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| 1 | Biogenic production of DMSP and its degradation to DMS—their roles in the global sulfur cycle显示文摘Dimethyl sulfide(DMS) is the most abundant form of volatile sulfur in Earth’s oceans, and is mainly produced by the enzymatic clevage of dimethylsulfoniopropionate(DMSP). DMS and DMSP play important roles in driving the global sulfur cycle and may affect climate. DMSP is proposed to serve as an osmolyte, a grazing deterrent, a signaling molecule, an antioxidant, a cryoprotectant and/or as a sink for excess sulfur. It was long believed that only marine eukaryotes such as phytoplankton produce DMSP. However, we recently discovered that marine heterotrophic bacteria can also produce DMSP, making them a potentially important source of DMSP. At present, one prokaryotic and two eukaryotic DMSP synthesis enzymes have been identified.Marine heterotrophic bacteria are likely the major degraders of DMSP, using two known pathways: demethylation and cleavage.Many phytoplankton and some fungi can also cleave DMSP. So far seven different prokaryotic and one eukaryotic DMSP lyases have been identified. This review describes the global distribution pattern of DMSP and DMS, the known genes for biosynthesis and cleavage of DMSP, and the physiological and ecological functions of these important organosulfur molecules, which will improve understanding of the mechanisms of DMSP and DMS production and their roles in the environment. | Xiao-Hua Zhang Ji Liu Jingli Liu Guipeng Yang Chun-Xu Xue Andrew R. J. Curson Jonathan D. Todd | 2019 | Science China(Life Sciences)2019，62，10： | 11 |
| 2 | White Matter Abnormalities in Major Depression Biotypes Identified by Diffusion Tensor Imaging显示文摘Identifying data-driven biotypes of major depressive disorder(MDD) has promise for the clarification of diagnostic heterogeneity. However, few studies have focused on white-matter abnormalities for MDD subtyping. This study included 116 patients with MDD and118 demographically-matched healthy controls assessed by diffusion tensor imaging and neurocognitive evaluation.Hierarchical clustering was applied to the major fiber tracts, in conjunction with tract-based spatial statistics, to reveal white-matter alterations associated with MDD.Clinical and neurocognitive differences were compared between identified subgroups and healthy controls. With fractional anisotropy extracted from 20 fiber tracts, cluster analysis revealed 3 subgroups based on the patterns of abnormalities. Patients in each subgroup versus healthy controls showed a stepwise pattern of white-matter alterations as follows: subgroup 1(25.9% of patient sample),widespread white-matter disruption;subgroup 2(43.1% of patient sample), intermediate and more localized abnormalities in aspects of the corpus callosum and left cingulate;and subgroup 3(31.0% of patient sample),possible mild alterations, but no statistically significant tract disruption after controlling for family-wise error. The neurocognitive impairment in each subgroup accompanied the white-matter alterations: subgroup 1, deficits in sustained attention and delayed memory;subgroup 2, dysfunction in delayed memory;and subgroup 3, no significant deficits. Three subtypes of white-matter abnormality exist in individuals with major depression, those having widespread abnormalities suffering more neurocognitive impairments, which may provide evidence for parsing the heterogeneity of the disorder and help optimize typespecific treatment approaches. | Sugai Liang Qiang Wang Xiangzhen Kong Wei Deng Xiao Yang Xiaojing Li Zhong Zhang Jian Zhang Chengcheng Zhang Xin-min Li Xiaohong Ma Junming Shao Andrew J. Greenshaw Tao Li | 2019 | Neuroscience Bulletin2019，35，5： | 9 |
