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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Using a bootstrap method to choose the sample fraction in tail index estimation显示文摘 | Danielsson J de Han L Peng L | 2001 | Journal of Multivariate Analysis2001，76，2： | 1 |
| 4 | The genome of Syntrophomonas wolfei: new insights into syntrophic metabolism and biohydrogen production 显示文摘 | Sieber JR Sims DR Han C Kim E Lykidis A Lapidus AL Mcdonnald E Rohlin L Culley DE Gunsalus R Mcinerney MJ | 2010 | Environ Microbiol2010，12，8： | 1 |
| 5 | Modulation of the human sperm acrosome reaction by effectors of the adenylate cyclase/ cyclic AMP second- messenger pathway显示文摘 | De Jonge C J Han H L Lawrie H | 1991 | J Exp Zool1991，258，1： | 1 |
| 6 | VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials显示文摘 | Diether Lambrechts Bart Claes Paul Delmar Joke Reumers Massimiliano Mazzone Betül T Yesilyurt Roland Devlieger Chris Verslype Sabine Tejpar Hans Wildiers Sanne de Haas Peter Carmeliet Stefan J Scherer Eric Van Cutsem | 2012 | Lancet Oncology2012，，7： | 1 |
| 7 | Direct stimulation of recep- topcontrolled phospholipase D1 by phosphocofilin 显示文摘 | Han L Stope M B de Jesus M L | 2007 | EM- BOJourna12007，26，19： | 1 |
| 8 | Modeling Piezoelectric Actuators显示文摘 | Han J M T A Adriaens Willem L de Koning Reinder Banning | 2000 | IEEE/ASME TRANSACTIONS ON MECHATRONICS2000，5，4： | 1 |
| 9 | Modeling piezoelectric actuators显示文摘 | Willem L de Koning Reinder Banning | 2000 | IEEE/ASME Transactions On Mechatronics2000，5，4： | 1 |
| 10 | Urinary albumin excretion is asso- ciated with renal functional abnormalities in a nondiabetic population显示文摘 | Paul E De Jong Hans L | 2000 | J Am Soc Nephrol2000，11，10： | 1 |
| 11 | Clinical outcomes of patients with duodenal adenocarcinoma and intestinal-type papilla of Vater adenocarcinoma显示文摘BACKGROUND Duodenal adenocarcinoma(DA)and intestinal-type papilla of Vater adenocarcinoma(it-PVA)are rare malignancies of the gastrointestinal tract.Current therapeutic options are translated nowadays from treatment strategies for patients with colorectal cancer due to histopathological similarities.AIM To retrospectively investigate the clinical outcome of patients with DA and it-PVA.METHODS All patients with DA and it-PVA diagnosed between 2000 and 2017 were included at two academic centers in the Netherlands.All patients with histopathologically-confirmed DA or it-PVA were eligible for inclusion.Clinical outcome was compared between DA and it-PVA per disease stage.In the subgroup of stage IV disease,survival after local treatment of oligometastases was compared with systemic therapy or supportive care.RESULTS In total,155 patients with DA and it-PVA were included.Patients with it-PVA more often presented with stage I disease,while DA was more often diagnosed at stage IV(P<0.001).Of all patients,79%were treated with curative intent.The median survival was 39 mo,and no difference in survival was found for patients with DA and it-PVA after stratification for disease stage.Seven(23%)of 31 patients with synchronous stage IV disease underwent resection of the primary tumor,combined with local treatment of oligometastases.Local treatment of metastases was associated with an overall survival of 37 mo,compared to 14 and 6 mo for systemic therapy and supportive care,respectively.CONCLUSION Survival of patients with DA and it-PVA is comparable per disease stage.These results suggest a potential benefit for local treatment strategies in selected patients with oligometastases,although additional prospective studies are needed. | Laura L Meijer Marin Strijker Jacob K de Bakker Jurgen GJ Toennaer Barbara M Zonderhuis Hans J van der Vliet Hanneke Wilmink Joanne Verheij Freek Daams Olivier R Busch Nicole CT van Grieken Marc G Besselink Geert Kazemier | 2020 | World Journal of Gastrointestinal Oncology2020，12，3： | 1 |
| 12 | On Nonnormal Matrices 显示文摘 | RAINER K HANS L DE VIRES R | 1974 | Linear Mgebra Appl1974，8，2： | 1 |
| 13 | Direct stimulation of receptor-co-ntrolled phospholipase D1by phospho-cofilin显示文摘 | Han L Stope MB de Jess ML | 2007 | EMBO J2007，26，19： | 1 |
| 14 | Modulation of the human sperm acrosome reaction by effectors of the adenylate cyclase/cyclic AMP second-messenger pathway 显示文摘 | DE JONGE C J HAN H L LAWRIE H | 1991 | J Exp Zoo1991，258，： | 1 |
| 15 | 5'- amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter显示文摘 | HAN H K DE VRUEH R L A RHIE J K | 1998 | Pharm Res1998，15，8： | 1 |
| 16 | Electrodeposited copper oxide films: Effect of bath pH on grain orientation and orientation-dependent interracial behavior 显示文摘 | WANG L C DE TACCONI N R HAN C R | 2007 | Thin Solid Films2007，515，5： | 1 |
| 17 | Heterotrophic cultures of microalgae: metabolism and potential products显示文摘 | PEREZ- GARCIA O ESCALANTE F M E DE -BAS- HAN L E | 2011 | Water Res2011，45，： | 1 |
| 18 | Polymorphisms in genescontrolling inflammation and tissue repair in rheumatoid arthritis:acase control study显示文摘 | Emonts M Hazes M J Houwing-Duistermaat J J van der Gaast-de Jongh C E de Vogel L Han H K | 2011 | BMC Med Genet2011，12，： | 1 |
| 19 | On Nonnormal Matrices 显示文摘 | RAINER K HANS L De V RUDOLF Wegmann | 1974 | Linear Algebra Appl1974，，08： | 1 |
| 20 | Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo显示文摘 | Fazal F Gu L Ihnatovych I Han Y Hu W Antic N Carreira F Blomquist JF Hope TJ Ucker DS Lanerolle P de | | 0，，： | 1 |
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