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| 1 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 2 | Sialic acid-binding immunoglobulin-like lectin 9 as a potential therapeutic target for chronic obstructive pulmonary disease显示文摘Chronic obstructive pulmonary disease(COPD)has become the third-leading cause of death worldwide,which is a severe economic burden to the healthcare system.Chronic bronchitis is the most common condition that contributes to COPD,both locally and systemically.Neutrophilic inflammation predominates in the COPD airway wall and lumen.Logically,repression of neutrophilia is an essential fashion to COPD treatment.However,currently available anti-neutrophilic therapies provide little benefit in COPD patients and may have serious side effects.Thus,there is an urgent need to explore an effective and safe anti-neutrophilic approach that might delay progression of the disease.Sialic acid-binding immunoglobulin-like lectin(Siglec)-9 is a member of the Siglec cell surface immunoglobulin family.It is noteworthy that Siglec-9 is highly expressed on human neutrophils and monocytes.Ligation of Siglec-9 by chemical compounds or synthetic ligands induced apoptosis and autophagic-like cell death in human neutrophils.Furthermore,administration of antibody to Siglec-E,mouse functional ortholog of Siglec-9,restrained recruitment and activation of neutrophils in mouse models of airway inflammation in vivo.Given the critical role that neutrophils play in chronic bronchitis and emphysema,targeting Siglec-9 could be beneficial for the treatment of COPD,asthma,fibrosis,and related chronic inflammatory lung diseases. | Zi Chen Shuang-Lan Xu Lin-Yang Ge Jin Zhu Tao Zheng Zhou Zhu Linfu Zhou | 2021 | Chinese Medical Journal2021，，7： | 5 |
| 3 | Mutations in EZH2 are associated with poor prognosis for patients with myeloid neoplasms显示文摘EZH2 is a component of the polycomb repressive complex 2(PRC2),which is a highly conserved histone methyltransferase that methylates lysine 27 of histone 3.EZH2 mutations are associated with oncogenesis and progression of cancers.However,the relationship between the clinical outcome of patients with myeloid malignancies and EZH2 mutations is controversial.Therefore,we performed a meta-analysis of 8 studies(n Z 2243 patients)that evaluates the correlation between EZH2 mutations and overall survival(OS)in patients with myeloid neoplasms.EZH2 mutations were associated with significantly worse OS(hazard ratio[HR]Z 2.37,95%confidential interval(CI),1.48e3.79).In a word,EZH2 mutations indicate a poor prognosis for patients with myeloid neoplasms. | Qi Zhang Qi Han Jie Zi Jinlong Ma Huihui Song Yulu Tian Mary McGrath Chunhua Song Zheng Ge | 2019 | Genes & Diseases2019，6，3： | 3 |
| 4 | Direct observation of chaotic resonances in optical microcavities显示文摘Optical microcavities play a significant role in the study of classical and quantum chaos.To date,most experimental explorations of their internal wave dynamics have focused on the properties of their inputs and outputs,without directly interrogating the dynamics and the associated mode patterns inside.As a result,this key information is rarely retrieved with certainty,which significantly restricts the verification and understanding of the actual chaotic motion.Here we demonstrate a simple and robust approach to directly and rapidly map the internal mode patterns in chaotic microcavities.By introducing a local index perturbation through a pump laser,we report a spectral response of optical microcavities that is proportional to the internal field distribution.With this technique,chaotic modes with staggered mode spacings can be distinguished.Consequently,a complete chaos assisted tunneling(CAT)and its time-reversed process are experimentally verified in the optical domain with unprecedented certainty. | Shuai Wang Shuai Liu Yilin Liu Shumin Xiao Zi Wang Yubin Fan Jiecai Han Li Ge Qinghai Song | 2021 | Light(Science & Applications)2021，10，8： | 3 |
| 5 | Integrated emergency department and general intensive care unit management on health outcomes显示文摘The emergency department(ED)should reliably provide the required medical treatment to patients who are in an emergency or are critically ill.However,the ED faced two challenges in China. | Shan-Lin Mao Zi Ge Hui Zhao Yan-Xue Wang Jun Cao Zhi-Jie Xia | 2021 | Chinese Medical Journal2021，，21： | 2 |
| 6 | THE ULTRASTRUCTURE AND ENZYME HISTOCHEMISTRY OF THE SUBSTANTIA GELATINOSA OF RAT SPINAL CORD UNDER THE INFLUENCE OF ELECTRO-ACUPUNCTURE ANALGESIA显示文摘Histochemistry and EM were used in this experiment to study the effect of EAon the spinal dorsal horn of rat. After 30 minutes EA, the pain threshold of EA rats were elevated400%, the acid phosphatase reaction in spinal dorsal horn of EA rats increased obviously, the roundagranular vesicles of the C-terminals of EA group was more than that of control’s. The results sug-gested that the histochemical components and numbers of synaptic vesicles in SG and their functionscould be regulated by acupuncture. | Pan Baohan Ge Zi, Institute of Acupuncture and Moxibustion, China Academy of TCM, Beijing 100700, China | 1993 | World Journal of Acupuncture-Moxibustion1993，3，1： | 1 |
| 7 | 血浆碱性成纤维细胞生长因子浓度增加与成人2型糖尿病患者的冠状动脉粥样硬化性心脏病发生相关显示文摘冠状动脉粥样硬化性心脏病(冠心病)是美国成年人的首要死亡原因。2型糖尿病患者具有不成比例的冠心病高发病率和病死率。血脂异常、高血压、促血栓形成因子和促炎症因子均能促进肥胖糖尿病患者的动脉粥样硬化的发生发展。然而,造成糖尿病患者的冠心病发生风险大幅度增加的病理生理机制目前还不明确。 | Zi mering MB Anderson RJ Ge L Moritz TE 叶鹏 | 2011 | 中华高血压杂志2011，19，5： | 1 |
