|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 世界生物精神病学会联合会(WFSBP)关于焦虑障碍、强迫症和创伤后应激障碍的药物治疗指南显示文摘这篇文章根据现有的随机、安慰剂或参照药物对照临床研究 ,向大家推荐焦虑障碍、强迫症的药物治疗。 5-HT再摄取抑制剂 (SSRI)是治疗惊恐障碍的一线药物。三环类抗抑郁药 (TCA)与SSRI疗效相当 ,但耐受性差。难治性患者 ,如没有药物依赖和耐受史 ,则可使用苯二氮 艹卓 类药物如阿普唑仑。由于单胺氧化酶抑制剂 (MAOI)苯乙肼会产生严重的不良反应 ,且会与其他药物和食物成分相互作用 ,因此只有当一线药物无效时才使用。广泛性焦虑者可用万拉法新和SSRI,也可选用丁螺环酮和丙咪嗪。SSRI可作为社交恐怖症的一线药物 ,MAOI、吗氯贝胺和苯二氮 艹卓 类药物作为二线药物。强迫症最好用SSRI或氯丙咪嗪治疗。 | Borwin Bandelow Josef Zohar Eric Hollander Siegfried Kasper Hans-J¨urgen M¨oller WFSBP Task 项志清 何燕玲 | 2003 | 中国心理卫生杂志2003，17，7： | 30 |
| 2 | 围手术期患者的安全:正确的患者、正确的手术、正确的部位——一项多因素、跨部门的干预性研究显示文摘背景为围手术期患者提供安全的环境非常重要。基于这一点,我们在围手术期实施了“患者安全第一”的政策。方法在干预性研究的第一阶段(2001—2002年),我们首先制定并实施干预性研究中组织和教育方面的内容。2003至2005年为研究的实施阶段。根据我们的零忍受原则,在手术等候区内一旦发现患者的麻醉或手术准备工作中有重大差错,该患者就被送回病房(失败),并等到差错得到纠正后再进行手术。结果共有15856例患者参加了研究。在研究实施阶段的3年中,有112例患者被送回病房(0.71%)。与2003年的数据相比,2004年和2005年发生的重大错误明显减少,且有统计学意义(2003、2004和2005年的数据分别为1.04%、0.59%和0.49%)。而且,逐步逻辑回归方法分析结果显示,手术前准备不充分所致重大错误的发生率逐年下降,具有统计学意义(比值比=1.48,95%CI:1.16~1.87)。此外,在2003、2004和2005年中,各年的失败发生平均间隔时间分别为6.6、11.2和14.7天(P〈0.03)。最后,不仅患者手术前准备工作在研究期间有显著改善(P〈0.0001);而且,使患者手术前准备工作评分为100%的可能性也有明显增加(P〈0.001)。结论教育和提高认识能减少围手术期的错误发生率。但是,即使有详细规划的制度,也无法达到无差错的环境。因此,检查和全面分析应该持续不断地进行。 | Edna Zohar Yossi Noga Ehud Davidson Margalit Kantor Brian Fredman 周全红(译) 江伟(校) | 2008 | 麻醉与镇痛2008，4，4： | 5 |
| 3 | Gastric mucin expression in Helicobacter pylori-related, nonsteroidal anti-inflammatory drug-related and idiopathic ulcers显示文摘AIM: To determine the pattern of secreted mucin expression in Helicobacter pylori (H. pylori)-related, nonsteroidal anti-inflammatory drug (NSAID)-related and idiopathic gastric ulcers. METHODS: We randomly selected 92 patients with H. pylori-associated (n = 30), NSAID-associated (n = 18), combined H. pylori and NSAID-associated gastric ulcers (n = 24), and patients with idiopathic gastric ulcers (n = 20). Immunohistochemistry for T-cell CD4/CD8, andfor mucin 5AC (MUC5AC) and mucin 6 (MUC6), was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system. RESULTS: MUC5AC was expressed on the surface epithelium (98.9%) and neck glands (98.9%) with minimal expression in the deep glands (6.5%). MUC6 was strongly expressed in the deep glands (97.8%), variable in the neck glands (19.6%) and absent in the surface epithelium (0%). The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients (P = 0.009). Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates. CONCLUSION: Idiopathic ulcers have a unique clinical profile. Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H. pylori and/or NSAID-associated ulcers. | Doron Boltin Marisa Halpern Zohar Levi Alex Vilkin Sara Morgenstern Samuel B Ho Yaron Niv | 2012 | World Journal of Gastroenterology2012，18，33： | 5 |
