|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Overexpression of blueberry FLOWERING LOCUS T is associated with changes in the expression of phytohormone-related genes in blueberry plants显示文摘Flowering locus T(FT)is a primary integrator in the regulation of plant flowering.Overexpressing a blueberry(Vaccinium corymbosum L.)FT gene(VcFT)(herein VcFT-OX)resulted in early flowering and dwarfing in‘Aurora’plants(herein‘VcFT-Aurora’).In this study,we found that VcFT-OX reduced shoot regeneration from leaf explants.To investigate the potential roles of the phytohormone pathway genes associated with VcFT-OX,differentially expressed(DE)genes in leaf tissues of‘VcFT-Aurora’plants were annotated and analyzed using non-transgenic‘Aurora’plants as a control.Three DE floral genes,including the blueberry SUPPRESSOR of Overexpression of constans 1(VcSOC1)(gibberellin related),Abscisic acid responsive elements-binding factor 2(VcABF2)and protein related to ABI3/VP1(VcABI3/VP1)(ethylene-related),are present under both the phytohormone-responsive and the dwarfing-related Gene Ontology terms.The gene networks of the DE genes overall showed the molecular basis of the multifunctional aspects of VcFT overexpression beyond flowering promotion and suggested that phytohormone changes could be signaling molecules with important roles in the phenotypic changes driven by VcFT-OX. | Xuan Gao Aaron E Walworth Charity Mackie Guo-qing Song | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 3 | 中国宣威家庭炉灶改造与慢性阻塞性肺病的风险——回顾性队列研究显示文摘目的 验证中国宣威县家庭燃煤炉的改造对慢性阻塞性肺病(COPD)发病率的影响。设计方法回顾性队列研究(随访时问1976至1992年),比较有烟囱组和无烟囱组COPD发病率的差异。研究对象 20453名参与者出生在没有安装排烟系统的家庭中,其中16606人(81.2%)后来家中的燃煤炉安装了烟囱。干预 在既往没有安装排风系统的家庭中安装烟囱。结果 给燃煤炉加装烟囱与COPD的发病率降低显著相关。与家中没有安装烟囱的参与者相比,Cox模型计算的男性相对危险度(RR)为0.58(95%可信区问0.49~0.70,P〈0.001);女性相对危险度为0.75(95%可信区间0.62~0.92,P=0.005)。Cox模型的设定不同,计算出的相对危险度也是不同的。改炉改灶的年限越长,COPD的相对危险度越低。无论男性和女性,改灶后10年内COPD发病危险陛下降都非常明确。结论 宣威居民COPD的发病率随着家庭燃煤炉改造后年限增加而显著降低。 | Robert S Chapman 何兴舟 Aaron E Blair 蓝青 许军 | 2006 | 英国医学杂志中文版2006，9，6： | 2 |
| 4 | Improved endpoint detector for isolated word recognition显示文摘 | Lori F Lamel Lawrence R Rabiner Aaron E Rosenberg | | 0，，04： | 1 |
| 5 | The influences of attitudes, beliefs and label information on perceptions of reduced-fat spread 显示文摘 | Aaron J I Mela D J Evans R E | 1994 | Appetite1994，22，： | 1 |
| 6 | Zika virus 显示文摘 | Basarab M Bowman C Aarons E J | 2016 | BMJ2016，，11： | 1 |
| 7 | Capillary electrophoresis of free fatty acids by indirect uhraviolet 显示文摘 | Maria V B Aaron E D Maria J L G | 2011 | Journal of Agriculture and Food Chemistry2011，59，10： | 1 |
| 8 | Reducing the adverse consequences of workplace aggression and violence: The Buffering effects of organizational support 显示文摘 | Schat Aaron CH Kelloway E | 2003 | J Occupational Health Psychology2003，8，： | 1 |
| 9 | The clinical relevance of hip joint simulator testing:In vitro and in vivo comparisons显示文摘 | Aaron E Greg S Aiguo W | 2005 | Wear2005，259，： | 1 |
| 10 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 11 | Adsorption of Zwitterionic Surfactant on Limestone Measured with High-Performance Liquid Chromatography: Micelle-Vesicle Influence 显示文摘 | David Aaron Nieto-Alvarez Luis S Zamudio-Rivera Erick E Luna-Rojero | 2014 | Langmuir2014，30，12： | 1 |
| 12 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 13 | Challenging Global Warming as a Social Problem:An Analysis of the Conservative Movement Counter-Claims显示文摘 | Aaron M Mc Cright Riley E Dunlap | 2000 | Social Problems2000，47，4： | 1 |
