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| 1 | Progresses on microwave remote sensing of land surface parameters显示文摘Highly accurate observations at various scales on the land surface are urgently needed for the studies of many areas,such as hydrology,meteorology,and agriculture.With the rapid development of remote sensing techniques,remote sensing has had the capacity of monitoring many factors of the Earth's land surface.Especially,the space-borne microwave remote sensing systems have been widely used in the quantitative monitoring of global snow,soil moisture,and vegetation parameters with their all-weather,all-time observation capabilities and their sensitivities to the characteristics of land surface factors.Based on the electromagnetic theories and microwave radiative transfer equations,researchers have achieved great successes in the microwave remote sensing studies for different sensors in recent years.This article has systematically reviewed the progresses on five research areas including microwave theoretical modeling,microwave inversion on soil moisture,snow,vegetation and land surface temperatures.Through the further enrichment of remote sensing datasets and the development of remote sensing theories and inversion techniques,remote sensing including microwave remote sensing will play a more important role in the studies and applications of the Earth systems. | SHI JianCheng DU Yang DU JinYang JIANG LingMei CHAI LinNa MAO KeBiao XU Peng NI WenJian XIONG Chuan LIU Qiang LIU ChenZhou GUO Peng CUI Qian LI YunQing CHEN Jing WANG AnQi LUO HeJia WANG YinHui | 2012 | Science China Earth Sciences2012，55，7： | 24 |
| 2 | SOX4 contributes to TGF-β-induced epithelialemesenchymal transition and stem cell characteristics of gastric cancer cells显示文摘SOX4 is highly expressed in gastric cancer(GC)and is associated with tumor grade,metastasis and prognosis,however the mechanism is not clear.We report herein that SOX4 was upregulated and overexpression of SOX4 was associated with increased expression of the markers of Epithelialemesenchymal transition(EMT)and stemness in clinic patient samples.In vitro,overexpression of SOX4 promoted the invasion as showed by Transwell assay and stemness of GC cells as assessed by sphere formation assay,which was suppressed by silencing SOX4 with shRNA.Further studies showed that SOX4 up-regulated the expression of EMT transcription factors Twist1,snail1 and zeb1 and stemness transcription factors SOX2 and OCT4,and promoted the nuclear translocation of β-catenin.Moreover,we revealed that TGF-β treatment significantly up-regulated the expression of SOX4 and silencing SOX4 reversed TGF-β induced invasion and sphere formation ability of GC cells.Finally,we showed that SOX4 promoted the lung metastasis and tumor formation ability of gastric cancer cells in nude mice.Our results suggest that SOX4 is a target TGF-β signaling and mediates TGF-β-induced EMT and stem cell characteristics of GC cells,revealing a novel role of TGF-β/SOX4 axis in the regulation of malignant behavior of GC. | Xudong Peng Guangyi Liu Hongxia Peng Anqi Chen Lang Zha Ziwei Wang | 2018 | Genes & Diseases2018，5，1： | 4 |
| 3 | Corrigendum to“SOX4 contributions to TGF-b-induced endothelial-mesenchymal transition and stem cell characteristics of gastric cancer cells”[Genes&Diseases 5(2018)49-61]显示文摘We regret that an error was made in“SOX4 contributions to TGF-b-induced endothelial-mesenchymal transition and stem cell characteristics of gastric cancer cells”(Genes&Diseases(2018)5,49e61).In this manuscript,the expression of SOX4 of cancer and adjacent tissues in 84 patients were detected,and 8 pairs of typical pictures were listed in Figure 1A.We note that we made an unintentional error.We confused some pictures(non-cancer tissues of NO.2 and 3)of Figure 1A due to the large number of IHC samples and pictures. | Xudong Peng Guangyi Liu Hongxia Peng Anqi Chen Lang Zha Ziwei Wang | 2021 | Genes & Diseases2021，8，6： | 1 |
