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| 1 | Epidemiology and risk factors of colorectal cancer in China显示文摘In China, colorectal cancer(CRC) ranked fourth and fifth in the highest incidence and mortality rates of all malignancies in 2018, respectively. Although these rates are below the world average, China placed first worldwide in the number of new CRC cases and CRC-related deaths because of its comparatively large population. This disease represents a threat to the health of population and incurs a heavy economic burden on the society and individuals. CRC has various risk factors, including age, sex, lifestyle, genetic factors, obesity, diabetes, gut microbiota status, and precancerous lesions. Furthermore, incidence and mortality rates of CRC are closely related to socioeconomic development levels, varying according to regional and population characteristics. Prevention is the main strategy to reduce incidence and mortality rates of CRC. This can be achieved through strategies stimulating lifestyle changes, healthy diet habits, and early screening for high-risk individuals. To reduce the burden of CRC, public health officials should promote prevention and management of modifiable risk factors through national policies. The rising incidence and mortality rates of CRC in China may be timely curbed by clarifying specific epidemiological characteristics, optimizing early screening strategies, and strictly implementing diagnosis and treatment guidelines. Thus, this study aimed to collect and report the current research status on epidemiology and risk factors of CRC in China. | Yong Yang Zihan Han Xin Li An Huang Jingyi Shi Jin Gu | 2020 | Chinese Journal of Cancer Research2020，32，6： | 42 |
| 2 | Searching for the Nano-Hertz Stochastic Gravitational Wave Background with the Chinese Pulsar Timing Array Data ReleaseⅠ显示文摘Observing and timing a group of millisecond pulsars with high rotational stability enables the direct detection of gravitational waves(GWs).The GW signals can be identified from the spatial correlations encoded in the times-of-arrival of widely spaced pulsar-pairs.The Chinese Pulsar Timing Array(CPTA)is a collaboration aiming at the direct GW detection with observations carried out using Chinese radio telescopes.This short article serves as a“table of contents”for a forthcoming series of papers related to the CPTA Data Release 1(CPTA DR1)which uses observations from the Five-hundred-meter Aperture Spherical radio Telescope.Here,after summarizing the time span and accuracy of CPTA DR1,we report the key results of our statistical inference finding a correlated signal with amplitude logA_(c)=-14.4_(-2.8)^(+1.0)for spectral index in the range ofα∈[-1.8,1.5]assuming a GW background(GWB)induced quadrupolar correlation.The search for the Hellings–Downs(HD)correlation curve is also presented,where some evidence for the HD correlation has been found that a 4.6σstatistical significance is achieved using the discrete frequency method around the frequency of 14 n Hz.We expect that the future International Pulsar Timing Array data analysis and the next CPTA data release will be more sensitive to the n Hz GWB,which could verify the current results. | Heng Xu Siyuan Chen Yanjun Guo Jinchen Jiang Bojun Wang Jiangwei Xu Zihan Xue RNicolas Caballero Jianping Yuan Yonghua Xu Jingbo Wang Longfei Hao Jingtao Luo Kejia Lee Jinlin Han Peng Jiang Zhiqiang Shen Min Wang Na Wang Renxin Xu Xiangping Wu Richard Manchester Lei Qian Xin Guan Menglin Huang Chun Sun Yan Zhu | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 3 |
