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| 1 | Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration显示文摘The capacity of 3D organoids to mimic physiological tissue organization and functionality has provided an invaluable tool to model development and disease in vitro.However,conventional organoid cultures primarily represent the homeostasis of self-organizing stem cells and their derivatives.Here,we established a novel intestinal organoid culture system composed of 8 components,mainly including VPA,EPZ6438,LDN193189,and R-Spondin 1 conditioned medium,which mimics the gut epithelium regeneration that produces hyperplastic crypts following injury;therefore,these organoids were designated hyperplastic intestinal organoids(Hyper-organoids).Single-cell RNA sequencing identified different regenerative stem cell populations in our Hyper-organoids that shared molecular features with in vivo injury-responsive Lgr5+stem cells or Clu+revival stem cells.Further analysis revealed that VPA and EPZ6438 were indispensable for epigenome reprogramming and regeneration in Hyper-organoids,which functioned through epigenetically regulating YAP signaling.Furthermore,VPA and EPZ6438 synergistically promoted regenerative response in gut upon damage in vivo.In summary,our results demonstrated a new in vitro organoid model to study epithelial regeneration,highlighting the importance of epigenetic reprogramming that pioneers tissue repair. | Molong Qu Liang Xiong Yulin Lyu Xiannian Zhang Jie Shen Jingyang Guan Peiyuan Chai Zhongqing Lin Boyao Nie Cheng Li Jun Xu Hongkui Deng | 2021 | Cell Research2021，31，3： | 9 |
| 2 | Short-term intensive atorvastatin therapy improves endothelial function partly via attenuating perivascular adipose tissue inflammation through 5-lipoxygenase pathway in hyperlipidemic rabbits显示文摘 | Wang Xiaoqiao Lin Yongqin Luo Niansang Chen Zhongqing Gu Miaoning Wang Jingfeng Chen Yangxin | 2014 | Chinese Medical Journal2014，，16： | 2 |
| 3 | Functionalized composite structures for new generation airframes: a review显示文摘 | Lin Ye Ye Lu Zhongqing Su Guang Meng | 2004 | Composites Science and Technology2004，，9： | 2 |
| 4 | Quantitative assessment of through-thickness crack size based on Lamb wave scattering in aluminium plates显示文摘 | Ye Lu Lin Ye Zhongqing Su Chunhui Yang | 2007 | NDT and E International2007，，1： | 1 |
| 5 | Generation of human hepatocytes from extended pluripotent stem cells显示文摘Dear Editor,Human pluripotent stem cells have great potential for application in regenerative medicine,as they permit the generation of different lineages of functional cell types via directed differentiation.1 However,application of conventional human pluripotent stem cells is limited due to several factors,including heterogeneity in pluripotency,differentiation bias,relatively slow proliferation,and poor single-cell survival.2 Toovercome these problems. | Qiming Wang Da Sun Zhen Liang Junyi Wang Xinxing Zhong Yulin Lyu Junning Cao Zhongqing Lin Yuanyuan Du Zhenchuan Miao Shichun Lu Cheng Li Jun Xu Yan Shi Hongkui Deng | 2020 | Cell Research2020，30，9： | 1 |
| 6 | Guided Lamb waves for identification of damage in composite structures: A review显示文摘 | Zhongqing Su Lin Ye Ye Lu | 2006 | Journal of Sound and Vibration2006，，3： | 1 |
| 7 | Guided Lamb waves for identification of damage in composite structures: A review 显示文摘 | SU Zhongqing YE Lin LU Ye | 2006 | Journal of Sound and Vibration2006，295，35： | 1 |
| 8 | Quantitative evaluation of crack orientation in aluminium plates based on lamb waves 显示文摘 | LU Ye YE Lin SU Zhongqing | 2007 | Smart Materials & Structures2007，16，5： | 1 |
| 9 | Sensitivity of fundamental mode shape and static deflection for damage identification in cantilever beams显示文摘 | Maosen Cao Lin Ye Limin Zhou Zhongqing Su Runbo Bai | 2010 | Mechanical Systems and Signal Processing2010，，2： | 1 |
