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| 1 | 太赫兹科学与技术研究回顾显示文摘太赫兹光谱系统利用远红外辐射获得分子的某些光谱信息 ,这些信息在电磁谱的其他波段中是很难得到的 .材料的研究是现代太赫兹系统中的重要的组成部分 ,一方面因为新的、大功率的太赫兹光源极大地依赖于如量子级联结构一类的新材料 ;另一方面 。 | Bradley Ferguson 张希成 | 2003 | 物理2003，32，5： | 88 |
| 2 | 微型无人机低空变量喷药系统设计与雾滴沉积规律研究显示文摘针对我国施药机械和农药使用技术严重落后带来的农药用量大、资源有效利用率低、农作物产量和品质下降等问题,设计了微型无人机脉宽调制型变量喷药系统,并利用风洞的可控多风速环境,通过荧光粉测试方法对悬停无人机变量喷药的雾滴沉积规律进行了试验研究。变量喷药系统由地面测控单元和机载喷施系统两部分组成,基于Lab Windows/CVI的地面测控软件,采用频率为10 Hz、占空比可调的脉冲信号经无线数传模块远程控制机载喷施系统;机载喷施系统以ARM Cortex-M3系列的STM32F103VC微处理器为核心,接收地面控制信号实时调节电动隔膜泵电动机转速,以改变系统喷雾压力和喷药量,实现变量喷雾调节。悬停风洞试验中,选择了PWM占空比、喷孔直径、电动离心喷头转速等变量,对不同距离和风速条件下雾滴沉积效果进行了试验研究。试验结果表明,风速是影响雾滴沉积效果的最显著因素,雾滴沉积以抛物线形式分布在采集区域,沉积高峰区随风速增加不仅远离喷头,且飘移沉积量逐渐减少;雾滴粒径在风速小于3 m/s时对沉积效果影响不显著,当风速大于3 m/s时,不同粒径的雾滴均发生飘移,飘移沉积量明显减少且沉积范围向远离喷头运动;粒径101.74μm的雾滴更易发生飘移,沉积高峰区集中在距离喷头4 m以外,且飘移沉积量明显低于粒径164.00μm与228.16μm的雾滴。 | 王玲 兰玉彬 WClint Hoffmann Bradley KFritz 陈度 王书茂 | 2016 | 农业机械学报2016，47，1： | 74 |
| 3 | 应用RAPD技术评价丁香品种间遗传关系显示文摘采用随机扩增多态DNA(RAPD)技术分析了6个丁香(Sarinaa)品种间的遗传关系。用17个单引物共扩增出83个DNA片段,其中清晰可辨、重复的片段62个,占总数的74.6%。被检测出品种特有标记,可作为区别不同品种的重要性状。品种flora和NaudNotcutt间相似系数高达98.1%,证明它们是同一品种不同无性系。通过品种间相似系数比较,确认品种Rochester是从品种Flora选育而来;品种Maiden’sBlush是由朝鲜丁香(Syringaobiatavar.dilatata)和欧丁香品种MrsMarryBickle杂交而来。 | 陈新露 赵祥云 Bradley N White James S.Pringle | 1995 | 园艺学报1995，22，2： | 55 |
| 4 | 新浪微博替代计量指标特征分析显示文摘通过对新浪微博替代计量指标进行统计分析,探索中文环境下替代计量指标的特征和规律。研究发现:新浪微博替代计量指标覆盖率不足1%,但由于追踪时间和追踪对象的局限,该数字可能被严重低估;新浪微博关注和讨论较多的论文来自'综合''生物化学、遗传学与分子生物学''保健科学''医学'及'生命科学'等学科;新浪微博替代计量指标的期刊分布满足对数曲线规律,除著名的综合性期刊如Nature等,预印本平台arXiv和开放存取期刊PLoS ONE等也获得了较多关注,生物学和医学的'明星期刊'最多;新浪微博主要关注最新论文,正式出版180天内受到关注的论文比例高达68.66%,同时也会关注经典论文;新浪微博发布者倾向宣传、推介和评论贴近生活、趣味性强、实用性高、涉及生命健康的学术论文,传递出引文无法体现的社会价值和学术价值;新浪微博替代计量指标呈现出显著的离散和集中分布特点,5.1%的学术论文获得了50%的新浪微博关注。此外,受新浪微博关注的论文在全球范围内获得远高于平均水平的关注度。 | 余厚强 Bradley M.Hemminger 肖婷婷 邱均平 | 2016 | 中国图书馆学报2016，42，4： | 41 |
| 5 | 多旋翼无人机旋翼下方风场对航空喷施雾滴沉积的影响显示文摘风场是影响航空喷施雾滴沉积分布特性的重要因素之一。为了揭示多旋翼无人机旋翼下方风场对雾滴沉积分布的影响机理,通过无人机旋翼风场测量系统测量多旋翼电动无人机旋翼下方的风场分布,同时结合航空喷施雾滴在水稻冠层的沉积情况,分析旋翼下方X、Y、Z 3个方向的风场对雾滴沉积分布的影响,并对试验结果进行了方差分析和回归分析。结果表明:在无人机旋翼下方3向风场中,X和Y向风速对有效喷幅区内雾滴沉积量的影响不显著,Z向风速的影响极显著;X向风速对有效喷幅区内雾滴沉积穿透性的影响不显著,Y和Z向风速的影响分别为显著和极显著;X和Y向风速对雾滴沉积飘移的影响均不显著,Z向风场的影响显著;且当水平方向上X、Y向风速峰值越小、垂直方向上Z向风速峰值越大时,雾滴沉积均匀性越好,最佳值达到36.44%。另外,有效喷幅区内雾滴沉积量与因素Z向风速之间的回归模型及有效喷幅区内雾滴沉积穿透性与因素Y和Z向风速之间的回归模型的决定系数R^2分别为0.868和0.842,表明模型可以为实际作业提供指导。 | 陈盛德 兰玉彬 BRADLEY K F 李继宇 刘爱民 毛越东 | 2017 | 农业机械学报2017，48，8： | 49 |
| 6 | Current status and future trends of precision agricultural aviation technologies显示文摘Modern technologies and information tools can be used to maximize agricultural aviation productivity allowing for precision application of agrochemical products.This paper reviews and summarizes the state-of-the-art in precision agricultural aviation technology highlighting remote sensing,aerial spraying and ground verification technologies.Further,the authors forecast the future of precision agricultural aviation technology with key development directions in precision agricultural aviation technologies,such as real-time image processing,variable-rate spraying,multi-sensor data fusion and RTK differential positioning,and other supporting technologies for UAV-based aerial spraying.This review is expected to provide references for peers by summarizing the history and achievements,and encourage further development of precision agricultural aviation technologies. | Yubin Lan Chen Shengde Bradley K Fritz | 2017 | International Journal of Agricultural and Biological Engineering2017，10，3： | 35 |