| 3 | Large piezoelectric response in a family of metal-free perovskite ferroelectric compounds from first-principles calculations显示文摘Metal-free organic perovskite ferroelectric materials have been shown recently to have a number of attractive properties,including high spontaneous polarization and piezoelectric coefficients.In particular,slow evaporation of solutions containing organic amines,inorganic ammoniums,and dilute hydrohalogen acid has been shown to produce several attractive materials in the MDABCO-NH_(4)-I_(3) family(MDABCO is N-methyl-N’-diazabicyclo[2,2,2]octonium).In the present work,we study by first-principles calculations the origin of polarizaiton,electronic density of state,piezoelectric response,and elastic properties of MDABCO-NH_(4)-X_(3)(X=Cl,Br,I).We find that the dipole moments of the MDABCO and NH_(4) groups are negligible,and the large spontaneous polarization of MDABCONH_(4)-I_(3) mainly results from MDABCO and NH_(4) being off-center relative to I ions.Although the piezoelectric response of organic materials is usually very weak,we observe large piezoelectric strain components,d_(x4) and d_(x5);the calculated d_(x5) is 119 pC/N for MDABCO-NH_(4)-Cl_(3),248 pC/N for MDABCO-NH_(4)-Br_(3) and 178 pC/N for MDABCO-NH_(4)-I_(3).The large value of dx5 is found to be closely related with the large value of elastic compliance tensor,s44.These results show that MDABCO-NH_(4)-X_(3) metal-free organic perovskites have large piezoelectric response with soft elastic properties. | Hui Wang Huihui Liu Zeyu Zhang Zihan Liu Zhenlong Lv Tongwei Li Weiwei Ju Haisheng Li Xiaowu Cai Han Han | 2019 | npj Computational Materials2019，，1： | 3 |
| 4 | Evaluation and intelligent deployment of coal and coalbed methane coupling coordinated exploitation based on Bayesian network and cuckoo search显示文摘Coal and coalbed methane(CBM)coordinated exploitation is a key technology for the safe exploitation of both resources.However,existing studies lack the quantification and evaluation of the degree of coordination between coal mining and coalbed methane extraction.In this study,the concept of coal and coalbed methane coupling coordinated exploitation was proposed,and the corresponding evaluation model was established using the Bayesian principle.On this basis,the objective function of coal and coalbed methane coordinated exploitation deployment was established,and the optimal deployment was determined through a cuckoo search.The results show that clarifying the coupling coordinated level of coal and coalbed methane resource exploitation in coal mines is conducive to adjusting the deployment plan in advance.The case study results show that the evaluation and intelligent deployment method proposed in this paper can effectively evaluate the coupling coordinated level of coal and coalbed methane resource exploitation and intelligently optimize the deployment of coal mine operations.The optimization results demonstrate that the safe and efficient exploitation of coal and CBM resources is promoted,and coal mining and coalbed methane extraction processes show greater cooperation.The observations and findings of this study provide a critical reference for coal mine resource exploitation in the future. | Quanle Zou Zihan Chen Zhiheng Cheng Yunpei Liang Wenjie Xu Peiran Wen Bichuan Zhang Han Liu Fanjie Kong | 2022 | International Journal of Mining Science and Technology2022，32，6： | 1 |
| 5 | Evaluation of the chemical profile from four germplasms sources of Pruni Semen using UHPLC-LTQ-Orbitrap-MS and multivariate analyses显示文摘Pruni Semen,the seed of several unique Prunus plants,is a traditional purgative herbal material.To determine the authentic sources of Pruni Semen,46 samples from four species were collected and analyzed.Ten compounds including multiflorin A(Mul A),a notable purative compound,were isolated and identified by chemical separation and nuclear magnetic resonance spectroscopy.Seventy-six communal components were identified by ultra-high performance liquid chromatography with linear ion trap-quadrupole Orbitrap mass spectrometry,and acetyl flavonoid glycosides were recognized as characteristic constituents.The flavonoids were distributed in the seed coat and cyanogenic glycosides in the kernel.Based on this,methods for identifying Pruni Semen from different sources were established using chemical fingerprinting,quantitative analysis of the eight principal compounds,hierarchical cluster analysis,principal component analysis,and orthogonal partial least squares