| 10 | Numerical simulation of the effect of hydrogen addition fraction on catalytic micro-combustion characteristics of methane-air 显示文摘 | Yan Yunfei Tang Weimin Zhang Li Pan Wenli Yang Zhongqing Chen Yanrong Lin Jiying | 2014 | International Journal of Hydrogen Energy2014，39，： | 1 |
| 11 | Guided Lamb waves for identifi- cation of damage in composite structures :A review显示文摘 | Su Zhongqing Ye Lin Lu Ye | 2006 | Journal of Sound and Vibration2006，295，： | 1 |
| 12 | Guided lamb waves foridentification of damage in composite structures; A review显示文摘 | Zhongqing Su Lin Ye Ye Lu | 2006 | Journal of Sound and Vibration2006，295，： | 1 |
| 13 | A damage identification technique for CF/EP composite laminates using distributed piezoelectric transducers显示文摘 | Zhongqing Su Lin Ye Xiongzhu Bu | 2002 | Composite Structures2002，57，4： | 1 |
| 14 | A correlationfiltering-based matching pursuit (CF-MP) for damage identification using Lamb waves显示文摘 | Li Fucai Su Zhongqing Ye Lin | 2006 | Smart Materiel and Structure2006，15，6： | 1 |
| 15 | Guided Lamb waves for identification of damage in composite structures: A review显示文摘 | SU Zhongqing YE Lin LU Ye | 2006 | Jourllal of Sound and Vibration2006，295，35： | 1 |
| 16 | A damage identification technique for CF/EP composite laminates using distributed piezoelectric transducers显示文摘 | Zhongqing Su Lin Ye Xiongzhu Bu | 2002 | Composite structures2002，57，： | 1 |
| 17 | Artificial neural network (ANN)-based crock identification in aluminum plates with lamb wave signals显示文摘 | LU Ye YE Lin SU Zhongqing | 2009 | Journal of Intelligent Material Systems and Structures2009，20，1： | 1 |
| 18 | Evaluation of Pt and Au pressure scales based on MgO absolute pressure scale显示文摘The equations of state(EOSs)of MgO produced by two independent scale-free methods,(1)the simultaneous elastic wave velocity and in situ synchrotron X-ray measurements(Kono et al.,2010;Li et al.,2006)and(2)the first-principles calculations(Wu et al.,2008),agree well with each other to at least 150 GPa and 2000 K.Furthermore,the EOS from first-principles calculations also agrees well with shock wave data,another pressure-scale-free data.These agreements strongly support that these EOSs provide reliable absolute pressure scales.Here we evaluate Au and Pt EOSs based on the EOS of Wu et al.(2008)using the simultaneously measured volume data of MgO,Au,and Pt from the literature.The primary pressure scales developed by Tange et al.(2009)and Yokoo et al.(2009)using only pressure-scale-free experimental data of MgO,Au,and Pt produce internal consistent pressure and agree with EOS of Wu et al.(2008).The Au EOS by Tsuchiya(2003)works well at room temperature but underestimates pressure at high temperature.The Au EOS by Fei et al.(2007)can well describe thermal pressure.The EOSs of Pt by Holmes et al.(1989)and Ono et al.(2011)work well at both room temperature and high temperature.The results also suggest that the discrepancy between bulk modulus of iron from experiments(Mao et al.,1990)and those from Earth's core(Dziewonski and Anderson,1981)is not originated from the overestimation of pressure by the EOS of Holmes et al.(1989).At high pressure and temperature,pressure uncertainty resulted from volume error becomes similarly important as the accuracy of the pressure scale. | WU ZhongQing LIN Feng | 2017 | Science China Earth Sciences2017，60，1： | 1 |
| 19 | Artificial neu- ral network (Ann)-based crack identification in alumi- num plates with Lamb wave signals显示文摘 | LU Ye YE Lin SU Zhongqing | 2009 | Journal of In- telligent Material Systems and Structures2009，20，1： | 1 |
| 20 | Guided Lamb waves for identification of damage in composite structural: a review显示文摘 | Su Zhongqing Ye Lin Lu Ye | 2006 | Journal of Sound and Vibration2006，295，3： | 1 |
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