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| 1 | Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections显示文摘Selection of the appropriate donor is essential to a successful allograft recipient outcome for solid organ transplantation. Multiple infectious diseases have been transmitted from the donor to the recipient via transplantation. Donor-transmitted infections cause increased morbidity and mortality to the recipient. In recent years, a series of high-profile transmissions of infections have occurred in organ recipients prompt-ing increased attention on the process of improving the selection of an appropriate donor that balances the shortage of needed allografts with an approach that mitigates the risk of donor-transmitted infection to the recipient. Important advances focused on improving donor screening diagnostics, using previously excluded high-risk donors, and individualizing the selection of allografts to recipients based on their prior infection history are serving to increase the donor pool and improve outcomes after transplant. This article serves to review the relevant literature surrounding this topic and to provide a suggested approach to the selection of an appropriate solid organ transplant donor. | Christopher S Kovacs Jr Christine E Koval David van Duin Amanda Guedes de Morais Blanca E Gonzalez Robin K Avery Steven D Mawhorter Kyle D Brizendine Eric D Cober Cyndee Miranda Rabin K Shrestha Lucileia Teixeira Sherif B Mossad | 2014 | World Journal of Transplantation2014，4，2： | 7 |
| 2 | Low-intensity pulsed ultrasound for regenerating peripheral nerves:potential for penile nerve显示文摘Peripheral nerve damage,such as that found after surgery or trauma,is a substantial clinical challenge.Much research continues in attempts to improve outcomes after peripheral nerve damage and to promote nerve repair after injury.In recent years,low-intensity pulsed ultrasound(LIPUS)has been studied as a potential method of stimulating peripheral nerve regeneration.In this review,the physiology of peripheral nerve regeneration is reviewed,and the experiments employing LIPUS to improve peripheral nerve regeneration are discussed.Application of LIPUS following nerve surgery may promote nerve regeneration and improve functional outcomes through a variety of proposed mechanisms.These include an increase of neurotrophic factors,Schwann cell(SC)activation,cellular signaling activations,and induction of mitosis.We searched PubMed for articles related to these topics in both in vitro and in vivo animal research models.We found numerous studies,suggesting that LIPUS following nerve surgery promotes nerve regeneration and improves functional outcomes.Based on these findings,LIPUS could be a novel and valuable treatment for nerve injury-induced erectile dysfunction. | Dong-Yi Peng Amanda B Reed-Maldonado Gui-Ting Lin Shu-Jie Xia Tom F Lue | 2020 | Asian Journal of Andrology2020，22，4： | 3 |
| 3 | Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice(ob/ob)显示文摘AIM:To investigate the colocalization,density and profile of neuronal areas of enteric neurons in the ileum of male obese mice.METHODS:The small intestinal samples of male mice in an obese group(OG)(C57BL/6J ob/ob)and a control group(CG)(+/+)were used.The tissues were analyzed using a double immunostaining technique for immunoreactivity(ir)of the P2X2 receptor,nitric oxide synthase(NOS),choline acetyl transferase(ChAT)and calretinin(Calr).Also,we investigated the density and profile of neuronal areas of the NOS-,ChAT-and Calrir neurons in the myenteric plexus.Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method.RESULTS:The analysis demonstrated that the P2X2receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG.Neuronal density values(neuron/cm2)decreased 31%(CG:6579±837;OG:4556±407)and 16.5%(CG:7796±528;OG:6513±610)in the NOS-ir and calretininir neurons in the OG,respectively(P<0.05).Density of ChAT-ir(CG:6200±310;OG:8125±749)neurons significantly increased 31%in the OG(P<0.05).Neuron size studies demonstrated that NOS,ChAT,and Calr-ir neurons did not differ significantly between the CG and OG groups.The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG.CONCLUSION:Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir,ChAT-ir and CalR-ir myenteric neurons. | Márcia Sanae Mizuno Amanda Rabello Crisma Primavera Borelli Bárbara Tavares Schfer Mariana Póvoa Silveira Patricia Castelucci | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 4 | Rapid and efficient reprogramming of human fetal and adult blood CD34~ cells into mesenchymal stem cells with a single factor显示文摘进体的干细胞的皮房间的直接变换在再生药打开了新治疗学的可能性。