| 7 | Development and prospect of unmanned aerial vehicle technologies for agricultural production management显示文摘Unmanned aerial vehicles have been developed and applied to support agricultural production management.Compared with piloted aircraft,an Unmanned Aerial Vehicle(UAV)can focus on small crop fields at lower flight altitudes than regular aircraft to perform site-specific farm management with higher precision.They can also“fill in the gap”in locations where fixed winged or rotary winged aircraft are not readily available.In agriculture,UAVs have primarily been developed and used for remote sensing and application of crop production and protection materials.Application of fertilizers and chemicals is frequently needed at specific times and locations for site-specific management.Routine monitoring of crop plant health is often required at very high resolution for accurate site-specific management as well.This paper presents an overview of research involving the development of UAV technology for agricultural production management.Technologies,systems and methods are examined and studied.The limitations of current UAVs for agricultural production management are discussed,as well as future needs and suggestions for development and application of the UAV technologies in agricultural production management. | Yanbo Huang Steven J.Thomson W.Clint Hoffmann Yubin Lan Bradley K.Fritz | 2013 | International Journal of Agricultural and Biological Engineering2013，6，3： | 22 |
| 8 | Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways显示文摘Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model.Advanced glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 levels.Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy.Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction.Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM.Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes.Nuclear factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 levels.The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-dependent.These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM. | Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao Yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 20 |
| 9 | Endoscopy and polyps-diagnostic and therapeutic advances in management显示文摘Despite multiple efforts aimed at early detection through screening, colon cancer remains the third leading cause of cancer-related deaths in the United States, with an estimated 51000 deaths during 2013 alone. The goal remains to identify and remove benign neoplastic polyps prior to becoming invasive cancers. Polypoid lesions of the colon vary widely from hyperplastic, hamartomatous and inflammatory to neoplastic adenomatous growths. Although these lesions are all benign, they are common, with up to one-quarter of patients over 60 years old will develop pre-malignant adenomatous