| 4 | Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers显示文摘AIM:To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori(H.pylori)-associated,non-steroidal inflammatory drug(NSAID)-associated and idiopathic-gastric ulcers.METHODS:We studied a cohort of randomly selected patients with H.pylori(group 1,n=30),NSAID(group 2,n=18),combined H.pylori and NSAID associated gastric ulcers(group 3,n=24),and patients with idiopathic gastric ulcers(group 4,n=20).Immunohistochemistry for MUC1,MUC4,MUC17,and staining for Erythrina cristagalli agglutinin and Sambucus nigra agglutinin(SNA)lectins was performed on sections from the ulcer margins.RESULTS:Staining intensity of MUC17 was higher in H.pylori ulcers(group 1)than in idiopathic ulcers(group4),11.05±3.67 vs 6.93±4.00 for foveola cells,and10.29±4.67 vs 8.00±3.48 for gland cells,respectively(P<0.0001).In contrast,MUC1 expression was higher in group 4 compared group 1,9.89±4.17 vs 2.93±5.13 in foveola cells and 7.63±4.60 vs 2.57±4.50 for glands,respectively(P<0.0001).SNA lectin staining was increased in group 4,in parallel to elevated MUC1expression,indicating more abundantα2-6 sialylation in that group.CONCLUSION:Cytoplasmic MUC17 staining was sig-nificantly decreased in the cases with idiopathic ulcer.The opposite was observed for both MUC1 and SNA lectin.This observation may reflect important pathogenic mechanisms,since different mucins with altered sialylation patterns may differ in their protection efficiency against acid and pepsin. | Yaron Niv Doron Boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K Batra Samuel B Ho | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 5 | Glycogenic hepatopathy显示文摘Background: Glycogenic hepatopathy(GH) is a disorder associated with uncontrolled diabetes mellitus,most commonly type 1, expressed as right upper quadrant abdominal pain, hepatomegaly and increased liver enzymes. The diagnosis may be difficult, because laboratory and imaging tests are not pathognomonic. Although GH may be suggested based on clinical presentation and imaging studies, the gold standard for diagnosis is a liver biopsy, showing a significant accumulation of glycogen within the hepatocytes. GH may be diagnosed also after elevated liver enzymes in routine blood tests. GH usually regresses after tight glycemic control. Progression to end-stage liver disease has never been reported. This review aims to increase the awareness to this disease, to suggest a pathway for investigation that may reduce the use of unnecessary tests, especially invasive ones.Data sources: A Pub Med database search(up to July 1, 2017) was done with the words 'glycogenic hepatopathy', 'hepatic glycogenosis', 'liver glycogenosis' and 'diabetes mellitus-associated glycogen storage hepatopathy'. Articles in which diabetes mellitus-associated liver glycogen accumulation was described were included in this review.Results: A total of 47 articles were found, describing 126 patients with GH. Hepatocellular disturbance was more profound than cholestatic disturbance. No synthetic failure was reported.Conclusions: GH may be diagnosed conservatively, based on corroborating medical history, physical examination, laboratory tests, imaging studies and response to treatment, even without liver biopsy. In case of doubt about the diagnosis or lack of clinical response to treatment, a liver biopsy may be considered.There is no role for noninvasive tests like fibroscan or fibrotest for the diagnosis of GH or for differentiation of this situation from nonalcoholic fatty liver disease. | Johad Khoury Yaniv Zohar Naim Shehadeh Tarek Saadi | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，2： | 5 |
