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| 1 | The emerging role of probiotics in neurodegenerative diseases:new hope for Parkinson’s disease?显示文摘Neurodegenerative disease etiology is still unclear,but different contributing factors,such as lifestyle and genetic factors are involved.Altered components of the gut could play a key role in the gut-brain axis,which is a bidirectional system between the central nervous system and the enteric nervous system.Variations in the composition of the gut microbiota and its function between healthy people and patients have been reported for a variety of human disorders comprising metabolic,autoimmune,cancer,and,notably,neurodegenerative disorders.Diet can alter the microbiota composition,affecting the gutbrain axis function.Different nutraceutical interventions have been devoted to normalizing gut microbiome dysbiosis and to improving biological outcomes in neurological conditions,including the use of probiotics.Preclinical and clinical investigations discussed in this review strengthen the correlation between intestinal microbiota and brain and the concept that modifying the microbiome composition may improve brain neurochemistry,modulating different pathways.This review will discuss the potential use of probiotics for Parkinson’s disease prevention or treatment or as adjuvant therapy,confirming that gut microbiota modulation influences different pro-survival pathways.Future investigations in Parkinson’s disease should consider the role of the gut-brain axis and additional comprehension of the underlying mechanisms is extremely necessary. | Vanessa Castelli Michele d’Angelo Massimiliano Quintiliani Elisabetta Benedetti Maria Grazia Cifone Annamaria Cimini | 2021 | Neural Regeneration Research2021，16，4： | 2 |
| 2 | Microstructure andfracture toughness of Si3N4+graphene platelet composites 显示文摘 | JAN D JERZY M ANNAMARIA D | 2012 | J EurCeram Soc2012，32，33： | 1 |
| 3 | Brain electrical source imaging in manic and depressive episodes of bipolar disorder显示文摘 | Annamaria Painold Pascal L Faber Patricia Milz Eva Z Reininghaus Anna K Holl Martin Letmaier Roberto D Pascual‐Marqui Bernd Reininghaus Hans‐Peter Kapfhammer Dietrich Lehmann | 2014 | Bipolar Disord2014，，7： | 1 |
| 4 | The Cy- elophilin Inhibitor Alisporivir Prevents Hepatitis C Vires - Mediated Mitochondrial Dysfunction显示文摘 | Giovanni Quarato Annamaria D' Aprile Bruno Gavillet | 2012 | Hepatology2012，55，5： | 1 |
| 5 | Bisphenol A in polycystic ovary syndrome and its association with liver–spleen axis显示文摘 | Giovanni Tarantino Rossella Valentino Carolina Di Somma Vittoria D’Esposito Federica Passaretti Genoveffa Pizza Valentina Brancato Francesco Orio Pietro Formisano Annamaria Colao Silvia Savastano | 2013 | Clin Endocrinol2013，，3： | 1 |
| 6 | Loss of Proline-Rich Tyrosine Kinase-2 Function Induces Spreading and Motility of Epithelial Prostate Cells显示文摘 | Francesca D A Marilena L A Annamaria K I | 2006 | J cellular Physiology2006，209，： | 1 |
| 7 | Multicentric, Randomized Phase III Trial of Two Different Adjuvant Chemotherapy Regimens plus Three Versus Twelve Months of Trastuzumab in Patients with HER2-Positive Breast Cancer (Short-HER Trial; NCT00629278)显示文摘 | Valentina Guarneri Antonio Frassoldati Paolo Bruzzi Roberto D’Amico Maurizio Belfiglio Annamaria Molino Oscar Bertetto Stefano Cascinu Francesco Cognetti Angelo Di Leo Paolo Pronzato Lucio Crinó Biagio Agostara PierFranco Conte | 2008 | Clinical Breast Cancer2008，，5： | 1 |
| 8 | bcl-2 overexpression enhancesNF-κ B activity and induces MMP 9 transcription in human MCF7-ADRbreast-cancer cells 显示文摘 | Annamaria B donatella D B | 2000 | Int JCancer2000，86，： | 1 |
| 9 | Complete genome sequence of a raccoon rabies virus isolate显示文摘 | Annamaria G S Susan A N D Bradley N W | 2008 | Virus Res2008，136，： | 1 |
| 10 | Combined approach based on principal component analysis and canonical discriminant analysis for investigation hyperspectral plant response显示文摘 | Anna M S Annamaria C Mariangela D | 2012 | Italian Journal of Agronomy2012，7，3： | 1 |
| 11 | New forms of international cooperation in doctoral training:internationalisation and the international doctorate-one goal,two distinct models 显示文摘 | ANNAMARIA S D R | 2008 | Higher education in europe2008，33，1： | 1 |
| 12 | Fine structure of leydig and sertoli cells in the testis of immature and mature spotted ray Torpedo marmorata显示文摘 | Marina P Annamaria L Barbara D | 2002 | Mole Reprod Devel2002，63，： | 1 |