polyps. Colonoscopy is the most effective screening tool to detect polyps and colon cancer, although several studies have demonstrated missed polyp rates from 6%-29%, largely due to variations in polyp size. This number can be as high as 40%, even with advanced (> 1 cm) adenomas. Other factors including sub-optimal bowel preparation, experience of the endoscopist, and patient anatomical variations all affect the detection rate. Additional challenges in decision-making exist when dealing with more advanced, and typically larger, polyps that have traditionally required formal resection. In this brief review, we will explore the recent advances in polyp detection and therapeutic options. | Scott R Steele Eric K Johnson Bradley Champagne Brad Davis Sang Lee David Rivadeneira Howard Ross Dana A Hayden Justin A Maykel | 2013 | World Journal of Gastroenterology2013，19，27： | 16 |
| 10 | 内蒙赤峰南部楼子店拆离断层系绿泥石化带的形成时代显示文摘楼子店拆离断层系是华北陆块北缘一条大型北东一南西向构造,低角度倾向南东。拆离断层系中韧性剪切带的走向线理与脆性断面上的倾向擦痕表明该断层发育过程中发生了运动学上的转向。拆离断层系绿泥石化带是伸展过程中构造层次递进变浅所致的退化变质作用产物,其中发育了早期近走向和晚期倾向两组线理,记录了上盘早期向北东的韧性剪切到晚期脆性倾向下滑的运动学转向过程。因此,绿泥石矿物的定年可限定这一构造热事件及运动学转向的时间。初步的绿泥石K-Ar定年表明,楼子店拆离断层系绿泥石化带形成始于~121Ma,114—112Ma间发生了运动学的转向。 | 王新社 郑亚东 刘玉琳 Ritts Bradley Friedman Scott | 2006 | 自然科学进展2006，16，7： | 15 |
| 11 | Evolutionary Lineages and Functional Diversification of Plant Hexokinases显示文摘从 10 种类表演定序数据一个植物 hexokinase (HXK ) 家庭包含 511 基因。机能上地,一个给定的家庭能包括新陈代谢的催化剂,葡萄糖发信号蛋白质,和非催化的、明显的规章的酶相当或相同的事物。这研究有二个目标。第一个目的是开发一个预兆的方法决定在种以内的蛋白质有哪个 HXK 功能打字。第二个目的是决定 HXK 依赖的葡萄糖发信号蛋白质是否发生在更原始的植物之中,以及在被子植物之中。用一条分子的发展史途径,与选择试验性的测试结合了,我们发现非催化的 HXK 相当或相同的事物可能发生在所有植物,包括相对原始的 Selaginella moellendorffi。我们也发现被子植物 HXK 的不同的系为催化活动并且为指向的亚 cellular 有明显的保存特征。最高植物的 HXK 在线粒体主要被表示,与发生在发生在 cytosol 的一个 monocot 系的质体,和 HXK 的一个系的 HXK。用原物短暂表示试金,我们发现 HXK 葡萄糖发信号蛋白质在所有更高的植物并且在 S 多半发生。moellendorffi 也。因此,由在新陈代谢或作为规章的代谢物的植物 HXK isoforms 的葡萄糖的使用作为普遍、保存过程发生。 | Rucha Karve Michael Lauria Annie Virnig Xiaoxia Xia Bradley L. Rauh Brandon d. Moore | 2010 | Molecular Plant2010，3，2： | 15 |
| 12 | 发展功能农业解决“隐性饥饿”显示文摘据估算,全世界有20亿人口由于微量营养素缺乏处于'隐性饥饿'状态,'隐性饥饿'正成为胁迫人体健康的重大隐患,在发展中国家表现尤为明显。欧美国家建议通过生产功能食品解决这一世界难题。研究表明,众多国家和国际组织很早就通过食品强化、工业强化、膳食多元化和食品增补等措施尝试消除'隐性饥饿',但因为经济、管理、基础设施等多种原因,迄今无法从根本上解决全球尤其是发展中国家面临的'隐性饥饿'问题。随着科学技术的发展,通过作物育种、农艺等生物强化技术生产功能农产品已成为新的热点,与传统技术手段相比经济可行、技术可靠、公众接受度高,已经取得初步成果,具有较好发展前景。为此,中国有关专家提出发展功能农业的战略,得到国家相关部门重视,开展了功能农业关键技术的研发和示范,一些技术取得重要突破。综合国内外经验和研究成果,要从根本上解决'隐性饥饿'问题,需要以全产业链方式发展功能农业产业,技术研究和制度建设同步进行,前者包括育种、农艺、微生物强化等6大技术体系的研发,后者重点是建立多主体、多部门联合实施机制。可以预见,功能农业有望在未来解决国内外'隐性饥饿'过程中发挥重要作用,借助'一带一路'的战略机遇,还可为中国农业供给侧结构性改革和国际化发展战略提供新思路和新策略。 | 梁龙 Bradley G.Ridoutt 谢斌 张洒洒 Awekey M.Gelaw 孟伟婷 王丽媛 郭岩彬 赵桂慎 | 2017 | 科技导报2017，35，24： | 15 |
| 13 | Disaster preparedness, pediatric considerations in primary blast injury, chemical, and biological terrorism显示文摘Both domestic and foreign terror incidents are an unfortunate outgrowth of our modern times from the Oklahoma City bombings, Sarin gas attacks in Japan, the Madrid train bombing, anthrax spores in the mail, to the World Trade Center on September 11 th, 2001. The modalities used to perpetrate these terrorist acts range from conventional weapons to high explosives, chemical weapons, and biological weapons all of which have been