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| 1 | The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγsignaling显示文摘Osteoporosis caused by aging is characterized by reduced bone mass and accumulated adipocytes in the bone marrow cavity. How the balance between osteoblastogenesis and adipogenesis from bone marrow mesenchymal stem cells(BMSCs) is lost upon aging is still unclear. Here, we found that the RNA-binding protein Musashi2(Msi2) regulates BMSC lineage commitment. Msi2 is commonly enriched in stem cells and tumor cells. We found that its expression was downregulated during adipogenic differentiation and upregulated during osteogenic differentiation of BMSCs. Msi2 knockout mice exhibited decreased bone mass with substantial accumulation of marrow adipocytes, similar to aging-induced osteoporosis. Depletion of Msi2 in BMSCs led to increased adipocyte commitment. Transcriptional profiling analysis revealed that Msi2 deficiency led to increased PPARγ signaling.RNA-interacting protein immunoprecipitation assays demonstrated that Msi2 could inhibit the translation of the key adipogenic factor Cebpα, thereby inhibiting PPAR signaling. Furthermore, the expression of Msi2 decreased significantly during the aging process of mice, indicating that decreased Msi2 function during aging contributes to abnormal accumulation of adipocytes in bone marrow and osteoporosis. Thus, our results provide a putative biochemical mechanism for aging-related osteoporosis, suggesting that modulating Msi2 function may benefit the treatment of bone aging. | Jinlong Suo Sihai Zou Jinghui Wang Yujiao Han Lingli Zhang Chenchen Lv Bo Jiang Qian Ren Long Chen Lele Yang Ping Ji Xianyou Zheng Ping Hu Weiguo Zou | 2022 | Bone Research2022，10，3： | 5 |
| 2 | Genome-wide evolution of MAPKs family and their expression in response to bacterial infection in seahorse Hippocampus erectus显示文摘Seahorses have evolved many unique biological traits,including a male brood pouch,the absence of caudal and pelvic fins,and the lack of spleen and gut-associated lymphatic tissue.The mitogenactivated protein kinases(MAPKs)are known to be involved in various important biological processes including growth,differentiation,immunity,and stress responses.Therefore,we hypothesized that the adaptive evolution and expression of the MAPK gene family in seahorse may differ from those of other teleost species.We identified positive selection sites in the erk2,erk5,jnk1,and p38αMAPK genes of the lined seahorse Hippocampus erectus and tiger-tailed seahorse Hippocampus comes.A novel expression profile of MAPK cascade genes was found in seahorse larvae during the first day after birth based on the RNA-seq data of H.erectus,which refl ected vital signs of immune response to its parental immune system.The expression patterns of the four positively selected MAPK genes were analyzed following the bacterial challenge of Vibrio fortis,revealing their upregulation pattern in brood pouch and other immune tissues.This study enriched our knowledge of the evolution of the H.erectus MAPK subfamilies,and could help better understanding the functional role of MAPKs in teleosts. | Kai WANG Xin WANG Qiang ZOU Han JIANG Rongrong ZHANG Yanan TIAN Lele ZHANG Qiang LIN | 2021 | Journal of Oceanology and Limnology2021，39，6： | 2 |
| 3 | Sensing carboxylesterase 1 in living systems by a practical and isoformspecific fluorescent probe显示文摘Carboxylesterase 1(CES1), one of the most abundant serine hydrolases in mammals, has drawn much attentions in recent years, owing to this enzyme involves in many physiological processes via hydrolysis of both endogenous esters and xenobiotic esters. Herein, to real-time monitor the activities of CES1 in various biological systems, a practical and iso form-specific fluorescent probe was developed on the basis of the substrate preference of CES1, as well as the structural and optical properties of BODIPY dyes. After screening of a panel of BODIPY ester derivatives, probe 1 displayed the best combination of specificity,sensitivity, enzymatic kinetics and applicability for monitoring CES1 activities in real samples. This probe was successfully used to detect CESl activities in several biological systems including tissue preparations,living cells, tissue slices and zebrafish. Furthermore, the biomedical applications of probe 1 for screening of CES1 inhibitors were also demonstrated using tissue preparations or living cells as enzyme sources. In summary, a practical and broadly applicable tool for real-time monitoring CES1 in biological systems was developed and well-characterized, which held great promise for further investigations on CES1-associated drug discovery, clinical practice and fundamental research. | Lele Ding Zhenhao Tian Jie Hou Tongyi Dou Qiang Jin Dandan Wang Liwei Zou Yadi Zhu Yunqing Song Jingnan Cui Guangbo Ge | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 4 | How can China reach its CO2 intensity reduction targets by 2020? A regional allocation based on equity and development 显示文摘 | YI Wenjing ZOU Lele GUO Jie | 2011 | Energy Policy2011，，39： | 1 |
| 5 | Carbon Price Volatility: Evi- dence from EU ETS显示文摘 | ZhenHua Feng LeLe Zou YiMing Wei | 2011 | Applied Energy2011，，88： | 1 |