| 4 | A dual plasmonic core-shell Pt/[TiN@TiO_(2)]catalyst for enhanced photothermal synergistic catalytic activity of VOCs abatement显示文摘Volatile organic compounds(VOCs)are ubiquitous organic pollutants affecting atmospheric environment and human health.The development of new efficient and environmentally friendly materials utilizing photothermal synergistic catalysis for purification of VOCs is still challenging.Herein,we design and prepare a core–shell TiN@TiO_(2)nanostructure integrating with nanoscaled Pt(Pt/[TiN@TiO_(2)])by an attractive quenching method.The strong light-harvesting capability of Pt and TiN components improve light-to-heat utilization efficiency by their intrinsic surface plasmon resonance effect.The TiO_(2)component upon the surface and the coexisting coupling effect of Pt0 and Pt2+enhance the photocatalytic effect of the system.As a result,the catalytic performance is significantly improved with toluene(120 ppm)conversion of 100%under the gas hourly space velocity of 72,000 mL·g^(−1)·h^(−1)and light illumination of 500 mW·cm^(−2).The desired catalyst thus achieves highly efficient coupling effect of photocatalysis and light-to-heat conversion for promoting VOCs abatement. | Anqi Li Qianpeng Zhang Shuaiqi Zhao Yanan Chong Peng Wu Yifei Li Xiaojing Jin Guangxu Chen Yongcai Qiu Shihe Yang Daiqi Ye | 2022 | Nano Research2022，15，8： | 0 |
| 5 | Molecular mechanism of lycopene cyclases regulating carotenoids ratio in different branches during tea leaf and flower development显示文摘Carotenoids are essential components in tea quality, contributing to leaf color and aroma. However, little information about carotenoids in different tea cultivars and their biosynthesis regulation mechanism during leaf development is known. Here we analyzed carotenoids by HPLC in the buds and leaves of 113 tea cultivars harvested on the same day. By profile clustering, carotenoids were divided into five groups. Same group cultivars displayed divergence in the total content of carotenoids but a similar molar ratio. To figure out the molecular mechanisms of this phenomenon, we further characterized all functional lycopene cyclases, which are the branch point of the carotenoid biosynthesis pathway. Two β-lycopene cyclases(CsLCYB1 and CsLCYB2) and one ε-lycopene cyclase(CsLCYE1) were cloned. Subcellular localization analysis showed that all cloned CsLCYs were localized in plastids. Enzyme activity assays in E. coli indicated both CsLCYBs catalyzed lycopene into β-carotene, and CsLCYE1 produced δ-carotene and ε-carotene. We found CsLCYB1 and CsLCYE1 predominantly expressed in leaf, while CsLCYB2was mainly expressed during flowering stages. Suppression by antisense oligonucleotides reduced CsLCYB1 and CsLCYE1 transcripts and led to reduction of both β,β-branch and β,ε-branch carotenoids in leaf. The expression levels of CsLCYB1 showed a significant positive correlation withβ,β-branch carotenoids in leaf. Our study provides carotenoid profiles of different tea cultivars, which can assist tea producers in selecting cultivars of interest. Meanwhile, we proposed the molecular mechanism of carotenoids reflecting the tenderness of tea plant leaf from a metabolic flux perspective, and suggested lycopene cyclase that could be applied to the breeding of tea varieties with different branch carotenoids. | Anqi Peng Xiaoyan Tang Yingying Feng Yun Huang Jilai Cui Kai Tian Mengqian Lu Yifan Zhao Yuting Pan Sanjin Wang Yutong Hu Wei Zhao Chuankui Song Qiang Wang | 2023 | Horticultural Plant Journal2023，9，6： | 0 |
| 6 | Deformation control criterion of shield tunnel under lateral relaxation of soft soil显示文摘Metro shield tunnels under the lateral relaxation of soil(LRS)are susceptible to significant lateral deformations,which jeopardizes the structural safety and waterproofing.However,deformation control standards for such situations have not been clearly defined.Therefore,based on a specific case,a model test is conducted to realize the LRS of a shield tunnel in a sandy stratum to reveal its effect on segment liners.Subsequently,a deformation control criterion is established.The LRS is simulated by linearly reducing the loads applied to the lateral sides of the segment structure.During lateral unloading,the lateral earth pressure coefficient on the segment decreases almost exponentially,and the structural deformation is characterized by horizontal expansion at the arch haunches and vertical shrinkage at the arch vault and arch bottom.Based on the mechanical pattern of the segment structure and the acoustic emission,the deformation response of a segment can be classified into three stages:elastic and quasi-elastic,damage,and rapid deformation development.For a shield tunnel with a diameter of approximately 6 m and under the lateral relaxation of sandy soil,when the ellipticity of the segment is less than 2.71%,reinforcement measures are not required.However,the segment deformation must be controlled when the ellipticity is 2.71%to 3.12%;in this regard,an ellipticity of 3%can be used as a benchmark in similar engineering projects. | Shimin WANG Xiaoyu PENG Hang ZHOU Xuhu HE Anqi ZHOU Bing CHEN | 2023 | Frontiers of Structural and Civil Engineering2023，17，5： | 0 |