discriminant analysis.The results showed that the samples were divided into two categories:one is the small seeds from Prunus humilis(Ph)and Prunus japonica(Pj),and the other is the big seeds from Prunus pedunculata(Pp)and Prunus triloba(Pt).The average content of Mul A was 3.02,6.93,0.40,and 0.29 mg/g,while the average content of amygdalin was 18.5,17.7,31.5,and 30.9 mg/g in Ph,Pj,Pp,and Pt,respectively.All the above information suggests that small seeds might be superior sources of Pruni Semen.This is the first comprehensive report on the identification of chemical components in Pruni Semen from different species. | Zihan Zhao Yue Liu Yushi Zhang Zeyu Geng Rina Su Lipeng Zhou Chao Han Zhanjun Wang Shuangcheng Ma Weidong Li | 2022 | Journal of Pharmaceutical Analysis2022，12，5： | 1 |
| 6 | Alteration of gut microbiota in type 2 diabetes complicated with cholelithiasis patients显示文摘To the Editor:Type 2 diabetes(T2D)and cholelithiasis are both common diseases with a high,prevalence.In China,the,prevalence of T2D,is.0.90% and that offadult cholelithiasis is 6.83%. | Jiajia Chen Linlin Yan Xingfan Ma Ping Yuan Fan Zhao Zihan Han Jingshan Liu Wenbo Wang Donghai Zhou Hongyu Zhao Nan Feng Dandan Huang Shoukui Hu Jin Gui | 2022 | Chinese Medical Journal2022，135，17： | 1 |
| 7 | The kinase p38αfunctions in dendritic cells to regulate Th2-cell differentiation and allergic inflammation显示文摘Dendritic cells(DCs)play a critical role in controlling T helper 2(Th2)cell-dependent diseases,but the signaling mechanism that triggers this function is not fully understood.We showed that p38αactivity in DCs was decreased upon HDM stimulation and dynamically regulated by both extrinsic signals and Th2-instructive cytokines.p38α-specific deletion in cDC1s but not in cDC2s or macrophages promoted Th2 responses under HDM stimulation.Further study showed that p38αin cDC1s regulated Th2-cell differentiation by modulating the MK2−c-FOS−IL-12 axis.Importantly,crosstalk between p38α-dependent DCs and Th2 cells occurred during the sensitization phase,not the effector phase,and was conserved between mice and humans.Our results identify p38αsignaling as a central pathway in DCs that integrates allergic and parasitic instructive signals with Th2-instructive cytokines from the microenvironment to regulate Th2-cell differentiation and function,and this finding may offer a novel strategy for the treatment of allergic diseases and parasitic infection. | Miaomiao Han Jingyu Ma Suidong Ouyang Yanyan Wang Tingting Zheng Peishan Lu Zihan Zheng Weiheng Zhao Hongjin Li Yun Wu Baohua Zhang Ran Hu Kinya Otsu Xinguang Liu Ying Wan Huabin Li Gonghua Huang | 2022 | Cellular & Molecular Immunology2022，19，7： | 1 |
| 8 | Exploration of playa surface crusts in Qehan Lake, China through field investigation and wind tunnel experiments显示文摘Globally,many lakes are drying up,leaving exposed lakebeds where wind erosion releases dust and sand rich in salt and harmful heavy metals into the atmosphere.Therefore,understanding the characteristics and spatial distribution of playa surface crusts is important to recognize the manifestation of salt dust storms.The objective of this study was to explore the playa surface crust types as well as their spatial distribution and evolution of Qehan Lake in Inner Mongolia Autonomous Region,China to understand the salt dust release potential of different types of playa surface crusts.Various crust characteristics were investigated by field sampling in Qehan Lake,and playa surface crusts were further divided into five types:vegetated areas,salt crusts,clay flats,curly crusts,and margins.It should be noted that curly crusts were distributed in clay flats and covered only a small area in Qehan Lake.The spatial distribution characteristics of playa surface crust types were obtained by supervised classification of remote sensing images,and the salt dust release potential of crusts was explored by the wind tunnel experiments.The field investigation of Qehan Lake revealed that playa surface crust types had a circum-lake