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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Mortality Associated With Atrial Fibrillation in Patients With Myocardial Infarction: A Systematic Review and Meta-Analysis显示文摘 | Patricia Jabre Véronique L. Roger Mohammad H. Murad Alanna M. Chamberlain Larry Prokop Frédéric Adnet Xavier Jouven | 2011 | Circulation2011，，15： | 2 |
| 3 | Enrichment of retinal ganglion and Müller glia progenitors from retinal organoids derived from human induced pluripotent stem cells-possibilities and current limitations显示文摘BACKGROUND Retinal organoids serve as excellent human-specific disease models for conditions affecting otherwise inaccessible retinal tissue from patients.They permit the isolation of key cell types affected in various eye diseases including retinal ganglion cells(RGCs)and Müller glia.AIM To refine human-induced pluripotent stem cells(hiPSCs)differentiated into threedimensional(3D)retinal organoids to generate sufficient numbers of RGCs and Müller glia progenitors for downstream analyses.METHODS In this study we described,evaluated,and refined methods with which to generate Müller glia and RGC progenitors,isolated them via magnetic-activated cell sorting,and assessed their lineage stability after prolonged 2D culture.Putative progenitor populations were characterized via quantitative PCR and immunocytochemistry,and the ultrastructural composition of retinal organoid cells was investigated.RESULTS Our study confirms the feasibility of generating marker-characterized Müller glia and RGC progenitors within retinal organoids.Such retinal organoids can be dissociated and the Müller glia and RGC progenitor-like cells isolated via magnetic-activated cell sorting and propagated as monolayers.CONCLUSION Enrichment of Müller glia and RGC progenitors from retinal organoids is a feasible method with which to study cell type-specific disease phenotypes and to potentially generate specific retinal populations for cell replacement therapies. | Kristine Karla Freude Sarkis Saruhanian Alanna McCauley Colton Paterson Madeleine Odette Annika Oostenink Poul Hyttel Mark Gillies Henriette Haukedal Miriam Kolko | 2020 | World Journal of Stem Cells2020，12，10： | 2 |
| 4 | Radial variations in xylem sap flux in a temperate red pine plantation forest显示文摘Background:Scaling sap flux measurements to whole-tree water use or stand-level transpiration is often done using measurements conducted at a single point in the sapwood of the tree and has the potential to cause significant errors.Previous studies have shown that much of this uncertainty is related to(i)measurement of sapwood area and(ii)variations in sap flow at different depths within the tree sapwood.Results:This study measured sap flux density at three depth intervals in the sapwood of 88-year-old red pine(Pinus resinosa)trees to more accurately estimate water-use at the tree-and stand-level in a plantation forest near Lake Erie in Southern Ontario,Canada.Results showed that most of the water transport(65%)occurred in the outermost sapwood,while only 26%and 9%of water was transported in the middle and innermost depths of sapwood,respectively.Conclusions:These results suggest that failing to consider radial variations in sap flux density within trees can lead to an overestimation of transpiration by as much as 81%,which may cause large uncertainties in water budgets at the ecosystem and catchment scale.This study will help to improve our understanding of water use dynamics and reduce uncertainties in sap flow measurements in the temperate pine forest ecosystems in the Great Lakes region and help in protecting these forests in the face of climate change. | Alanna V.Bodo M.Altaf Arain | 2021 | Ecological Processes2021，10，1： | 2 |
| 5 | B Lymphocyte- Specific c - Myc Expression Stimulates Early and Functional Expansion of the Vasculature and Lymphatics during Lymphomagenesis显示文摘 | Alanna R Pau M Kimberly A | 2003 | Am J Pat hol2003，163，6： | 1 |
