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| 1 | EFFECTS OF ACUPUNCTURE ON IMMUNE RESPONSE RELATED TO OPIOID-LIKE PEPTIDES显示文摘Experimental research has recently shown that acupuncture induces the formation of opioid-like peptides (OLPs) in animals. In order to provide further evidence, we tested the β-endorphin levels and other parameters (VIP, lymphocyte subsets, NK cells and monocyte phagocytosis) in a group of 90 patients suffering from various painful disorders treated with acupuncture. Zusanli (St 36) and Hegu (LI 4) acupoints were selected. A homogeneous group of 30 subjects was used as control. Evaluation of the above parameters was made with 3 series of blood tests before treatment, 30 minutes and 24 hours after acupuncture treatment. In the acupuncture group, the following results were achieved: 1) A considerable increase in β-endorphin levels remained high even 24 hours after acupuncture treatment. In addition, we demonstrated an inverted correlation between β-endorphins and VIP; 2) 30 minutes after acupuncture session, 80% of the treated patients showed a significant increase of CD3 and CD4 values and an increase of CD8 24 hours after stimulation; 3) Monocyte phagocytosis was increased in 45% of the treated subjects 30 minutes from starting treatment, and in 100% of them after 24 hours. The percentage of NK cells was also increased in 40% of cases after 30 minutes, and in 50% after 24 hours. However, in the control group, no such significant changes in immune parameters were found. | FILOMENA PETTI ALFIO BANGRAZI ALDO LIGUORI GABRIELLA REALE FLORA IPPOLITI | 1998 | Journal of Traditional Chinese Medicine1998，18，1： | 20 |
| 2 | Depression and chronic heart failure in the elderly: an intriguing relationship显示文摘长期的心失败和压抑的混乱有高流行和发生在老。几研究显示出消沉怎么趋于加重共存的长期的心失败和它的临床的结果并且反过来也如此,在特别老。在长期的心失败和消沉在之间的否定协同老可以被接近仅仅考虑位于两个这些条件下面的 multifaceted pathophysiological 特征,例如行为因素, neurohormonal 激活,煽动性的调停人, hypercoagulability 和脉管的损坏。不过,在这二个条件之间的 pathophysiological 连接还很好没被建立。尽管有在长期的心失败的消沉的高流行老病人和它的否定预示的价值,因为分享的症状,它特别经常是未被认出的。用可靠问询表,屏蔽心情混乱因此与长期的心失败在老病人被推荐,就算不能由心理健康职业运动员代替诊断会见。在这个背景,消沉的治疗要求包括的一条多学科的途径:心理疗法,抗抑郁剂,锻练训练和 electroconvulsive 治疗。尽管有冲突结果,有选择血清素举起禁止者的药理学治疗改进生活的质量但是不保证更好的结果。锻练训练在改进生活和预后的质量是有效的,但是同时心脏的康复服务是极大地 underutilized。 | Ilaria Liguori Gennaro Russo Francesco Curcio Giuseppe Sasso David Della-Morte Gaetano Gargiulo Flora Pirozzi Francesco Cacciatore Domenico Bonaduce Pasquale Abete Gianluca Testa | 2018 | Journal of Geriatric Cardiology2018，15，6： | 16 |
| 3 | Study on Cytokines IL-2,IL-6,IL-10 in Patients of Chronic Allergic Rhinitis Treated with Acupuncture显示文摘Objectives: To observe the plasmatic concentration of IL-6, IL-10 and IL-2 in the patient of chronic allergic rhinitis before and after acupuncture therapy. Methods: Cytokine levels were determined before and after treatment in 30 healthy volunteers (Group A) and 90 patients of chronic allergic rhinitis (Group B) with an increased plasma IL-10 level. Group B was then divided into 3 subgroups: 30 patients treated with real acupuncture (Group B1); 30 patients treated with sham acupuncture (Group B2); 30 non-treated patients (Group B3). Results: The allergic subjects of group B1, compared with controls, showed a significant reduction of IL-10 after a specific treatment with acupuncture (P<0.05). On the other hand, in those patients treated with sham acupuncture (B2) as well as in non-treated patients (B3), the IL-10 values remained high and unchanged. There was a statistically significant change in IL-2 values at 24 hours (P<0.05) after real acupuncture (Groups A, B1), however the values remained within normal ranges. The IL-6 do not change after therapy. Conclusion: The acupuncture treatment can reduce plasmatic level of IL-10 in chronic allergic rhinitis. | FILOMENA BANGRAZI PETTI M.Sc.Ph.D. ALDO LIGUORI M.D. FLORA IPPOLITI M.D.Ph.D. | 2002 | Journal of Traditional Chinese Medicine2002，22，2： | 12 |
| 4 | Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer显示文摘The prognosis of patients with metastatic colorectal cancer(m CRC) remain poor despite the impressive improvement of treatments observed over the last 20 years that led to an increase in median overall survival from 6 mo, with the only best supportive care, to approximately 30 mo with the introduction of active chemotherapy drugs and targeted agents. The monoclonal antibodies(mo Abs) cetuximab and panitumumab, directed against the epidermal growth factor receptor(EGFR), undoubtedly represent a major step forward in the treatment of m CRC, given the relevant efficacy in terms of progression-free survival, overall survival, response rate, and quality of life observed in several phase