used in the recent past. While these weapons platforms can cause significant injury requiring critical care the mechanism of injury, pathophysiology and treatment of these injuries are unfamiliar to many critical care providers. Additionally the pediatric population is particularly vulnerable to these types of attacks. In the event of a mass casualty incident both adult and pediatric critical care practitioners will likely be called upon to care for children and adults alike. We will review the presentation, pathophysiology, and treatment of victims of blast injury, chemical weapons, and biological weapons. The focus will be on those injuries not commonly encountered in critical care practice, primary blast injuries, category A pathogens likely to be used in terrorist incidents, and chemical weapons including nerve agents, vesicants, pulmonary agents, cyanide, and riot control agents with special attention paid to pediatric specific considerations. | Mitchell Hamele William Bradley Poss Jill Sweney | 2014 | World Journal of Critical Care Medicine2014，3，1： | 14 |
| 14 | The adult human testis transcriptional cell atlas显示文摘Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and differentiation,alongside complex germ cell-niche interactions,to ensure long-term fertility and faithful genome propagation. Here,we performed single-cell RNA sequencing of -6500 testicular cells from young adults. We found five niche/somatic cell types (Leydig,myoid,Sertoli,endothelial,macrophage),and observed germline-niche interactions and key human-mouse differences. Spermatogenesis,including meiosis,was reconstructed computationally,revealing sequential coding,non-coding,and repeat-element transcriptional signatures. Interestingly,we identified five discrete transcriptional/developmental spermatogonial states,including a novel early SSC state,termed State 0. Epigenetic features and nascent transcription analyses suggested developmental plasticity within spermatogonial States. To understand the or丨gin of State 0,we profiled testicular cells from infants,and identified distinct similarities between adult State 0 and infant SSCs. Overall,our datasets describe key transcriptional and epigenetic signatures of the normal adult human testis,and provide new insights into germ cell developmental transitions and plasticity. | Jingtao Guo Edward J. Grow Hana Mlcochova Geoffrey J. Maher Cecilia Lindskog Xichen Nie Yixuan Guo Yodai Takei Jina Yun Long Cai Robin Kim Douglas T. Carrell Anne Goriely James M. Hotaling Bradley R. Cairns | 2018 | Cell Research2018，28，12： | 12 |
| 15 | Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial显示文摘AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia. | Richard Jaszewski Sabeena Misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk Edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar | 2008 | World Journal of Gastroenterology2008，14，28： | 10 |
| 16 | 雷米普利抑制自发性高血压大鼠细胞凋亡研究显示文摘为了研究血管紧张素转化酶抑制剂对自发性高血压大鼠细胞凋亡的作用,对雄性高血压大鼠(SHR),分别从3周龄和5周龄起按每日1mg/kg剂量,给予雷米普利口服治疗,至10周龄时停药,第16周龄时处死,并以年龄、性别配对的SHR以及WKY大鼠作对照。测定各组血压、心脏与体重比,并以定量DNA末端最大标记量(Lmax)的TdT法、电镜、原位DNA末端标记技术(TUNEL)和放射自显影分析DNA梯形带的方法检测心肌细胞凋亡。结果显示:早期雷米普利治疗不仅能显著降低SHR血压、心脏与体重比,而且能抑制SHR年龄依赖性的细胞凋亡;SHR治疗组典型的DNA梯形带消失,TUNEL标记产物明显减少,其Lmax与WKY对照组比较无明显差别(P>0.1),但较未治疗SHR组减少70.7%。上述结果表明,雷米普利能抑制SHR高血压的形成和心肌肥厚,并可阻止高血压形成过程中产生的细胞凋亡。 | 彭黎明 CHRIS BRADLEY JAMES LIU | 1999 | 华西医科大学学报1999，30，1： | 9 |