band distribution from the inside to the outside of this lake,which were successively vegetated areas,clay flats,salt crusts,and margins.The spatial distribution patterns of playa surface crust types were mainly controlled by the hydrodynamics of the playa,soil texture,and groundwater.There was a significant negative correlation between crust thickness and electrical conductivity.The results of the wind tunnel experiments showed that the initial threshold of friction wind velocity for the salt dust release was higher in clay flats(0.7–0.8 m/s)than in salt crusts(0.5–0.6 m/s).Moreover,the particle leap impact processes occurring under natural conditions may reduce this threshold value.Salinity was the main factor controlling the difference in the initial threshold of friction wind velocity for the salt dust release of clay flats and salt crusts.This study provides a scientific reference for understanding how salt dust is released from a lakebed,which may be used for ecological restoration of dry salt lakes. | LIU Dongwei HAN Lijing KOU Zihan GAO Xinyu WANG Jingjing | 2023 | Journal of Arid Land2023，15，5： | 0 |
| 9 | Observation of electron–phonon coupling and linear dichroism in PL spectra of ultra-small CsPbBr3 nanoparticle solution显示文摘Blue-emission(~480 nm)CsPbBr3 nanoparticles with ultra-small size(~2.1 nm)are synthesized using the liquid nitrogen freezing with the ligand of dodecylbenzene sulfonic acid(DBSA).Asymmetric narrow emissions at the low energy side,with the full width at half-maximum of~20 nm,are observed in solution and film at room temperature.The spectral asymmetry is mainly ascribed to phonon vibronic replica with averaged phonon energy of~40 meV.Moreover,exciting this CsPbBr3 nanoparticles solution using linearly polarized 6 ns pulsed laser at 355 nm,we observe polarized emission with polarization degree(PPL)of~7%,and PPL decreases more than 20%in the vibronic progression.However,the PPL goes to zero in frozen solutions as well as in films.Thus we speculate the polarized emission is due to the photoinduced re-alignment of nanoparticles,and the diminished PPL at the phonon side band may be due to the non-adiabatic electronic-to-vibronic transitions.The novel phenomena from the ultra-small CsPbBr3 nanoparticle demonstrated in this work may provide fundamental insights into its photophysics with direct implications for optoelectronics. | Chengqiang Wang Tao Song Pingyuan Yan Shu Hu Chenhong Xiang Zihan Wu Heng Li Haibin Zhao Lili Han Chuanxiang Sheng | 2023 | eScience2023，3，6： | 0 |
| 10 | Giant quartic-phonon decay in PVD-grownα-MoO_(3) flakes显示文摘Elementary excitations,such as in-plane anisotropic phonons and phonon polaritons(PhPs),inα-MoO_(3) play key roles in its outstanding physical properties like high carrier mobility and ultralow phonon thermal conductivity().Understanding the excitation mechanisms like phonon–phonon interactions is the most fundamental step to further applications.Here,we report on the systematic Raman investigations on phonon anisotropy and anharmonicity of representative Mo–O stretching vibration phonon modes(SVPMs)in physical vapor deposition(PVD)-grownα-MoO_(3) flakes.Polarizations of SVPMs verify the phonon anisotropy.The abnormal temperature dependence of SVPMs reveals that giant quartic-phonon decay dominates the phonon anharmonicity inα-MoO_(3).An ultrashort phonon lifetime of~0.34 ps gives evidence of theoretically predicted ultralow inα-MoO_(3).Our findings give deep insight into the phonon–phonon interactions inα-MoO_(3) and provide an indicator for its extreme thermal device applications. | Yongsong Wang Xiao Guo Siwen You Junjie Jiang Zihan Wang Fangping Ouyang Han Huang | 2023 | Nano Research2023，16，1： | 0 |