| 8 | Cloud Radiative Feedbacks during the ENSO Cycle Simulated by CAMS-CSM显示文摘This study evaluated the simulated cloud radiative feedbacks(CRF)during the El Ni?o–Southern Oscillation(ENSO)cycle in the latest version of the Chinese Academy of Meteorological Sciences climate system model(CAMS-CSM).We conducted two experimental model simulations:the Atmospheric Model Intercomparison Project(AMIP),forced by the observed sea surface temperature(SST);and the preindustrial control(PIcontrol),a coupled run without flux correction.We found that both the experiments generally reproduced the observed features of the shortwave and longwave cloud radiative forcing(SWCRF and LWCRF)feedbacks.The AMIP run exhibited better simulation performance in the magnitude and spatial distribution than the PIcontrol run.Furthermore,the simulation biases in SWCRF and LWCRF feedbacks were linked to the biases in the representation of the corresponding total cloud cover and precipitation feedbacks.It is interesting to further find that the simulation bias originating in the atmospheric component was amplified in the PIcontrol run,indicating that the coupling aggravated the simulation bias.Since the PIcontrol run exhibited an apparent mean SST cold bias over the cold tongue,the precipitation response to the SST anomaly(SSTA)changes during the ENSO cycle occurred towards the relatively warmer western equatorial Pacific.Thus,the corresponding cloud cover and CRF shifted westward and showed a weaker magnitude in the PIcontrol run versus observational data.In contrast,the AMIP run was forced by the observational SST,hence representing a more realistic CRF.Our results demonstrate the challenges of simulating CRF in coupled models.This study also underscores the necessity of realistically representing the climatological mean state when simulating CRF during the ENSO cycle. | Lin CHEN Lijuan HUA Xinyao RONG Jian LI Lu WANG Guo ZHANG Ming SUN Zi'an GE | 2019 | Journal of Meteorological Research2019，33，4： | 1 |
| 9 | Combined kinematic and static analysis of an articulated lower limb traction device for a rehabilitation robotic system显示文摘This paper presents a design of an articulated lower limb traction device(ALLTD) with joint torque generators for a cable-driven parallel rehabilitation robotic system(CDPRRS). An earlier version of the ALLTD uses a rigid link to model the lower limbs of a patient. This paper extends this scenario to include articulations in the lower limbs and analyzes the resulting two-link mechanism. Due to the force-displacement coupled structure, the inverse and forward kinematics of the ALLTD model are analyzed in combination with the requirement for static force balance. Examples using the limb parameters of Chinese adults are provided to show the efficacy of our model. The workspaces and cable tensions of the model indicate that the ALLTD could satisfy the rehabilitation training needs of patients with various lengths of lower limbs. | LI Yuan ZI Bin YANG ZhengMeng GE Jeffrey | 2021 | Science China(Technological Sciences)2021，64，6： | 1 |
| 10 | Spectrophotometric determination of heparin with safranine T and their interaction mechanism显示文摘 | ZHANG Dong-hui LU Li-yuan GE Run-sheng ZI Yan-qin | 2007 | Journal of Chemistry and Chemical Engineering2007，1，1： | 0 |
| 11 | A SURVEY OF THE THIRD WFAS WORLD CONFERENCE显示文摘There were about 3000 delegates,from 39countries and regions,attending this confer-ence,held at Kyoto International ConferenceHall, Kyoto,Japan,20-23,Nov.,1993.About 407 lectures and papers in total,involv-ing therapeutic mechanism,basic theories,meridian and acupoint exploration etc.were ex-changed in oral presentation,video and posterdisplay.In the symposium,invited lectures | Ge Zi Secretariat of WFAS | 1993 | World Journal of Acupuncture-Moxibustion1993，3，4： | 0 |
| 12 | Synthesis of Novel Hydrophobic Media and Purification of Recombinant HBsAg显示文摘IntroductionSincethelasttwentyyears,hydrophobicinteractionchromatography(HIC)techniquehasbeensuccessfulyappliedtopurifyingman... | WANG Yan *,WANG Qun, XIAO Neng qing , LIU Da wei, YE Shi de, LUO Xuan GUAN Gui fan, WEI Zi li and CHEN Wan ge (Changchun Institute of Biological Products, Changchun, 130062 Department of Biochemistry , Peking University, Beijing, 10087 | 1999 | Chemical Research in Chinese Universities1999，15，1： | 0 |
| 13 | Efficient utilization of glass fiber separator for low-cost sodium-ion batteries显示文摘The separator is a key component of sodium-ion battery,which greatly affects the electrochemical performances and safety characteristics of the battery.Conventional glass fiber separator cannot meet the requirements of large-scale application because of high cost and poor mechanical properties.Herein,the novel composite separators are prepared by a simple slurry sieving process using glass fiber separator scraps and ordinary qualitative filter paper as raw materials.As the composite mass ratio is 1:1,the composite separator has excellent comprehensive properties,including tensile strength of 15.8 MPa,porosity of 74.3%,ionic conductivity of 1.57×10^(-3)S·cm^(-1)and thermal stability at 210℃.The assembled sodium-ion battery shows superior cycling performance(capacity retention of 94.1%after 500 cycles at 1C)and rate capacity(retention rate of 87.3%at 10C),and it maintains fine interface stability.The above results provide some new ideas for the separator design of high-performance and low-cost sodium-ion batteries. | Xiaohang Ma Zhijie Chen Tianwen Zhang Xueqian Zhang Yuan Ma Yanqing Guo Yiyong Wei Mengyuan Ge Zhiguo Hou Zhenfa Zi | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，10： | 0 |
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