| 13 | Intratumoural FOXP3-positive regulatory T cells are associated with adverse prognosis in radically resected gastric cancer显示文摘 | Giuseppe Perrone Pier Adelchi Ruffini Vincenzo Catalano Cathie Spino Daniele Santini Pietro Muretto Chiara Spoto Costantino Zingaretti Valerio Sisti Paolo Alessandroni Paolo Giordani Andrea Cicetti Silvia D’Emidio Sergio Morini Annamaria Ruzzo Mauro Magna | 2008 | European Journal of Cancer2008，，13： | 1 |
| 14 | TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation显示文摘 | Tina Di Palma Barbara D’Andrea Giovanna Lucia Liguori Annamaria Liguoro Tiziana de Cristofaro Dolores Del Prete Andrea Pappalardo Anna Mascia Mariastella Zannini | 2008 | Experimental Cell Research2008，，2： | 1 |
| 15 | Role of apoptosis and Fas/Fasl system in the oogenesis of the spotted ray Torpedo marmorata显示文摘 | Loredana R Barbara D Annamaria L | 2003 | Mol Reprod Dev2003，66，1： | 1 |
| 16 | Therapeutic advances in neural regeneration for Huntington’s disease显示文摘Huntington’s disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the HTT gene which is responsible for the production of the huntingtin (Htt) protein. In physiological conditions, Htt is involved in many cellular processes such as cell signaling, transcriptional regulation, energy metabolism regulation, DNA maintenance, axonal trafficking, and antiapoptotic activity. When the genetic alteration is present, the production of a mutant version of Htt (mHtt) occurs, which is characterized by a plethora of pathogenic activities that, finally, lead to cell death. Among all the cells in which mHtt exerts its dangerous activity, the GABAergic Medium Spiny Neurons seem to be the most affected by the mHtt-induced excitotoxicity both in the cortex and in the striatum. However, as the neurodegeneration proceeds ahead the neuronal loss grows also in other brain areas such as the cerebellum, hypothalamus, thalamus, subthalamic nucleus, globus pallidus, and substantia nigra, determining the variety of symptoms that characterize Huntington’s disease. From a clinical point of view, Huntington’s disease is characterized by a wide spectrum of symptoms spanning from motor impairment to cognitive disorders and dementia. Huntington’s disease shows a prevalence of around 3.92 cases every 100,000 worldwide and an incidence of 0.48 new cases every 100,000/year. To date, there is no available cure for Huntington’s disease. Several treatments have been developed so far, aiming to reduce the severity of one or more symptoms to slow down the inexorable decline caused by the disease. In this context, the search for reliable strategies to target the different aspects of Huntington’s disease become of the utmost interest. In recent years, a variety of studies demonstrated the detrimental role of neuronal loss in Huntington’s disease condition highlighting how the replacement of lost cells would be a reasonable strategy to overcome the neurodegeneration. In this view, numerous have been the attempts in several preclinical models of Huntington’s disease to evaluate the feasibility of invasive and non-invasive approaches. Thus, the aim of this review is to offer an overview of the most appealing approaches spanning from stem cell-based cell therapy to extracellular vesicles such as exosomes in light of promoting neurogenesis, discussing the results obtained so far, their limits and the future perspectives regarding the neural regeneration in the context of Huntington’s disease. | Francesco D’Egidio Vanessa Castelli Giorgia Lombardozzi Fabrizio Ammannito Annamaria Cimini Michele d’Angelo | 2024 | Neural Regeneration Research2024，19，9： | 0 |
| 17 | Human IgG1 antibodies suppress angiogenesis in a target-independent manner显示文摘Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s population.The most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human VEGFA.Although bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in mice.Here we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(CD64)and c-Cbl,impairing macrophage migration.Other approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized mice.This anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated signaling.Furthermore,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA mice.Finally,mice deficient in FcγRI exhibited increased developmental and pathological angiogenesis.These findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies. | Sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 0 |
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