| 11 | In situ performance and stability tests of large-area flexible polymer solar cells in the 35-km stratospheric environment显示文摘Flexible organic solar cells(FOSCs)are one of the most promising power sources for aerospace aircraft due to their atractive advantages with high power-per-weight ratio and excellent mechanical flexibility.Understanding the performance and stability of high-performance FOSCs is essential for the further development of FOSCs for aerospace applications.In this paper,after systematic investigations on the performance of the state-of-the-art high-performance solar cells under thermal cycle and intensive UV irradiation conditions,in situ performance and stability tests of the solar cells in the 35 km stratospheric environment were carried out through a high-altitude balloon uploading.The encapsulated FOSCs with an area of 0.64 cm^(2)gave the highest power density of 15.26 mW/cm^(2)and an efficiency over 11%,corresponding to a power-per-weight ratio of over 3.32 k W/kg.More importantly,the cells showed stable power output during the 3-h continuous flight at 35 km and only 10%performance decay after return to the lab,suggesting promising stability of the FOSCs in the stratospheric environment. | Zihan Xu Guoning Xu Qun Luo Yunfei Han Yu Tang Ying Miao Yongxiang Li Jian Qin Jingbo Guo Wusong Zha Chao Gong Kun Lu Jianqi Zhang Zhixiang Wei Rong Cai Yanchu Yang Zhaojie Li Chang-Qi Ma | 2023 | National Science Review2023，10，4： | 0 |
| 12 | Generalized assembly of sandwich-like 0D/2D/0D heterostructures with highly exposed surfaces toward superior electrochemical performances显示文摘Heterostructures composed of two-dimensional(2D)nanosheets and zero-dimensional(0D)nanoparticles(NPs)have attracted increasing attention because of the synergy arising from the coupling interactions between the two mixed-dimensional components.Despite recent advances,it remains a challenge to fabricate 2D/0D heterostructures with clean and accessible surfaces,which is highly desirable for the diversity of catalytic,sensing,and energy storage applications.Herein,we report a generalized methodology that enables the facile assembly of sandwich-like 0D/2D/0D heterostructures with facilitated mass-transport channels and exposed surface active sites.A ligand-exchange strategy with HBF4 is employed to strip off the surface-coating ligands of colloidal NPs,rendering them positively charged and dispersible in polar solvents.This allows subsequent electrostatic assembly of NPs with oppositely charged 2D nanosheets to afford sandwich-like 0D/2D/0D heterostructures.The barely covered surfaces and the advantageous architectures of such sandwich-like 0D/2D/0D heterostructures induce the desired synergistic effect,making them particularly suitable for electrochemical energy storage and conversion.We demonstrate this by employing MXene/NiFe_(2)O_(4) and MXene/Fe3O4 heterostructures for high-performance electrocatalytic oxygen evolution and supercapacitors,respectively. | Shuqing Xue Guanhong Wu Mingzhong Li Zihan Liu Yuwei Deng Wenqian Han Xuanyu Lv Siyu Wan Xiangyun Xi Dong Yang Angang Dong | 2022 | Nano Research2022，15，1： | 0 |
| 13 | Two-dimensional ferromagnetic superlattices显示文摘Mechanically exfoliated two-dimensional ferromagnetic materials(2D FMs)possess long-range ferromagnetic order and topologically nontrivial skyrmions in few layers.However,because of the dimensionality effect,such few-layer systems usually exhibitmuch lower Curie temperature(TC)compared to their bulk counterparts.It is therefore of great interest to explore effective approaches to enhance their TC,particularly in wafer-scale for practical applications.Here,we report an interfacial proximity-induced high-TC 2D FM Fe3GeTe2(FGT)via A-type antiferromagnetic material CrSb(CS)which strongly couples to FGT.A superlattice structure of(FGT/CS)n,where n stands for the period of FGT/CS heterostructure,has been successfully produced with sharp interfaces by molecular-beam epitaxy on 2-inch wafers.By performing elemental specific X-ray magnetic circular dichroism(XMCD)measurements,we have unequivocally discovered that TC of 4-layer Fe3GeTe2 can be significantly enhanced from 140 K to 230 K because of the interfacial ferromagnetic coupling.Meanwhile,an inverse proximity effect occurs in the FGT/CS interface,driving the interfacial antiferromagnetic CrSb into a ferrimagnetic state