| 7 | Design of artificial small regulatory trans-RNA for gene knockdown in Bacillus subtilis显示文摘Bacillus subtilis as the Gram-positive model bacterium has been widely used in synthetic biology and biotechnology while the regulatory RNA tools for B.subtilis are still not fully explored.Here,a bottom-up approach is proposed for designing artificial trans-acting sRNAs.By engineering the intrinsic sRNA SR6,a minimized core scaffold structure consisting of an 8 bp stem,a 4 nt loop,and a 9 nt polyU tail was generated and proven to be sufficient for constructing sRNAs with strong repression activity(83%).Moreover,we demonstrate this artificial sRNA system functions well in an hfq-independent manner and also achieves strong repression efficiency in Escherichia coli(above 80%).A structure-based sRNA design principle was further developed for the automatic generation of custom sRNAs with this core scaffold but various sequences,which facilitates the manipulation and avoids structure disruption when fusing any base-pairing sequence.By applying these auto-designed sRNAs,we rapidly modified the cell morphology and biofilm formation,and regulated metabolic flux toward acetoin biosynthesis.This sRNA system with cross-species regulatory activities not only enriched the gene regulation toolkit in synthetic biology for B.subtilis and E.coli but also enhanced our understanding of trans-acting sRNAs. | Guobin Yin Anqi Peng Luyao Zhang Yang Wang Guocheng Du Jian Chen Zhen Kang | 2023 | Synthetic and Systems Biotechnology2023，8，1： | 0 |
| 8 | Mutations in the DNA polymerase binding pathway affect the immune microenvironment of patients with small-cell lung cancer and enhance the efficacy of platinum-based chemotherapy显示文摘Background:Small-cell lung cancer(SCLC)is characterized by its high malignancy and is associated with a poor prognosis.In the early stages of the disease,platinum-based chemotherapy is the recommended first-line treatment and has demonstrated efficacy.However,SCLC is prone to recurrence and is generally resistant to chemotherapy in its later stages.Methods:Here,we collected samples from SCLC patients who received platinum-based chemotherapy,performed genomic and transcriptomic analyses,and validated our results with publicly available data.Results:SCLC patients with DNA polymerase binding pathway mutations had an improved prognosis after platinum chemotherapy compared with patients without such mutations.Patients in the mutant(MT)group had higher infiltration of T cells,B cells,and M1 macrophages compared with patients without DNA polymerase binding pathway mutations.Conclusions:DNA polymerase binding pathway mutations can be used as prognostic markers for platinum-based chemotherapy in SCLC. | Anqi Lin Weiming Mou Lingxuan Zhu Tao Yang Chaozheng Zhou Jian Zhang Peng Luo | 2023 | Cancer Innovation2023，2，6： | 0 |
| 9 | Expert recommendations on collection and annotation of otoscopy images for intelligent medicine显示文摘Middle and outer ear diseases are common otological diseases worldwide.Otoscopy and otoendoscopy exami-nations are essential first steps in the evaluation of patients with otological diseases.Misdiagnosis often occurs when the doctor lacks experience in interpreting the results of otoscopy or otoendoscopy,leading to delays in treatment or complications.Using deep learning to process otoscopy images and developing otoscopic artificial-intelligence-based decision-making systems will become a significant trend in the future.However,the uneven quality of otoscopy images is among the major obstacles to development of such artificial intelligence systems,and no standardized process for data acquisition,and annotation of otoscopy images in intelligent medicine has yet been fully established.The standards for data storage and data management are unified with those of other specialties and are introduced in detail here.This expert recommendation criterion improved and standardized the collection and annotation procedures for otoscopy images and fills the current gap in otologic intelligent medicine;it would thus lay a solid foundation for the standardized collection,storage,and annotation of oto-scopy images and the application of training algorithms,and promote the development of automatic diagnosis and treatment for otological diseases.The full text introduced image collection(including patient preparation,equipment standards,and image storage),image annotation standards,and quality control. | Yuexin Cai Junbo Zeng Liping Lan Suijun Chen Yongkang Ou Linqi Zeng Qintai Yang Peng Li Yubin Chen Qi Li Hongzheng Zhang Fan Shu Guoping Chen Wenben Chen Yahan Yang Ruiyang Li Anqi Yan Haotian Lin Yiqing Zheng | 2022 | Intelligent Medicine2022，2，4： | 0 |
