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| 1 | Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies显示文摘Background:Because of the increasing life expectancy in our society,aging-related neurodegenerative disorders are one of the main issues in global health.Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline.Among these diseases,Alzheimer’s disease(AD)and dementia with Lewy bodies(DLB)are the most common types of degenerative dementia.Although both show specific features,an important neuropathological and clinical overlap between them hampers their correct diagnosis.In this work,we identified molecular biomarkers aiming to improve the misdiagnosis between both diseases.Methods:Plasma extracellular vesicles(EVs)-from DLB,AD and healthy controls-were isolated using size-exclusion chromatography(SEC)and characterized by flow cytometry,Nanoparticle Tracking Analysis(NTA)and cryo-electron microscopy.Next Generation Sequencing(NGS)and related bibliographic search was performed and a selected group of EV-associated microRNAs(miRNAs)was analysed by qPCR.Results:Results uncovered two miRNAs(hsa-miR-451a and hsa-miR-21-5p)significantly down-regulated in AD samples respect to DLB patients,and a set of four miRNAs(hsa-miR-23a-3p,hsa-miR-126-3p,hsa-let-7i-5p,and hsamiR-151a-3p)significantly decreased in AD respect to controls.The two miRNAs showing decreased expression in AD in comparison to DLB provided area under the curve(AUC)values of 0.9 in ROC curve analysis,thus suggesting their possible use as biomarkers to discriminate between both diseases.Target gene analysis of these miRNAs using prediction online tools showed accumulation of phosphorylation enzymes,presence of proteasome-related proteins and genes involved in cell death among others.Conclusion:Our data suggest that plasma-EV associated miRNAs may reflect a differential profile for a given dementia-related disorder which,once validated in larger cohorts of patients,could help to improve the differential diagnosis of DLB versus AD. | Ana Gámez-Valero Jaume Campdelacreu Dolores Vilas Lourdes Ispierto Ramón Reñé RamiroÁlvarez MPilar Armengol Francesc E.Borràs Katrin Beyer | 2019 | Translational Neurodegeneration2019，8，1： | 4 |
| 2 | Bacterial infections in cirrhosis: Epidemiological changes with invasive procedures and norfloxacin prophylaxis显示文摘 | Javier Fernández Miquel Navasa Juliá Gómez Jordi Colmenero Jordi Vila Vicente Arroyo Juan Rodés | 2002 | Hepatology2002，，1： | 3 |
| 3 | Germanene: a novel two-dimensional germanium allotrope akin to graphene and silicene显示文摘 | M E Dávila L Xian S Cahangirov A Rubio G Le Lay | 2014 | New Journal of Physics2014，，： | 3 |
| 4 | Initial experience with EUS-guided cholangiopancreatography for biliary and pancreatic duct drainage: a Spanish national survey显示文摘 | Juan J. Vila Manuel Pérez-Miranda Enrique Vazquez-Sequeiros Monder Abu-Suboh Abadia Antonio Pérez-Millán Ferrán González-Huix Joan Gornals Julio Iglesias-Garcia Carlos De la Serna José R. Aparicio José C. Subtil Alberto álvarez Felipe de la Morena Jesús G | 2012 | Gastrointestinal Endoscopy2012，，6： | 2 |
| 5 | Hydrodynamics and mass transfer characteristics of gas-liquid ejectors显示文摘 | Balamurugan S Mayank D Lad Vilas G Gaikar | 2007 | Chemical Engineering Journal2007，137，： | 1 |
| 6 | Modeling and optimizing of steam pyrolysis of dimethyl formamide by using response surface methodology coupled with Box-Behnken design 显示文摘 | Deepak D D Vilas G G Shekhar K | 2012 | Journal of Analytical and Applied Pyrolysis2012，96，： | 1 |
| 7 | Oral cloze: a backup exercise for interpreting 显示文摘 | Anaya D~vila Garibi G & Lopez Islas J | 1990 | Meta: Journal des traducteurs / Meta: Translators''Journal1990，，3： | 1 |
| 8 | Relationship of lipid oxidation with subclinical atherosclerosis and 10-year coronary events in general population显示文摘 | Miquel Gómez Joan Vila Roberto Elosua Lluís Molina Jordi Bruguera Joan Sala Rafel Masià Maria Isabel Covas Jaume Marrugat Montserrat Fitó | 2014 | Atherosclerosis2014，，1： | 1 |
| 9 | Improvement in motor and cognitive impairment after hyperbaric oxygen therapy in a selected group of patients with eerebrovaseular disease:a p'ospeetive single-blind controlled trial 显示文摘 | Vila J F Balearee P E Abiusi G R | 2005 | Undersea Hyper Med2005，32，5： | 1 |
| 10 | Serum vaspin concentration in relation to insulinsen sitivity following RYGB- induced weight loss 显示文摘 | Handisurya A Riedl M Vila G | 2009 | Obes Surg2009，20，： | 1 |
| 11 | Laboratory animal models for human Taenia solium 显示文摘 | vila G Teran N Aguilar-Vega L | 2006 | Parasitol Int2006，，： | 1 |
| 12 | Psychopathology and quality of life for adolescents with asthma and their parents显示文摘 | Vila G Hayder R Bertrand C | 2003 | Psychoso- matics2003，44，4： | 1 |
| 13 | Optimization of Water Supply Operation显示文摘 | Vilas Nitivattananon Elaine C Sadowski Rafael G Qunimpo | 1996 | Water Resources Planning and Management1996，122，5： | 1 |
| 14 | Antioxidant effects of an aqueous extract of Ilex paraguariensis显示文摘 | Troiani G Dávila V | 2000 | Biochemical and Biophysical Research Communications2000，，269： | 1 |
| 15 | Iodine status and thyroid volume changes during pregnancy: results of a survey in Aran Valley (Catalan Pyrenees) 显示文摘 | Vila L Legaz G Barrionuevo C etal | 2008 | J Endocrinol Invest2008，31，10： | 1 |
| 16 | B-type natriuretie peptide (BNP) affects the initial response to intravenous glucose : a randomised placebo-controlled cross-over study in healthy men 显示文摘 | Heinisch BB Vila G Resl M | 2012 | Diabetologia2012，55，5： | 1 |
| 17 | Xanthogranulomatous cholecystitis : Report of two cases显示文摘 | McCoy J J Vila R Petrossian G | 1976 | JSC Med Assoc1976，72，： | 1 |
| 18 | Statistical evaluation of combined daily gauge observations and rainfall satellite estimates over continental South America显示文摘 | VILA D A GONCALVES L G TOLL D L | 2009 | Journal of Hydrometeorology2009，10，2： | 1 |
| 19 | B-type natriuretic peptide modulates ghrelin,hunger,and satiety in healthy men显示文摘 | Vila G Grimm G Resl M | 2012 | Diabetes2012，61，10： | 1 |
| 20 | The relationship between insulin resistance and the cardiovascular biomarker growth differentiation factor-15 in obese patients显示文摘 | VILA G RIEDL M ANDERWALD C | 2011 | Clin Chem2011，57，2： | 1 |
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