as evidenced by double-switching behavior in hysteresis loops and the XMCD spectra.Density functional theory calculations show that the Fe-Te/Cr-Sb interface is strongly FMcoupled and doping of the spin-polarized electrons by the interfacial Cr layer gives rise to the TC enhancement of the Fe3GeTe2 films,in accordance with our XMCDmeasurements.Strikingly,by introducing rich Fe in a 4-layer FGT/CS superlattice,TC can be further enhanced to near room temperature.Our results provide a feasible approach for enhancing the magnetic order of few-layer 2D FMs in wafer-scale and render opportunities for realizing realistic ultra-thin spintronic devices. | Shanshan Liu Ke Yang Wenqing Liu Enze Zhang Zihan Li Xiaoqian Zhang Zhiming Liao Wen Zhang Jiabao Sun Yunkun Yang Han Gao Ce Huang Linfeng Ai Ping Kwan Johnny Wong Andrew Thye Shen Wee Alpha TN’Diaye Simon AMorton Xufeng Kou Jin Zou Yongbing Xu Hua Wu Faxian Xiu | 2020 | National Science Review2020，7，4： | 0 |
| 14 | Development of digital organ-on-a-chip to assess hepatotoxicity and extracellular vesicle-based anti-liver cancer immunotherapy显示文摘Organ-on-a-chip systems have been increasingly recognized as attractive platforms to assess toxicity and to develop new therapeutic agents.However,current organ-on-a-chip platforms are limited by a“single pot”design,which inevitably requires holistic analysis and limits parallel processing.Here,we developed a digital organ-on-a-chip by combining a microwell array with cellular microspheres,which significantly increased the parallelism over traditional organ-on-a-chip for drug development.Up to 127 uniform liver cancer microspheres in this digital organ-on-a-chip format served as individual analytical units,allowing for analysis with high consistency and quick response.Our platform displayed evident anti-cancer efficacy at a concentration of 10μM for sorafenib,and had greater alignment than the“single pot”organ-on-a-chip with a previous in vivo study.In addition,this digital organ-on-a-chip demonstrated the treatment efficacy of natural killer cell-derived extracellular vesicles for liver cancer at 50μg/mL.The successful development of this digital organ-on-a-chip platform provides high-parallelism and a low-variability analytical tool for toxicity assessment and the exploration of new anticancer modalities,thereby accelerating the joint endeavor to combat cancer. | Guohua Wu Jianguo Wu Zihan Li Shengyu Shi Di Wu Xuanbo Wang Han Xu Hui Liu Yixiao Huang Rending Wang Jia Shen Zhihong Dong Shuqi Wang | 2022 | Bio-Design and Manufacturing2022，5，3： | 0 |
| 15 | Strategies and opportunities of micro/nano delivery systems for targeted therapy of ulcerative colitis:Focus on underlying mechanisms and future perspectives显示文摘Ulcerative colitis(UC)is a common progressive inflammatory disease whose incidence has increased rapidly in recent years,and can develop into colorectal cancer in severe cases.There are currently no adequate or effective treatments for UC due to the fact that some patients have found suboptimal results after repeated administration,while others have experienced adverse effects.With the rapid development of nanotechnology,developing innovative colon-targeting platforms is essential to improving efficacy,reducing side effects,and improving patient compliance.In this review,we summarize the pathophysiological characteristics of UC and the most recent status of numerous nanodrug delivery systems based on different targeting mechanisms in treating UC.Oral,intravenous,and rectal drug delivery nanoparticles targeting the colon are discussed,which can provide ideas for the design of colon-targeting nanoparticles for the treatment of colon diseases,especially for the treatment of UC.Last but not least,we provide a glimpse into the future of colon-targeted delivery systems,as well as future advancements in the field. | Zihan Liu Han Liu Jialing Cheng Hongliang Wang Yanfang Yang Jun Ye Yuling Liu | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 16 | Unlocking the potential of amorphous calcium carbonate: