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| 1 | Red ginseng and cancer treatment显示文摘The ginseng family,including Panax ginseng(Asian ginseng),Panax quinquefolius(American ginseng),and Panax notoginseng(notoginseng),is commonly used herbal medicine.White ginseng is prepared by air-drying after harvest,while red ginseng is prepared by a steaming or heating process.The anticancer activity of red ginseng is significantly increased,due to the production of active anticancer ginsenosides during the steaming treatment,compared with that of white ginseng.Thus far,anticancer studies have been mostly focused on Asian ginseng.In this article,we review the research progress made in the anticancer activities of red Asian ginseng,red American ginseng and red notoginseng.The major anticancer mechanisms of red ginseng compounds include cell cycle arrest,induction of apoptosis/paraptosis,and inhibition of angiogenesis.The structure-function relationship analysis has revealed that the protopanaxadiol group ginsenosides have more potent effects than the protopanaxatriol group.Sugar molecules in ginsenosides inversely impact the antiproliferative potential of these compounds.In addition,ginsenoside stereoselectivity and double bond position also influence the anticancer activity.Future studies should focus on characterizing active red ginseng derivatives as potential anticancer drugs. | WANG Chong-Zhi Samantha ANDERSON DU Wei HE Tong-Chuan YUAN Chun-Su | 2016 | Chinese Journal of Natural Medicines2016，14，1： | 17 |
| 2 | Targeted Antimicrobial Therapy Against Streptococcus mutans Establishes Protective Non-cariogenic Oral Biofilms and Reduces Subsequent Infection显示文摘Aim Dental biofilms are complex communities composed largely of harmless bacteria. Certain pathogenic species including Streptococcus mutans (S. mutans) can become predominant when host factors such as dietary sucrose intake imbalance the biofilm ecology. Current approaches to control S. mutans infection are not pathogen-specific and eliminate the entire oral community along with any protective benefits provided. Here, we tested the hypothesis that removal of S. mutans from the oral community through targeted antimicrobial therapy achieves protection against subsequent S. mutans colonization. Methodology Controlled amounts of S. mutans were mixed with S. mutans-free saliva, grown into biofilms and visualized by antibody staining and cfu quantization. Two specifically-targeted antimicrobial peptides (STAMPs) against S. mutans were tested for their ability to reduce S. mutans biofilm incorporation upon treatment of the inocula. The resulting biofilms were also evaluated for their ability to resist subsequent exogenous S. mutans colonization. Results S. mutans colonization was considerably reduced (9 ± 0.4 fold reduction, P=0.01) when the surface was preoccupied with saliva-derived biofilms. Furthermore, treatment with S. mutans-specific STAMPs yielded S. mutans-deficient biofilms with significant protection against further S. mutans colonization (5 minutes treatment: 38 ± 13 fold reduction P=0.01; 16 hours treatment: 96 ± 28 fold reduction P=0.07). Conclusion S. mutans infection is reduced by the pre- sence of existing biofilms. Thus maintaining a healthy or 'normal' biofilm through targeted antimicrobial therapy (such as the STAMPs) could represent an effective strategy for the treatment and prevention of S. mutans colonization in the oral cavity and caries progression. | Li-na Li Li-hong Guo Renate Lux Randal Eckert Daniel Yarbrough Jian He Maxwell Anderson Wen-yuan Shi | 2010 | International Journal of Oral Science2010，2，2： | 5 |
