field in urology even though there are a variety of procedures to treat it at present,as no one approach is superior over another.This paper reviewed the surgical options for the management of different sites and types of anterior urethral stricture,providing a brief discussion of the controversies regarding this issue and suggesting possible future advancements.Among the existing procedures,simple dilation and direct vision internal urethrotomy are more commonly used for short urethral strictures(<1 cm,soft and no previous intervention).Currently,urethroplasty using buccal mucosa or penile skin is the most widely adopted clinical techniques and have proved successful.Nonetheless,complications such as donor site morbidity remain problem.Tissue engineering techniques are considered as a promising solution for urethral reconstruction,but require further investigation,as does stem cell therapy. | Li Cheng Sen Li Zicheng Wang Bingwei Huang Jian Lin | 2018 | Asian Journal of Urology2018，5，2： | 3 |
| 6 | Neutrophil-derived heparin binding protein triggers vascular leakage and synergizes with myeloperoxidase at the early stage of severe burns(With video)显示文摘Background:Burn shock caused by vascular leakage is one of the main causes of high mortality in severe burn injury.However,the pathophysiological mechanism of vascular leakage is still unclear.The purpose of this study was to explore the molecular mechanism of vascular leakage in the early stage of severe burn and provide a new target for the treatment of severe burns.Methods:Neutrophils were isolated from human peripheral blood by magnetic beads sorting.ELISA was used to detect neutrophil-derived granule proteins and glycocalyx injury products in plasma.The vascular leakage and neutrophil movement were assessed by in vivo laser confocal imaging in mice,and high-quality video were provided.Adhesion-related molecules were investigated by qRT-PCR.The damage to glycocalyx of mice vascular endothelial cellswas observed by transmission electron microscope and scanning electron microscope.Proteomic analysis,flow cytometry and immunofluorescence were used to further study the relationship between human peripheral blood neutrophil-derived hypochlorite(HOCl)and CD44 of human vascular endothelial cells.Results:In this study,we found that rapidly increasing activated neutrophils secrete heparin binding protein(HBP)andmyeloperoxidase(MPO)after severe burn injury.Increased HBP triggers vascular leakage with synergy of MPO,results in systemic edema and burn shock.Furthermore,we found that the MPO catalytic product HOCl but not MPO triggers CD44 extracellular domain shedding from vascular endothelial cells to damage the glycocalyx.Damage to the glycocalyx results in firm adhesion of neutrophils and increases vascular leakage.However,MPO inhibitors partially protect the glycocalyx of vascular endothelial cells.The combination of HBP and MPO inhibitors markedly reduces vascular leakage and systemic edema in the early stage of severe burns.Conclusions:Taken together,these data reveal that neutrophil-derived HBP and MPO play an important synergies role in triggering vascular leakage at the early stage of severe burns.Targeted intervention in these two biomolecules may introduce new strategies for helping to reduce large amount of fluid loss and subsequent burn shock. | Lu Liu Yiming Shao Yixuan Zhang Yunxi Yang Jiamin Huang Linbin Li Ran Sun Yuying Zhou Yicheng Su Bingwei Sun | 2021 | Burns & Trauma2021，9，1： | 3 |