| 6 | How can China reach its CO2 mtensity reduction target by 2020? A regionalallocation based on equity and development 显示文摘 | Yi Wenjing Zou Lele Guo Jie | 2011 | Energy Policy2011，39，24： | 1 |
| 7 | Impact of Inter-Sectoraltrade on National and Global CO2 Emissions: an Empiricalanalysis of China and US显示文摘 | Guo Jie Zou Lele Wei Yiming | 2010 | Energy Policy2010，38，12： | 1 |
| 8 | Impact of inter-scctoral trade on national and global CO2 emissions: an empirical analysis of China and US显示文摘 | GUO Jie ZOU Lele WEI Yiming | 2010 | Energy Policy2010，38，3： | 1 |
| 9 | The impact of house-hold consumption on energy use and CO2emissions in China显示文摘 | ZHEN Huafeng ZOU Lele WEI Yiming | 2011 | Energy2011，36，1： | 1 |
| 10 | Forewarning of sustainable utilization of regional water resources: a model based on BP neural network and set pair analysis显示文摘 | Jin Juliang Wei Yiming Zou Lele | 2012 | Natural Hazards2012，62，1： | 1 |
| 11 | Impact of inter-sectoral trade on national and global CO2 emissions:an empirical analysis of China and US显示文摘 | Guo Jie Zou Lele Wei Yiming | | 0，，12： | 1 |
| 12 | How can China reach its CO2 intensity reduction targets by 2020? A regional allocation based on eq- uity and development 显示文摘 | YI Wenjing ZOU Lele GUO Jie | 2011 | Energy Policy2011，39，1： | 1 |
| 13 | How can China reach its CO2 intensity reduction targets by 2020? A regional allocation based on equity and development显示文摘 | YI Wenjing ZOU Lele GUO Jie | | 0，，05： | 1 |
| 14 | How can China reach its COz intensity reduction targets by 2020? A regional allocation based on equity and development显示文摘 | YI Wenjing ZOU Lele GUO Jie | 2011 | Energy Policy2011，39，5： | 1 |
| 15 | Risk evaluation of Chinas natural disaster systems:an approach based on tri= angular fuzzy numbers and stochastic simulation显示文摘 | Jin Juliang Wei Yiming Zou Lele | 2012 | Na- ture Hazards2012，62，1： | 1 |
| 16 | How can China reach its CO2 intensity reduction targets by 2020? a regional allocation based on equity and development显示文摘 | YI Wenjing ZOU Lele GUO Jie | 2011 | Energy Policy2011，39，5： | 1 |
| 17 | Prelithiation strategies for silicon-based anode in high energy density lithium-ion battery显示文摘Green energy storage devices play vital roles in reducing fossil fuel emissions and achieving carbon neutrality by 2050.Growing markets for portable electronics and electric vehicles create tremendous demand for advanced lithium-ion batteries(LIBs)with high power and energy density,and novel electrode material with high capacity and energy density is one of the keys to next-generation LIBs.Silicon-based materials,with high specific capacity,abundant natural resources,high-level safety and environmental friendliness,are quite promising alternative anode materials.However,significant volume expansion and redundant side reactions with electrolytes lead to active lithium loss and decreased coulombic efficiency(CE)of silicon-based material,which hinders the commercial application of silicon-based anode.Prelithiation,preembedding extra lithium ions in the electrodes,is a promising approach to replenish the lithium loss during cycling.Recent progress on prelithiation strategies for silicon-based anode,including electrochemical method,chemical method,direct contact method,and active material method,and their practical potentials are reviewed and prospected here.The development of advanced Si-based material and prelithiation technologies is expected to provide promising approaches for the large-scale application of silicon-based materials. | Tianqi Jia Geng Zhong Yao Lv Nanrui Li Yanru Liu Xiaoliang Yu Jinshuo Zou Zhen Chen Lele Peng Feiyu Kang Yidan Cao | 2023 | Green Energy & Environment2023，8，5： | 0 |
| 18 | Few-Atom Copper Catalyst for the Electrochemical Reduction of CO to Acetate:Synergetic Catalysis between Neighboring Cu Atoms显示文摘Single-atom catalysts(SACs)are gaining increasing recognition because of their superior catalytic properties for various reactions.However,the performance of SACs is often limited by the lack of neighboring metal centers to cooperate in catalysis.Herein,a synergetic interaction between neighboring Cu atoms of a few-atom catalyst(FAC)on graphdiyne(GDY)is found to greatly enhance the production of acetate in the CO electroreduction reaction relative to Cu SACs.In a 1.0 M KOH electrolyte,this Cu FAC exhibits an acetate Faradaic efficiency of 53.8±1.5%,an ultrahigh relative purity of up to 97 wt%for liquid products,and excellent stability over 23 h continuous electrolysis at–0.8 V versus reversible hydrogen electrode.Theoretical studies suggest that the intersite catalytic communication between two neighboring metal atoms confined in each pore of GDY facilitates the formation of acetic acid through either stepwise hydrogenation of CH_(2)CO^(*)or the direct reaction of H_(2)Owith CH_(2)CO^(*).Our study demonstrates the unprecedented synergetic catalysis of Cu FAC in promoting the selective CO electroreduction toward acetate production. | Weifeng Rong Haiyuan Zou Sha Tan Enyuan Hu Fan Li Chao Tang Hao Dai Shuting Wei Yongfei Ji Lele Duan | 2023 | CCS Chemistry2023，5，5： | 0 |
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