|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Enhanced Expression of miR-425 Promotes Esophageal Squamous Cell Carcinoma Tumorigenesis by Targeting SMAD2显示文摘Esophageal squamous cell carcinoma(ESCC) is one of the most common and deadly cancers in the world. Currently, clinical therapy of ESCC remains limited and the five-year survival rate is poor. The function of miR-425 has been reported in multiple human cancers.However, the tumorigenic role and clinical significance of miR-425 in ESCC remains unclear. We found that enhanced expression of miR-425 in ESCC cell lines not only promoted cell proliferation and colony formation, but also increased cellular metastasis. Furthermore, we revealed the mechanism that miR-425 inhibited the expression of SMAD2 by targeting the second binding site in the 30-untranslated region(30-UTR) in ESCC. This mode of action influenced not only SMAD2 mRNA expression but also protein expression. In addition, we detected the expression of miR-425 in ESCC tissues and plasma. Moreover, we analyzed the relationship between miR-425 expression and SMAD2 m RNA expression. We found that miR-425 was overexpressed in ESCC tissues and the plasma relative to adjacent normal tissues and plasma of healthy individuals. Furthermore, there was a negative correlation between miR-425 expression and SMAD2. Taken together, our results show that miR-425 functions as an oncogene by targeting the 30-UTR of SMAD2 and indicate the potential utility of plasma miR-425 as a novel biomarker for ESCC diagnosis. | Lingyan Liu Zitong Zhao Wei Zhou Xinyi Fan Qimin Zhan Yongmei Song | 2015 | Journal of Genetics and Genomics2015，42，11： | 10 |
| 2 | TRAP1 Shows Clinical Significance and Promotes Cellular Migration and Invasion through STAT3/MMP2 Pathway in Human Esophageal Squamous Cell Cancer显示文摘Tumor necrosis factor receptor-associated protein 1(TRAP1), an important member of mitochondrial heat shock protein 90 family, is involved in multiple biological processes in several types of tumors. However, its pathological role in esophageal squamous cell cancer(ESCC) remains unknown. Herein, we demonstrated the clinical value of TRAP1, and its role in apoptosis and motility in ESCC. The clinical potential of TRAP1 was investigated through immunohistochemical analysis in 328 ESCC samples, which revealed that strong TRAP1 expression was associated with increased risk of lymph node metastasis, while high TRAP1 expression correlated with poor prognosis. Expression of TRAP1 was found to be an independent prognostic factor for patients with ESCC. Additionally, the upregulation of TRAP1 antagonized cisplatin-induced apoptosis while its downregulation sensitized cells to cisplatin-induced apoptosis. As revealed by the transwell assay, TRAP1 overexpression promoted cellular migration and invasion as compared to the control groups. In contrast,silencing of endogenous TRAP1 expression attenuated the ability of migration and invasion. Finally, the molecular mechanism investigated in the present study demonstrated that TRAP1-mediated migration and invasion occurred through STAT3/MMP2 signaling pathway. In conclusion, TRAP1 may be considered as a molecular predictive marker for prognosis and a novel molecular candidate for therapeutic target in ESCC. | Yunwei Ou Lingyan Liu Liyan Xue Wei Zhou Zitong Zhao Bainan Xu Yongmei Song Qimin Zhan | 2014 | Journal of Genetics and Genomics2014，41，10： | 8 |
| 3 | Soils in Islands of South China Sea and their ages显示文摘 | GONG Zitong LIU Liangwu ZHOU Ruirong | 1995 | Sciantia Geologica Sinica1995，，： | 1 |