| 3 | Transcriptome analysis reveals long noncoding RNAs involved in fiber development in cotton (Gossypium arboreum)显示文摘Long noncoding RNAs(lnc RNAs)play important roles in various biological regulatory processes in yeast,mammals,and plants.However,no systematic identification of lnc RNAs has been reported in Gossypium arboreum.In this study,the strand-specific RNA sequencing(ss RNA-seq)of samples from cotton fibers and leaves was performed,and lnc RNAs involved in fiber initiation and elongation processes were systematically identified and analyzed.We identified 5,996 lnc RNAs,of which 3,510 and 2,486 can be classified as long intergenic noncoding RNAs(linc RNAs)and natural antisense transcripts(lnc NAT),respectively.Linc RNAs and lnc NATs are similar in many aspects,but have some differences in exon number,exon length,and transcript length.Expression analysis revealed that 51.9%of linc RNAs and 54.5%of lnc NATs transcripts were preferentially expressed at one stage of fiber development,and were significantly highly expressed than protein-coding transcripts(21.7%).During the fiber and rapid elongation stages,rapid and dynamic changes in lnc RNAs may contribute to fiber development in cotton.This work describes a set of lnc RNAs that are involved in fiber development.The characterization and expression analysis of lnc RNAs will facilitate future studies on their roles in fiber development in cotton. | Changsong Zou Qiaolian Wang Cairui Lu Wencui Yang Youping Zhang Hailiang Cheng Xiaoxu Feng Mtawa Andrew Prosper Guoli Song | 2016 | Science China(Life Sciences)2016，59，2： | 9 |
| 4 | Rice OsFLS2-Mediated Perception of Bacterial Flagellins Is Evaded by Xanthomonas oryzae pvs. oryzae and oryzicola显示文摘细菌的 flagellins 被受体 kinase FLAGELLIN SENSITIVE2 (FLS2 ) 经常认出并且在双子叶的植物激活被触发 MAMP 的免疫。然而,单子叶植物的米饭的能力理解糟糕认出关键米饭病原体和它的生物关联遗体的 flagellins。我们证明在 Arabidopsis 的宫外地表示的 OsFLS2 察觉到得到的 flg22 肽和 invitro 净化了 Acidovorax avenae (Aa ) 以一种表示水平依赖者方式的 flagellin,但是不认出净化的 flagellins 或衍生物 flg22 Xanthomonas oryzae pvs 的 Xo 肽。oryzae (Xoo ) 和 oryzicola (Xoc ) 。一致地, flg22 肽和净化的 Aa flagellin,然而并非 Xoo/Xoc flagellins,在米饭导致象防卫基因正式就职和 MAPK 激活那样的各种各样的有免疫力的回答。由米饭的 flagellin 的感觉确实导致强壮的抵抗到 Xoo 感染,在米饭的预告的处理与 Aa flagellin 离开以后,出现。OsFLS2 被发现在它的感觉特性或敏感不同于 AtFLS2 到不同 flg22 序列。另外, Xoc flagellin 的 translational 以后修正被编码 glycosyltransferase rbfC,而是这有的小效果的删除在 Xoc 活动性上改变, rpfC 变化 detectably 没在米饭上减少 Xoc 毒力。从 Xoo/Xoc 的编码 flagellin 警察的删除堵住了游泳活动性而且显著地没改变 Xoo/Xoc 毒力。当在米饭躲避古老的 flagellin 察觉系统时,这些结果建议 Xoo/Xoc 带允许活动性的 flg22 区域氨基酸变化,它为另外的细菌的病原体保留识别能力。 | Shanzhi Wang Zhe Sun Huiqin Wang Lijuan Liu Fen Lu Jun Yang Min Zhang Shiyong Zhang Zejian Guo Andrew F. Bent Wenxian Sun | 2015 | Molecular Plant2015，8，7： | 7 |
| 5 | Application of a collaborative modelling and strategic fuzzy decision support system for selecting appropriate resilience strategies for seaport operations显示文摘The selection of an appropriate resilience investment strategy to optimize the operational efficiency of a seaport is a challenging task given that many criteria need to be considered and modelled under an uncertain environment.The design of such a complex decision system consists of many subjective and imprecise parameters contained in different quantitative and qualitative forms.This paper proposes a fuzzy multi-attribute decision making methodology for the selection of an appropriate resilience investment strategy in a succinct and straightforward manner.The decision support model allows for a collaborative modelling of the system by multiple analysts in a group decision making process.Fuzzy analytical hierarchy process(FAHP) was utilized to analyse the complex structure of the system to obtain the weights of all the criteria while fuzzy technique for order of preference by similarity to ideal solution(TOPSIS) was employed to facilitate the ranking process of the resilience strategies.Given that it is often financially difficult to invest in all the resilience strategies,it is envisaged that the proposed approach could provide decision makers with a flexible and transparent tool for selecting appropriate resilience strategies aimed at increasing the resilience of seaport operations. | Andrew John Zaili Yang Ramin Riahi Jin Wang | 2014 | Journal of Traffic and Transportation Engineering(English Edition)2014，1，3： | 6 |