| 14 | Comparing the immunogenicity of glycosidase-directed resiquimod prodrugs mediated by cancer cell metabolism显示文摘We have recently developed an enzyme-directed immunostimulant(EDI)prodrug motif,which is metabolized to active immunostimulant by cancer cells and,following drug efflux,activates nearby immune cells,resulting in immunogenicity.In this study,we synthesized several EDI prodrugs featuring an imidazoquinoline immunostimulant resiquimod(a Toll-like receptor 7/8 agonist)covalently modified with glycosidase enzyme-directing groups selected from substrates of β-glucuronidase,α-mannosidase,or β-galactosidase.We compared the glycosidase-dependent immunogenicity elicited by each EDI in RAW-Blue macrophages following conversion to active immunostimulant by complementary glycosidase.At a cellular level,we examined EDI metabolism across three cancer cell lines(B16 melanoma,TC2 prostate,and 4T1 breast cancer).Comparing the relative immunogenicity elicited by each EDI/cancer cell combination,we found that B16 cells produced the highest EDI prodrug immunogenicity,achieving>95% of that elicited by unmodified resiquimod,followed by TC2 and 4T1 cells(40% and 30%,respectively).Immunogenicity elicited was comparable for a given cell type and independent of the glycosidase substrate in the EDIs or differences in functional glycosidase activity between cell lines.Measuring drug efflux of the immunostimulant payload and efflux protein expression revealed that EDI/cancer cell-mediated immunogenicity was governed by efflux potential of the cancer cells.We determined that,following EDI conversion,immunostimulant efflux occurred through both P-glycoprotein-dependent and P-glycoprotein-independent transport mechanisms.Overall,this study highlights the broad ability of EDIs to couple immunogenicity to the metabolism of many cancers that exhibit drug efflux and suggests that designing future generations of EDIs with immunostimulant payloads that are optimized for drug efflux could be particularly beneficial. | Austin T Ryan Anunay J Pulukuri Maryam Davaritouchaee Armina Abbasi Aaron T Hendricksen Larissa K Opp Anthony J Burt Amy E Nielsen Rock J Mancini | 2020 | Acta Pharmacologica Sinica2020，41，7： | 1 |
| 15 | Power-law distributions in empirical data 显示文摘 | Aaron Clauset Cosma Rohilla Shalizi NEWMAN M E J | 2009 | SIAM Review2009，51，： | 1 |
| 16 | Synthesis of High Aspect Ratio Quantum- size CdS Nanorods and Their Surface-dependent Photoluminescence 显示文摘 | Aaron E S Ali G Preeti S | 2008 | Langmuir2008，24，： | 1 |
| 17 | Sanford Treefall gap size effects on above-and below-ground Processes in a tropical wet forest显示文摘 | Julie S Denslow Aaron M Ellison Robert E | 1998 | Journal of Ecology1998，86，： | 1 |
| 18 | Preparation and properties of some transition metal phosphorus trisulfide compounds 显示文摘 | Barry E Taylor John Steger Aaron Wold | 1973 | J Solid StateChem1973，7，4： | 1 |
| 19 | The Impact of Defense Expenses in Medical Malpractice Claims 显示文摘 | Aaron E Carroll Parul D | 2012 | The Graying of America : Challenges and Controversies2012，13，3： | 1 |
| 20 | The United Kingdom public health re- sponse to an imported laboratory confirmed case of a no- vel coronavirus in September 2012显示文摘 | Pebody R G Chand M A Thomas H L Green H K Boddington N L Carvalho C Brown C S Anderson S R Rooney C Crawley-Boevey E Irwin D J Aarons E Tong C Newsholme W Price N Langrish C Tucker D Zhao H Phin N Crofts J Bermingham A Gil- gunn-Jones E Brown K E Evans B Catchpole M Watson J M | 2012 | Euro Surveill2012，17，20： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员