| 4 | STING agonist-boosted mRNA immunization via intelligent design of nanovaccines for enhancing cancer immunotherapy显示文摘Messenger RNA(mRNA)vaccine is revolutionizing the methodology of immunization in cancer.However,mRNA immunization is drastically limited by multistage biological barriers including poor lymphatic transport,rapid clearance,catalytic hydrolysis,insufficient cellular entry and endosome entrapment.Herein,we design a mRNA nanovaccine based on intelligent design to overcome these obstacles.Highly efficient nanovaccines are carried out with machine learning techniques from datasets of various nanocarriers,ensuring successful delivery of mRNA antigen and cyclic guanosine monophosphate-adenosine monophosphate(cGAMP)to targets.It activates stimulator of interferon genes(STING),promotes mRNA-encoded antigen presentation and boosts antitumour immunity in vivo,thus inhibiting tumour growth and ensuring long-term survival of tumour-bearing mice.This work provides a feasible and safe strategy to facilitate STING agonist-synergized mRNA immunization,with great translational potential for enhancing cancer immunotherapy. | Lei Zhou Wenzhe Yi Zehong Zhang Xiaoting Shan Zitong Zhao Xiangshi Sun Jue Wang Hao Wang Hualiang Jiang Mingyue Zheng Dangge Wang Yaping Li | 2023 | National Science Review2023，10，10： | 0 |
| 5 | 诱导性多能干细胞的低基因组稳定性使非同源末端连接增加显示文摘背景与目的诱导性多能干细胞(induced pluripotent stem cells,iPSCs)和胚胎干细胞(embryonic stem cells,ESCs)具有许多共同特征,包括相似的形态、基因表达和体外分化谱。然而,iPSCs的基因组稳定性远低于ESCs。在本研究中,我们研究了iPSCs中DNA损伤修复的改变是否为其具有更大诱变倾向的原因。方法将小鼠iPSCs、ESCs和胚胎成纤维细胞暴露于电离辐射(4 Gy),导致双链DNA断裂。照射4 h后使用全基因组重测序评估DNA损伤修复的保真度。我们还分析了分别源自iPSCs或ESCs的小鼠的基因组稳定性。结果照射后,与胚胎干细胞和胚胎成纤维细胞相比,iPSCs具有较低的DNA损伤修复能力,有更多的体细胞突变和短片段插入缺失。iPSCs有更多的非同源末端连接DNA修复和更少的同源重组DNA修复。源自iPSCs的小鼠比ESCs小鼠以及C57对照小鼠的DNA损伤修复能力更低。结论本研究结果部分表明,iPSCs的低基因组稳定性及其在体内的高致瘤性是由DNA损伤修复的低保真度所致。 | Minjie Zhang Liu Wang Ke An Jun Cai Guochao Li Caiyun Yang Huixian Liu Fengxia Du Xiao Han Zilong Zhang Zitong Zhao Duanqing Pei Yuan Long Xin Xie Qi Zhou Yingli Sun | 2019 | 癌症2019，38，8： | 0 |
| 6 | CAPILLARY PRESSURE-SATURATION RELATIONSHIPS IN ROCK FRACTURE显示文摘Understanding and quantifying unsaturated flow through fractures in rocky slope is important for design and construction of drainage system in large-scale hydraulic engineering. The data of the hysteretic relationship between capillary pressure and water saturation are primary for simulating unsaturated flow in fractures and analyzing the stability of high rocky slope. The drainage and imbibition curves are measured for a single fracture in granite sample got at construction site of the Three Gorges Project (TGP). The method used in this study for measuring the capillary pressure-saturation relationship , under the conditions of no normal load to rock sample, is generally following the laboratory technique developed by Reitsma and Kueper. A distinct entry pressure, indicating rise to initiate nonwetting phase invasion, was observed. The drainage curve is found to be well represented by van Genuchten porous media capillary pressure function. | Ye, Zitong Yang, Jinzhong Han, Bing Zhou, Chuangbing | 1997 | Journal of Hydrodynamics1997，9，1： | 0 |
| 7 | Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry显示文摘Bioorthogonal chemistry reactions occur in physiological conditions without interfering with normal physiological processes.Through metabolic engineering,bioorthogonal groups can be tagged onto cell membranes,which selectively attach to cargos with paired groups via bioorthogonal reactions.Due to its simplicity,high efficiency,and specificity,bioorthogonal chemistry has demonstrated great application potential in drug delivery.On the one hand,bioorthogonal reactions improve therapeutic agent delivery to target sites,overcoming off-target distribution.On the other hand,nanoparticles and biomolecules can be linked to cell membranes by bioorthogonal reactions,providing approaches to developing multi-functional drug delivery systems(DDSs).In this review,we first describe the principle of labeling cells or pathogenic microorganisms with bioorthogonal