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| 1 | Capecitabine plus oxaliplatin compared with 5-fluorouracil plus oxaliplatinin metastatic colorectal cancer: Meta-analysis of randomized controlled trials显示文摘 | Chengyao Zhang Jiawu Wang Haitao Gu Daihua Zhu Yang Li Peng Zhu Yaxu Wang Jijian Wang | 2012 | Oncology Letters2012，，4： | 2 |
| 2 | Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis显示文摘Dear Editor,Cancer cells often upregulate the expression of ligands for the inhibitory immune checkpoints receptor to escape anti-tumor immunity1. Targeting inhibitory immune checkpoints has become one of the most promising anticancer therapeutic inventions. Infiltration of myeloid cells, especially phagocytic cells, to tumors is often associated with chemotherapy resistance and progression of various cancer types. Phagocytosis of cancer cells is the major mechanism for these myeloid cells-mediated antitumor activity. However, many types of cancer cells express high level of ‘don’t eat me’ signals on the cell surface to escape the phagocytic cells-mediated antitumor immunity. | Zhiqiang Wu Linjun Weng Tengbo Zhang Hongling Tian Lan Fang Hongqi Teng Wen Zhang Jing Gao Yun Hao Yaxu Li Hu Zhou Ping Wang | 2019 | Cell Research2019，29，6： | 1 |
| 3 | Experimental study on corrosion progress of interior bond section of anchor cables under chloride attack显示文摘 | Fumin Li Zhenguo Liu Yu Zhao Yaxu Qu Rong Lu | 2014 | Construction and Building Materials2014，，： | 1 |
| 4 | Sensodess field orientation control of in- duction machines based on a mutual MRAS scheme 显示文摘 | LI Zhen LONG Yaxu | 1998 | IEEE Transactions on Industrial Electronics1998，45，5： | 1 |
| 5 | Relationship between Industrial Coupling Coordination and Carbon Intensity in the Bohai Rim Economic Circle显示文摘Coordinated development of new high-tech industries and traditional industries is crucially important for economic growth and environmental sustainability,and it has become a focus of academic and governmental bodies.This study establishes the comprehensive evaluation index system of high-tech industries and traditional industries,and uses the method of principal component analysis,coupling and coupling coordination degree model to determine the level of industry coordinated development.Then,Pearson correlation test is used to further analyze the correlation between regional industrial coupling coordination and carbon intensity of the seven provinces in the Bohai Rim Economic Circle(BREC).The results are as follows.(1)There is a negative correlation between industrial coupling coordination and carbon intensity.(2)The degree of industrial coordination of Beijing,Tianjin,and Shandong is significantly higher than other provinces in the BREC,as both the high-tech industries and traditional industries of these three provinces have reached a high level of development and achieved high coupling.The high-tech industries of the three provinces show positive changes,whereas the traditional industries show negative changes,which indicates that the new high-tech industries are driving the upgrading of the traditional industries by the application of high technologies.(3)From 2011 to 2016,the number of provinces with a low degree of high-tech and traditional industrial coordination fell from three to one.The traditional industries in Hebei and Inner Mongolia have been upgraded by strengthening their technological innovation with the introduction of rapid high-tech industrial development.These findings are a useful reference for regional industrial coupling coordination and carbon emission reduction. | Mei Song Liyan Zhang Mingxin Zhang Dandan Li Yaxu Zhu | 2021 | Energy Engineering2021，118，1： | 0 |
