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| 1 | Factors Predictive of Adverse Events Following Endoscopic Papillary Large Balloon Dilation: Results from a Multicenter Series显示文摘 | Soo Jung Park Jin Hong Kim Jae Chul Hwang Ho Gak Kim Don Haeng Lee Seok Jeong Sang-Woo Cha Young Deok Cho Hong Ja Kim Jong Hyeok Kim Jong Ho Moon Sang-Heum Park Takao Itoi Hiroyuki Isayama Hirofumi Kogure Se Joon Lee Kyo Tae Jung Hye Sun Lee Todd H. Baron | 2013 | Digestive Diseases and Sciences2013，，4： | 2 |
| 2 | Long- term retinal function and structure rescue using capsid mutant AAV8 vector in the rdl0 mouse, a model of recessive retinitis pigmentosa 显示文摘 | Pang J J Dai X Boye SE Barone I Boye SL Mao S | 2011 | Mol Therm2011，19，2： | 1 |
| 3 | Perforation in colorectal stenting: a meta-analysis and a search for risk factors显示文摘 | Emo E. van Halsema Jeanin E. van Hooft Aaron J. Small Todd H. Baron Jesús García-Cano Jae Hee Cheon Moon Sung Lee Se Hwan Kwon Stéphanie Mucci-Hennekinne Paul Fockens Marcel G.W. Dijkgraaf Alessandro Repici | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 4 | Radiological and clinical findings in acute and chronic exogenous lipoid pneumonia 显示文摘 | Baron SE Haramati I B Rivera VT | 2003 | J Thorac hnaging2003，18，4： | 1 |
| 5 | Radiological and clinical findings in acute and chronic exogenous lipoid pneumonia显示文摘 | Baron SE Haramati LB Rivera VT | 2003 | J Thorac Imaging2003，18，： | 1 |
| 6 | Radiologieal and clinical findings in acute and chronic exogenous lipoid pneumonia 显示文摘 | Baron SE Haramati LB Rivera VT | 2003 | J Thorae Imaging2003，18，4： | 1 |
| 7 | Guidance on the diag- nosis and clinical management of atopic eczema 显示文摘 | Baron SE Cohen SN Archer CB | 2012 | Clin Exp Dermatol2012，37，1： | 1 |
| 8 | Subunit rotavirus vaccine administered parenterally to rabbits induces active protective immunity 显示文摘 | Ciarlet M Crawford SE Barone C | 1998 | J Virol1998，72，11： | 1 |
| 9 | Radiological andclinical findings in acute and chronic exogenous lipoidpneumonia显示文摘 | Baron SE Haramati LB Riviera VT | 2003 | J Thorac Imaging2003，18，4： | 1 |
| 10 | A clinical and therapeutic study of 29 patients with infantile acne显示文摘 | Cunliffe WJ Baron SE Coulson IH | 2001 | Br J Dermatol2001，145，3： | 1 |
| 11 | Guidance on thediagnosis and clinical management of atopic eczema 显示文摘 | Baron SE Cohen SN Archer CB | 2012 | Clin Exp Dermatol2012，37，1： | 1 |
| 12 | Factors Predictive of Adverse Events Following Endoscopic Papillary Large Balloon Dilation: Results from a Multicenter Series显示文摘 | Soo Jung Park Jin Hong Kim Jae Chul Hwang Ho Gak Kim Don Haeng Lee Seok Jeong Sang-Woo Cha Young Deok Cho Hong Ja Kim Jong Hyeok Kim Jong Ho Moon Sang-Heum Park Takao Itoi Hiroyuki Isayama Hirofumi Kogure Se Joon Lee Kyo Tae Jung Hye Sun Lee Todd H. Baron | 2013 | Digestive Diseases and Sciences2013，，4： | 1 |
| 13 | Effects of infectious hematopoietic necrosis virus and infectious pancreatic necrosis vires infection on hematopoietic precursors of zebrafish显示文摘 | Lapatra SE Barone L | 2002 | Blood Cell Molec Dis2002，25，5： | 1 |
| 14 | Guidance on the diagnosis and clinical management of atopic eczema显示文摘 | Baron SE Cohen SN Archer CB | | 0，，： | 1 |
| 15 | Guidance on the diagnosis and clinical management atopic eczema显示文摘 | Baron SE Cohen SN Archer GB | 2012 | J CIin Exp Dermatol2012，37，1： | 1 |
| 16 | Radiological and clinical findings in acute and chronic exogenous lipoid pneumonia显示文摘 | Baron SE Haramati LB Rivera VT | 2003 | J Thorac Imaging2003，18，： | 1 |
