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| 1 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 2 | A framework infrageneric classification of Carex (Cyperaceae) and its organizing principles显示文摘Phylogenetic studies of Carex L.(Cyperaceae)have consistently demonstrated that most subgenera and sections are para-or polyphyletic.Yet,taxonomists continue to use subgenera and sections in Carex classification.Why?The Global Carex Group(GCG)here takes the position that the historical and continued use of subgenera and sections serves to(i)organize our understanding of lineages in Carex,(ii)create an identification mechanism to break the~2000 species of Carex into manageable groups and stimulate its study,and(iii)provide a framework to recognize morphologically diagnosable lineages within Carex.Unfortunately,the current understanding of phylogenetic relationships in Carex is not yet sufficient for a global reclassification of the genus within a Linnean infrageneric(sectional)framework.Rather than leaving Carex classification in its current state,which is misleading and confusing,we here take the intermediate steps of implementing the recently revised subgeneric classification and using a combination of informally named clades and formally named sections to reflect the current state of our knowledge.This hybrid classification framework is presented in an order corresponding to a linear arrangement of the clades on a ladderized phylogeny,largely based on the recent phylogenies published by the GCG.It organizes Carex into six subgenera,which are,in turn,subdivided into 62 formally named Linnean sections plus 49 informal groups.This framework will serve as a roadmap for research on Carex phylogeny,enabling further development of a complete reclassification by presenting relevant morphological and geographical information on clades where possible and standardizing the use of formal sectional names. | Eric H.Roalson Pedro Jiménez-Mejías Andrew L.Hipp Carmen Benítez-Benítez Leo P.Bruederle Kyong-Sook Chung Marcial Escudero Bruce A.Ford Kerry Ford Sebastian Gebauer Berit Gehrke Marlene Hahn Muhammad Qasim Hayat Mathias H.Hoffmann Xiao-Feng Jin Sangtae Kim Isabel Larridon Étienne Léveillé-Bourret Yi-Fei Lu Modesto Luceño Enrique Maguilla Jose IgnacioMárquez-Corro Santiago Martín-Bravo Tomomi Masaki Mónica Míguez Robert F.C.Naczi Anton A.Reznicek Daniel Spalink Julian R.Starr Uzma Tamara Villaverde Marcia J.Waterway Karen L.Wilson and Shu-Ren Zhang | 2021 | Journal of Systematics and Evolution2021，59，4： | 3 |
| 3 | Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry显示文摘 | Martin H?glund Fredrik Sandin Karin Hellstr?m Mats Bj?reman Magnus Bj?rkholm Mats Brune Arta Dreimane Marja Ekblom S?ren Lehmann Per Ljungman Claes Malm Berit Markev?rn Kristina Myhr-Eriksson Lotta Ohm Ulla Olsson-Str?mberg Anders Sj?lander Hans Wadenvik | 2013 | Blood2013，，： | 1 |
| 4 | Low iron stores are related to higher blood concentrations of manganese, cobalt and cadmium in non - smoking, Norwegian women in the HUNT 2 study 显示文摘 | Margrete M H Lise B A Berit B I | 2010 | Environl Res2010，110，5： | 1 |
| 5 | Medium - chain triglycerides 显示文摘 | Berit M Maria P Jurgen S | 2006 | Int Dairy J2006，16，： | 1 |
| 6 | Life cycle assessment of milk production- a comparison of conventional and organic (arming 显示文摘 | CHRISTEL C BERIT M | 2000 | Journal of Cleaner Production2000，，8： | 1 |
