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| 1 | Pancreatic cancer serum biomarker PC-594:Diagnostic performance and comparison to CA19-9显示文摘AIM:To investigate serum PC-594 fatty acid levels as a potential biomarker in North American pancreatic cancer(PaC) patients,and to compare its performance to CA19-9.METHODS:Using tandem mass spectrometry,we evaluated serum PC-594 levels from 84 North American patients with confirmed PaC and 99 cancer-free control subjects.We determined CA19-9 levels by ELISA.Significance between Pa C patients and controls,and association with clinical variables was determined by analysis of variance and t-tests.Diagnostic performance was evaluated by receiver-operator characteristic(ROC)curve analysis,and PC-594 correlation with age and CA19-9 determined by regression analysis.RESULTS:Mean PC-594 levels were 3.7 times lower in Pa C patients compared to controls(P < 0.0001).The mean level in PaC patient serum was 0.76 ± 0.07 μmol/L,and the mean level in control subjects was 2.79 ± 0.15 μmol/L.There was no correlation between PC-594 and age,disease stage or gender(P > 0.05).Using 1.25 μmol/L as a PC-594 threshold produced a relative risk(RR) of 9.4(P < 0.0001,95%CI:5.0-17.7).The area under the receiver-operator characteristic curve(ROCAUC) was 0.93(95%CI:0.91-0.95) for PC-594 and 0.85(95%CI:0.82-0.88) for CA19-9.Sensitivity at 90% specificity was 87% for PC-594 and 71% for CA19-9.Six Pa C patients with CA19-9 above 35 U/m L showed normal PC-594 levels,while 24 Pa C patients with normal CA19-9 showed low PC-594 levels.Eighty-five of the 99 control subjects(86%) showed normal levels of both markers.CONCLUSION:PC-594 biomarker levels are significantly reduced in North American Pa C patients,and showed superior diagnostic performance compared to CA19-9. | Shawn A Ritchie Bassirou Chitou Qingan Zheng Dushmanthi Jayasinghe Wei Jin Asuka Mochizuki Dayan B Goodenowe | 2015 | World Journal of Gastroenterology2015，21，21： | 3 |
| 2 | Design of a Multi--Vehicle Control Sys tern: System Design and User Interaction显示文摘 | WElL Shawn A | 2006 | Advances in Hu man Performance and Cognitive Engineering Research2006，，7： | 1 |
| 3 | Complicatons of ERCP 显示文摘 | J Shawn Mallery Todd H Baron Jason A Kom initz | 2003 | American Society For Gastrointestinal Endoscopy2003，57，6： | 1 |
| 4 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 5 | A genetic linkage map for hazelnut( Corylus avellana L)based on RAPD and SSR markers显示文摘 | Shawn A M Rebecca N B Eduardo R N | | 0，，02： | 1 |
| 6 | Comparison of Enterococcus measurements in freshwater at two recreational beaches by quantitative polymerase chain reaction and membrane filter culture analysis 显示文摘 | Richard A Haugland Shawn C | 2005 | Water Research2005，39，： | 1 |
| 7 | Transfemoral placementof intraluminal polyurethane prosthesis for abdominal aortic an-eurysm显示文摘 | Balko A* Piaseki GJ Shawn DM | 1986 | J Surg Res1986，，： | 1 |
| 8 | A comparison of supplemental calcium soap of palm fatty acids versus tallow in a corn-based finishing diet for feedlot steers 显示文摘 | Crystal M W Sahng W H Shawn L A etal | 2015 | J Anim Sei Technol2015，57，1： | 1 |
| 9 | Template Synthesis of Bismuth Telluride Nanowires显示文摘 | Shawn A S Brinda B I Charles R M | 1999 | Advanced Materials1999，11，5： | 1 |
| 10 | The Speetum of pneumatosis intestinalis 显示文摘 | Shawn D St Peter Maher A Abbas Keith A Kelly | 2003 | Arch Surg2003，138，1： | 1 |
| 11 | Thermally Actuated Shape-memory Polymers: Experiments, Theory and Numeri- cal Simulations 显示文摘 | VIKAS S SHAWN A C LALLIT A | 2010 | Journal of the Mechanics and Physics of Solids2010，58，8： | 1 |
| 12 | Topical tetracaine prior to arterial puncture: a randomized, placebo-controlled clinical trial显示文摘 | Shawn D Aaron Katherine L Vandemheen Sheila A Naftel Mary-Jo Lewis Marc A Rodger | 2003 | Respiratory Medicine2003，，11： | 1 |
| 13 | Surgery for early-stage non-small cell lung cancer:a systematic review of the video-assisted thoracoscopic surgery versus thoracotomy approaches to lobectomy 显示文摘 | Bryan A Whitson BA Shawn S | 2008 | Ann Thorac Surg2008，86，6： | 1 |
| 14 | A Bragg grating-tuned fiber laser strain sensor system显示文摘 | Alavie A T Shawn Karr, | 1993 | IEEE Photonics Tech-nology Letters1993，5，2： | 1 |
| 15 | Information on selected water quality characteristics for the production of black sea bass,Centropristis striata,Juveniles显示文摘 | Heidi L A Shawn P Y Joseph R T | 2004 | Journal of Applied Aquaculture2004，15，34： | 1 |
| 16 | Moving mass trim control for aerospace vehicles显示文摘 | Rush D R Beverly R S Shawn A K | | 0，，： | 1 |
| 17 | Are you buying too much friction reducer because of your biocide显示文摘 | Shawn M R Paul R H Michael O A | 2009 | SPE 1195692009，，： | 1 |
| 18 | Spatio-temporal distribution of stored- product insects around food processing and storage facilities 显示文摘 | Semeao A A Campbell J F Shawn J M H | 2013 | Agriculture Ecosystems and Environment2013，165，： | 1 |
| 19 | QTL associated with horizontal resistance to soybean cyst nematode in Glycine soja PI464925B显示文摘 | Shawn M J W Barry J S Terry R A | 2007 | Theoretical and Applied Genetics2007，114，3： | 1 |
| 20 | Bimolecularcrystals of fullerenes in conjugated polymers and theimplications of molecular mixing for solar cells显示文摘 | Mayer A C Michael F T Shawn R S | 2009 | Advanced Functional Materials2009，19，： | 1 |
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