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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | 用熔解曲线法分析插入/缺失多态性和Y染色体SNPs多态性显示文摘随着单核苷酸多态性SNPs (SingleNucleotidePolymorphisms)及插入 /缺失多态性Indels (Insertion/Dele tion)的分型技术研究的深入 ,SNPs和Indels在法医学上的应用将受到深刻的影响。本文研究和探讨Indels的分型方法 ,通过测定扩增DNA片段在溶液中的溶解曲线图确定每个样品的基因型 ,称为溶解曲线Indels基因分型方法(McI/D)。溶解曲线图由被测样品DNA片段的特殊溶解温度组成 ,扩增结果直接由仪器分析不需要繁杂的PCR后期操作。 | 叶健 郑秀芬 季安全 Esteban J Parra Donna M Sosnoski Mark D Shriver | 2001 | 中国法医学杂志2001，16，4： | 3 |
| 3 | Technical efficiency in the use of health care resources: a comparison of OECD countries显示文摘 | Donna Retzlaff-Roberts Cyril F Chang Rose M Rubin | 2003 | Health policy2003，，1： | 2 |
| 4 | Technical efficiency in the use of health care resources: a comparison of OECD countries显示文摘 | Donna Retzlaff-Roberts Cyril F Chang Rose M Rubin | 2003 | Health policy2003，，1： | 2 |
| 5 | Ownership of Human Tissue:A proposal for federal recognition of human research participants'property Rights in Their Biological Material显示文摘 | Gitter donna M | 2004 | Washington&Lee law Review2004，61，29： | 1 |
| 6 | The Impact of E-commerce on Supply Chain Relationships 显示文摘 | Susan L Golicic Donna F Davis Teresa M McCar-thy John T Mentzer | 2002 | International Journal of Physical Distribution & Logistics Management2002，32，910： | 1 |
| 7 | Root planing fllowing short-term pocket distertion显示文摘 | Donna M Peter J | 1997 | J Periodontol1997，68，7： | 1 |
| 8 | Clinical relevance of transmembrane drug as a mechanism of multidrug resistance显示文摘 | Donna M Bradshaw Robert J | 1998 | Journal of Clinical Oncology1998，16，11： | 1 |
| 9 | Necrotizing fasciitis:adramatic surgical emergency显示文摘 | Catena F La Donna M Ansaloni L | | 0，，01： | 1 |
| 10 | Adverse effects of semen processing on human spem DNA integrity显示文摘 | Victor M Keith J Donna P | 1999 | J Urol1999，161，282： | 1 |
| 11 | Antimicrobial peptide expression is developmentally regulated in the ovine gastrointestinal tract显示文摘 | KENNETH M HUTTNER K M DONNA J | 1998 | American Society for Nutritional Sciences1998，128，2： | 1 |
| 12 | Walnut diet reduces accumulation of polyubiquitinated proteins and inflam- mation in the brain of ag~ rats 显示文摘 | Shibu M Poulose Donna F Bielinski Barbara Shukitt-Hale | 2013 | Journal of Nutritional Biochem- istry2013，24，： | 1 |
| 13 | CDC2/CDK1 Expression in Esophageal Adenocarcinoma and Precursor Lesions Serves as a Diagnostic and Cancer Progression Marker and Potential Novel Drug Target显示文摘 | Donna E Hansel Surajit Dhara RuChih C Huang Raheela Ashfaq Mari Deasel Yutaka Shimada Harold S Bernstein John Harmon Malcolm Brock Arlene Forastiere M Kay Washington Anirban Maitra Elizabeth Montgomery | 2005 | The American Journal of Surgical Pathology2005，，3： | 1 |
| 14 | Responses of three grass species to creosote during phytoremediation显示文摘 | Xiao-Dong Huang Yousef El-Alawi Donna M Penrose Bernard R Glick Bruce M Greenberg | 2004 | Environmental Pollution2004，，3： | 1 |
| 15 | Immunophenotypic markers and antiretroviral therapy (IMART):T cell activation and maturation help predict treatment response显示文摘 | Donna M Ronald J B Ryung S K | 2004 | JID2004，189，15： | 1 |
| 16 | Adapting parentchild interaction therapy for young children with separation anxiety disorder显示文摘 | Donna B Pincus Sheila M Eyberg Molly L Choate | 2005 | Education and Treatment of Children2005，28，2： | 1 |
| 17 | Necrotizing fasciitis:Adramatic surgical emergency显示文摘 | Catena F La Donna M Ansaloni L | | 0，，01： | 1 |
| 18 | 母乳喂养史和子宫内膜异位症发生的风险:前瞻性队列研究显示文摘目的研究经产妇母乳喂养、纯母乳喂养、产后闭经时间与子宫内膜异位症发病率的关系。设计前瞻胜队列研究。 | Leslie V Farland A Heather Eliassen Rulla M Tamimi Donna Spiegelman Karin B Michels Stacey A Missmer 龚丽云 王淑珍 | 2018 | 英国医学杂志中文版2018，21，3： | 1 |
| 19 | Advance three - dimensional evaluation of acetabuium - trauma Volumetic image processing显示文摘 | Euiot KF Donna M Dobert AD | 1989 | J Trauma1989，29，1： | 1 |
| 20 | Silica aerogels with enhanced durability, 30-nm mean pore-size, and improved immersibility in liquids 显示文摘 | Erik M L Michael S D Donna M E | 2004 | Non-CrystaUine Solids2004，350，： | 1 |
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