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| 1 | Proteome analysis of hepatocellular carcinoma by laser capture microdissection显示文摘 | Ai J Tan Y Ying W Hong Y Liu S Wu M Qian X Wang H | 2006 | 第二军医大学学报2006，27，5： | 14 |
| 2 | Surveillance-response systems: the key to elimination of tropical diseases显示文摘Tropical diseases remain a major cause of morbidity and mortality in developing countries.Although combined health efforts brought about significant improvements over the past 20 years,communities in resource-constrained settings lack the means of strengthening their environment in directions that would provide less favourable conditions for pathogens.Still,the impact of infectious diseases is declining worldwide along with progress made regarding responses to basic health problems and improving health services delivery to the most vulnerable populations.The London Declaration on Neglected Tropical Diseases(NTDs),initiated by the World Health Organization’s NTD roadmap,set out the path towards control and eventual elimination of several tropical diseases by 2020,providing an impetus for local and regional disease elimination programmes.Tropical diseases are often patchy and erratic,and there are differing priorities in resources-limited and endemic countries at various levels of their public health systems.In order to identify and prioritize strategic research on elimination of tropical diseases,the‘First Forum on Surveillance-Response System Leading to Tropical Diseases Elimination’was convened in Shanghai in June 2012.Current strategies and the NTD roadmap were reviewed,followed by discussions on how to identify and critically examine prevailing challenges and opportunities,including inter-sectoral collaboration and approaches for elimination of several infectious,tropical diseases.A priority research agenda within a‘One Health-One World’frame of global health was developed,including(i)the establishment of a platform for resource-sharing and effective surveillance-response systems for Asia Pacific and Africa with an initial focus on elimination of lymphatic filariasis,malaria and schistosomiasis;(ii)development of new strategies,tools and approaches,such as improved diagnostics and antimalarial therapies;(iii)rigorous validation of surveillance-response systems;and(iv)designing pilot studies to transfer Chinese experiences of successful surveillance-response systems to endemic countries with limited resources. | Ernest Tambo Lin Ai Xia Zhou Jun-Hu Chen Wei Hu Robert Bergquist Jia-Gang Guo Jürg Utzinger Marcel Tanner Xiao-Nong Zhou | 2014 | Infectious Diseases of Poverty2014，3，1： | 14 |
| 3 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 4 | TRPS1是一种高度敏感和特异的乳腺癌标志物,尤其对三阴性乳腺癌显示文摘基于雌激素受体(ER)/孕激素受体(PR)及人类表皮生长因子受体2(HER2)表达,乳腺癌分为ER阳性、PR阳性、HER2阳性(15%)及三阴性(TNBC,15%)。ER阳性及PR阳性分别被称为管腔A型及管腔B型,二者约占乳腺癌的70%。TNBC具有未分化表型,通常与基底样乳腺癌重叠,复发率高,转移早,缺乏乳腺起源的肿瘤标志物。 | Ai D Yao J Yang F 方三高(译) 魏建国(校) | 2021 | 诊断病理学杂志2021，28，5： | 7 |
| 5 | Towards a global One Health index: a potential assessment tool for One Health performance显示文摘Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge. | Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou | 2022 | Infectious Diseases of Poverty2022，11，3： | 3 |
