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| 1 | Constraint-induced movement therapy promotes brain functional reorganization in stroke patients with hemiplegia显示文摘Stroke patients with hemiplegia exhibit flexor spasms in the upper limb and extensor spasms in the lower limb, and their movement patterns vary greatly. Constraint-induced movement therapy is an upper limb rehabilitation technique used in stroke patients with hemiplegia; however, studies of lower extremity rehabilitation are scarce. In this study, stroke patients with lower limb hemiplegia underwent conventional Bobath therapy for 4 weeks as baseline treatment, followed by constraint-induced movement therapy for an additional 4 weeks. The 10-m maximum walking speed and Berg balance scale scores significantly improved following treatment, and lower extremity motor function also improved. The results of functional MRI showed that constraint-induced movement therapy alleviates the reduction in cerebral functional activation in patients, which indicates activation of functional brain regions and a significant increase in cerebral blood perfusion. These results demonstrate that constraint-induced movement therapy promotes brain functional reorganization in stroke patients with lower limb hemiplegia. | Wenqing Wang Aihui Wang Limin Yu Xuesong Han Guiyun Jiang Changshui Weng Hongwei Zhang Zhiqiang Zhou | 2012 | Neural Regeneration Research2012，7，32： | 4 |
| 2 | The interaction between the helicase DHX33 and IPS-1 as a novel pathway to sense double-stranded RNA and RNA viruses in myeloid dendritic cells显示文摘在优核质,有 DExD/H helicase 家庭,的至少 60 个成员许多哪个能察觉到病毒的 nucleic 酸。由屏蔽所有已知的家庭成员,我们在 myeloid 作为一个新奇双 stranded RNA (dsRNA ) 传感器识别了 helicase DHX33 树枝状的房间(mDCs ) 。用小 heteroduplex RNA (shRNA ) 的 DHX33 击倒堵住了 mDCs 的能力生产类型我干扰素(IFN ) 响应 poly 我: C 和 reovirus。DHX33 的 HELICc 领域被显示 poly 绑我: C。在 DHX33 和 IPS-1 之间的相互作用被 DHX33 和 IPS-1 的 C 终端领域的 HELICc 区域调停(也指了 MAVS 和维萨卡) 。由 RNA 干扰的 DHX33 表示的抑制堵住了 poly 我: 地图 kinases 的导致 C 的激活, NF-κ B 和 IRF3。在 helicase DHX33 和 IPS-1 之间的相互作用独立于 RIG-I/MDA5 并且可以是为 poly 察觉到的一条新奇小径我: 在 mDCs 的 C 和 RNA 病毒。 | Ying Liu Ning Lu Bin Yuan Leiyun Weng Feng Wang Yong-Jun Liu Zhiqiang Zhang | 2014 | Cellular & Molecular Immunology2014，11，1： | 2 |
| 3 | Flotation performance of a novel Gemini collector for kaolinite at low temperature显示文摘How to sustainably produce bauxite by effective reverse froth flotation of kaolinite at low temperature is an urgent problem to be solved in the field of mineral processing.In this work,a novel amino-based Gemini surfactant butadiyl-1,4-bis(dimethyl dodecylammonium bromide)(BBDB) was prepared and first utilized as a novel collector for kaolinite flotation.Its flotation performance for kaolinite was compared with that of the common monomolecular surfactant 1-dodecylamine(DDA) by micro-flotation tests.The tests results indicated that 95% kaolinite recovery was obtained using 2.0×10^(-4) mol/L BBDB at 25℃ which was half of the dosage when DDA obtained the maximum kaolinite recovery of81%.At extremely low temperature(0℃),3.0×10^(-4) mol/L BBDB could still collect 91% kaolinite,while DDA showed a frustrating ability.The contact angle tests indicated that BBDB could still significantly improve the hydrophobicity of the kaolinite surface(contact angle 71.7°) than DDA(contact angle only25.8°) at 0℃.The Krafft point comparison tests indicated that BBDB had a much lower Krafft point(below0℃) than DDA.Fourier transform infrared spectroscopy(FTIR)-spectrum analysis and zeta potential measurements showed that BBDB was physically adsorbed on the surface of kaolinite through electrostatic interaction. | Shiyong Zhang Zhiqiang Huang Hongling Wang Rukuan Liu Chen Cheng Shuyi Shuai Yajing Hu Zhiqun Guo Xinyang Yu Guichun He Weng Fu | 2021 | International Journal of Mining Science and Technology2021，31，6： | 2 |