| 10 | Workability and Strength of Ceramsite Self-Compacting Concrete with Steel Slag Sand显示文摘This study focuses on the workability and compressive strength of ceramsite self-compacting concrete with fine aggregate partially substituted by steel slag sand(CSLSCC)to prevent the pollution of steel slag in the environment.The SF,J-ring,visual stability index,and sieve analysis tests are primarily employed in this research to investigate the workability of freshly mixed self-compacting concrete containing steel slag at various steel slag sand replacement rates.The experiment results indicate that CSLSCC with the 20%volume percentage of steel slag(VPS)performs better workability,higher strength,and higher specific strength.The 7-day compressive strength of CSLSCC with the 0.4 of the water-binder ratio(W/B),decreases with the increase of steel slag content,while the 28-day compressive strength increases significantly.The ceramsite self-compacting concrete with good comprehensive performance can be obtained when the substitution rate of steel slag sand for fine aggregate is less than 20%(volume percentage). | Suiwei Pan Anqi Ren Yongli Peng Min Wu Wanguo Dong Chunlin Liu Depeng Chen | 2023 | Journal of Renewable Materials2023，11，2： | 0 |
| 11 | Glioma cell membrane camouflaged cinobufotalin delivery system for combinatorial orthotopic glioblastoma therapy显示文摘Glioblastoma(GBM)belongs to the deadliest primary malignancies with high mortality rate and poor prognosis.Over the past decades,less progress has been made to treat GBM,owing largely to the lack of effective chemotherapeutics and poor drug accumulation in the glioma tissue.In order to address this issue,we present an efficient biomimetic nanocomposite(Cu_(2−x)Se-CB@MEM,CCM),consisting of Cu_(2−x)Se nanoparticle core modified by cinobufotalin(CB),a toad venom extract,which is camouflaged with glioma cell Ln229 membrane.It is demonstrated that CB can decrease the protein activity of inosine monophosphate dehydrogenase 1(IMPDH1),a key target correlated with prognosis,through intermolecular hydrogen bonding with amino acid residues ARG-105 and ASP-77.The glioma cell membrane-camouflage endows the CCM with blood-brain barrier penetration and homology tumor-targeted ability.The optimized cinobufotalin based chemotherapy combining with the near-infrared-II(NIR-II)irradiation shows outstanding inhibition effect to glioma cells,by blocking cell cycle and inducing apoptosis.In vivo mice bearing orthotopic Ln229 GBM treated with CCM+NIR-II(CCM+L)have significantly suppressed tumor growth and extended survival,without side effect.The glioma cell membrane camouflaged nanocomposite of Cu_(2−x)Se and cinobufotalin with its significant anti-glioma property and well biosafety will provide novel alternatives for clinical treatment of GBM. | Zibin Song Liqian Zhao Weiyi Fang Siyun Guo Anqi Xu Zhengming Zhan Yonghua Cai ShuaiShuai Xue Peng Chai Qiuhua Jiang Peng Zhao Ye Song | 2023 | Nano Research2023，16，8： | 0 |
| 12 | CD209 signaling pathway as a biomarker for cisplatin chemotherapy response in small cell lung cancer显示文摘One of the bottlenecks in the clinical treatment of small cell lung cancer(SCLC)is its susceptibility to multidrug resistance.While SCLC is sensitive to platinum-based chemotherapy at the initial stage of treatment,it can rapidly become drug-resistant,allowing tumor growth to accelerate.A significant decrease in drug sensitivity after recurrence and multidrug resistance can seriously interfere with the effectiveness of treatment,making sensitivity maintenance one of the urgent challenges to be solved.Therefore,discovering prognostic markers for cisplatin chemotherapy and understanding the mechanisms of cisplatin resistance have great practical significance for improving the outcomes of sCLC patients. | Anqi Lin Hong Yang Jian Zhang Peng Luo | 2024 | Genes & Diseases2024，11，3： | 0 |
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