A star ascending in the realm of biomedical application显示文摘Calcium-based biomaterials have been intensively studied in the field of drug delivery owing to their excellent biocompatibility and biodegradability.Calcium-based materials can also deliver contrast agents,which can enhance real-time imaging and exert a Ca^(2+)-interfering therapeutic effect.Based on these characteristics,amorphous calcium carbonate(ACC),as a brunch of calcium-based biomaterials,has the potential to become a widely used biomaterial.Highly functional ACC can be either discovered in natural organisms or obtained by chemical synthesis However,the standalone presence of ACC is unstable in vivo.Additives are required to be used as stabilizers or core-shell structures formed by permeable layers or lipids with modified molecules constructed to maintain the stability of ACC until the ACC carrier reaches its destination.ACC has high chemical instability and can produce biocompatible products when exposed to an acidic condition in vivo,such as Ca^(2+) with an immune-regulating ability and CO_(2) with an imaging-enhancing ability.Owing to these characteristics,ACC has been studied for selfsacrificing templates of carrier construction,targeted delivery of oncology drugs,immunomodulation,tumor imaging,tissue engineering,and calcium supplementation.Emphasis in this paper has been placed on the origin,structural features,and multiple applications of ACC.Meanwhile,ACC faces many challenges in clinical translation,and long-term basic research is required to overcome these challenges.We hope that this study will contribute to future innovative research on ACC. | Han Liu Zhiyang Wen Zihan Liu Yanfang Yang Hongliang Wang Xuejun Xia Jun Ye Yuling Liu | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 17 | Tuning 2D magnetism in Fe_(3+X)GeTe_(2) films by element doping显示文摘Two-dimensional(2D)ferromagnetic materials have been discovered with tunable magnetism and orbital-driven nodal-line features.Controlling the 2D magnetism in exfoliated nanoflakes via electric/magnetic fields enables a boosted Curie temperature(T_(C))or phase transitions.One of the challenges,however,is the realization of high T_(C) 2D magnets that are tunable,robust and suitable for large scale fabrication.Here,we report molecular-beam epitaxy growth of wafer-scale Fe_(3+X)GeTe_(2) films with T_(C) above room temperature.By controlling the Fe composition in Fe_(3+X)GeTe_(2),a continuously modulated T_(C) in a broad range of 185–320 K has been achieved.This widely tunable TC is attributed to the doped interlayer Fe that provides a 40%enhancement around the optimal composition X=2.We further fabricated magnetic tunneling junction device arrays that exhibit clear tunneling signals.Our results show an effective and reliable approach,i.e.element doping,to producing robust and tunable ferromagnetism beyond room temperature in a large-scale 2D Fe_(3+X)GeTe_(2) fashion. | Shanshan Liu Zihan Li Ke Yang Enze Zhang Awadhesh Narayan Xiaoqian Zhang Jiayi Zhu Wenqing Liu Zhiming Liao Masaki Kudo Takaaki Toriyama Yunkun Yang Qiang Li Linfeng Ai Ce Huang Jiabao Sun Xiaojiao Guo Wenzhong Bao Qingsong Deng Yanhui Chen Lifeng Yin Jian Shen Xiaodong Han Syo Matsumura Jin Zou Yongbing Xu Xiaodong Xu Hua Wu Faxian Xiu | 2022 | National Science Review2022，9，6： | 0 |
| 18 | Involvement of PGC7 and UHRF1 in the regulation of DNA methylation of the IG-DMR in the imprinted Dlk1-Dio3 locus显示文摘The gene dosage at the imprinted Dlk1-Dio3 locus is critical for cell growth and development.A relatively high gene expression within the Dlk1-Dio3 region,especially the active expression of Gtl2,has been identified as the only reliable marker for cell pluripotency.The DNA methylation state of the IG-DNA methylated regions(DMR),which is located upstream of the Gtl2 gene,dominantly contributes to the control of gene expression in the Dlk1-Dio3 locus.However,the precise mechanism underlying the regulation of DNA methylation in the IG-DMR remains largely unknown.Here,we use the F9 embryonal carcinoma