| 6 | Mammalian ALKBH1 serves as an N^6-mA demethylase of unpairing DNA显示文摘N^6-methyladenine(N^6-mA)of DNA is an emerging epigenetic mark in mammalian genome.Levels of N^6-mA undergo drastic fluctuation during early embryogenesis,indicative of active regulation.Here we show that the 2-oxoglutarate-dependent oxygenase ALKBH1 functions as a nuclear eraser of N^6-mA in unpairing regions(e.g.,SIDD,Stress-Induced DNA Double Helix Destabilization regions)of mammalian genomes.Enzymatic profiling studies revealed that ALKBH1 prefers bubbled or bulged DNAs as substrate,instead of single-stranded(ss-)or double-stranded(ds-)DNAs.Structural studies of ALKBH1 revealed an unexpected“stretch-out”conformation of its“Flip1”motif,a conserved element that usually bends over catalytic center to facilitate substrate base flipping in other DNA demethylases.Thus,lack of a bending“Flip1”explains the observed preference of ALKBH1 for unpairing substrates,in which the flipped N^6-mA is primed for catalysis.Co-crystal structural studies of ALKBH1 bound to a 21-mer bulged DNA explained the need of both flanking duplexes and a flipped base for recognition and catalysis.Key elements(e.g.,an ALKBH1-specificα1 helix)as well as residues contributing to structural integrity and catalytic activity were validated by structurebased mutagenesis studies.Furthermore,ssDNA-seq and DIP-seq analyses revealed significant co-occurrence of base unpairing regions with N^6-mA in mouse genome.Collectively,our biochemical,structural and genomic studies suggest that ALKBH1 is an important DNA demethylase that regulates genome N^6-mA turnover of unpairing regions associated with dynamic chromosome regulation. | Min Zhang Shumin Yang Raman Nelakanti Wentao Zhao Gaochao Liu Zheng Li Xiaohui Liu Tao Wu Andrew Xiao Haitao Li | 2020 | Cell Research2020，30，3： | 6 |
| 7 | Herbal hepatoxicity from Chinese skullcap: A case report显示文摘The use of herbal supplements has increased considerably over the last decade. We report a case of an elderly woman who began taking Move Free Advanced for arthritis, which in addition to glucosamine and chondroitin, contained two herbal ingredients, Chinese skullcap and Black Catechu. Our patient presented with significant cholestasis and hepatitis which significantly improved after discontinuation of the supplement. Since neither the patient nor the treating physician recognized this supplement as a potential hepatotoxin, she resumed taking the supplement and again suffered from considerable hepatotoxicity. Liver biopsy at that time was consistent with acute drug induced liver injury. She, once again, recovered after discontinuation of the supplement. Review of the literature confirms that Chinese skullcap has been implicated as a possible hepatotoxic agent which was demonstrated in this case. | Leslie Yang Andrew Aronsohn John Hart Donald Jensen | 2012 | World Journal of Hepatology2012，4，7： | 6 |
| 8 | Inferring the Tree of Life of the order Cypriniformes, the earth's most diverse clade of freshwater fishes: Implications of varied taxon and character sampling显示文摘The phylogenetic relationships of species are fundamental to any biological investigation, including all evolutionary studies. Accurate inferences of sister group relationships provide the researcher with an historical framework within which the attributes or geographic origin of species (or supraspecific groups) evolved. Taken out of this phylogenetic context, interpretations of evolutionary processes or origins, geographic distributions, or speciation rates and mechanisms, are subject to nothing less than a biological experiment without