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| 1 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 2 | Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough显示文摘Pediatric cough is a heterogeneous condition in terms of symptoms and the underlying disease mechanisms.Symptom phenotypes hold complicated interactions between each other to form an intricate network structure.This study aims to investigate whether the network structure of pediatric cough symptoms is associated with the prognosis and outcome of patients.A total of 384 cases were derived from the electronic medical records of a highly experienced traditional Chinese medicine (TCM) physician.The data were divided into two groups according to the therapeutic effect,namely,an invalid group (group A with 40 cases of poor efficacy) and a valid group (group B with 344 cases of good efficacy).Several well-established analysis methods,namely,statistical test,correlation analysis,and complex network analysis,were used to analyze the data.This study reports that symptom networks of patients with pediatric cough are related to the effectiveness of treatment: a dense network of symptoms is associated with great difficulty in treatment.Interventions with the most different symptoms in the symptom network may have improved therapeutic effects. | Mengxue Huang Jingjing Wang Runshun Zhang Zhuying Ni Xiaoying Liu Wenwen Liu Weilian Kong Yao Chen Tiantian Huang Guihua Li Dan Wei Jianzhong Liu Xuezhong Zhou | 2020 | Frontiers of Medicine2020，14，3： | 4 |
| 3 | MicroRNAs and their roles in osteoclast differentiation显示文摘Osteoclasts,which are derived from monocyte-macrophage precursors,are exclusive bone resorption cells.Limited evidence indicates that a class of small non-coding single-stranded RNAs known as“microRNAs”(miRNAs)is also involved in bone resorption.Although various miRNAs regulate cell proliferation and differentiation,few miRNAs have been reported to play a key role in the regulation of osteoclast differentiation.In this short review,the biology and functional mechanisms of miRNAs in osteoclastogenesis are summarized.The profiling,function,and target prediction of miRNAs are discussed as well. | Zhuying Xia Chao Chen Peng Chen Hui Xie Xianghang Luo | 2011 | Frontiers of Medicine2011，5，4： | 2 |
| 4 | Production of cloned transgenic cow expressing omega-3 fatty acids显示文摘 | Xia Wu Hongsheng Ouyang Biao Duan Daxin Pang Li Zhang Ting Yuan Lian Xue Daibang Ni Lei Cheng Shuhua Dong Zhuying Wei Lin Li Ming Yu Qing-Yuan Sun Da-Yuan Chen Liangxue Lai Yifan Dai Guang-Peng Li | 2012 | Transgenic Research2012，，3： | 1 |
| 5 | Yield and arsenateuptake of arbuscular mycorrhizal tomato colonized byGlomus mosseae BEG167 in As spiked soil underglasshouse conditions 显示文摘 | Liu Y ZhuY G Chen B D | 2005 | Environment Internation-al2005，31，6： | 1 |
| 6 | Meserine, a Novel Carbamate AC hE Inhibitor, Ameliorates Scopolamine‐Induced Dementia and Alleviates Amyloidogenesis of APP / PS 1 Transgenic Mice显示文摘 | Bi‐Yun Shao Zheng Xia Qiong Xie Xin‐Xing Ge Wei‐Wei Zhang Jian Sun Pan Jiang Hao Wang Wei‐Dong Le Zhui‐Bai Qiu Yang Lu Hong‐Zhuan Chen | 2014 | CNS Neurosci Ther2014，，： | 1 |
| 7 | Parenteral Nutrition Support in China and Its Modern Trends显示文摘Parenteral mutrition support (PN)is one of the most important achievements in surgical science and practice of the last 40 years.From 1971,clinical applications of PN have spread from Beijing and Shanghai to Nanking,Tianjin,and to other big cities throughout the country.Over the past decade,clinical and laboratory research activities have also expanded from what once only a few medical colleges to encompass many medical centers. | Jiang ZM ,Li KW ,Wang XR,Zhang SY ,Yang NF,He KZ,Shu H ,Qi Y ,Chen TY ,ZhuY and Wu WRFrom Department of Surgery ,Peking Union Medical College Hospital,Beijing 100730,China. | 1993 | 中华临床营养杂志1993，11，1： | 0 |
| 8 | 组蛋白脱甲基酶LSD1通过抑制Wnt信号传导促进脂肪细胞分化显示文摘脂肪组织对于动物的生理活动至关重要。白色脂肪的主要作用是储存能量,而棕色脂肪通过UCP1-介导的能量消耗过程调控非颤抖性产热。虽然我们对表观遗传学机制在多种分化过程中的调节作用有所认识,但对于棕色脂肪细胞分化的表观遗传调控了解甚少。 | Yan Chen Jeesun Kim Ruipeng Zhang Xiaoqin Yang Yong Zhang Jianwu Fang Zhui Chen Lin Teng Xiaowei Chen Hui Ge Peter Atadja En Li Taiping Chen 戚炜 | 2017 | 科学新闻2017，19，4： | 0 |