这里,我们证明人的导致的间充质的干细胞(iMSCs ) 能高效地从绳索血(CB ) 被产生 - 或由有一个单个因素的直接 reprogramming 的成年的外部血(PB )-CD34+ 房间, OCT4。面对一个 GSK3 禁止者, 16% OCT4-transduced CD34 + 房间在 2 个星期以内被变换成 iMSCs。有效直接 reprogramming 与两 episomal 被完成调停向量的短暂 OCT4 表示和 lentiviral 调停向量的 OCT4 transduction。iMSCs 快车 MSC 标记,类似于骨头髓(BM ) 在形态学的 -MSCs,并且在 vitro multilineage 区别能力拥有,还与 BM-MSCs 相比有一个更大的 proliferative 能力。类似于 BM-MSCs,植入的 iMSCs 形式骨头和结缔组织,并且是在老鼠的 non-tumorigenic。然而, BM-MSCs 不而 iMSCs 确实形成肌肉纤维,显示 iMSCs 的一个潜在的功能的优点。另外,我们观察到 OCT4 表示的高水平为起始的 reprogramming 和最佳的 iMSC 自强被要求,当 OCT4 表示的减小为 multilineage 区别被要求时。我们的方法将贡献病人特定的 iMSCs 的产生,它能在再生药有应用。这发现可以也为血房间的直接变换便于策略的发展进临床的重要性的房间的另外的类型。 | Xianmei Meng Rui-Jun Su David J Baylink Amanda Neises Jason B Kiroyan Wayne Yuk-Wai Lee Kimberly J Payne Daila S Gridley Jun Wang K-H William Lau Gang Li Xiao-Bing Zhang | 2013 | Cell Research2013，23，5： | 2 |
| 5 | The analytical investigation of synthetic street drugs containing cathinone analogs显示文摘 | Amanda M L Philip B S Adriana D A | 2014 | Forensic Sci Int2014，234，： | 1 |
| 6 | Demonstration of TCDD-attenuated P450 steroidogenic enzyme mRNA levels in rat granulosa cells in vitro using competitive RT-PCR显示文摘 | Asok K D Barbara A B W Amanda L T | 2000 | Mol Cell Endocrinol2000，164，： | 1 |
| 7 | Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication显示文摘 | Renate K?nig Yingyao Zhou Daniel Elleder Tracy L. Diamond Ghislain M.C. Bonamy Jeffrey T. Irelan Chih-yuan Chiang Buu P. Tu Paul D. De Jesus Caroline E. Lilley Shannon Seidel Amanda M. Opaluch Jeremy S. Caldwell Matthew D. Weitzman Kelli L. Kuhen Sourav B | 2008 | Cell2008，，1： | 1 |
| 8 | Revealing the structural and mechanical characteristics of ovine teeth显示文摘 | Simona O B Amanda J K Paul C | 2014 | J Mech Behav Biomed Mater2014，33，3： | 1 |
| 9 | Analysis of multiple data sets reveals no association between the insulin gene variable number tandem repeat element and polycystic ovary syndrome or related traits显示文摘 | Brenda LP Lema H Amanda B | 2005 | J Clin Endocrinol Metab2005，90，5： | 1 |
| 10 | Analysis of laboratory critical valuereporting at a large academic medical center显示文摘 | Anand SD Arjun R Amanda B | 2006 | Am J Clin Pathol2006，125，5： | 1 |
| 11 | On target classification using kinematic data显示文摘 | Branko R Neil G Amanda B | 2004 | Information Fusion2004，12，5： | 1 |
| 12 | The natural history of renal stone fragments following ureteroscopy 显示文摘 | DAVID A R AMANDA M VISHAL B | 2011 | Urology2011，77，3： | 1 |
| 13 | Expression of Distinct Self-Incompatibility Specificities in Arabidopsis thaliana显示文摘 | Boggs Nathan A Dwyer Kathleen G Shah Paurush McCulloch Amanda A Bechsgaard Jesper Schierup Mikkel H Nasrallah Mikhail E Nasrallah June B | 2009 | Genetics2009，，4： | 1 |
| 14 | The role of glutathione-S-transferase polymorphisms in ovarian cancer survival显示文摘 | Christina M Nagle Georgia Chenevix-Trench Amanda B Spurdle | 2007 | European Journal of Cancer2007，43，2： | 1 |
| 15 | Emotional Neglect and Family Struc-ture:Impact on Student Functioning显示文摘 | Mary JW Theresa K Amanda B | 2003 | Child Abuse and Neglect2003，27，： | 1 |
| 16 | A very early rehabilitation trial for stroke (AVERT) phase II safety and feasibility显示文摘 | Julie B Helen D Amanda T Pet at al | 2008 | Stroke2008，39，： | 1 |
| 17 | Gaseous emissions from co-combustion of sewage sludge and coal/wood in a fluidized bed 显示文摘 | B Lecknera Amanda L-E Luckeb K | 2004 | Fuel2004，83，： | 1 |
| 18 | Suckling behaviour in domestic foals and the development of abnormal oral behavior显示文摘 | Christine J N Amanda J B | 2005 | Anim Behav2005，70，： | 1 |
| 19 | Apoptosis,chemoresistance,and breast cancer:insights from the MCF-7 cell model system显示文摘 | Rebecca S Matthew B Amanda P | 2003 | Exp Biol Med2003，228，9： | 1 |
| 20 | Structural organization of human Cu-transporting ATPases :learning from building blocks 显示文摘 | Amanda N B ujwal S Svethlana L | 2010 | Biol In- org Chem2010，15，1： | 1 |
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