| 4 | Application of an antibody chip for screening differentially expressed proteins during peach ripening and identification of a metabolon in the SAM cycle to generate a peach ethylene biosynthesis model显示文摘Peach(Prunus persica)is a typical climacteric fruit that produces ethylene rapidly during ripening,and its fruit softens quickly.Stony hard peach cultivars,however,do not produce large amounts of ethylene,and the fruit remains firm until fully ripe,thus differing from melting flesh peach cultivars.To identify the key proteins involved in peach fruit ripening,an antibody-based proteomic analysis was conducted.A mega-monoclonal antibody(mAb)library was generated and arrayed on a chip(mAbArray)at a high density,covering~4950 different proteins of peach.Through the screening of peach fruit proteins with the mAbArray chip,differentially expressed proteins recognized by 1587 mAbs were identified,and 33 corresponding antigens were ultimately identified by immunoprecipitation and mass spectrometry.These proteins included not only important enzymes involved in ethylene biosynthesis,such as ACO1,SAHH,SAMS,and MetE,but also novel factors such as NUDT2.Furthermore,protein–protein interaction analysis identified a metabolon containing SAHH and MetE.By combining the antibody-based proteomic data with the transcriptomic and metabolic data,a mathematical model of ethylene biosynthesis in peach was constructed.Simulation results showed that MetE is an important regulator during peach ripening,partially through interaction with SAHH. | Wenfang Zeng Liang Niu Zhaohui Wang Xiaobei Wang Yan Wang Lei Pan Zhenhua Lu Guochao Cui Weining Weng Mingqiao Wang Xun Meng Zhiqiang Wang | 2020 | Horticulture Research2020，7，1： | 2 |
| 5 | Mapping QTL for flowering time-related traits under three plant densities in maize显示文摘Flowering time is an indicator of adaptation in maize and a key trait for selection in breeding.The genetic basis of flowering time in maize,especially in response to plant density,remains unclear.The objective of this study was to identify maize quantitative trait loci(QTL)associated with flowering time-related traits that are stably expressed under several plant densities and show additive effects that vary with plant density.Three hundred recombinant inbred lines(RIL)derived from a cross between Ye 478 and Qi 319,together with their parents,were planted at three plant densities(90,000,120,000,and 150,000 plants ha^(-1))in four environments.The five traits investigated were days to tasseling(DTT),days to silking(DTS),days to pollen shed(DTP),interval between anthesis and silking(ASI),and interval between tasseling and anthesis(TAI).A high-resolution bin map was used for QTL mapping.In the RIL population,the DTT,DTS,and DTP values increased with plant density,whereas the ASI and TAI values showed negligible response to plant density.A total of 72 QTL were identified for flowering time-related traits,including 15 stably expressed across environments.Maize flowering time under different densities seems to be regulated by complex pathways rather than by several major genes or an independent pathway.The effects of some stable QTL,especially qDTT8-1 and qDTT10-4,varied with plant density.Fine mapping and cloning of these QTL will shed light on the mechanism of flowering time and assist in breeding earlymaturing maize inbred lines and hybrids. | Liwei Wang Zhiqiang Zhou Ronggai Li Jianfeng Weng Quanguo Zhang Xinghua Li Baoqiang Wang Wenying Zhang Wei Song Xinhai Li | 2021 | The Crop Journal2021，9，2： | 2 |
| 6 | Influence of mixed aluminoxane systems on ethylenenorbornene copol-ymerization catalyzed bymetallocene显示文摘 | Wang Qi Weng Jianhua Fan Zhiqiang | 1997 | Macromol Rapid Commun1997，，18： | 1 |
| 7 | An efficient algorithm for automatic phase correction of NMR spectra based on entropy minimization 显示文摘 | Li Chen Zhiqiang Weng LaiYoong Goh | 2002 | J Magn Resort2002，158，： | 1 |
