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| 1 | Diagnosis of pancreatic tumors by endoscopic ultrasound-guided fine-needle aspiration显示文摘AIM: To evaluate the diagnostic accuracy of endoscopic ultrasound-guided fi ne-needle aspiration (EUS-FNA) for pancreatic solid tumors larger or smaller than 3 cm, and cystic lesions. METHODS: From January/1997 to December/2006, 611 patients with pancreatic tumors were subjected to EUS-FNA. The fi nal diagnosis was obtained either by surgery (356 cases) or after a mean clinical follow-up of 11.8 mo in the remaining patients. RESULTS: There were 405 solid tumors, 189 cystic lesions and 17 mixed. Pancreatic specimens for cytological assessment were successfully obtained by EUS-FNA in 595 (97.4/) cases. There were 352 (57.6/) malignancies and 259 (42.4/) benign tumors. Among the malignancies, pancreatic adenocarcinomas accounted for 67/ of the lesions. Overall, the sensitivity, specifi city, positive and negative predictive values, and accuracy of EUS-FNA were, respectively, 78.4/, 99.2/, 99.3/, 77.2/ and 87.2/. Specif ically for solid tumors, the same parameters for neoplasms larger and smaller than 3 cm were, respectively, 78.8/ vs 82.4/, 100/ vs 98.4/, 100/ vs 99/, 54.8/ vs 74.1/ and 83.1/ vs 87.8/. For cystic lesions, the values were, respectively, 72.2/, 99.3/, 97.5/, 91/ and 92.2/. CONCLUSION: EUS-FNA can be used to sample pancreatic tumors in most patients. Even though the negative predictive value is inadequate for large solid tumors, the results are rather good for small solid tumors, especially concerning the sensitivity, negative predictive value and diagnostic accuracy. Among all pancreatic lesions, EUS-FNA for cystic lesions canreveal the best negative predictive value and diagnostic accuracy, both higher than 90/. | José Celso Ardengh César Vivian Lopes Luiz Felipe Pereira de Lima Juliano Rodrigues de Oliveira Filadélfi o Venco Giulio Cesare Santo José Luiz Pimenta Módena | 2007 | World Journal of Gastroenterology2007，13，22： | 17 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Gut-microbiome-brain axis:the crosstalk between the vagus nerve,alpha-synuclein and the brain in Parkinson's disease显示文摘This critical review of the literature shows that there is a close link between the microbiome,the gut,and the brain in Parkinson's disease.The vagus nerve,the main component of the parasympathetic nervous system,is involved in the regulation of immune response,digestion,heart rate,and control of mood.It can detect microbiota metabolites through its afferents,transferring this gut information to the central nervous system.Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression,as well as treatment responses.These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's disease.More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit. | Júlio César Claudino dos Santos Leandro Freitas Oliveira Felipe Micelli Noleto Camilla Teixeira Pinheiro Gusmão Gerly Anne de Castro Brito Glauce Socorro de Barros Viana | 2023 | Neural Regeneration Research2023，18，12： | 2 |
| 4 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 5 | Piplartine, an amide alkaloid from Piper tuberculatum , presents anxiolytic and antidepressant effects in mice显示文摘 | F. Cícero Bezerra Felipe Jucélio Trajano Sousa Filho Louise Emanuele de Oliveira Souza Jefferson Alexandre Silveira Daniel Esdras de Andrade Uchoa Edilberto Rocha Silveira Otília Deusdênia Loiola Pessoa Glauce S. de Barros Viana | 2006 | Phytomedicine2006，，： | 1 |
| 6 | Site-specific release of nascent chains from ribosomes at a sense codon显示文摘 | Doronina V A Wu C de Felipe P | | 0，，13： | 1 |
| 7 | The role of NADH- oxidation in acetoin and diacetyl production from glucose in Lactococcus lactis 显示文摘 | LOPEZ DE FELIPE F STARRENBURG M J C HUGENHOLTZ J | 1997 | FEMS Microbiol Lett1997，156，： | 1 |
