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| 1 | Pituitary adenylate cyclase-activating polypeptide and its receptors:from structure to functions显示文摘 | David Vaudry Bruno J Gonzalez | 2000 | Pharmacol Rev2000，52，2： | 1 |
| 2 | Enteral glutamine infusion modulates ubiquitination of heat shock proteins, Grp-75 and Apg-2, in the human duodenal mucosa显示文摘 | Julien Bertrand Alexis Goichon Philippe Chan Saida Azhar Stéphane Lecleire Nathalie Donnadieu David Vaudry Anne-Fran?oise Cailleux Pierre Déchelotte Mo?se Co?ffier | 2014 | Amino Acids2014，，4： | 1 |
| 3 | Structure–activity relationships of urotensin II and URP显示文摘 | Jér?me Leprince David Chatenet Christophe Dubessy Alain Fournier Bruno Pfeiffer Elizabeth Scalbert Pierre Renard Pierre Pacaud Hassan Oulyadi Isabelle Ségalas-Milazzo Laure Guilhaudis Daniel Davoust Marie-Christine Tonon Hubert Vaudry | 2007 | Peptides2007，，5： | 1 |
| 4 | Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice显示文摘BACKGROUND Irritable bowel syndrome and bladder pain syndrome often overlap and are both characterized by visceral hypersensitivity.Since pelvic organs share common sensory pathways,it is likely that those syndromes involve a cross-sensitization of the bladder and the colon.The precise pathophysiology remains poorly understood.AIM To develop a model of chronic bladder-colon cross-sensitization and to investigate the mechanisms involved.METHODS Chronic cross-organ visceral sensitization was obtained in C57BL/6 mice using ultrasound-guided intravesical injections of acetic acid under brief isoflurane anesthesia.Colorectal sensitivity was assessed in conscious mice by measuring intracolonic pressure during isobaric colorectal distensions.Myeloperoxidase,used as a marker of colorectal inflammation,was measured in the colon,and colorectal permeability was measured using chambers.c-Fos protein expression,used as a marker of neuronal activation,was assessed in the spinal cord(L6-S1 level)using immunohistochemistry.Green fluorescent protein on the fractalkine receptor-positive mice were used to identify and count microglia cells in the L6-S1 dorsal horn of the spinal cord.The expression of NK1 receptors and MAPK-p38 were quantified in the spinal cord using western blot.RESULTS Visceral hypersensitivity to colorectal distension was observed after the intravesical injection of acetic acid vs saline(P<0.0001).This effect started 1 h post-injection and lasted up to 7 d postinjection.No increased permeability or inflammation was shown in the bladder or colon 7 d postinjection.Visceral hypersensitivity was associated with the increased expression of c-Fos protein in the spinal cord(P<0.0001).In green fluorescent protein on the fractalkine receptor-positive mice,intravesical acetic acid injection resulted in an increased number of microglia cells in the L6-S1 dorsal horn of the spinal cord(P<0.0001).NK1 receptor and MAPK-p38 levels were increased in the spinal cord up to 7 d after injection(P=0.007 and 0.023 respectively).Colorectal sensitization was prevented by intrathecal or intracerebroventricular injections of minocycline,a microglia inhibitor,by intracerebroventricular injection of CP-99994 dihydrochloride,a NK1 antagonist,and by intracerebroventricular injection of SB203580,a MAPK-p38 inhibitor.CONCLUSION We describe a new model of cross-organ visceral sensitization between the bladder and the colon in mice.Intravesical injections of acetic acid induced a long-lasting colorectal hypersensitivity to distension,mediated by neuroglial interactions,MAPK-p38 phosphorylation and the NK1 receptor. | Karim Atmani Fabien Wuestenberghs Maximilien Baron Illona Bouleté Charlène Guérin Wafa Bahlouli David Vaudry Jean Claude do Rego Jean-Nicolas Cornu Anne-Marie Leroi Moïse Coëffier Mathieu Meleine Guillaume Gourcerol | 2022 | World Journal of Gastroenterology2022，28，48： | 1 |
| 5 | The RFamide neuropeptide 26RFa and its role in the control of neuroendocrine functions显示文摘 | Nicolas Chartrel Jessy Alonzeau David Alexandre Lydie Jeandel Rodrigo Alvear-Perez Jér?me Leprince Jean Boutin Hubert Vaudry Youssef Anouar Catherine Llorens-Cortes | 2011 | Frontiers in Neuroendocrinology2011，，4： | 1 |
| 6 | Fluorescence Resonance Energy Transfer Competitive Binding Assay for Secretin Receptor (Class B-GPCR)显示文摘 | Vijayalakshmi Senthil Jerome Leprince David Vaudry Billy Kwok Chong Chow | 2014 | Journal of Pharmacy and Pharmacology2014，2，5： | 0 |
| 7 | Sustained activation of P2X7 induces MMP-2- evoked cleavage and functional purinoceptor inhibition显示文摘P2X7 purinoceptor 支持幸存或 cytotoxicity 取决于细胞外的腺苷 triphosphate (ATP ) 刺激紧张控制它的离子隧道或 P2X7 依赖的大毛孔(LP ) 工作。管理这运作的分叉和功能的特质的机制是听说病的。在 P2X7 的持续激活触发活跃矩阵 metalloproteinase 的版本的地方,我们发现了一个反馈环 2 (MMP-2 ) ,它经由 MMP-2-dependent 受体劈开停止离子隧道和 LP 回答。这机制在象巨噬细胞, dystrophic myoblasts, P2X7-transfected HEK293,和人的瘤房间一样多样的房间操作。给也堵住的那项浆液出生的 MMP-2 活动受体功能,在 vivo 的 P2X7 回答可以与可渗透的 capillaries 在机关减少。因此,这机制代表 P2X7 功能的重要调整,依赖房间自治、体外的因素。确实,它与高 P2X7 表示层次在巨噬细胞和人的癌症房间从导致 ATP 的 cytotoxicity 允许避免。最后,我们证明那 P2X7 脱离在 vivo 在煽动的 dystrophic 肌肉消除了 gelatinase 活动。因此, P2X7 对手能在煽动性的疾病和癌症的治疗被用作高度有毒的 MMP 禁止者的一种选择。 | Christopher N. J. Young Natalia Chira Justyna Róg Rasha Al-Khalidi Magalie Benard Ludovic Galas Philippe Chan David Vaudry Krzysztof Zablocki Dariusz C. Górecki | 2018 | Journal of Molecular Cell Biology2018，10，3： | 0 |
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