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| 1 | Sleep-related hypoxemia aggravates systematic inflammation in emphysematous rats显示文摘背景睡觉骚乱在有肺气肿的病人是普通的。这研究试图带着老鼠在肺气肿( SRHIE )开发睡觉相关的血氧不足( SRH )的一个新奇模型,并且在肺探索 SRHIE 的煽动性的地位,肝,胰,七十五只男 Wistar 老鼠根据暴露条件每组与 15 被分到 5 个组的颈动脉动脉和整个 blood.Methods 。协议与组织缺氧暴露的度和肺气肿由香烟烟暴露引起了的先存在的严厉变化了:( 1 ) SRH 控制( SRHCtrl )组,假冒的烟暴露(烟暴露,暴露了每天 15 支香烟吸烟两次, 16 个星期)并且 SRH 暴露(12.5% O2 , 3 个小时, SRH 暴露,均匀地把全部的组织缺氧时间( 1.5 个小时或 3 个小时)划分成 4 个时期( 22.5 分钟或 45 分钟)并且均匀地散布这些组织缺氧时期直到脑电图识别的老鼠的生理的睡觉时间,到星期 16 的星期 9 );(2 ) 肺气肿控制(ECtrl ) 组,烟暴露和假冒的 SRH 暴露(21% O2, 3 个小时) ;(3 ) 在肺气肿(SRHShort ) 的短 SRH 组,烟暴露和短 SRH 暴露(12.5% O2, 1.5 个小时) ;(4 ) 在肺气肿(SRHMild ) 的温和 SRH 组,烟暴露和温和 SRH 暴露(15% O2, 3 个小时) ;(5 ) 在肺气肿(SRHStand ) 的标准 SRH 组,烟暴露和 SRH 暴露(12.5% O2, 3 个小时) 。ECtrl, SRHShort, SRHMild 和 SRHStand 组是有 emphysematous 老鼠的组。在暴露的结束前的二天,在每个组的 5 只老鼠随机为动脉的血气体分析被选择。在在各个的 10 只老鼠组织的剩余的,我们为平淡的测试获得了血样品和 bronchoalveolar lavage 液体(BALF ) 。我们也为病理学的得分和肝的大小获得了肺,肝,胰,和正确颈动脉动脉的织物块氧化应力(测量肝的氧化压力酶, superoxide dismutase (草皮)活动,过氧化氢酶(猫)活动和 malondialdehyde ( MDA )集中) .Results Emphysematous 组有更高的平均数线性拦截( MLI )并且吝啬的牙槽的数字(人)价值比 SRHCtrl 组。在 SRHStand 组的 MLI 价值是最高(生病 P 0.05 ) 。在 SRHStand 老鼠的 O2Sat SRH 暴露是什么时候(83.45 ? 韴 ?( | FENG Jing Ambrose An-Po Chiang WU Qi CHEN Bao-yuan CUI Lin-yang LIANG Dong-chun ZHANG Ze-li YAO Wo | 2010 | Chinese Medical Journal2010，，17： | 15 |
| 2 | 高温连续干燥与干燥-通风联合对稻谷品质的影响显示文摘利用不同的干燥方式对稻谷进行干燥,降至安全水分含量12%(湿基),测定干燥后稻谷的整精米率(head rice yield,HRY)、脂肪酸值以及RVA特征值。结果表明:对于连续干燥作业,缓苏过程中存在一个临界缓苏时间,达到临界缓苏时间能显著提高整精米率,且干燥温度越高,该临界缓苏时间的出现越明显;但干燥温度高于60℃,且一次降水幅度不小于9.4%,缓苏温度与干燥温度相同时,通过延长缓苏时间,整精米率难以达到70%;对于干燥-通风联合作业,干燥温度高于60℃,且缓苏温度不低于干燥温度时,虽能保持较高整精米率(>72%),但稻米的RVA特征值(峰值黏度、最低黏度、崩解值、最终黏度、回生值)总体上随着干燥温度、缓苏温度的升高和缓苏时间的延长而增加,且存在一些波动,干燥温度、缓苏时间对其影响显著性低于缓苏温度。两种干燥方式的脂肪酸值都存在不同于恒低温干燥持续增加的变化趋势。 | 杨国峰 周雯 Rose Prabin Kingsly Ambrose 夏宝林 仇红娟 刘强 张越 陈江 | 2014 | 食品科学2014，35，17： | 13 |
| 3 | 真空干燥-常压缓苏后稻米品质指标的相关性研究显示文摘以不同干燥温度、相对真空度为因素对稻谷进行真空干燥-常压缓苏实验,研究其干燥后稻米爆腰增率、整精米率及蒸煮质构品质变化,分析其相关性,并通过扫描电镜观察不同干燥条件对稻谷籽粒显微形态的影响。结果表明:干燥温度和真空度对稻谷干燥后爆腰增率及整精米率影响极显著(p<0.01)。干燥温度、真空度且二者交互作用对米饭质构特性有极显著影响(p<0.01)。经过对稻谷干燥后各品质相关性分析,得出稻谷爆腰增率与其蒸煮硬度、胶黏性及胶着性呈极显著的正相关性(p<0.01),稻谷整精米率与硬度、胶黏性、胶着性呈极显著负相关性(p<0.01),且二者均与弹性、咀嚼性及内聚性没有相关性。干燥温度越高,相对真空度越大,干燥速率越大,淀粉粒与蛋白质的结合度越小,结构越稀松,干燥裂纹越粗大,数量越多。 | 刘兵 仇红娟 刘强 万忠民 杨国峰 陈江 Rose Prabin Kingsly Ambrose | 2016 | 食品工业科技2016，37，1： | 8 |