| 8 | Neurokinin-1 receptor-expressing neurons in the amygdala modulate morphinereward and anxiety behaviors in the mouse显示文摘 | Gadd CA Murtra P De Felipe C | 2003 | J Neurosci2003，23，： | 1 |
| 9 | The Colider and Roosevelt olcanic rocks (sw amazonian craton): geochemistry and sm-nd isotope characteristics of a silicic large igneous province显示文摘The volcanic rocks of the Colíder and Roosevelt formations are extensively exposed in the south-central portion of the Amazonian Craton where effusive and pyroclastic rocks have been mapped.Both units,topped by chemical sediments and oceanic facies as rhyolite and andesite lavas,rhyodacite,and porphyritic dacite,with frequent intercalations of pyroclastic and epiclastic deposits.Whole-rock geochemistry for 55 samples of rhyolitic to andesitic composition suggests the involvement of fertile mantle-derived components with E-MORB to OIB compositions.The analyzed rocks display calc-alkaline to shoshonitic affinity consistent with generation related to an active continental margin.The whole-rock Sm-Nd isotope data from selected felsic volcanic rocks of the Colíder and Roosevelt formations yield negative initial eNd values between–3 and–9,indicating the predominantly crustal nature of the parental magmas with early Archean to late Paleoproterozoic(ca.2.5–2.0 Ga)depleted mantle model ages. | Bruna Saar de Almeida Mauro César Geraldes Carlos Augusto Sommer Felipe Corrales Antonio Joāo Paes de Barros | 2021 | Acta Geochimica2021，40，6： | 1 |
| 10 | Impaired IL-1betainduced neutrophil accumulation in tachykinin NK1 receptor knockout mice显示文摘 | Ahluwalia A De Felipe C O'Brien J | 1998 | Br J Pharmacol1998，124，6： | 1 |
| 11 | Treatment of erythrodermic psoriasis withetanercept显示文摘 | Esposito M Mazzotta A de Felipe C | 2006 | Br J Dermatol2006，155，1： | 1 |
| 12 | Site-specific release of nascent chains from ribosomes at a sense codon显示文摘 | Doronina V A Wu C De Felipe P | | 0，，13： | 1 |
| 13 | Site-specific re- lease of nascent chains from ribosomes at a sense eodon显示文摘 | Dmvnina V A Wu C de Felipe P | 2008 | Mol Cell Biol2008，28，13： | 1 |
| 14 | Altered nociception, analgesia and aggression in mice lacking the receptor for substance P 显示文摘 | De Felipe C Herrero J F O'Brien J A | 1998 | Nature1998，392，6674： | 1 |
| 15 | Altered nociception,analgesia and aggression in mice lacking the receptor for substance P显示文摘 | De Felipe C Herrero J F O'Brien J A | 1998 | Nature1998，392，： | 1 |
| 16 | Functional and genetic characterization of calmodulin from the dimorphic and pathogenic fungus Paracoccidioides brasiliensis显示文摘 | Maria José A. de Carvalho Rosália S. Amorim Jesuino Bruno S. Daher Ildinete Silva-Pereira Sonia M. de Freitas Célia M.A. Soares M.Sueli S. Felipe | 2003 | Fungal Genetics and Biology2003，，3： | 1 |
| 17 | Altered nociception,analgesia and aggression in mice lacking the receptor for substance P显示文摘 | Herrero JF O'Brien JA | 1998 | Nature1998，392，6674： | 1 |
| 18 | Polymorphisms of antioxidant enzymes, blood pressure and risk of hypertension显示文摘 | María L Mansego Griselda De Marco Solar Mónica Pineda Alonso Fernando Martínez Guillermo T Sáez Juan C Martin Escudero Josep Redón Felipe J Chaves | 2011 | Journal of Hypertension2011，，3： | 1 |
| 19 | Can partial nephrectomy preserve renal function and modify survival in comparison with radical nephrectomy?显示文摘 | José Medina-Polo Javier Romero-Otero Alfredo Rodríguez-Antolín Mario Domínguez-Esteban Juan Passas-Martínez Felipe Villacampa-Aubá David Lora-Pablos Agustín Gómez De La Cámara Rafael Díaz-González | 2011 | Scandinavian Journal of Urology and Nephrology2011，，2： | 1 |
| 20 | Altered nocice ption,analgesia and aggression in mice lacking the rece ptor for suostance p显示文摘 | De Felipe C Herrero JF O Brien JA | 1998 | Nature1998，392，2： | 1 |
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