| 9 | Quality of life and influencing factors between local and itinerant populations during the COVID-19 pandemic显示文摘Objective:To determine the difference in quality of life and its influencing factors between local and itinerant populations in Nanjing during COVID-19.Methods:The quality of life questionnaire,which was based on the Brief Scale of WHO Quality of Life and redesigned by the research group,was used to randomly investigate 1150 people in 5 districts of Nanjing.Results:A total of 1112 valid questionnaires were collected(local population,n=558;itinerant population,n=554).The quality of life of the itinerant population was significantly lower than the local population.The itinerant population scores in physiology,psychology,social relationships,and environment were lower than the local population(all P values<0.05).COVID-19 had a greater impact on the itinerant population than on the local population,especially in medical assistance,enjoyment of life,and interpersonal relationships(all P values<0.05).Conclusion:The itinerant population had a lower quality of life than that of the local population during the prevention and control pandemic of COVID-19,thus more social support and help is warranted. | Han-Lu Cao Yi-Yang Cao Xie Wei Wen-Shu Zhao Yi Zhang Wen-Fei Kong Xiang-Ning Yang Wan-Xuan Li Ze-Han Yu Zhui Zhang Jing-Ning Zhao Xuan Han Cao Chen Ning Ding | 2022 | Psychosomatic Medicine Research2022，4，3： | 0 |
| 10 | Expert consensus on management of analgesia and sedation for patients with severe coronavirus disease 2019显示文摘The coronavirus disease 2019(COVID-19)has been declared a global pandemic and is a major public health issue worldwide.COVID-19 is a systemic disease damaging multiple organs,including the lung as the main target organ. | Xiang-Hong Yang Bo Hu You Shang Jiao Liu Ming Zhong Xiu-Lling Shang Zhi-Xiong Wu Zhui Yu Ren-Hua Sun Hong-Liang Wang Ming-Yan Zhao Mei Meng Qiang-Hong Xu Xia Zheng De-Chang Chen | 2020 | Chinese Medical Journal2020，，18： | 0 |
| 11 | The role of microRNAs in adipocyte differentiation显示文摘Adipocytes differentiate from mesenchymal stem cells(MSCs)in a process known as adipogenesis.The programme of adipogenesis is regulated by the sequential activation of transcription factors and several signaling pathways.There is growing evidence indicating that a class of small non-coding single-stranded RNAs known as“microRNAs(miRNAs)”also are involved in this process.In this review,we summarize the biology and functional mechanisms of miRNAs in adipocyte differentiation.In addition,we further discuss the miRNAs profiling,the miRNAs function and miRNAs target prediction in the adipogenesis. | Rong Zhang Di Wang Zhuying Xia Chao Chen Peng Cheng Hui Xie Xianghang Luo | 2013 | Frontiers of Medicine2013，7，2： | 0 |
| 12 | Hematochezia due to rectal invasion by an internal iliac artery aneurysm: A case report显示文摘BACKGROUND This case report presents the rare occurrence of hematochezia due to an internal iliac artery aneurysm leading to an arterioenteric fistula,expanding the differential diagnosis for gastrointestinal bleeding.It emphasizes the importance of considering vascular origins in cases of atypical hematochezia,particularly in the absence of common gastrointestinal causes,and highlights the role of imaging and multidisciplinary management in diagnosing and treating such unusual presentations.CASE SUMMARY A 75-year-old man with a history of hypertension presented with 12 d of hematochezia,experiencing bloody stools 7-8 times per day.Initial computed tomography(CT)scans revealed an aneurysmal rupture near the right internal iliac artery with suspected hematoma development.Hemoglobin levels progressively decreased to 7 g/dL.Emergency arterial angiography and iliac arterycovered stent placement were performed,followed by balloon angioplasty.Despite initial stabilization,minor rectal bleeding and abdominal pain persisted,leading to further diagnostic colonoscopy.This identified a neoplasm and potential perforation at the proximal rectum.An exploratory laparotomy confirmed the presence of a hematoma and an aneurysm invading the rectal wall,necessitating partial rectal resection,intestinal anastomosis,and ileostomy.Postoperative recovery was successful,with no further bleeding incidents and normal follow-up CT and colonoscopy results after six months.CONCLUSION In cases of unusual gastrointestinal bleeding,it is necessary to consider vascular causes for effective diagnosis and intervention. | Fang Li Bin Zhao Yong-Qiang Liu Guo-Qing Chen Rong-Feng Qu Chao Xu Zhui Long Jin-Song Wu Mao Xiong Wei-Hang Liu Li Zhu Xiao-Ling Feng Lei Zhang | 2024 | World Journal of Clinical Cases2024，12，11： | 0 |
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