controls. Cypriniformes is the most diverse clade of freshwater fishes with estimates of diversity of nearly 3,500 species. These fishes display an amazing array of morphological, ecological, behavioral, and geographic diversity and offer a tremendous opportunity to enhance our understanding of the biotic and abiotic factors associated with diversification and adaptation to environments. Given the nearly global distribution of these fishes, they serve as an important model group for a plethora of biological investigations, including indicator species for future cli-matic changes. The occurrence of the zebrafish, Danio rerio, in this order makes this clade a critical component in understanding and predicting the relationship between mutagenesis and phenotypic expressions in vertebrates, including humans. With the tremendous diversity in Cypriniformes, our understanding of their phylogenetic relationships has not proceeded at an acceptable rate, despite a plethora of morphological and more recent mo-lecular studies. Most studies are pre-Hennigian in origin or include relatively small numbers of taxa. Given that analyses of small numbers of taxa for molecular characters can be compromised by peculiarities of long-branch attraction and nodal-density effect, it is critical that significant progress in our understanding of the relationships of these important fishes occurs with increasing sampling of species to mitigate these potential problems. The recent Cypriniformes Tree of Life initiative is an effort to achieve this goal with morphological and molecular (mitochondrial and nuclear) data. In this early synthesis of our understanding of the phylogenetic relationships of these fishes, all types of data have contributed historically to improving our understanding, but not all analyses are complementary in taxon sampling, thus precluding direct understanding of the impact of taxon sampling on achieving accurate phylogenetic inferences. However, recent molecular studies do provide some insight and in some instances taxon sampling can be implicated as a variable that can influence sister group relationships. Other instances may also exist but without inclusion of more taxa for both mitochondrial and nuclear genes, one cannot distinguish between inferences being dictated by taxon sampling or the origins of the molecular data. | Richard L. MAYDEN Kevin L. TANG Robert M. WOOD Wei-Jen CHEN Mary K. AGNEW Kevin W. CONWAY Lei YANG Andrew M. SIMONS Henry L. BART Phillip M. HARRIS Junbing LI Xuzhen WANG Kenji SAITOH Shunping HE Huanzhang LIU Yiyu CHEN Mutstmi NISHIDA Masaki MIYA | 2008 | 植物分类学报2008，46，3： | 5 |
| 9 | SuperDARN CUTLASS Finland radar observations of high-latitude magnetic reconnections under northward interplanetary magnetic field (IMF) conditions显示文摘A number of backscatter power enhancement events with 'equatorward-moving radar auroral forms' in the high-latitude ionosphere were observed by SuperDARN CUTLASS Finland radar when the IMF was northward during 09:00 -10:00 UT on 26 March 2004. These events were also associated with sunward flow enhancements at each location in the Northern Hemisphere which were shown in ionospheric convections measured by the SuperDARN radars. These are typical features of high-latitude (lobe) magnetic reconnections. The durations of the velocity enhancements imply that the evolution time of the lobe reconnections is about 8-16 min from their origin at the reconnection site to their addition to the magnetotail lobe again. In additional, the Double Star TC-1 spacecraft was moving from magnetosheath into magnetosphere, and crossing the magnetopause near the subsolar region during this interval, and observed typical low-latitude magnetic reconnection signatures. This infers that the dayside high- and low-latitude reconnections may occur simultaneously. | ZHANG QingHe LIU RuiYuan YANG HuiGen HU HongQiao ZHANG BeiChen DUNLOP Malcolm LESTER Mark BOGDANOVA Yulia WALSH Andrew | 2012 | Science China(Technological Sciences)2012，55，5： | 5 |