| 8 | Nucleophilic Trifluoromethylthiolation of Allylic Bromides: A Facile Preparation of Allylic Trifluoromethyl Thioethers显示文摘allylic trifluoromethyl thioethers 的灵巧的准备被使用铜试剂完成。反应(bpy ) 有各种各样的 allylic 溴化物的 Cu (SCF3 ) 负担得起需要的 trifluoromethylthiolation 产品在对有高立体声的优秀收益好 -- 并且 regioselectivity。象烷基, alkoxy, trifluoromethyl, nitro,卤化物和 geranyl 那样的普通的功能的组很好被容忍。 | Jianwei Tan Guoting Zhang Yangli Ou Yaofeng Yuan Zhiqiang Weng | 2013 | Chinese Journal of Chemistry2013，31，7： | 1 |
| 9 | Influence ofmixed aluminoxane systems on ethylenenorbornene copol-ymerization catalyzed by metallocene显示文摘 | Wang Qi Weng Jianhua Fan Zhiqiang | 1997 | Macromol Rap-id Commun1997，，18： | 1 |
| 10 | Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis显示文摘Dear Editor,Cancer cells often upregulate the expression of ligands for the inhibitory immune checkpoints receptor to escape anti-tumor immunity1. Targeting inhibitory immune checkpoints has become one of the most promising anticancer therapeutic inventions. Infiltration of myeloid cells, especially phagocytic cells, to tumors is often associated with chemotherapy resistance and progression of various cancer types. Phagocytosis of cancer cells is the major mechanism for these myeloid cells-mediated antitumor activity. However, many types of cancer cells express high level of ‘don’t eat me’ signals on the cell surface to escape the phagocytic cells-mediated antitumor immunity. | Zhiqiang Wu Linjun Weng Tengbo Zhang Hongling Tian Lan Fang Hongqi Teng Wen Zhang Jing Gao Yun Hao Yaxu Li Hu Zhou Ping Wang | 2019 | Cell Research2019，29，6： | 1 |
| 11 | An efficient algorithm for automatic phase correction of NMR spectra based on entropy minimization显示文摘 | Chen Li Weng Zhiqiang Goh LaiYoong | 2002 | J Magn Reson2002，158，： | 1 |
| 12 | Influence ofmixed aluminoxane systems on ethylenenorbornene copoly-merization catalyzed by metallocene显示文摘 | Wang Qi Weng Jianhua Fan Zhiqiang | 1997 | Macromol RapidCommun1997，，18： | 1 |
| 13 | Lycopene and ci-trulline contents in watermelon(Citrullus lanatus)fruit with dif-ferent ploidy and changes during fruit development显示文摘 | Liu Wenge Zhao Shengjie Cheng Zhiqiang | 2010 | Acta Horti-culturae2010，871，： | 1 |
| 14 | Synthesis of 2-trifluoromethyl chromenes via double carbonyl-ene reaction显示文摘A new protocol for the synthesis of diversely substituted 2-trifluoromethyl chromenes from the cyclization reaction of o-isopropenylphenols with trifluoroacetic anhydride has been developed,which proceeds via sequential trifluoroacetylation and double carbonyl-ene reaction followed by elimination reaction.This methodology exhibits good functional group tolerance,and derivatization of the 2-trifluoromethyl chromene product resulted in other valuable scaffolds. | Shouxiong Chen Hui Wang Qi Lin Zhiqiang Weng | 2022 | Organic Chemistry Frontiers2022，9，3： | 0 |
| 15 | Flotation separation of wolframite from calcite using a new trisiloxane surfactant as collector显示文摘Since wolframite is usually associated with calcite,the separation and enrichment of wolframite by froth flotation remains a great challenge.Herein,a novel trisiloxane surfactant N-(2-aminoethyl)-3-ami nopropyltrisiloxane(AATS)was successful synthesized,which was used for the separation of wolframite from calcite for the first time.The flotation separation performance of AATS was studied by flotation test,and its adsorption mechanism was explored based on contact angle,infrared spectrum analysis(FTIR),zeta potential and density functional theory(DFT)calculation.The results of microflotation test and binary mixed ore flotation test pointed that AATS had excellent selectivity and more prominent collection capacity for the flotation of wolframite when compared with industrial reagent sodium oleate(NaOL).The measurement results of contact angle proved that AATS improved the hydrophobicity of the wolframite surface.The highly