| 6 | Mucin gene expression in bile of patients with and without gallstone disease,collected by endoscopic retrograde cholangiography显示文摘AIM:To investigate the pattern of mucin expression and concentration in bile obtained during endoscopic retrograde cholangiography(ERC) in relation to gallstone disease.METHODS:Bile samples obtained at ERC from 29 consecutive patients,17 with and 12 without gallstone disease were evaluated for mucin content by gel filtration on a Sepharose CL-4B column.Dot blot analysis for bile mucin apoproteins was performed with antibodies to Mucin 1(MUC1) ,MUC2,MUC3,MUC5AC,MUC5B and MUC6.Staining intensity score(0-3) was used as a measure of antigen expression.RESULTS:MUC1,MUC2,MUC3,MUC5AC,MUC5B and MUC6 were demonstrated in 34.4%,34.4%,51.7%,51.7%,55.1% and 27.5% of bile samples,respectively.The staining intensity scores were 0.62 ± 0.94,0.58 ± 0.90,0.79 ± 0.97,1.06 ± 1.22,1.20 ± 1.26 and 0.41 ± 0.73,respectively.Mean mucin concentration measured in bile by the Sepharose CL-4B method was 22.8 ± 24.0 mg/mL(range 3.4-89.0 mg/mL) .Mean protein concentration was 8.1 ± 4.8 mg/mL(range 1.7-23.2 mg/mL) .CONCLUSION:High levels of MUC3,MUC5AC and MUC5B are expressed in bile aspirated during ERC examination.A specific pattern of mucin gene expression or change in mucin concentration was not found in gallstone disease. | Alexander Vilkin Alex Geller Zohar Levi Yaron Niv | 2009 | World Journal of Gastroenterology2009，15，19： | 4 |
| 7 | 基于神经科学的临床精神药理学命名系统显示文摘精神药物(psychotropic drug)也被称为精神治疗药物(psychotherapeutie drug),用于治疗各种精神障碍已有六十多年历史,传统上根据其治疗适应证进行命名分类,如治疗精神病性障碍的精神药物被命名为抗精神病药,治疗抑郁障碍的药物被命名为抗抑郁药,治疗躁狂发作的药物被命名为抗躁狂药或心境稳定剂,治疗焦虑障碍的药物被命名为抗焦虑药。这种命名系统在现代精神药理学发展初期,可帮助医生学习和认识不断上市的各种精神药物。但是随着近年来神经科学和精神药理学研究的进展,这种命名法常给使用者及患者带来诸多困惑和疑问,如患者常常质疑医生:我明明是抑郁障碍,医生为什么给我处方抗精神病药?甚至强化了患者的病耻感。 | 司天梅 于欣 Shigeto Yamawaki Joseph Zohar | 2017 | 中华精神科杂志2017，50，1： | 2 |
| 8 | Assessment and Validation of the New Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI)显示文摘 | Eyal Gal Alex Geller Gerald Fraser Zohar Levi Yaron Niv | 2008 | Digestive Diseases and Sciences2008，，7： | 2 |
| 9 | Attention deficit hyperactivity disorder and gastrointestinal morbidity in a large cohort of young adults显示文摘BACKGROUND Although the association of attention deficit hyperactivity disorder(ADHD)with psychiatric disorders is well known,its association with somatic diseases is unclear.Only few studies have investigated the gastrointestinal(GI)morbidity in adult patients with ADHD.AIM To measure gastrointestinal comorbidity and its burden on healthcare in young adults with ADHD.METHODS The cohort included subjects aged 17-35 years recruited to the Israel Defense Forces in 2007-2013,33380 with ADHD and 355652 without(controls).The groups were compared for functional and inflammatory conditions of the gastrointestinal tract and clinic and specialist visits for gastrointestinal