| 10 | Practical high-performance lead-free piezoelectrics:structural flexibility beyond utilizing multiphase coexistence显示文摘Due to growing concern for the environment and human health, searching for high-performance lead-free piezoceramics has been a hot topic of scientific and industrial research. Despite the significant progress achieved toward enhancing piezoelectricity, further efforts should be devoted to the synergistic improvement of piezoelectricity and its thermal stability. This study provides new insight into these topics.A new KNN-based lead-free ceramic material is presented, which features a large piezoelectric coefficient(d33) exceeding 500 pC/N and a high Curie temperature(Tc) of ~200℃. The superior piezoelectric response strongly relies on the increased composition-induced structural flexibility due to lattice softening and decreased unit cell distortion. In contrast to piezoelectricity anomalies induced via polymorphic transition, this piezoelectricity enhancement is effective within a broad temperature range rather than a specific small range. In particular, a hierarchical domain architecture composed of nano-sized domains along the submicron domains was detected in this material system, which further contributes to the high piezoelectricity. | Qing Liu Yichi Zhang Jing Gao Zhen Zhou Dong Yang Kai-Yang Lee Andrew Studer Manuel Hinterstein Ke Wang Xiaowen Zhang Longtu Li Jing-Feng Li | 2020 | National Science Review2020，7，2： | 5 |
| 11 | Preferential gene retention increases the robustness of cold regulation in Brassicaceae and other plants after polyploidization显示文摘Cold stress profoundly affects plant growth and development and is a key factor affecting the geographic distribution and evolution of plants.Plants have evolved adaptive mechanisms to cope with cold stress.Here,through the genomic analysis of Arabidopsis,three Brassica species and 17 other representative species,we found that both cold-related genes(CRGs)and their collinearity were preferentially retained after polyploidization followed by genome instability,while genome-wide gene sets exhibited a variety of other expansion mechanisms.The coldrelated regulatory network was increased in Brassicaceae genomes,which were recursively affected by polyploidization.By combining our findings regarding the selective retention of CRGs from this ecological genomics study with the available knowledge of cold-induced chromosome doubling,we hypothesize that cold stress may have contributed to the success of polyploid plants through both increasing polyploidization and selectively maintaining CRGs during evolution.This hypothesis requires further biological and ecological exploration to obtain solid supporting evidence,which will potentially contribute to understanding the generation of polyploids and to the field of ecological genomics. | Xiao-Ming Song Jin-Peng Wang Peng-Chuan Sun Xiao Ma Qi-Hang Yang Jing-Jing Hu Sang-Rong Sun Yu-Xian Li Ji-Gao Yu Shu-Yan Feng Qiao-Ying Pei Tong Yu Nan-Shan Yang Yin-Zhe Liu Xiu-Qing Li Andrew H.Paterson Xi-Yin Wang | 2020 | Horticulture Research2020，7，1： | 4 |
| 12 | MoS2-wrapped silicon nanowires for photoelectro- chemical water reduction显示文摘铝二硫化物的集成(瞬间 < 潜水艇 class= “ a-plus-plus ” > 2 ) 高度被需要到高表面区域光阴极上为太阳动力的氢进化反应最小化过电位(她的) 。因为他们到 decouple 光吸收和少数搬运人的运输的大电气化学地可得到的表面区域和固有的能力,半导体 nanowires (NW ) 为在 photoelectrochemistry 的使用是有益的。这里,硅(Si ) NW 数组为瞬间作为一个模型光阴极系统被采用 < 潜水艇 class= “ a-plus-plus ” > 2 包装纸,并且他们的太阳开车她的活动被评估。光阴极由组成一明确的瞬间<潜水艇class=“ a-plus-plus ”> 2 /TiO 2 /Si 同轴的 NW heterostructure ,它产出光电流密度依赖 15 妈/厘米<啜class=“ a-plus-plus ”> 2 (在 0 V 对可逆的氢电极( RHE ))与在采用的操作条件下面的好稳定性。这个工作表明地球丰富的 electrocatalysts 结合了电极能提供的高表面区域 NW 比得上为 photocathodic 氢的高贵金属催化剂的性能进化。 | Liming Zhang Chong Liu Andrew Barnabas Wong Joaquin Resasco Peidong Yang | 2015 | Nano Research2015，8，1： | 4 |