Ⅲ clinical trials among different lines of treatment. However, the anti-EGFR mo Abs were shown only to be effective in a subset of patients. For instance, KRAS and NRAS mutations have been identified as biomarkers of resistance to these drugs, improving the selection of patients who might derive a benefit from these treatments. Nevertheless, several other alterations might affect the response to these drugs, and unfortunately, even the responders eventually become resistant by developing secondary(or acquired) resistance in approximately 13-18 mo. Several studies highlighted that the landscape of responsible alterations of both primary and acquired resistance to anti-EGFR drugs biochemically converge into MEK-ERK and PIK3CA-AKT pathways. In this review, we describe the currently known mechanisms of primary and acquired resistance to anti-EGFR mo Abs together with the various strategies evaluated to prevent, overcame or revert them. | Vincenzo Sforza Erika Martinelli Fortunato Ciardiello Valentina Gambardella Stefania Napolitano Giulia Martini Carminia della Corte Claudia Cardone Marianna L Ferrara Alfonso Reginelli Giuseppina Liguori Giulio Belli Teresa Troiani | 2016 | World Journal of Gastroenterology2016，22，28： | 6 |
| 5 | Intrahepatic vascular changes in non-alcoholic fatty liver disease: potential role of insulin-resistance and endothelial dysfunction显示文摘Metabolic syndrome is a cluster of several clinical conditions characterized by insulin-resistance and high cardiovascular risk. Non-alcoholic fatty liver disease is the liver expression of the metabolic syndrome, and insulin resistance can be a frequent comorbidity in several chronic liver diseases, in particular hepatitis C virus infection and/or cirrhosis. Several studies have demonstrated that insulin action is not only relevant for glucose control, but also for vascular homeostasis. Insulin regulates nitric oxide production, which mediates to a large degree the vasodilating, antiinflammatory and antithrombotic properties of a healthy endothelium, guaranteeing organ perfusion. The effects of insulin on the liver microvasculature and the effects of IR on sinusoidal endothelial cells have been studied in animal models of non-alcoholic fatty liver disease. The hypotheses derived from these studies and the potential translation of these results into humans are critically discussed in this review. | Marcos Pasarín Juan G Abraldes Eleonora Liguori Beverley Kok Vincenzo La Mura | 2017 | World Journal of Gastroenterology2017，23，37： | 6 |
| 6 | Circumferential mucosal dissection and esophageal perforation in a patient with eosinophilic esophagitis显示文摘A young man with a previous history of episodes of mild solid food dysphagia was admitted with a total dysphagia. The esophagogastroduodenoscopy (EGDS) showed an extensive disruption of mucosal layer with a cul-de-sac in the lower part of the esophagus. Soon after the procedure, the patient suffered from an acute chest pain and subsequent CT scan demonstrated an intramural circumferential dissection of thoracic esophagus, and a mediastinal emphysema. An emergency right thoracotomy was performed, followed by a total esophagectomy with esophagogastroplasty and jejunostomy. The histopathology confirmed that mucosal and submucosal layers were circumferentially detached from muscular wall and showed an eosinophilic infiltration of the whole organ with necrosis and erosions of mucosal, submucosal and muscular layers. The diagnosis was esophageal perforation in eosinophilic esophagitis. | Gennaro Liguori Maurizio Cortale Fabrizio Cimino Michele Sozzi | 2008 | World Journal of Gastroenterology2008，14，5： | 4 |
| 7 | 离子交换树脂固载金属纳米粒子:可持续化学的有效、多功能催化剂平台(英文)显示文摘This paper reviews the recent achievements in the immobilization of metal nanoparticles on ion-exchange resins and the related catalytic application. The focus is on the production processes for fine and commodity chemicals for which a low environmental impact has been demonstrated. The most significant papers that appeared in the literature from January 2010 to July 2014 have been covered. Their uses in unselective processes, bulk chemicals production, fuel cells components, as well as the use of metal-free ion-exchange resins in acid / base-catalysed reactions, were not included. | Francesca Liguori Carmen Moreno-Marrodan Pierluigi Barbaro | 2015 | 催化学报2015，36，8： | 3 |
| 8 | Inguinal recurrence of malignant mesothelioma of the tunica vaginalis: one case report with delayed recurrence and review of the literature显示文摘亲爱的先生,我是 Giovanni Liguori 从泌尿学的部门, Trieste 的大学,意大利。我们 wrtite 到你讨论大桶集成通信适配器的恶意的间皮瘤阴道。恶意的间皮瘤最经常包含肋膜或到石棉的腹洞和暴露是为它的发展的一个著名风险因素[1 ] 。在他们注意在几个月的功课期间的阴囊的胀大以后,大多数病人寻求治疗。在临床的评价以后,这些瘤经常被相信代表阴囊积水或 epididymal 包囊。作为结果,大多数病人开始为一个怀疑的良性的实体保存地被对待,恶意的诊断经常手术后地被做。 | Giovanni Liguori Giulio Garaffa Carlo Trombetta Rossana Bussani Stefano Bucci Emanuele Belgrano | 2007 | Asian Journal of Andrology2007，9，6： | 2 |
