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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Complex role for the immune system in initiation and progression of pancreatic cancer显示文摘The immune system plays a complex role in the development and progression of pancreatic cancer. Inflammation can promote the formation of premalignant lesions and accelerate pancreatic cancer development. Conversely, pancreatic cancer is characterized by an immunosuppressive environment, which is thought to promote tumor progression and invasion. Here we review the current literature describing the role of the immune response in the progressive development of pancreatic cancer, with a focus on the mechanisms that drive recruitment and activation of immune cells at the tumor site, and our current understanding of the function of the immune cell types at the tumor. Recent clinical and preclinical data are reviewed, detailing the involvement of the immune response in pancreatitis and pancreatic cancer, including the role of specific cytokines and implications for disease outcome. Acute pancreatitis is characterized by a predominantly innate immune response, while chronic pancreatitis elicits an immune response that involves both innate and adaptive immune cells, and often results in profound sys-temic immune-suppression. Pancreatic adenocarcinoma is characterized by marked immune dysfunction driven by immunosuppressive cell types, tumor-promoting immune cells, and defective or absent inflammatory cells. Recent studies reveal that immune cells interact with cancer stem cells and tumor stromal cells, and these interactions have an impact on development and progression of pancreatic ductal adenocarcinoma(PDAC). Finally, current PDAC therapies are reviewed and the potential for harnessing the actions of the immune response to assist in targeting pancreatic cancer using immunotherapy is discussed. | Kristin S Inman Amanda A Francis Nicole R Murray | 2014 | World Journal of Gastroenterology2014，20，32： | 11 |
| 3 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 4 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 5 | Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6Chi and Ly6Clo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice显示文摘 | Christophe Combadière Stéphane Potteaux Mathieu Rodero Tabassome Simon Adeline Pezard Bruno Esposito Régine Merval Amanda Proudfoot Alain Tedgui Ziad Mallat | 2008 | Circulation2008，，13： | 2 |
| 6 | Treatment of Sleep Problems in a 5-year-old Boy with Autism Using Behavioural Principles显示文摘 | Sophie W Jan M Amanda R | 2001 | Autism2001，，2： | 1 |
| 7 | Experimental studies on the role of backfill and pipeline characteristics in the application of acoustic leak location to underground pipelines 显示文摘 | Amanda M C Lance E R | 1997 | Review of Progress in Quantitative Nondestructive Evaluation1997，16，： | 1 |
| 8 | Management of lateral neck masses in adults显示文摘 | Michael G Amanda H Aurelia R | 2000 | BMJ2000，320，3： | 1 |
| 9 | Experimental studies on the role of backfill and pipeline characteristics in the application of acoustic leak location to under around pipelines显示文摘 | Clark M Amanda Rewerts Lance E Robbers Ron R | 1997 | Review of Progress in Quantitative Non-destructive Evaluation1997，16，4： | 1 |
| 10 | ASPP2 Binds Par-3 and Controls the Polarity and Proliferation of Neural Progenitors during CNS Development显示文摘 | Roberta Sottocornola Christophe Royer Virginie Vives Luca Tordella Shan Zhong Yihua Wang Indrika Ratnayaka Mark Shipman Amanda Cheung Carles Gaston-Massuet Patrizia Ferretti Zoltán Molnár Xin Lu | 2010 | Developmental Cell2010，，1： | 1 |
| 11 | Comparing the traditional with the modern:A greener,solvent-free dihydropyrimidone synthesis显示文摘 | EVANGELOS A ELTON C AMANDA R E | 2003 | Journal of Chemical Education2003，86，6： | 1 |
| 12 | HPLC-MS analysis of phenolic compounds and purine alkaloids in green and black tea显示文摘 | DANIELE D R AMANDA J S WILLIAM M | 2004 | J of Agricultral and Food Chemistry2004，，10： | 1 |
| 13 | Analysis of laboratory critical valuereporting at a large academic medical center显示文摘 | Anand SD Arjun R Amanda B | 2006 | Am J Clin Pathol2006，125，5： | 1 |
| 14 | Prevention of central venous catheter-related bloodstreaminfections :is it time to add simulation training to theprevention bundle显示文摘 | Amanda R Marc C George E | 2012 | Journal of Clinical Anesthesia2012，24，7： | 1 |
| 15 | Selective Induction of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Atrial and Ventricular Myocardium in Patients With Atvial Fibrillation显示文摘 | Amanda R Hemon BS Abigails | 2006 | Am/Cardiol2006，97，： | 1 |
| 16 | Analysis of laboratory critical value reporting at a large academic medical center 显示文摘 | Anand SD Arjun R Amanda BC | 2006 | Am J Clin Pathol2006，125，5： | 1 |
| 17 | Relationship of early hyperglycemia to mortality in trauma patients显示文摘 | Amanda M Laird MD Preston R | 2004 | J of Trauma2004，56，5： | 1 |
| 18 | Experimental Studies on the Role of Backfill and Pipeline Characteristics in the Application of Acoustic Leak Location to Underground Pipelines显示文摘 | Amanda M C Lance E R | 1997 | Review of Progress in Quantitative Nondestructive Evaluation1997，16，： | 1 |
| 19 | On target classification using kinematic data显示文摘 | Branko R Neil G Amanda B | 2004 | Information Fusion2004，12，5： | 1 |
| 20 | The natural history of renal stone fragments following ureteroscopy 显示文摘 | DAVID A R AMANDA M VISHAL B | 2011 | Urology2011，77，3： | 1 |
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