groups.We then highlight recent breakthroughs in developing active targeting DDSs to tumors,immune systems,or bacteria by bioorthogonal chemistry,as well as applications of bioorthogonal chemistry in developing functional bio-inspired DDSs(biomimetic DDSs,cell-based DDSs,bacteria-based and phage-based DDSs)and hydrogels.Finally,we discuss the difficulties and prospective direction of bioorthogonal chemistry in drug delivery.We expect this review will help us understand the latest advances in the development of active targeting and multi-functional DDSs using bioorthogonal chemistry and inspire innovative applications of bioorthogonal chemistry in developing smart DDSs for disease treatment. | Wenzhe Yi Ping Xiao Xiaochen Liu Zitong Zhao Xiangshi Sun Jue Wang Lei Zhou Guanru Wang Haiqiang Cao Dangge Wang Yaping Li | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 0 |
| 8 | Using deep learning to solve computer security challenges:a survey显示文摘Although using machine learning techniques to solve computer security challenges is not a new idea,the rapidly emerging Deep Learning technology has recently triggered a substantial amount of interests in the computer security community.This paper seeks to provide a dedicated review of the very recent research works on using Deep Learning techniques to solve computer security challenges.In particular,the review covers eight computer security problems being solved by applications of Deep Learning:security-oriented program analysis,defending return-oriented programming(ROP)attacks,achieving control-flow integrity(CFI),defending network attacks,malware classification,system-event-based anomaly detection,memory forensics,and fuzzing for software security. | Yoon-Ho Choi Peng Liu Zitong Shang Haizhou Wang Zhilong Wang Lan Zhang Junwei Zhou Qingtian Zou | 2018 | Cybersecurity2018，1，1： | 0 |
| 9 | Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide. It is urgent to develop new drugs to improve the prognosis of ESCC patients. Here, we found benzydamine, a locally acting non-steroidal anti-inflammatory drug, had potent cytotoxic effect on ESCC cells. Benzydamine could suppress ESCC proliferation in vivo and in vitro. In terms of mechanism, CDK2 was identified as a target of benzydamine by molecular docking, pull-down assay and in vitro kinase assay. Specifically, benzydamine inhibited the growth of ESCC cells by inhibiting CDK2 activity and affecting downstream phosphorylation of MCM2, c-Myc and Rb, resulting in cell cycle arrest. Our study illustrates that benzydamine inhibits the growth of ESCC cells by downregulating the CDK2 pathway. | Yubing Zhou Xinyu He Yanan Jiang Zitong Wang Yin Yu Wenjie Wu Chenyang Zhang Jincheng Li Yaping Guo Xinhuan Chen Zhicai Liu Jimin Zhao Kangdong Liu Zigang Dong | 2023 | Frontiers of Medicine2023，17，2： | 0 |
| 10 | Transgenerational analysis of H3K4me3 and H3K27me3 by ChIP-Seq links epigenetic inheritance to metabolism显示文摘Histone methylation is a kind of important epigenetic modification which occurs on the lysine residue or arginine residue of histone tails(Zhang and Reinberg,2001).It takes part in multiple biological processes,including gene expression,genomic stability,stem cell maturity,genetic imprinting,mitosis and development(Fischle et al.,2005).Abnormal histone methylation pattern | Ke An Fengxia Du Hao Meng Guochao Li Minjie Zhang Zongzhi Liu Zitong Zhao Zilong Zhang Di Yu Dong Wang Caiyun Yang Wencui Ma Lin Yuan Meiting Zhou Lili Duan Li Jin Hui Li Yan Zhang Jianzhong Su Jie Qiao Yingli Sun | 2018 | Journal of Genetics and Genomics2018，45，3： | 0 |