| 6 | SET1A催化YAP甲基化修饰调控YAP细胞核转运和促进肿瘤发生显示文摘文章简介YAP作为Hippo信号通路主要效应因子之一,在Hippo通路受抑的条件下,从细胞质转运至细胞核调控基因表达和促进肿瘤发生。虽然YAP锚定在细胞质中的调控机制已经被广泛研究,但是YAP激活后入核在细胞核中持续积累的分子机制并不十分清楚。 | 方兰 滕鸿琦 王益林 廖光红 Linjun Weng Yaxu Li Xinbo Wang Jiali Jin Chenchen Jiao Lei Chen Xiaoping Peng Jiayu Chen Yongzhi Yang Houqin Fang Dongyan Han Cheng Li Xueling Jin Shihao Zhang Zhongchen Liu Min Liu Qing Wei Lujian Liao Xin Ge Bin Zhao Dawang Zhou HuanLong Qin Jun Zhou 王平 | 2019 | 科学新闻2019，0，2： | 0 |
| 7 | Effect of High Pressure and Heat Treatment on Microstructure of Cu-AI Alloy显示文摘 | Shuqing Chen Jianshe Li Yaxue Kang Yanmei Li | 2011 | 材料科学与工程(中英文A版)2011，1，1X： | 0 |
| 8 | Cryo-EM structures of human monkeypox viral replication complexes with and without DNA duplex显示文摘Dear Editor,The outbreak of human monkeypox in May 2022 across nonendemic countries is unusual compared to previous reports.A recent study indicates that the basic reproduction number(R_(0))of monkeypoxvirus(MPxV)is>1 in populations of men who have sex with men,and MPxV is reported to be transmitted via close contact and airborne droplets,suggesting that monkeypox poses a great threat to the global health. | Yunxia Xu Yaqi Wu Yuanyuan Zhang Ruixin Fan Yaxue Yang Danyang Li Shimin Zhu Biao Yang Zhengyu Zhang Changjiang Dong | 2023 | Cell Research2023，33，6： | 0 |
| 9 | Internal Reference Gene Selection for Quantitative Real-Time RT-PCR Normalization in Potato Tissues显示文摘Quantitative real-time PCR(qRT-PCR)is widely used for investigating gene expression patterns and has many advantages,including its high sensitivity,fidelity,and specificity.Selecting a satisfactory internal reference gene is crucial for obtaining precise gene expression results in qRT-PCR analyses.In this study,the transcriptomic data of 2 potato varieties were screened for housekeeping genes with stable expression patterns.A total of 77 putative genes were selected,which were highly and stably expressed.Then,qRT-PCR analyses were performed to examine the expression levels of these 77 candidate reference genes in various potato tissues,including leaves,flowers,stolons,and tubers.Gene expression was represented by analyzing the Ct values at given threshold.Through geNorm and NormFinder program analyses,10 candidate genes with the most stable expression patterns were obtained,including RPL19,RPS15,RPS9,EF1α,TrxP1,RPS8,NTF,CAM,AACM,and RPS28.Moreover,through the comprehensive analyses of 4 statistical algorithms(i.e.,geNorm,NormFinder,BestKeeper,and RefFinder),results indicated that the most appropriate internal reference genes were RPL19 and EF1α.The obtained stable reference genes will contribute to future qRT-PCR analyses on potato tissue-related gene expression. | Gang Li Yao Zhou Yaqi Zhao Yaxue Liu Yuwei Ke Xiaoqing Jin Haoli Ma | 2020 | Phyton-International Journal of Experimental Botany2020，89，2： | 0 |
| 10 | Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein(QPCTL)with antitumor efficacy显示文摘Dear Editor,Immune checkpoint therapies manipulating the immune system to eliminate tumor cells have shown remarkable clinical efficacy in treating various cancers.CD47,an emerging efficient immune checkpoint,is crucial for cancer cells to evade macrophagemediated phagocytosis by interaction with signal-regulatory proteinα(SIRPα).Antibodies blocking the CD47/SIRPαinteraction have been effective to promote macrophage-mediated phagocytosis in various types of cancer in mice and humans.CD47 is not only highly expressed in tumor cells,but also normal cells,such as red blood cells(RBCs).Thus,during clinical trials involving cancer patients,anti-CD47 antibodies may promote the macrophagesmediated phagocytosis of RBCs,ultimately inducing undesirable anemia side effects.In contrast,small molecule inhibitors interrupting CD47/SIRPαaxis have shown potential to overcome the anemia,possibly due to their lower immunogenicity and shorter half-life compared to antibodies.1 Hence,developing the novel strategies,especially those without the anemia side effect,to intervene in CD47/SIRPαinteraction will benefit cancer immunotherapy. | Lei Yu Pengcheng Zhao Yaoliang Sun Zening Zheng Wenhao Du Lishan Zhang Yaxu Li Longyan Xie Shilin Xu Ping Wang | 2024 | Signal Transduction and Targeted Therapy2024，9，1： | 0 |