| 3 | Development and evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria显示文摘Dental caries (tooth decay) is caused by a specific group of cariogenic bacteria, like Streptococcus mutans, which convert dietary sugars into acids that dissolve the mineral in tooth structure. Killing cariogenic bacteria is an effective way to control or prevent tooth decay. In a previous study, we discovered a novel compound (Glycyrrhizol A), from the extraction of licorice roots, with strong antimicrobial activity against cariogenic bacteria. In the current study, we developed a method to produce these specific herbal extracts in large quantities, and then used these extracts to develop a sugar-free lollipop that effectively kills cariogenic bacteria like Streptococcus mutans. Further studies showed that these sugar-free lollipops are safe and their antimicrobial activity is stable. Two pilot human studies indicate that a brief application of these lollipops (twice a day for ten days) led to a marked reduction of cariogenic bacteria in oral cavity among most human subjects tested. This herbal lollipop could be a novel tool to promote oral health through functional foods. | Chu-hong Hu Jian He Randal Eckert Xiao-yang Wu Li-na Li Yan Tian Renate Lux Justin A. Shuffer Faina Gelman Janet Mentes Sue Spackman Janet Bauer Maxwell H. Anderson Wen-yuan Shi | 2011 | International Journal of Oral Science2011，3，1： | 3 |
| 4 | Active fluid flow in the Eugene Island Area, offshore Louisiana 显示文摘 | Anderson R N He Wei Hobart M A | 1991 | Geophysics1991，10，4： | 1 |
| 5 | Interpretation of genetic variants of uncer- tain significance in atypical hemolytic uremic syndrome 显示文摘 | Kavanagh D Anderson HE | 2012 | Kidney Int2012，81，1： | 1 |
| 6 | The nuclear protein HMGB1 as a pro-inflammatory mediator 显示文摘 | Harris HE Anderson U | 2004 | Eur J Immunol2004，34，6： | 1 |
| 7 | The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking显示文摘 | Karel F. Liem Alyson Ashe Mu He Peter Satir Jennifer Moran David Beier Carol Wicking Kathryn V. Anderson | 2012 | The Journal of Cell Biology2012，，6： | 1 |
| 8 | HIV - 1 - associated dementia: a metabolic encephalopathy perpetrated by virus- infected and immune -competent mononuclear phagocytes显示文摘 | Anderson E Zink W Gendelman HE | 2002 | J Acquir Immune Defic Syndr2002，31，2： | 1 |
| 9 | Phytoplankton Biomass and Production in Subtropical Hong Kong Waters: Influence of the Pearl River Outflow显示文摘 | Alvin Y. T. Ho Jie Xu Kedong Yin Yuelu Jiang Xiangcheng Yuan Lei He Donald M. Anderson Joseph H. W. Lee Paul J. Harrison | 2010 | Estuaries and Coasts2010，，1： | 1 |
| 10 | The prevalence of non-alcoholic fatty liver disease in children and adolescents:a systematic review and meta-analysis显示文摘 | Anderson EL Howe LD Jones HE | 2015 | PLoS One2015，10，01： | 1 |
| 11 | Comparative effects of betaadrenergie blocking drugs on experimental ventrieular fibrillation threshold显示文摘 | Anderson JL Roder HE Green LS | 1983 | Am J Cardiol1983，51，： | 1 |
| 12 | CDD: a conserved domain database for interactive domain family analysis显示文摘 | MARCHLER-BAUER A ANDERSON J B DERBYSHIRE M K DEWEESE-SCOTT C GONZALES N R GWADZ M HAO L HE S HURWITZ D I JACKSON J D KE Z KRYLOV D LANCZYCKI C J LIEBERT C A LIU C LU F LU S MARCHLER G H MULLOKANDOV M SONG J S THANKI N YAMASHITA R A YIN J J ZHANG D BRYANT S H | 2007 | Nucleic Acids Res2007，35，： | 1 |
| 13 | Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults显示文摘 | Doweli SF Anderson LJ Gary HE | 1996 | J Infect Dis1996，174，： | 1 |
| 14 | Design and activity of a dual-targeted'anticrobial peptide显示文摘 | HE J ANDERSON M H SHI W | 2009 | Int J Antimicrob Agents2009，33，6： | 1 |
| 15 | CDD: a conserved domain database for interactive domain family analysis 显示文摘 | Marchler-Bauer A Anderson J B Derbyshire M K DeWeese-Scott C Gonzales N R Gwadz M Hao L He S Hurwitz D I Jackson J D Ke Z Krylov D Lanczycki C J Liebert C A Liu C Lu F Lu S Marchler G H Mullokandov M Song J S Thanki N Yamashita R A Yin J J Zhang D Bryant S H | 2007 | Nucleic Acids Res2007，，： | 1 |
| 16 | Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer:National Surgical Adjuvant Breast and Bowel Project Protocol B-27显示文摘 | Bear HD Anderson S Smith HE | 2006 | J Clin Oncol2006，24，13： | 1 |
| 17 | Isolation of an autonomously replicatiing DNA fragment from the region of defective bacteriophage PBSX of Bacillus subtilis显示文摘 | Ruler HE Bott KF | 1982 | J Bacteriology1982，150，3： | 1 |
| 18 | The prevalence of non-alcoholic fatty liver disease in children and adolescents:a systematic review and meta-analysis显示文摘 | Anderson EL Howe LD Jones HE | 2015 | PLoS One2015，10，01： | 1 |
| 19 | A review of theinteraction among dietary antioxidants and reactive Oxygen species显示文摘 | Seifried HE Anderson DE Fisher El | 2007 | JNutr Biochem2007，18，9： | 1 |
| 20 | 显示文摘 | Overhiser RW Haber HE | 1998 | J Am Coll Cardiol1998，31，： | 1 |
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