| 11 | Lower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining显示文摘Background:Induced pluripotent stem cells(iPSCs)and embryonic stem cells(ESCs)share many common features,including similar morphology,gene expression and in vitro differentiation profiles.However,genomic stability is much lower in iPSCs than in ESCs.In the current study,we examined whether changes in DNA damage repair in iPSCs are responsible for their greater tendency towards mutagenesis.Methods:Mouse iPSCs,ESCs and embryonic fibroblasts were exposed to ionizing radiation(4 Gy)to introduce dou-ble-strand DNA breaks.At 4 h later,fidelity of DNA damage repair was assessed using whole-genome re-sequencing.We also analyzed genomic stability in mice derived from iPSCs versus ESCs.Results:In comparison to ESCs and embryonic fibroblasts,iPSCs had lower DNA damage repair capacity,more somatic mutations and short indels after irradiation.iPSCs showed greater non-homologous end joining DNA repair and less homologous recombination DNA repair.Mice derived from iPSCs had lower DNA damage repair capacity than ESC-derived mice as well as C57 control mice.Conclusions:The relatively low genomic stability of iPSCs and their high rate of tumorigenesis in vivo appear to be due,at least in part,to low fidelity of DNA damage repair. | Minjie Zhang Liu Wang Ke An Jun Cai Guochao Li Caiyun Yang Huixian Liu Fengxia Du Xiao Han Zilong Zhang Zitong Zhao Duanqing Pei Yuan Long Xin Xie Qi Zhou Yingli Sun | 2018 | Cancer Communications2018，38，1： | 0 |
| 12 | Using deep learning to solve computer security challenges:a survey显示文摘Although using machine learning techniques to solve computer security challenges is not a new idea,the rapidly emerging Deep Learning technology has recently triggered a substantial amount of interests in the computer security community.This paper seeks to provide a dedicated review of the very recent research works on using Deep Learning techniques to solve computer security challenges.In particular,the review covers eight computer security problems being solved by applications of Deep Learning:security-oriented program analysis,defending return-oriented programming(ROP)attacks,achieving control-flow integrity(CFI),defending network attacks,malware classification,system-event-based anomaly detection,memory forensics,and fuzzing for software security. | Yoon-Ho Choi Peng Liu Zitong Shang Haizhou Wang Zhilong Wang Lan Zhang Junwei Zhou Qingtian Zou | 2020 | Cybersecurity2020，3，1： | 0 |
| 13 | Developments and Applications of Tunneling Magnetoresistance Sensors显示文摘Magnetic sensors based on tunneling magnetoresistance(TMR)effect exhibit high sensitivity,small size,and low power consumption.They have gained a lot of attention and have potential applications in various domains.This study first introduces the development history and basic principles of TMR sensors.Then,a comprehensive description of TMR sensors linearization and Wheatstone bridge configuration is presented.Two key performance parameters,the field sensitivity and noise mechanisms,are considered.Finally,the emerging applications of TMR sensors are discussed. | Shaohua Yan Zitong Zhou Yaodi Yang Qunwen Leng Weisheng Zhao | 2022 | Tsinghua Science and Technology2022，27，3： | 0 |
| 14 | Magnetic coupling governed pinning directions in magnetic tunnel junctions under magnetic field annealing with zero magnetic field cooling显示文摘With the rapid development of emerging concepts,such as the Internet of things and big data,the use of various magnetoresistance(MR)sensors,especially tunneling MR(TMR)in magnetic tunnel junctions(MTJs),for information perception is considered the critical first step.A typical topic in this field is the construction of a Wheatstone bridge structure to restrain the temperature drift and amplify the magnetic response signal. | Weibin CHEN Shaohua YAN Zhiqiang CAO Shiyang LU Xiaonan ZHAO Runrun HAO Zitong ZHOU Zhi LI Kun ZHANG Shishen YAN Qunwen LENG | 2023 | Science China(Information Sciences)2023，66，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员