| 7 | Untangling the contributions of meteorological conditions and human mobility to tropospheric NO_(2) in Chinese mainland during the COVID-19 pandemic in early 2020显示文摘In early 2020,unprecedented lockdowns and travel bans were implemented in Chinese mainland to fight COVID-19;which led to a large reduction in anthropogenic emissions.This provided a unique opportunity to isolate the effects from emission and meteorology on tropospheric nitrogen dioxide(N0_(2)).Comparing the atmospheric N0_(2) in 2020 with that in 2017,we found the changes of emission have led to a 49.3±23.5%reduction,which was〜12%more than satellite-observed reduction of 37.8±16.3%.The discrepancy was mainly a result of changes of meteorology,which have contributed to an 8.1±14.2%increase of N02.We also revealed that the emission-induced reduction of N02 has significantly negative correlations to human mobility,particularly that inside the city.The intra-city migration index derived from Baidu Location-Based-Service can explain 40.4%it 17.7%variance of the emission-induced reduction of N0_(2) in 29 megacities,each of which has a population of over 8 million in Chinese mainland. | Yuxiang Zhang Haixu Bo Zhe Jiang Yu Wang Yunfei Fu Bingwei Cao Xuewen Wang Jiaqi Chen Rui Li | 2021 | National Science Review2021，8，11： | 2 |
| 8 | Neutrophil extracellular traps contribute to myofibroblast differentiation and scar hyperplasia through the Toll-like receptor 9/nuclear factor Kappa-B/interleukin-6 pathway显示文摘Background:Inflammation is an important factor in pathological scarring.The role of neutrophils,one of the most important inflammatory cells,in scar hyperplasia remains unclear.The purpose of this article is to study the correlation between neutrophil extracellular traps(NETs)and scar hyperplasia and identify a new target for inhibiting scar hyperplasia.Methods:Neutrophils were isolated from human peripheral blood by magnetic-bead sorting.NETs in plasma and scars were detected by enzyme-linked immunosorbent assays(ELISAs),immunofluorescence and flow cytometry.Immunohistochemistry was used to assess neutrophil(CD66B)infiltration in hypertrophic scars.To observe the entry of NETs into fibroblasts we used immunofluorescence and flow cytometry.Results:We found that peripheral blood neutrophils in patients with hypertrophic scars were more likely to form NETs(p<0.05).Hypertrophic scars showed greater infiltration with neutrophils and NETs(p<0.05).NETs activate fibroblasts in vitro to promote their differentiation and migration.Inhibition of NETs with cytochalasin in wounds reduced the hyperplasia of scars in mice.We induced neutrophils to generate NETs with different stimuli in vitro and detected the proteins carried by NETs.We did not find an increase in the expression of common scarring factors[interleukin(IL)-17 and transforming growth factor-β(TGF-β),p>0.05].However,inhibiting the production of NETs or degrading DNA reduced the differentiation of fibroblasts intomyofibroblasts.In vitro,NETs were found to be mediated by Toll-like receptor 9(TLR-9)in fibroblasts and further phosphorylated nuclear factor Kappa-B(NF-κB).We found that IL-6,which is downstream of NF-κB,was increased in fibroblasts.Additionally,IL-6 uses autocrine and paracrine signaling to promote differentiation and secretion.Conclusions:Our experiments found that NETs activate fibroblasts through the TLR-9/NF-κB/IL-6 pathway,thereby providing a new target for regulating hypertrophic scars. | Yiming Shao Zaiwen Guo Yunxi Yang Lu Liu Jiamin Huang Yi Chen Linbin Li Bingwei Sun | 2022 | Burns & Trauma2022，10，1： | 2 |