| 13 | Defective T wave combined with incomplete right bundle branch block: a new electrocardiographic index for diagnosing atrial septal defect显示文摘 | WANG Mu-xuan WU Gui-fu GU Jing-li LI Li LU Kun YANG Da CHEN Long ZHANG Xi LUO Fu-tian Andrew D. Michaels MA Hong | 2012 | Chinese Medical Journal2012，，6： | 4 |
| 14 | Creation and control of high-dimensional multi-partite classically entangled light显示文摘Vector beams,non-separable in spatial mode and polarisation,have emerged as enabling tools in many diverse applications,from communication to imaging.This applicability has been achieved by sophisticated laser designs controlling the spin and orbital angular momentum,but so far is restricted to only two-dimensional states.Here we demonstrate the first vectorially structured light created and fully controlled in eight dimensions,a new state-of-the-art.We externally modulate our beam to control,for the frst time,the complete set of classical Greenberger-Horne-Zeilinger(GHZ)states in paraxial structured light beams,in analogy with high-dimensional multi-partite quantum entangled states,and introduce a new tomography method to verify their fidelity.Our complete theoretical framework reveals a rich parameter space for further extending the dimensionality and degrees of freedom,opening new pathways for vetorilly structured light in the classical and quantum regimes. | Yjie Shen Iaac Nape Xilin Yang Xing Fu Mali Gong Darryl Naidoo Andrew Forbes | 2021 | Light(Science & Applications)2021，10，5： | 4 |
| 15 | Humus-Rich Compost Increases Lettuce Growth, Nutrient Uptake, Mycorrhizal Colonisation, and Soil Fertility显示文摘Sandy soils, typical of Australia's west, either have little or no habitat protection for microbes including arbuscular mycorrhizal(AM) fungi, which are essential for nutrient cycling. To minimize this problem, the application of organic matter, such as humus-rich composts, is necessary during vegetable crop production. This study aimed at determining the effects of humus-rich composts on either indigenous or inoculated AM fungal colonisation in roots, lettuce(Lactuca sativa L. var. Quechua) growth, and soil fertility improvement. Four different humus-rich composts with varying humus contents were applied at the same standard rate to lettuce grown under glasshouse conditions for 10 weeks after sowing and compared with two low-humus composts and non-amended soil(control). Humus-rich composts significantly increased lettuce shoot growth, root growth, and AM fungal colonisation in roots. Humus contents in the composts were also correlated with lettuce shoot and root growth. Soil dissolved organic carbon, microbial biomass carbon, and fertility were increased with the application of humus-rich composts. These humus-rich composts, especially the compost of higher humic acid with and without AM inoculation, might have a significant role in sustainable vegetable production, for example lettuce growth. Overall, the results indicate that supplementation with humus-rich compost is highly beneficial to enhance soil fertility and potentially maintain the sustainability of vegetable production. | Zakaria M.SOLAIMAN Hongjun YANG Deb ARCHDEACON Orna TIPPETT Michaela TIBI Andrew S.WHITELEY | 2019 | Pedosphere2019，29，2： | 3 |
| 16 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 17 | Involvement of 90-kuD ribosomal S6 kinase in collagen type Ⅰ expression in rat hepatic fibrosis显示文摘AIM: To investigate the relationship between 90-kuD ribosomal S6 kinase (p90RSK) and collagen type □expression during the development of hepatic fibrosis in vivo and in vitro.METHODS: Rat hepatic fibrosis was induced by intraperitoneal injection of dimethylnitrosamine. The protein expression and cell location of p90RSK and their relationship with collagen type □were determined by co-immunofluoresence and confocal