| 6 | Perceptions of the effectiveness of Advanced Practice Nurses on a neurosurgery unit in a Canadian Tertiary Care Centre:A pre-and-post implementation design显示文摘Objectives:A framework for the advanced practice nurse(APN)role was developed in our Canadian Tertiary Care Centre,delineating five domains of advanced nursing practice:clinical practice,consultation,research,education and leadership.The goal of this study was to evaluate perceptions of the effectiveness of the implementation of an innovative APN role on an in-patient Neurosurgery unit.Methods:A pre-and-post implementation design,incorporating both qualitative and quantitative data,was utilized.An innovative APN role was implemented within the Neurosurgery program focusing on the clinical domain and required the successful candidates to be NP prepared.This APN role was designed to improve patient flow,documentation,communication and patient and staff satisfaction.Three primary outcomes were measured:pre-implementation questionnaire(nurses),post-implementation questionnaire(nurses and residents)and number of pages to the on-call resident.Results:Survey scores by nurses and residents indicated improvement across all aspects studied.Average scores increased from 1.1 to 2.6,reflecting an overall statistically significant increase.The number of pages to the on-call resident also showed a decrease.Conclusion:Perceptions of patient care delivery and professional collaboration improved following implementation of the APN role.Responses indicated that APNs significantly impacted patient care and improved nurses and residents'job satisfaction. | Alanna M.Keenan Erin E.Mutterback Kristi M.Velthuizen Monika E.Pantalone Kira L.Gossack-Keenan | 2018 | International Journal of Nursing Sciences2018，5，2： | 1 |
| 7 | Feasibility and preliminary efficacy of high intensity interval training in type 2 diabetes 显示文摘 | Tasuku Terada Alanna Friesen Baljot S Chahal | 2013 | Diabetes Research and Clinical Practice2013，99，2： | 1 |
| 8 | CD4 + CD25 + Foxp3 + Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model显示文摘 | Pushpa Pandiyan Heather R. Conti Lixin Zheng Alanna C. Peterson Douglas R. Mathern Nydiaris Hernández-Santos Mira Edgerton Sarah L. Gaffen Michael J. Lenardo | 2011 | Immunity2011，，： | 1 |
| 9 | Fortification: new findings and implications显示文摘 | Johanna T Dwyer Catherine Woteki Regan Bailey Patricia Britten Alicia Carriquiry P Courtney Gaine Dennis Miller Alanna Moshfegh Mary M Murphy Marianne Smith Edge | 2014 | Nutr Rev2014，，2： | 1 |
| 10 | Association of Serum Uric Acid With Incident Atrial Fibrillation (from the Atherosclerosis Risk in Communities [ARIC] Study)显示文摘 | Leonardo Tamariz Sunil Agarwal Elsayed Z. Soliman Alanna M. Chamberlain Ronald Prineas Aaron R. Folsom Marietta Ambrose Alvaro Alonso | 2011 | The American Journal of Cardiology2011，，9： | 1 |
| 11 | Colonic schistosomiasis and early rectal cancer: coincidence or causal relationship?显示文摘 | Andreas Probst Tina Schaller Alanna Ebigbo Helmut Messmann | 2014 | Endoscopy2014，，： | 1 |
| 12 | Allelic variations in angiogenic pathway genes are associated with preeclampsia显示文摘 | Sindhu K. Srinivas Alanna C. Morrison Christina M. Andrela Michal A. Elovitz | 2010 | American Journal of Obstetrics and Gynecology2010，，5： | 1 |
| 13 | Tumor-associated macrophages as a source of fonctional dendritic cells in ovairan cancer patients clinical显示文摘 | Christina SC Edward YW Alanna JT | 2002 | Immunology2002，102，3： | 1 |
| 14 | von Willebrand factor:a marker of endothelial dysfunction in vascular disorders显示文摘 | LipGregoryYH AlannA | 1997 | Cardiovascular Research1997，34，： | 1 |
| 15 | G-Protein β3 Subunit and α-Adducin Polymorphisms and Risk of Subclinical and Clinical Stroke显示文摘 | Alanna C. Morrison Peter A. Doris Aaron R. Folsom F. Javier Nieto Eric Boerwinkle | 2001 | Stroke: Journal of the American Heart Association2001，，4： | 1 |
| 16 | Von Willebrand factor:a marker of endothelial dysfunction in vascular disorders显示文摘 | Lip - Gregory - YH Alanna | 1997 | Cardiovascular Research1997，34，： | 1 |
| 17 | A Review of Safety, Efficacy, and Utilization of Erythropoietin, Darbepoetin, and Peginesatide for Patients with Cancer or Chronic Kidney Disease: A Report from the Southern Network on Adverse Reactions (SONAR)显示文摘 | Charles Bennett David Spiegel Iain Macdougall LeAnn Norris Zaina Qureshi Oliver Sartor Stephen Lai Martin Tallman Dennis Raisch Sheila Smith Samuel Silver Alanna Murday James Armitage David Goldsmith | 2012 | Semin Thromb Hemost2012，，08： | 1 |
| 18 | Vitamin D Status Is Associated With Arterial Stiffness and Vascular Dysfunction in Healthy Humans显示文摘 | Ibhar Al Mheid Riyaz Patel Jonathan Murrow Alanna Morris Ayaz Rahman Lucy Fike Nino Kavtaradze Irina Uphoff Craig Hooper Vin Tangpricha R. Wayne Alexander Kenneth Brigham Arshed A. Quyyumi | 2011 | Journal of the American College of Cardiology2011，，2： | 1 |
| 19 | Pediatric brain natriuretic peptide and N-terminal pro-brain natriuretic peptide reference intervals显示文摘 | Steven JS Offie PS Alanna JB | 2006 | Clinica Chimica Acta2006，366，6： | 1 |
| 20 | Microvesicles: medi- ators of extracellular communication during cancer progression 显示文摘 | Vandhana MC James WC Alanna S | 2010 | JCellSci2010，123，10： | 1 |
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