| 9 | Stable ZnO/ionic liquid hybrid materials: novel dual-responsive superhydrophobic layers to light and anions显示文摘Novel dual-responsive superhydrophobic hybrid materials,ZnO/SAMs(self-assembled monolayers)of ionic liquids(ILs)with different counter-anions(I-,BF4-,PF6-and Tf2N-),were synthesized and characterized.ZnO nanoparticles were first deposited on glass surfaces to produce roughness.Next,SAMs of fluorinated-alkyl-3-(3-triethoxysilylpropyl)-4,5-dihydro-imidazoliumiodide(abb.[C8Ftespim]I)were grafted onto these surfaces via-Si-O-covalent bonds using self-assembly technique.The Iion could be subsequently exchanged with BF4-,PF6-or Tf2N-through a simple aqueous anion-exchange reaction.The ZnO/ILs hybrid layers were characterized by atomic-force microscopy(AFM),scanning-electron microscopy(SEM)and X-ray photoelectron spectroscopy(XPS).Their wettability was estimated through the measurements of static and dynamic contact angles(CAs).Compared to corresponding films of ZnO/[C8Ftespim]I with CAs 140.7°±2.0°,films of ZnO/[C8Ftespim]PF6 and ZnO/[C8Ftespim]Tf2N showed CAs with 154.0°±2.0°and 152.0°±2.0°,respectively that remained for a long time.This result suggests that anion-exchange can afford superhydrophobic materials.In addition,the wettability of ZnO/[C8Ftespim]X hybrid layers can be reversibly switched by altering ultraviolet(UV)irradiation and dark storage,which shows a photo-induced reversible switch of wettability.The synergistic action of ZnO nanoparticles and SAMs of ILs produced light-anion dual-responsive superhydrophobic materials with ideal stability. | LI HongLiang XIN BingWei FENG Lei HAO JingCheng | 2014 | Science China Chemistry2014，57，7： | 2 |
| 10 | Deep eutectic solvent strategy enables an octahedral Ni–Co precursor for creating high-performance NiCo_(2)O_(4) catalyst toward oxygen evolution reaction显示文摘Deep eutectic solvents(DESs)have gained much attention in the fabrication of advanced nanoelectrocatalysts due to their amazing template function.However,their stabilizing function for easily hydrolyzed inorganic nanomaterials is rarely studied.Here,a DES-mediated strategy was reported to synthesize octahedral Ni–Co precursor(NiCo–NH_(3) complex),which could be directly transformed into NiCo_(2)O_(4) nanooctahedrons after thermal decomposition.The NiCo–NH_(3) precursor in octahedral shape was achieved with the DES-mediated crystallization in the choline chloride(ChCl)/glycerol.The ChCl/glycerol DES not only tailored the morphology of the as-prepared precursor by template effect but also inhibited its hydrolysis,ensuring the successful fabrication of octahedral NiCo–NH_(3) complex precursor with high yield.The NiCo–NH_(3) complex precursor was converted to well-defined NiCo_(2)O_(4) nanooctahedrons,where the calcination temperature and time were explored in detail.It revealed that DES could participate in the conversion process to control the morphology of calcination product.The resultant NiCo_(2)O_(4) nanooctahedrons demonstrated excellent electroactivity and remarkable durability for oxygen evolution reaction(OER).The present strategy not only offers an efficient OER electrocatalyst but also enriches the approaches of DESs in designing advanced nanocatalysts. | Chenyun Zhang Bingwei Xin Tingting Chen Hao Ying Zhonghao Li Jingcheng Hao | 2022 | Green Energy & Environment2022，7，6： | 1 |
| 11 | Experimental and Theoretical Studies of Serpentine Microstructures Bonded To Prestrained Elastomers for Stretchable Electronics显示文摘 | Yihui Zhang Shuodao Wang Xuetong Li Jonathan A. Fan Sheng Xu Young Min Song Ki‐Joong Choi Woon‐Hong Yeo Woosik Lee Sharaf Nafees Nazaar Bingwei Lu Lan Yin Keh‐Chih Hwang John A. Rogers Yonggang Huang | 2014 | Mater2014，，14： | 1 |
| 12 | An automatic registration algorithm for the scattered point clouds based on the curvature feature显示文摘 | He Bingwei Lin Zeming Li YF | 2013 | Optics & Laser Technology2013，46，： | 1 |
| 13 | An automatic registration algorithm for the scattered point clouds based on the curvature feature显示文摘 | Bingwei He Zeming Lin Y.F. Li | 2013 | Optics and Laser Technology2013，，： | 1 |