| 7 | Hydrogen Evolution:Mo S2Nanoparticles as Catalyst for Hydrogen Evolution显示文摘 | Berit H Poul G M Jacob B | 2005 | Journal of the American Chemical Society2005，127，： | 1 |
| 8 | Management of ovarian cysts显示文摘 | Ulla BK Ann T Berit M | 2004 | Acta Obstet Gynecol Scand2004，83，11： | 1 |
| 9 | A Base Integer Programming Model and Benchmark Suite for Liner-Shipping Network Design显示文摘 | Brouer Berit D Alvarez J Fernando Plum Christian E M Pisinger David Sigurd Mikkel M | 2014 | Transportation Science2014，，： | 1 |
| 10 | Colloidal gold conjugated monoclonal antibodies, studied in the BIAcore biosensor and in the Nycocard immunoassay format显示文摘 | Berit Johne Kari Hansen Einar M?rk Jostein Holtlund | 1995 | Journal of Immunological Methods1995，，1： | 1 |
| 11 | DXYS267:DYS393 and its X chromosome counterpart显示文摘 | Tobias G Bjθrnar O | 2000 | Forensic Sci Int2000，112，2： | 1 |
| 12 | Agricultural land use in life cycle assessment (LCA) : case studies of three vegetable oil crops 显示文摘 | Berit M Christel C Lisa B | 2000 | Journal of Cleaner Production2000，8，： | 1 |
| 13 | Drug-induced hypoglycaemia in type 2 diabetes显示文摘 | Berit Inkster Nicola N Zammitt Brian M Frier | 2012 | Expert Opinion on Drug Safety2012，，4： | 1 |
| 14 | Atomic-scale insight and design principles for turbine engine thermal barrier coatings from theory显示文摘 | KRISTEN A M BERIT H EMILY A C | 2011 | PNAS2011，108，14： | 1 |
| 15 | 瑞典南部伦讷河HBV-NP模型参数精度及其对氮情景模拟的影响显示文摘HBV-NP模型是新近开发的水质模型,它描述氮和磷的周转和通量,是在降水/径流HBV概念模型的基础上发展而来。HBV-NP模型被用来模拟瑞典南部伦讷(Rnnea)河流域的氮量。本模型中,伦讷河流域被分为64个子流域,使用了6个站的流量测值和12个站的氮量测值来校准参数,结合不同的时间段、目标函数及氮负荷水平执行了8个自动校准。校准使用了Nash-Sutcliffe R^2标准的一种地区性扩展解释。对此标准进行评估时,时间步长和采样点都做了误差加和。此后,用由校准得来的8套参数进行了将入海氮负荷削减30%的组合措施的情景模拟。模型参数并非惟一由校准定义的,然而,在现有输入来源、变量及数据条件下,模拟的入海氮负荷的相关减少量对参数设置的选择来说并不多么敏感。 | Gran Lindstrm Jrgen Rosberg Berit Arheimer 寒江 | 2005 | AMBIO-人类环境杂志2005，34，B11： | 1 |
| 16 | Non-compliance in surveillance for patients with previous resection of large (≥ 1 cm) colorectal adenomas显示文摘AIM: To assess the extent and reasons of non- compliance in surveillance for patients undergoing polypectomy of large (≥ 1 cm) colorectal adenomas. METHODS: Between 1995 and 2002, colorectal adenomas ≥ 1 cm were diagnosed in 210 patients and subsequently documented at the Erlangen Registry of Colorectal Polyps. One hundred and fi fty-eight patients (75.2%) could be contacted by telephone and agreed to be interviewed. Additionally, records were obtained from the treating physicians. RESULTS: Fifty-four out of 158 patients (34.2%) neglected any surveillance. Reasons for non-compliance included lack of knowledge concerning surveillance intervals (45.8%), no symptoms (29.2%), fear of examination (18.8%) or old age/severe illness (6.3%). In a multivariate analysis, the factors including female gender (P = 0.036) and age > 62 years (P = 0.016) proved to be signif icantly associated with non-compliance in surveillance. CONCLUSION: Efforts to increase compliance in surveillance are of utmost importance. This applies particularly to women’s compliance. Effective strategies for avoiding metachronous colorectal adenoma and cancer should focus on both the improvement in awareness and knowledge of patients and information about physicians for surveillance. | Wolfgang M Brueckl Berit Fritsche Brigitte Seifert FrankBoxberger Heinz Albrecht Roland S Croner Axel Wein Eckhart G Hahn | 2006 | World Journal of Gastroenterology2006，12，45： | 0 |
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