| 17 | Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice显示文摘BACKGROUND Irritable bowel syndrome and bladder pain syndrome often overlap and are both characterized by visceral hypersensitivity.Since pelvic organs share common sensory pathways,it is likely that those syndromes involve a cross-sensitization of the bladder and the colon.The precise pathophysiology remains poorly understood.AIM To develop a model of chronic bladder-colon cross-sensitization and to investigate the mechanisms involved.METHODS Chronic cross-organ visceral sensitization was obtained in C57BL/6 mice using ultrasound-guided intravesical injections of acetic acid under brief isoflurane anesthesia.Colorectal sensitivity was assessed in conscious mice by measuring intracolonic pressure during isobaric colorectal distensions.Myeloperoxidase,used as a marker of colorectal inflammation,was measured in the colon,and colorectal permeability was measured using chambers.c-Fos protein expression,used as a marker of neuronal activation,was assessed in the spinal cord(L6-S1 level)using immunohistochemistry.Green fluorescent protein on the fractalkine receptor-positive mice were used to identify and count microglia cells in the L6-S1 dorsal horn of the spinal cord.The expression of NK1 receptors and MAPK-p38 were quantified in the spinal cord using western blot.RESULTS Visceral hypersensitivity to colorectal distension was observed after the intravesical injection of acetic acid vs saline(P<0.0001).This effect started 1 h post-injection and lasted up to 7 d postinjection.No increased permeability or inflammation was shown in the bladder or colon 7 d postinjection.Visceral hypersensitivity was associated with the increased expression of c-Fos protein in the spinal cord(P<0.0001).In green fluorescent protein on the fractalkine receptor-positive mice,intravesical acetic acid injection resulted in an increased number of microglia cells in the L6-S1 dorsal horn of the spinal cord(P<0.0001).NK1 receptor and MAPK-p38 levels were increased in the spinal cord up to 7 d after injection(P=0.007 and 0.023 respectively).Colorectal sensitization was prevented by intrathecal or intracerebroventricular injections of minocycline,a microglia inhibitor,by intracerebroventricular injection of CP-99994 dihydrochloride,a NK1 antagonist,and by intracerebroventricular injection of SB203580,a MAPK-p38 inhibitor.CONCLUSION We describe a new model of cross-organ visceral sensitization between the bladder and the colon in mice.Intravesical injections of acetic acid induced a long-lasting colorectal hypersensitivity to distension,mediated by neuroglial interactions,MAPK-p38 phosphorylation and the NK1 receptor. | Karim Atmani Fabien Wuestenberghs Maximilien Baron Illona Bouleté Charlène Guérin Wafa Bahlouli David Vaudry Jean Claude do Rego Jean-Nicolas Cornu Anne-Marie Leroi Moïse Coëffier Mathieu Meleine Guillaume Gourcerol | 2022 | World Journal of Gastroenterology2022，28，48： | 1 |
| 18 | Radiological and clinical findings in acute and chronic exogenous lipoid pneumonia显示文摘 | Baron SE Haramati LB Rivera VT | 2003 | J Thorac Imaging2003，18，9： | 1 |
| 19 | Guidance on the diagnosis and clinical management of atopic eczema 显示文摘 | Baron SE Cohen SN Archer CB | 2012 | Clin Exp Dermatol2012，371，： | 1 |
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