symptoms/disease during service(to 2016).Findings were analyzed by generalized linear models adjusted for background variables.RESULTS Compared to controls,the ADHD group had more diagnoses of functional gastrointestinal disorders(referred to as FGID),namely,dyspepsia[odds ratio(OR):1.48,95%confidence interval(CI):1.40-1.57,P<0.001],chronic constipation(OR:1.64,95%CI:1.48-1.81,P<0.001),and irritable bowel syndrome(OR:1.67,95%CI:1.56-1.80,P<0.001)but not of organic disorders(inflammatory bowel disease,celiac disease).They had more frequent primary care visits for gastrointestinal symptoms[rate ratio(RR):1.25,95%CI:1.24-1.26,P<0.001]and referrals to gastrointestinal specialists(RR:1.96,95%CI:1.88-2.03,P<0.001)and more episodes of recurrent gastrointestinal symptoms(RR:1.29,95%CI:1.21-1.38,P<0.001).Methylphenidate use increased the risk of dyspepsia(OR:1.49,95%CI:1.28-1.73,P<0.001)and constipation(OR:1.42,95%CI:1.09-1.84,P=0.009).CONCLUSION ADHD in young adults is associated with an excess of FGID and increased use of related health services.Research is needed to determine if an integrative approach treating both conditions will benefit these patients and cut costs. | Sivan Kedem Shlomit Yust-Katz Dan Carter Zohar Levi Ron Kedem Adi Dickstein Salah Daher Lior H Katz | 2020 | World Journal of Gastroenterology2020，26，42： | 2 |
| 10 | Obsessive-compulsive disorder: boundary issues显示文摘 | Fineberg NA Saxena S Zohar J | 2007 | CNS Spectr2007，，： | 1 |
| 11 | Fostering students' knowledge and argumentation skills through dilemmas in human genetics显示文摘 | Zohar A Nemet F | 2002 | Journal of Research in Science Teaching2002，39，： | 1 |
| 12 | Blunted HPA axis response to stress influences susceptibility to posttraumatic stress response in rats显示文摘 | Cohen H Zohar J Gidron Y | 2006 | Biol Psychiatry2006，59，： | 1 |
| 13 | A Review of Research on Meta- cognition in Science Education显示文摘 | ZOHAR A BARZILAI S | 2013 | Studies in Science Ed- ucation2013，49，2： | 1 |
| 14 | Localization and expression of aromatase mRNA in adult zebrafish显示文摘 | Goto Kazeto R Kight K E Zohar Y | 2004 | Gen Comp Endocrinol2004，139，1： | 1 |
| 15 | Stromal mesenchymal progentor cellsin process citation显示文摘 | Ghilzon R McCulloch CA Zohar R | 1999 | Leuk Lymphoma1999，32，34： | 1 |
| 16 | Translation Theory Today : A Call for Transfer Theory 显示文摘 | Even - Zohar Itamar | 1981 | Poetics Today1981，，4： | 1 |
| 17 | Translation of Childrens' Liter- ature as a Function of its Position in the Liter- ary Polysiste 显示文摘 | Shavit Zohar | 1981 | Poetics Today1981，12，4： | 1 |
| 18 | Characterization of stromal progenitor cells enriched by flow cytometry 显示文摘 | Zohar R Sodek J McCullon CA | 1997 | Blood1997，90，9： | 1 |
| 19 | Strornal mesenchmal progenitor cells in process Citation显示文摘 | Ghilzon R McCulloch CA Zohar R | 1999 | Leuk Lymphoma1999，32，34： | 1 |
| 20 | Microwave-assisted extraction of bioactive saponins from chickpea(Cicer arietinum L)显示文摘 | Zohar K Hilla G S Oded Y | 2005 | Journal of the Science of Food and Agriculture2005，85，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员