| 9 | Multi-disciplinary clinic models for the management of non-alcoholic fatty liver disease显示文摘In recent years,there has been an increasing interest in the implementation of multi-disciplinary clinic(MDC)models in the medical field,in an effort to improve coordination of care due to the increasing complexity of medical practice.It is therefore unsurprising that there is such interest in non-alcoholic fatty liver disease(NAFLD),which is now the most prevalent liver disease worldwide. | Mirko Zoncapè Antonio Liguori Emmanuel A.Tsochatzis | 2022 | Hepatobiliary Surgery and Nutrition2022，11，4： | 2 |
| 10 | Esophageal cell proliferation in gastroesophageal reflux disease: Clinical-morphological data before and after pantoprazole显示文摘AIM: To evaluate esophageal mucosal defense mechanisms at an epithelial level to establish if pantoprazole treatment can induce ultrastructural healing and improvement in the proliferation activity of the esophageal epithelium in gastroesophageal reflux disease (GERD). METHODS: This was a single-blinded study for pHmonitoring, and histological, ultrastructural and MIB1 immunostaining evaluation. Fifty eight patients with GERD were enrolled and underwent 24 h pH-monitoring and endoscopy. Patients were treated for 12 and 24 mo with pantoprazole. Esophageal specimens were taken for histological and ultrastructural evaluation, before and after the treatment. RESULTS: With transmission electron microscopy, all patients with GERD showed ultrastructural signs of damage with dilation of intercellular spaces (DIS). After 3 mo of therapy the mean DIS values showed asignificant reduction and the mean MIB1-LI values of GERD showed an increase in cell proliferation. A further 3 mo of therapy significantly increased cell proliferation only in the erosive esophagitis (ERD) group. CONCLUSION: Three months of pantoprazole therapy induced ultrastructural healing of mucosal damage in 89% and 93% of ERD and non-erosion patients, respectively. Moreover, long-term pantoprazole treatment may be helpful in increasing the capability for esophageal cell proliferation in GERD, particularly in ERD patients. | Carlo Calabrese Davide Treré Giuseppina Liguori Veronica Gabusi Manuela Vici Giovanna Cenacchi Massimo Derenzini Giulio Di Febo | 2009 | World Journal of Gastroenterology2009，15，8： | 2 |
| 11 | Fertility preservation after bilateral severe testicular trauma显示文摘 | Giovanni Liguori Nicola Pavan Gianluca d'Aloia Stefano Bucci Bernardino de Concilio Giorgio Mazzon Giangiacomo Ollandini Carlo Trombetta | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 12 | Management of malignant hilar biliary obstruction by endoscopy results and prognostic factors显示文摘 | M. Ducreux MD Cl. Liguory MD J. F. Lefebvre MD O. Ink MD A. Choury MD J. Fritsch MD D. Bonnel MD S. Derhy MD J. P. Etienne MD | 1992 | Digestive Diseases and Sciences1992，，5： | 2 |
| 13 | Detection of microsporidia in surface water:a one-year follow-up study显示文摘 | Foumier S Liguory O Santillana-Hayat M | 2000 | FEMS Immunol Med Microbiol2000，29，2： | 1 |
| 14 | Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation显示文摘 | Deng X Stachlewitz RF Liguori M J et d | 2006 | J Pharmacol Exp Ther2006，319，3： | 1 |
| 15 | Uncertainty characterization in image-based measurements:a preliminary discussion显示文摘 | De Santo M Liguori C Pietrosanto A | 2000 | IEEE Trans- actions on Instrumentation and Measurement2000，49，5： | 1 |
| 16 | Treatment of vari-cocele in subfertile men : the Cochrane Review - a contraryopinion显示文摘 | Ficarra V Cerruto MA Liguori G | 2006 | Eur Urol2006，49，2： | 1 |
| 17 | 'Warm-up' phenomenon detected by electrocardiographic ambulatory monitoring in adult and older patients显示文摘 | Napoli C Liguori A Cacciatore F | 1999 | J Am Geriatr Soc1999，47，9： | 1 |
| 18 | The beneficial effects of antioxidant supplementation in enteral feeding in critically ill patients:a prospective,randomized,double-blind,placebo-controlled trial显示文摘 | Crimi E Liguori A Condorelli M | 2004 | Anesth Analg2004，99，： | 1 |
| 19 | IFFTC-Based Procedure for Hidden Tone Detection 显示文摘 | LIGUORI Consolatina PAOLILLO Alfredo | 2007 | IEEE Transac- tions on Instrumentation and Measurement2007，56，1： | 1 |
| 20 | Microneurographic evaluation of sympathetic activity in small fiber neuropathy 显示文摘 | Liguori R Giannoccaro M P Di Stasi V | 2011 | Neurophysiol Clin2011，，122： | 1 |
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