selective adsorption mechanism of AATS surfactant on mineral surfaces were further researched and analyzed by FTIR and zeta potential.The results revealed that AATS surfactant had significant adsorption effect on wolframite,yet almost no adsorption on calcite.DFT calculation indicated that AATS produced electrostatic adsorption with wolframite surface through—N+H3 group. | Shuyi Shuai Zhiqiang Huang Vladimir E.Burov Vladimir Z.Poilov Fangxu Li Hongling Wang Rukuan Liu Shiyong Zhang Chen Cheng Wenyuan Li Xinyang Yu Guichun He Weng Fu | 2023 | International Journal of Mining Science and Technology2023，33，3： | 0 |
| 16 | Annual Report of Radioactive Waste Facilities Operation in 2017显示文摘301,a division of the department of radiochemistry,is in charge of the management of radioactive waste and the safety of the relative facilities to meet the request of the scientific research.There are 20radioactive waste facilities,including 9facilities which are closed and monitored due to the aging or the task has | YANG Xiuhua GAO Zhigang QI Zhiqiang SHEN Zheng LI Wenge | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 17 | A Convenient Process for the Preparation of Heteroaryl Trifluoromethyl Selenoethers显示文摘由 heteroaryl 溴化物与的 trifluoromethylselenolation 的 heteroaryl trifluoromethyl selenoethers 的准备[(bpy ) CuSeCF 3]2 被调查。用这条途径,很多 trifluoromethylselenolated 杂环的混合物被综合在对优秀收益好。这个过程容忍,这被表明许多功能的组。 | Qinli Tian Zhiqiang Weng | 2016 | Chinese Journal of Chemistry2016，34，5： | 0 |
| 18 | Genomic prediction of yield performance among single-cross maize hybrids using a partial diallel cross design显示文摘Genomic prediction(GP)in plant breeding has the potential to predict and identify the best-performing hybrids based on the genotypes of their parental lines.In a GP experiment,34 elite inbred lines were selected to make 285 single-cross hybrids in a partial-diallel cross design.These lines represented a mini-core collection of Chinese maize germplasm and comprised 18 inbred lines from the Stiff Stalk heterotic group and 16 inbred lines from the Non-Stiff Stalk heterotic group.The parents were genotyped by sequencing and the 285 hybrids were phenotyped for nine yield and yield-related traits at two locations in the summer sowing area(SUS)and three locations in the spring sowing area(SPS)in the main maizeproducing regions of China.Multiple GP models were employed to assess the accuracy of trait prediction in the hybrids.By ten-fold cross-validation,the prediction accuracies of yield performance of the hybrids estimated by the genomic best linear unbiased prediction(GBLUP)model in SUS and SPS were 0.51 and 0.46,respectively.The prediction accuracies of the remaining yield-related traits estimated with GBLUP ranged from 0.49 to 0.86 and from 0.53 to 0.89 in SUS and SPS,respectively.When additive,dominance,epistasis effects,genotype-by-environment interaction,and multi-trait effects were incorporated into the prediction model,the prediction accuracy of hybrid yield performance was improved.The ratio of training to testing population and size of training population optimal for yield prediction were determined.Multiple prediction models can improve prediction accuracy in hybrid breeding. | Ping Luo Houwen Wang Zhiyong Ni Ruisi Yang Fei Wang Hongjun Yong Lin Zhang Zhiqiang Zhou Wei Song Mingshun Li Jie Yang Jianfeng Weng Zhaodong Meng Degui Zhang Jienan Han Yong Chen Runze Zhang Liwei Wang Meng Zhao Wenwei Gao Xiaoyu Chen Wenjie Li Zhuanfang Hao Junjie Fu Xuecai Zhang Xinhai Li | 2023 | The Crop Journal2023，11，6： | 0 |