| 4 | Genetic Analysis of ele Mutants and Comparative Mapping of ele1 Locus in the Control of Organ Internal Asymmetry in Garden Pea显示文摘Previous study has shown that during zygomorphic development in garden pea(Pisum sativum L.),the organ internal(IN) asymmetry of lateral and ventral petals was regulated by a genetic locus,SYMMETRIC PETAL 1(SYP1),while the dorsoventral(DV) asymmetry was determined by two CYC-like TCP genes or the PsCYC genes,KEELED WINGS(K) and LOBED STANDARD 1(LST1).In this study,two novel loci,ELEPHANT EAR-LIKE LEAF 1(ELE1) and ELE2 were characterized.These mutants exhibit a similar defect of IN asymmetry as syp1 in lateral and ventral petals,but also display pleiotropic effects of enlarged organ size.Genetic analysis showed that ELE1 and ELE2 were involved in same genetic pathway and the enlarged size of petals but not compound leaves in ele2 was suppressed by introducing k and lst1,indicating that the enlargement of dorsal petal in ele2 requires the activities of K and LST1.An experimental framework of comparative genomic mapping approach was set up to map and clone LjELE1 locus in Lotus japonicus.Cloning the ELE1 gene will shed light on the underlying molecular mechanism during zygomorphic development and further provide the molecular basis for genetic improvement on legume crops. | Xin Li Li-Li Zhuang Mike Ambrose M. Phil. Catherine Rameau Xiao-He Hu Jun Yana Da Luo | 2010 | Journal of Integrative Plant Biology2010，52，6： | 6 |
| 5 | PerformanceVis:Visual analytics of student performance data from an introductory chemistry course显示文摘We present PerformanceVis,a visual analytics tool for analyzing student admission and course performance data and investigating homework and exam question design.Targeting a university-wide introductory chemistry course with nearly 1000 student enrollment,we consider the requirements and needs of students,instructors,and administrators in the design of PerformanceVis.We study the correlation between question items from assignments and exams,employ machine learning techniques for student grade prediction,and develop an interface for interactive exploration of student course performance data.PerformanceVis includes four main views(overall exam grade pathway,detailed exam grade pathway,detailed exam item analysis,and overall exam&homework analysis)which are dynamically linked together for user interaction and exploration.We demonstrate the effectiveness of PerformanceVis through case studies along with an ad-hoc expert evaluation.Finally,we conclude this work by pointing out future work in this direction of learning analytics research. | Haozhang Deng Xuemeng Wang Zhiyi Guo Ashley Decker Xiaojing Duan Chaoli Wang G.Alex Ambrose Kevin Abbott | 2019 | Visual Informatics2019，3，4： | 5 |
| 6 | MicroRNA Pathways in Flies and Worms显示文摘 | Victor Ambros | 2003 | Cell2003，，6： | 5 |