| 17 | Magnetic Helical Micro-and Nanorobots:Toward Their Biomedical Applications显示文摘Magnetic helical micro- and nanorobots can perfo rm 3D navigation in various liquids with a sub-micrometer precision under low-strength rotating magnetic fields(< 10 m T). Since magnetic fields with low strengths are harmless to cells and tissues, magnetic helical micro/nanorobots are promising tools for biomedical applications, such as minimally invasive surgery, cell manipulation and analysis, and targeted therapy. This review provides general information on magnetic helical micro/nanorobots, including their fabrication, motion control, and further functionalization for biomedical applications. | Famin Qiu Bradley J.Nelson | 2015 | Engineering2015，1，1： | 9 |
| 18 | 心力衰竭患者中持续气道正压通气抑制中枢性睡眠呼吸暂停与未实施心脏移植存活率的关系:一项对CANPAP试验的事后分析显示文摘背景:在CANPAP[加拿大中枢性睡眠呼吸暂停(CSA)合并心力衰竭患者经持续气道正压通气(CPAP)治疗]试验的主要分析中,CPAP对患者的未实施心脏移植存活率无影响;然而,CPAP仅使平均呼吸暂停低通气指数降至睡眠期间19次/h。 | Arzt M. Floras J.S. Logan A.G. T.D. Bradley 刘相飞 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，，11： | 7 |
| 19 | Minimally invasive surgery for rectal cancer: Are we there yet?显示文摘Laparoscopic colon surgery for select cancers is slowly evolving as the standard of care but minimally invasive approaches for rectal cancer have been viewed with significant skepticism. This procedure has been performed by select surgeons at specialized centers and concerns over local recurrence, sexual dysfunction and appropriate training measures have further hindered widespread acceptance. Data for laparoscopic rectal resection now supports its continued implementation and widespread usage by expeienced surgeons for select patients. The current controversies regarding technical approaches have created ambiguity amongst opinion leaders and are also addressed in this review. | Bradley J Champagne Rohit Makhija | 2011 | World Journal of Gastroenterology2011，17，7： | 7 |
| 20 | Variant selection in stationary shoulder friction stir welded Ti-6Al-4V alloy显示文摘Stationary shoulder friction stir welding of Ti-6Al-4V of 7 mm thickness was conducted with varying welding speeds and rotation speeds. Variant selection analysis was carried out based on the inherited phase texture and the reconstructed phase texture. The weld surfaces became significantly smoother with increasing welding speed and decreasing rotation speed. Heat input decreased greatly with increased welding speed and it decreased slightly with decreased rotation speed. The orientation relationship between the prior grains was measured based on the reconstructed electron backscattered diffraction(EBSD) data. Weak Variant selection has occurred in all the welds because most of the prior grains did not share {110} poles. Strong links between crystal orientation of the prior grains and hardness have been found. | Xiaoqing Jiang Bradley P.Wynne Jonathan Martin | 2018 | Journal of Materials Science & Technology2018，34，1： | 7 |
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