| 19 | Endoscopy demand among county people in southeast China:A cross-sectional study显示文摘Objective The popularization of gastroenteroscopy and the introduction of comfortable medical care have further promoted the growth of people's demand,especially the demand for painless endoscopy.This cross-sectional study aims to investigate the current situation and change in county people's demand for endoscopy to promote the development of endoscopy centers in county hospitals in southeast China.Methods From October to December 2021,patients and their family members who came to the Gastroenterology Department in Suichang County People's Hospital of Zhejiang Province were randomly selected to complete the questionnaire.A total of 838 valid questionnaires were collected.Additionally,the original software data of the Endoscopy Center were sampled and retrieved(from October to December every year from 2018 to 2021)for statistical analysis of real-world data.Those who would choose painless endoscopy the next time in the valid questionnaires were included in the painless endoscopy group,while those who would choose ordinary endoscopy the next time were included in the ordinary endoscopy group.Results The stepwise forward binary logistic regression model analysis showed that,patients with“secondhand smoke exposure”were more willing to choose painless endoscopy(OR=1.459,95%CI:1.050-2.028,p=0.025).However,patients with an education level of“primary and below”and“junior high school”,and patients who are suffering from“currently experiencing abdominal distension”,were more willing to choose ordinary endoscopy(OR=0.270,95%CI:0.149-0.488,p<0.001;OR=0.528,95%CI:0.330-0.845,p=0.008;OR=0.536,95%CI:0.334-0.861,p=0.010).Patients with previous experience in painless endoscopy tended to choose painless endoscopy the next time,while patients with previous experience in ordinary endoscopy tended to choose ordinary endoscopy the next time(χ^(2)=140.97,p<0.001).From 2018 to 2021,the proportion of painless endoscopy has increased yearly(p<0.001).Most patients indicated that they would“regularly review gastroenteroscopy”(477/838,56.9%).Conclusions With Suichang County of Zhejiang Province as the representative,the demand for painless endoscopy for people's gastrointestinal cancer detection in southeast China has been increasing yearly.The development of endoscopy centers in county-level hospitals can basically meet the demand growth.Meanwhile,advanced concepts such as comfortable medical care and regular follow-up are gradually popularized at the grassroots level in southeast China. | Huihui Yan Zhenghua Lin Shuangjing Gao Chenyu Fan Mengyue Jiang Liying Que Lanfang Zhou Yingdi Weng Jing Shu Tongyun Zhang Jian Hu Zhiqiang Liu Xi Ye Jianting Cai Guangfa Liao | 2023 | Laparoscopic, Endoscopic and Robotic Surgery2023，6，1： | 0 |
| 20 | A differentially methylated region of the ZmCCT10 promoter affects flowering time in hybrid maize显示文摘Flowering time(FT) is a key maize domestication trait, variation in which allows maize to grow in a wide range of latitudes. Although previous studies have investigated the genetic control of FT-related traits per se, few studies of FT hybrid performance have been published. We characterized the genomic architecture associated with hybrid performance for FT in a hybrid panel by testcrossing Chang 7–2 with 328Ye478 × Qi319 recombinant inbred lines(RILs). We identified 11 quantitative trait loci(QTL) for hybrid performance in FT-related traits, including a major QTL qFH10 that controls hybrid performance and heterosis in a summer maize-growing region. However, this locus acts in regulating FT traits per se only in a spring maize-growing region. We validated ZmCCT10 as a candidate gene for qFH10 and found that differences between hybrids and their parental lines in DNA methylation in the differentially methylated region(DMR, –700 to –1520) of the ZmCCT10 promoter affected gene expression pattern and thereby FT in the summer maize-growing region. | Zhiqiang Zhou Xin Lu Chaoshu Zhang Mingshun Li Zhuanfang Hao Degui Zhang Hongjun Yong Jienan Han Xinhai Li Jianfeng Weng | 2023 | The Crop Journal2023，11，5： | 0 |
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