| 7 | LATHYROIDES, Encoding a WUSCHEL-Related Homeoboxl Transcription Factor, Controls Organ Lateral Growth, and Regulates Tendril and Dorsal Petal Identities in Garden Pea (Pisum sativum L.)显示文摘在器官开发期间,许多关键管理者在植物染色体被识别了,它在植物种类之中起一个保存作用控制器官身份或决定器官尺寸和形状。这些关键管理者是否能获得多样的功能并且集成于在不同种类之中的不同分子的小径,是吸引人的,产生在自然的机关形式的巨大的差异。在这研究,我们描绘了并且克隆 LATHYROIDES (板条) ,在豌豆的一个古典地点,其变化在卷须和背面的花瓣开发上显示机关和占优势的效果的侧面的生长的多种的改变。板条编码 WUSCHEL 相关的 homeobox1 (WOX1 ) 抄写因素,它在决定器官有保存功能在不同植物种类之中的侧面的生长。而且,我们证明那板条调整了卷须更少(TL ) 的表示水平,在在复合的叶的卷须开发的控制的一个关键因素,和板条遗传上与 LOBED 标准(LST ) 交往了,一个花的背面的因素,影响背面的花瓣身份。因此,板条在豌豆在机关开发期间起多重作用:控制机关维持一个保存函数侧面的长出,并且在复合的叶调制机关身份并且两侧对称花开发分别地。我们的数据显示一个关键管理者能在机关开发的不同方面起重要作用并且在机关开发的控制奉献给分子的机制的复杂性以便在不同种类创造不同机关形式。 | Li-Li Zhuang Mike Ambrose Catherine Rameau Lin Weng Jun Yang Xiao-He Hu Da Luo Xin Li | 2012 | Molecular Plant2012，5，6： | 5 |
| 8 | Significance of depression in obstructive sleep apnea patients and the relationship between the comorbidity and continuous positive airway pressure treatment显示文摘妨碍的睡觉呼吸暂停( OSA )是最普通的睡觉相关的呼吸混乱并且由上面的航线的周期性的倒塌描绘,与 OSA 从睡觉,血的减少的氧浸透,和过多的白天 sleepiness.Patients 引起重复唤起在增加心血管、脑血管的疾病的风险,当前打 2 糖尿病,认知缺陷,和 depression.1,2 ,连续积极航线压力( CPAP )为 p 作为标准治疗被识别了CPAP 然而在客观、主观的瞌睡和生活评价,认知功能和 depression.3 的几 quality3 显示出重要改进,到 CPAP 治疗的非坚持的报告从 29% ~ 83% ,和非坚持的原因之一是 depression.4 的 | FENG Jing CHEN Bao-yuan Ambrose An-Po Chiang | 2010 | Chinese Medical Journal2010，，12： | 4 |
| 9 | Clinical significance of hepatic derangement in severe acute respiratory syndrome显示文摘AIM: Elevation of alanine aminotransferase (ALT) level is commonly seen among patients suffering from severe acute respiratory syndrome (SARS). We report the progression and clinical significance of liver derangement in a large cohort of SARS patient.METHODS: Serial assay of serum ALT was followed in patients who fulfilled the WHO criteria of SARS. Those with elevated ALT were compared with those with normal liver functions for clinical outcome. Serology for hepatitis B virus (HBV) infection was checked. Adverse outcomes were defined as oxygen desaturation, need of intensive care unit (ICU) and mechanical ventilation and death.RESULTS: Two hundred and ninety-four patients were included in this study. Seventy (24%) patients had elevated serum ALT on admission and 204 (69%) patients had elevated ALT during the subsequent course of illness. Using peak ALT >5×ULN as a cut-off and after adjusting for potential confounding factors, the odds ratio of peak ALT>5x ULN for oxygen desaturation was 3.24 (95%CI 1.23-8.59, P = 0.018), ICU care was 3.70 (95% CI 1.38-9.89, P = 0.009), mechanical ventilation was 6.64 (95%CI 2.22-19.81, P = 0.001) and death was 7.34(95%CI 2.28-24.89, P = 0.001). Ninety-three percent of the survived patients had ALT levels normalized