microscopy. Subsequently, RNAi strategy was employed to silence p90RSK mRNA expression in HSC-T6, an activated hepatic stellate cell (HSC) line. The expression of collagen type □in HSC-T6 cells was assessed by Western blotting and real-time polymerase chain reaction. Furthermore, HSCs were transfected with expression vectors or RNAi constructs of p90RSK to increase or decrease the p90RSK expression, then collagen type □promoter activity in the transfected HSCs was examined by reporter assay. Lastly HSC-T6 cells transfected with p90RSK siRNA was treated with or without platelet-derived growth factor (PDGF)-BB at a final concentration of 20 μg/L and the cell growth was determined by MTS conversion.RESULTS: In fibrotic liver tissues, p90RSK was overexpressed in activated HSCs and had a significant positive correlation with collagen type □levels.In HSC-T6 cells transfected with RNAi targeted to p90RSK, the expression of collagen type □was down-regulated (61.8% in mRNA, P < 0.01, 89.1% in protein, P < 0.01). However, collagen type □promoter activity was not increased with over-expression of p90RSK and not decreased with low expression either, compared with controls in the same cell line (P = 0.076). Furthermore, p90RSK siRNA exerted the inhibition of HSC proliferation, and also abolished the effect of PDGF on the HSC proliferation.CONCLUSION: p90RSK is over-expressed in activated HSCs and involved in regulating the abnormal expression of collagen type □through initiating the proliferation of HSCs. | Miao-Fang Yang Jun Xie Xiao-Yi Gu Xiao-Hua Zhang Andrew K Davey Shuang-Jie Zhang Ji-Ping Wang Ren-Min Zhu | 2009 | World Journal of Gastroenterology2009，15，17： | 3 |
| 18 | Perovskite Solar Fibers:Current Status,Issues and Challenges显示文摘Perovskite-based solar cells with high power conversion efficiencies(PCEs)are currently being demonstrated in solid-state device designs.Their elevated performances can possibly be attained with different non-standard geometries,for example,the fiber-shaped perovskite solar cells,in the light of careful design and engineering.Fiber-shaped solar cells are promising in smart textiles energy harvesting towards next-generation electronic applications and devices.They can be made with facile process and at low cost.Recently,fiber-shaped perovskite solar devices have been reported,particularly with the focus on the proof-of-concept in such non-traditional architectures.In this line,there are so many technical aspects which need to be addressed,if these photovoltaic(PV)cells are to be industrialized and produced massively.Herein,a well-organized and comprehensive discussion about the reported devices in this arena is presented.The challenges that need to be addressed,the possible solutions and the probable applications of these PV cells are also discussed.More still,the perovskite fiber-shaped PV cells with other fiber PV devices reported in literature in terms of their scope,characteristic designs,performances,and other technical considerations have been summarised. | Andrew Balilonda Qian Li Mike Tebyetekerwa Rogers Tusiime Hui Zhang Rajan Jose Fatemeh Zabihi Shengyuan Yang Seeram Ramakrishna Meifang Zhu | 2019 | Advanced Fiber Materials2019，1，2： | 3 |
| 19 | Detection of Circulating Pancreas Epithelial Cells in Patients with Pancreatic Cystic Lesions显示文摘 | Andrew D. Rhim Fredrik I. Thege Steven M. Santana Timothy B. Lannin Trisha N. Saha Shannon Tsai Lara R. Maggs Michael L. Kochman Gregory G. Ginsberg John G. Lieb Vinay Chandrasekhara Jeffrey A. Drebin Nuzhat Ahmad Yu- Xiao Yang Brian J. Kirby Ben Z. Stang | 2013 | Gastroenterology2013，，： | 3 |
| 20 | Formation of the highest sand dunes on Earth显示文摘 | Xiaoping Yang Louis Scuderi Tao Liu Philippe Paillou Hongwei Li Jufeng Dong Bingqi Zhu Weiwei Jiang Andrew Jochems Gary Weissmann | 2011 | Geomorphology2011，，1： | 2 |
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