| 6 | 老年高血压和糖尿病患者的死亡率和大血管风险:强化药物治疗的效果显示文摘本研究是为了确定强化药物治疗(intensive drug therapy,IDT)对年龄≥65岁患有2型糖尿病(type 2diabetes mellitus,T2DM)和高血压的患者全因死亡、充血性心力衰竭(congestive heart failure,CHF)、因心肌梗死住院与脑卒中或短暂性脑缺血发作(transient ischemic attack,TIA)的影响。方法:研究对象为来自美国医疗保险数据库的高血压和T2DM患者。采用倾向评分匹配方法对非强化药物治疗组和IDT组进行匹配。使用Cox比例风险模型计算HR。结果:IDT与增加的CHF(HR=2.32,95%CI2.32~2.38)、心肌梗死(HR=4.27,95%CI 4.05~4.52)和脑卒中或TIA(HR=1.80,95%CI 1.70~1.89)风险相关,但也与降低的死亡风险(HR=0.95;95%CI 0.93~0.97)相关。遵循糖尿病管理指南治疗可降低CHF(HR=0.73,95%CI 0.71~0.73)、心肌梗死(HR=0.64,95%CI 0.62~0.67)、脑卒中或TIA(HR=0.82,95%CI 0.78~0.86)和死亡(HR=0.29,95%CI 0.28~0.29)的风险。结论:在高危人群中使用IDT可延缓死亡的发生,但不影响严重大血管病变的发生。IDT对高危患者的保护作用所带来的益处超过多药治疗产生的不良健康问题。 | Yashkin AP Kravchenko J Yashin AI Sloan F 陈云(编译) 叶鹏(审校) | 2018 | 中华高血压杂志2018，26，12： | 2 |
| 7 | Effects of matrine,artemisinin, tetrandrine on cytosolic i in guinea pig ventricular myocytes 显示文摘 | Ai J Gao HH He SZ | 2001 | Acta Pharmacol Sin2001，22，6： | 2 |
| 8 | A New Triterpenoid Saponin from the Seeds of Deccaria segetalis显示文摘A new triterpenoid saponin, named segetoside k, has been isolated from the seeds of Vaccaria segetalis. On the basis of chemical reaction and spectral analysis, the structure of segetoside K was established as:olean-12-ene-23a, 286-dioic acid 36, 16a-dihydroxy-28-O- [βD-glucopyranosyl-(1 →3)]-β-D-glucopyra-nosyl-(l →2)-β-D-glucopyranosyl-(l→6)-β-D- glucopyranoside(1). | Sheng Min SANG Min Liang ZOU Ai Na LAO Zhong Liang CHEN Jun UZAWA and Yasuo FUJIMOTO (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 20003 1 The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama 351-01, J | 2000 | Chinese Chemical Letters2000，11，1： | 2 |
| 9 | Effects of matrine,artemisinin,tetrandrine on cytosolic i in guinea pig ventricular myocytes显示文摘 | Ai J Gao HH He SZ | 2001 | Acta Pharmocol Sin2001，22，6： | 2 |
| 10 | Quantitative analysis of injuried,necrotic,and apoptotic cells in a new experimental model of intracerebral hemorrhage 显示文摘 | Qureshi AI Ling GS Khan J | 2001 | Crit Care Med2001，29，1： | 1 |
| 11 | Physicochemicai properties of caseinstarch interaction obtained by extrusion process显示文摘 | FERNANDEZ-GUTIERRES J A MARTIN-MARTfNEZ E S MARTINEZ-BUSYOS F et ai | 2004 | Starch2004，56，： | 1 |
| 12 | Study on a New Kind of Combined Machining Technology of Ultrasonic Machining and Electrical Discharge Machining显示文摘 | Jia Z X Zhang J H Ai X | 1997 | Machine Tools & Manufacture1997，37，2： | 1 |
| 13 | Dexamethasone and ursodeoxycholic acid protect against the arrhythmogenic effect of taurocholate in an in vitro study of rat cardiomyocytes显示文摘 | Gorelik J Shevchuk AI Diakonov I | 2003 | Br J Obstet Gynecol2003，110，5： | 1 |
| 14 | Expression and phosphorylation of the na-pump regulatory subunit phospholemman in heart failure显示文摘 | Bossuyt J Ai X Moorman JR | 2005 | Circ Res2005，97，6： | 1 |
| 15 | Foodborne Botulism in the United States显示文摘 | Sobel J Tucker N Sulka A et aI | 2004 | Emerg Infect Dis2004，10，： | 1 |
| 16 | Prognostic implication of creatine kinase elevation following elective coronary interventions 显示文摘 | Kong TQ Davidson C J Meyers SN et aI | 1997 | JAMA1997，277，6： | 1 |
| 17 | The origin of bone formed in composite grafts of porous calcium phosphate ceramic loaded with marrow cells 显示文摘 | Goldberg VM Caplan AI | 1991 | Clin Orthop1991，269，： | 1 |
| 18 | The Osteogenic potential of culture-expanded rat marrow mesenchymal cells assayed in vivo in calcium phosphate ceramic blocks显示文摘 | Goldberg VM Caplan AI | 1991 | Clin Orthop1991，262，： | 1 |
| 19 | Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases显示文摘 | Choi J Levey AI Weintraub ST | 2004 | J Biol Chem2004，279，13： | 1 |
| 20 | TWIST2 demonstrates differential methylation in immunoglobulin variable heavy chain mutated and nnmutated chronic lymphocytic leukemia显示文摘 | Raval A Lueas D M MatkovicJ J et aI | 2005 | J Clin Oncol2005，23，17： | 1 |
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