cell line,a low pluripotent cell model,to identify the mechanism responsible for DNA methylation in the IG-DMR,and find that the interaction of PGC7 with UHRF1 is involved in maintaining DNA methylation and inducing DNA hypermethylation in the IG-DMR region.PGC7 and UHRF1 cooperatively bind in the IG-DMR to regulate the methylation of DNA and histones in this imprinted region.PGC7 promotes the recruitment of DNMT1 by UHRF1 to maintain DNA methylation in the IG-DMR locus.The interaction between PGC7 and UHRF1 strengthens their binding to H3K9me3 and leads to further enrichment of H3K9me3 in the IG-DMR by recruiting the specific histone methyltransferase SETDB1.Consequently,the abundance of H3K9me3 promotes DNMT3A to bind to the IG-DMR and increases DNA methylation level in this region.In summary,we propose a new mechanism of DNA methylation regulation in the IG-DMR locus and provide further insight into the understanding of the difference in Gtl2 expression levels between high and low pluripotent cells. | Mengying Yu Yingxiang Liu Zhuo Han Wei Du Bingxue Chen Lei Zhang Hongni Xue Zihan Zhang Zekun Guo | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 0 |
| 19 | Relay-type sensing mode:A strategy to push the limit on nanomechanical sensor sensitivity based on the magneto lever显示文摘Ultrasensitive molecular detection and quantization are crucial for many applications including clinical diagnostics,functional proteomics,and drug discovery;however,conventional biochemical sensors cannot satisfy the stringent requirements,and this has resulted in a long-standing dilemma regarding sensitivity improvement.To this end,we have developed an ultrasensitive relay-type nanomechanical sensor based on a magneto lever.By establishing the link between very weak molecular interaction and five orders of magnitude larger magnetic force,analytes at ultratrace level can produce a clearly observable mechanical response.Initially,proof-of-concept studies showed an improved detection limit up to five orders of magnitude when employing the magneto lever,as compared with direct detection using probe alone.In this study,we subsequently demonstrated that the relay-type sensing mode was universal in application ranging from micromolecule to macromolecule detection,which can be easily extended to detect enzymes,DNA,proteins,cells,viruses,bacteria,chemicals,etc.Importantly,we found that,sensitivity was no longer subject to probe affinity when the magneto lever was sufficiently high,theoretically,even reaching single-molecule resolution. | Depeng Rao Tianhao Yan Zihan Qiao Yu Wang Yongpei Peng Han Tu Shangquan Wu Qingchuan Zhang | 2023 | Nano Research2023，16，2： | 0 |
| 20 | Thermoplastic elastomer enhanced interface adhesion and bending durability for flexible organic solar cells显示文摘Stable interface adhesion and bending durability of flexible organic solar cells(FOSCs)is a basic requirement for its real application in wearable electronics.Unfortunately,the device performance always degraded during continuous bending.Here,we revealed the weak interface adhesion force between MoO_(3) hole transporting layer(HTL)and the organic photoactive layer was the main reason of poor bending durability.The insertion of an interface bonding layer with a thermoplastic elastomer,polystyrene-blockpoly(ethylene-ran-butylene)-block-polystyrene(SEBS)effectively improved the interface adhesion force of MoO_(3) HTL and the active layer and decreased the modulus,which ensured higher than 90%of the initial efficiency remaining after 10000 bending.Meanwhile,the FOSCs gave an efficiency of 14.18%and 16.15%for the PM6:Y6 and PM6:L8-BO devices,which was among the highest performance of FOSCs.These results demonstrated the potential of improving the mechanical durability of FOSCs through thermoplastic elastomer interface modification. | Zihan Xu Yunfei Han Yuanyuan Bai Xingze Chen Jingbo Guo Lianping Zhang Chao Gong Qun Luo Ting Zhang Chang-Qi Ma | 2022 | npj Flexible Electronics2022，6，1： | 0 |
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