or were on the improving trend during follow-up. Chronic hepatitis B was not associated with worse clinical outcomes.CONCLUSION: Reactive hepatitis is a common complication of SARS-coronavirus infection. Those patients with severe hepatitis had worse clinical outcome. | Henry Lik-Yuen Chan Ambrose Chi-Pong Kwan Ka-Fai To Sik-To Lai Paul Kay-Sheung Chan Wai-Keung Leung Nelson Lee Alan Wu Joseph Jao-Yiu Sung | 2005 | World Journal of Gastroenterology2005，11，14： | 4 |
| 10 | Mitotic Spindle Organization by the Preprophase Band显示文摘在更高的工厂,微导管(MT ) 的 preprophase 乐队(PPB ) 在有丝分裂以前预报房间部门地点并且指定 MT 的组织进包围原子核的一支双极的前期锭子。然而,管理 bipolarity 的这个 PPB 依赖的机构的机制是不清楚的。这里,我们从为在调停衔接 PPB 和前期原子核的 MT 建议一个角色的实时房间成像研究的现在的证据这功能。与从空 kinesin 植物的基因证据一起,从药处理的结果建议这些 MT 贡献前期锭子的 bipolarity,取向,和位置。明确地,当桥 MT 的不一致的分布向最高的桥 MT 密度的区域与前期锭子移植,变丑,和提高的 bipolarity 相关时,这些桥 MT 的缺席与 bipolarity 的缺乏被联系。这行为不要求基于肌动球朊的力量,并且被与 taxol 压制 MT 动力学提高。这些观察发生在迟了的前期期间,并且与环形的锭子杆的渐渐的关门是重合的。把数据基于这些,我们为前期锭子的桥 MT 依赖者组织描述假想机制。 | J. Christian Ambrose Richard Cyr | 2008 | Molecular Plant2008，1，6： | 4 |
| 11 | 百脉根BIO和豌豆突变位点ELE2的比较基因组定位(英文)显示文摘豆科两侧对称花的花瓣具有背腹(DV)的分化以及可变的器官内部(IN)非对称性,在大小与形状上显示出不同的发育特征;因而花瓣的发育为克隆决定植物器官的形状与大小的关键基因提供了很好的实验系统。本研究对百脉根中BIO基因进行研究。百脉根bio突变体具有多效性,既影响花器官内部的对称性也影响器官的大小和育性,豌豆ele突变体的表型与bio相似。定位结果表明BIO和ELE2位于豆科基因组的共线性区段,提示BIO和ELE2可能是同源基因突变所致。本研究利用比较基因组定位方法,将BIO和ELE2候选基因锚定在豆科模式植物百脉根和蒺藜苜蓿基因组含有11个同源基因的BAC重叠群上。BIO和ELE2基因的克隆将有助于揭示豆科花瓣形态和大小调控的分子机理,进而为豆科作物遗传改良提供分子理论基础。 | 李信 赫圣博 庄黎丽 Sato Shusei TabataSatoshi Ambrose Mike Rameau Catherine 杨军 胡筱荷 罗达 | 2010 | 基因组学与应用生物学2010，29，1： | 3 |
| 12 | HIV-1gp41胞外域对新生隐球菌致人脑微血管内皮细胞骨架改变的影响显示文摘目的探讨HIV-1 gp41胞外域gp41-I90肽对新生隐球菌致人脑微血管内皮细胞骨架改变的影响。方法以人脑微血管内皮细胞作为体外血脑屏障模型,在细胞培养玻片或transwell小室上长成单层,用HIV-1 gp41-I90预处理后,再用新生隐球菌感染细胞单层,免疫荧光方法检测细胞骨架蛋白actin(肌动蛋白)和filamin(肌动蛋白连接蛋白)的形态变化,并测定gp41-I90处理的人脑微血管内皮细胞单层对辣根过氧化物酶和新生隐球菌的通过率。结果 gp41-I90能明显增强新生隐球菌所致的人脑微血管内皮细胞骨架蛋白actin和filamin的改变,actin和filamin的丝状排列扭曲,纹理稀疏;gp41-I90处理的人脑微血管内皮细胞单层通透性增强,对辣根过氧化物酶和新生隐球菌的通过率明显增加。结论 HIV-1 gp41胞外域gp41-I90肽促进新生隐球菌黏附和侵入血脑屏障,与其增强新生隐球菌所致人脑微血管内皮细胞骨架改变有关。 | 龙敏 曹虹 Ambrose Jong | 2011 | 南方医科大学学报2011，31，3： | 3 |
| 13 | The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation显示文摘 | Philip H. Olsen Victor Ambros | 1999 | Developmental Biology1999，，2： | 2 |
| 14 | A novel glasses-free virtual reality rehabilitation system on improving upper limb motor function among patients with stroke:A feasibility pilot study显示文摘Background:Virtual reality(VR)technology is increasingly used in stroke rehabilitation.This study aimed to investigate the effectiveness of using the glasses-free VR training to improve motor function of upper limb in patients with stroke.Methods:Twelve patients