| 11 | Bio-inspired multifunctional metallic glass显示文摘As a novel class of metallic materials, bulk metallic glasses(BMGs) have attracted a great deal of attention owing to their technological promise for practical engineering applications. In nature, biological materials exhibit inherent multifunctional integration, which provides some inspiration for scientists and engineers to construct multifunctional artificial materials. In this contribution, inspired by superhydrophobic self-cleaning lotus leaves, multifunctional bulk metallic glasses(BMG) materials have been fabricated through the thermoplastic forming-based process followed by the SiO_2/soot deposition. To mimic the microscale papillae of the lotus leaf, the BMG micropillar with a hemispherical top was first fabricated using micro-patterned silicon templates based on thermoplastic forming. The deposited randomly distributed SiO_2/soot nanostructures covered on BMG micropillars are similar to the branch-like nanostructures on papillae of the lotus leaf. Micro-nanoscale hierarchical structures endow BMG replica with superhydrophobicity, a low adhesion towards water, and self-cleaning, similar to the natural lotus leaf. Furthermore, on the basis of the observation of the morphology of BMG replica in the Si mould, the formation mechanism of BMG replica was proposed in this work. The BMG materials with multifunction integration would extend their practical engineering applications and we expect this method could be widely adopted for the fabrication of other multifunctional BMG surfaces. | Yaxu He Yun Peng Zhou Li Jiang Ma Xiyao Zhang Kesong Liu Weihua Wang Lei Jiang | 2016 | Science China Chemistry2016，59，3： | 0 |
| 12 | Diverse functions of GmNLA1 members in controlling phosphorus homeostasis highlight coordinate response of soybean to nitrogen and phosphorus availability显示文摘Nitrogen(N) and phosphorus(P) are two essential mineral nutrients for plant growth,which are required in relative high amount in plants.Plants have evolved a series of strategies for coordinately acquiring and utilizing N and P.However,physiological and molecular mechanisms underlying of N and P interactions remain largely unclear in soybean(Glycine max).In this study,interactions of N and P were demonstrated in soybean as reflected by significant increases of phosphate(Pi) concentration in both leaves and roots by N deficiency under Pi sufficient conditions.A total of four nitrogen limitation adaptation(NLA),encoding RING-type E3 ubiquitin ligase were subsequently identified in soybean genome.Among them,transcription of Gm NLA1-1 and Gm NLA1-3 was decreased in soybean by N starvation under Pi sufficient conditions,not for Gm NLA1-2.Suppression of all three Gm NLA1 members was able to increase Pi concentration regardless of the P and N availability in the growth medium,but decrease fresh weight under normal conditions in soybean hairy roots.However,comparted to changes in control lines at two N levels,N deficiency only resulted in a relatively higher increase of Pi concentration in Gm NLA1-1 or Gm NLA1-3 suppression lines,strongly indicating that Gm NLA1-1 and Gm NLA1-3 might regulate P homeostasis in soybean response to N starvation.Taken together,our result suggest that redundant and diverse functions present in Gm NLA1 members for soybean coordinate responses to P and N availability,which mediate P homeostasis. | Ming Zhou Yaxue Li Xing Lu Panmin He Cuiyue Liang Jiang Tian | 2023 | The Crop Journal2023，11，4： | 0 |
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