| 14 | Population turnover promotes fungal stability in a semi-arid grassland under precipitation shifts显示文摘土壤中细菌和真菌的稳定性在维持土壤生态系统功能方面起着重要作用,环境条件的改变直接影响细菌和真菌的组成与结构。已有研究表明,土壤真菌群落稳定性对降水变化响应的敏感性比细菌低,但其内在机制还不清楚。在内蒙古典型草原建立3年的增减降雨实验平台,设置5个降水梯度,包括分别增加和减少30%和60%的降水量以及对照,比较控制不同的降水水平对土壤细菌和真菌多样性的影响,包括α多样性,β多样性和细菌/真菌群落组成的变化。本研究开发了一个概念模型来反映不同降水条件下土壤细菌和真菌的稳定性特征,其中模型山谷的深度表示微生物抵抗力(Resistance),谷的宽度代表生态弹性(Ecological Resilience)。结果表明,增加和减少60%的降水量均显著降低了细菌的丰富度,同时显著增加了细菌均匀度,但对真菌的丰富度和均匀度没有显著的影响。降水对细菌α多样性的影响高于真菌,说明细菌对水分胁迫的敏感性大于真菌。而真菌群落的周转比细菌快,包括组成变化(Composition Variation),多样性指数和变异系数(Coefficient Variation),反映了真菌群落具有较高的群落可变性,使得降水变化对真菌群落的影响较小。概念模型中两种相反的情景表示细菌和真菌对降水变化不同的响应模式:真菌群落对水分胁迫响应不敏感,可以用宽谷中的一个球来表示,球虽然在较大范围内往复摆动,但仍接近稳定状态;而细菌群落对水分响应敏感,即稳定性低,可以表示为一个球在较窄的谷里远离平衡态的位置摆动。基于本研究结果,半干旱草原真菌群落比细菌群落具有更高的稳定性,该结论对于量化群落稳定性特征具有重要意义。 | Nannan Wang Lei Li Bingwei Zhang Shiping Chen Wei Sun Yukun Luo Kuanhu Dong Xingguo Han Jianhui Huang Xiaofeng Xu Changhui Wang | 2020 | Journal of Plant Ecology2020，13，4： | 0 |
| 15 | GSDMD in peripheral myeloid cells regulates microglial immune training and neuroinflammation in Parkinson's disease显示文摘Peripheral bacterial infections without impaired blood brain barrier integrity have been attributed to the pathogenesis of Parkinson's disease(PD).Peripheral infection promotes innate immune training in microglia and exacerbates neuroinflammation.However,how changes in the peripheral environment mediate microglial training and exacerbation of infection-related PD is unknown.In this study,we demonstrate that GSDMD activation was enhanced in the spleen but not in the CNS of mice primed with low-dose LPS.GSDMD in peripheral myeloid cells promoted microglial immune training,thus exacerbating neuroinflammation and neurodegeneration during PD in an IL-1R-dependent manner.Furthermore,pharmacological inhibition of GSDMD alleviated the symptoms of PD in experimental PD models.Collectively,these findings demonstrate that GSDMD-induced pyroptosis in myeloid cells initiates neuroinflammation by regulating microglial training during infection-related PD.Based on these findings,GSDMD may serve as a therapeutic target for patients with PD. | Bingwei Wang Yan Ma Sheng Li Hang Yao Mingna Gu Ying Liu You Xue Jianhua Ding Chunmei Ma Shuo Yang Gang Hu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 0 |
| 16 | Effect of Industrial Alumina Powder Particle Size on Preparation of Active α-Al_(2)O_(3) Micropowder显示文摘To study the effect of the particle size of industrial alumina powder on the properties of active alumina micropowder(α-Al_(2)O_(3) micropowder),the fine powders with the median diameter of 50,30,10,and 5 pm,respectively,were obtained by grinding industrial alumina powder(the median diameter of 80 pm),and the active alumina micropowders were prepared by firing the industrial alumina powders before and after grinding at 1320℃ for 5 h.The effect of the particle size of the industrial alumina powder on the microstructure and properties of the active alumina micropowder was researched.The results indicate that the initial particle size of the industrial alumina powder has a great influence on the grain morphology of the active alumina micropowder;when the median diameter is larger than 30 pm,the α-Al_(2)O_(3) grains show wormlike aggregates state after calcination and when it is around or less than 10 pm,the α-Al_(2)O_(3) are round,spherical and well dispersed grains with the particle size of 0.3-1.0 pm.With the initial particle size of the industrial alumina powder decreasing,the α-Al_(2)O_(3) phase transition rate increases and the true density gradually increases;moreover,the α-Al_(2)O_(3) powder shows better dispersity and flowability. | LI Youqi WANG Bingwei ZHANG Yucui Bl Changlu ZHAO Jizeng | 2021 | China's Refractories2021，30，3： | 0 |
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