with stroke were recruited to participate in the intervention of 3 weeks.At the baseline and post intervention,two times of evaluation including Fugl-Meyer upper-extremity scale(FMS-UE),transcranial magnetic stimulation(TMS)measurement and motion evaluation were performed.Results:No significant difference was observed between two groups at baseline evaluation.After the intervention,the FMS-UE scores presented a greater improvement in the VR group compared with the control group.TMS measurement showed that there was significant difference in cortex latency and central motor conduction time between two groups after the intervention,but no significant difference in the amplitude of motor event potential was observed.In addition,there was a significant correlation between game scores and FMS-UE scores.Conclusions:The novel glasses-free VR training was at least as effective as conventional occupational therapy in upper limb motor function,improving nerve conduction time and corticospinal excitability in patient with stroke. | Haoyu Xie Hantao Zhang Haowen Liang Hang Fan Jianying Zhou Wai Leung Ambrose Lo Le Li | 2021 | Medicine in Novel Technology and Devices2021，，3： | 2 |
| 15 | 教学查房显示文摘床边教学犹如行走在拉紧的绳索上。在提供全面、安全的临床服务时,临床教学者必须平衡大学生和毕业后学习者之间的不同需要。在患者面前的教学会格外紧张,因为患者扮演主角并且也是最仔细的听众。教学查房在医学教育上仍是一种强有力的教学方式,因为它能让大家真实地感受到病患护理和专业化临床实践的复杂性。这种查房其持久不朽的价值在于具有塑造专业化,提高临床推理。和揭示医疗操作准则的潜力。 | Jean Ker Peter Cantillon Lucy Ambrose 谭微(译) 许小平(校) | 2009 | 英国医学杂志中文版2009，12，1： | 2 |
| 16 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 17 | CHADS 2 and CHA 2 DS 2 -VASc Scores in the Prediction of Clinical Outcomes in Patients With Atrial Fibrillation After Catheter Ablation显示文摘 | Tze-Fan Chao Yenn-Jiang Lin Hsuan-Ming Tsao Chin-Feng Tsai Wei-Shiang Lin Shih-Lin Chang Li-Wei Lo Yu-Feng Hu Ta-Chuan Tuan Kazuyoshi Suenari Cheng-Hung Li Beny Hartono Hung-Yu Chang Kibos Ambrose Tsu-Juey Wu Shih-Ann Chen | 2011 | Journal of the American College of Cardiology2011，，23： | 2 |
| 18 | Reconstructing northern Chinese Neolithic subsistence practices by isotopic analysis显示文摘 | Pechenkina E A Ambrose S H Xiaolin M | 2005 | Journal of Archaeological Science2005，32，： | 1 |
| 19 | Genotypes of Pneumocystis jiroveci isolates obtained in Harare,Zimbabwe,and London,United Kingdom显示文摘 | Lindley AR Ambrose HE | 2003 | Antimicrob Agents Chemother2003，47，12： | 1 |
| 20 | Pharmacodynamics of fluoroquinolones against streptococcus pneumoniae in pa tients with community-acquired respiratory tract infections 显示文摘 | Ambrose PG Grasela DM Grasela TH | 2001 | Antimicrob Agents Chemother2001，45，： | 1 |
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