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| 1 | Patent Foramen Ovale, Subclinical Cerebrovascular Disease, and Ischemic Stroke in a Population-Based Cohort显示文摘 | Marco R. Di Tullio Zhezhen Jin Cesare Russo Mitchell S.V. Elkind Tatjana Rundek Mitsuhiro Yoshita Charles DeCarli Clinton B. Wright Shunichi Homma Ralph L. Sacco | 2013 | Journal of the American College of Cardiology2013，，1： | 1 |
| 2 | Effect of obesity and overweight on left ventricular cliastolic function显示文摘 | CESARE R S ZHEZHEN J KIREHENBAUM J M | | 0，，： | 1 |
| 3 | Higher ambulatory blood pressure is associated with aortic valve calcification in the elderly-a populationbased study显示文摘 | Shinichi I Cesare R Zhezhen J | 2013 | Hypertension2013，61，1： | 1 |
| 4 | Small extracellular vesicles derived from hypoxic preconditioned dental pulp stem cells ameliorate inflammatory osteolysis by modulating macrophage polarization and osteoclastogenesis显示文摘Extensive macrophage inflammatory responses and osteoclast formation are predominant during inflammatory or infective osteolysis.Mesenchymal stem cell(MSC)-derived small extracellular vesicles(MSC-sEV)have been shown to exert therapeutic effects on bone defects.However,cultured MSCs are typically exposed to normoxia(21%O2)in vitro,which differs largely from the oxygen concentration in vivo under hypoxic conditions.It is largely unknown whether sEV derived from dental pulp stem cells(DPSCs)cultured under hypoxic conditions(Hypo-sEV)exert better therapeutic effects on lipopolysaccharide(LPS)-induced inflammatory osteolysis than those cultured under normoxic conditions(Nor-sEV)by simultaneously inhibiting the macrophage inflammatory response and osteoclastogenesis.In this study,we show that hypoxia significantly induces the release of sEV from DPSCs.Moreover,Hypo-sEV exhibit significantly improved efficacy in promoting M2 macrophage polarization and suppressing osteoclast formation to alleviate LPS-induced inflammatory calvarial bone loss compared with Nor-sEV.Mechanistically,hypoxia preconditioning markedly alters the miRNA profiles of DPSC-sEV.MiR-210-3p is enriched in Hypo-sEV,and can simultaneously induce M2 macrophage generation and inhibit osteoclastogenesis by targeting NF-κB1 p105,which attenuates osteolysis.Our study suggests a promising potential for hypoxia-induced DPSC-sEV to treat inflammatory or infective osteolysis and identifies a novel role of miR-210-3p in concurrently hindering osteoclastogenesis and macrophage inflammatory response by inhibiting NF-kB1 expression. | Jun Tian Weiyang Chen Yuhua Xiong Qianer Li Siyi Kong Mengjie Li Chunfeng Pang Yu Qiu Zhezhen Xu Qimei Gong Xi Wei | 2023 | Bioactive Materials2023，，4： | 1 |
| 5 | Multiinstitutional use of defibrotidein 88 patients after stem cell transplantation with severe veno-occlusive disease and multisystem organ failure: response without significant toxicity in a high-risk population and factor predictive of outcome 显示文摘 | PAUL G R CAROL M ZHEZHEN J | 2002 | Blood2002，100，： | 1 |
| 6 | Ab initio study of the effects of helium on the mechanical properties of different erbium hydrides显示文摘Although rare-earth metals have increasingly received attention for use in the storage and transportation of the tritium used in nuclear fusion reactions,they still face great challenges,such as the effect of helium on the mechanical properties of different erbium hydrides.In this work,first principles are used to study the mechanical properties(elastic constants,Young's modulus,transverse shear modulus and bulk modulus)of different erbium hydrides exposed to helium.The Young's modulus,the transverse shear modulus and the bulk modulus are given based on the elastic constants calculated according to first principles.It is found that the mechanical properties of all three erbium hydrides decrease in the presence of helium,and the decline of the mechanical properties of ErH_3 is the most serious.To explain the reason for the decrease in the mechanical properties,the densities of the states of erbium hydrides are calculated.During the calculations,helium embrittlement is not found and the ductility of the erbium hydrides improves following the production of helium at the helium concentrations considered in this work. | Mingwen Zhang Li Li Zhezhen Zhao Jinlan Nie Xiaotao Zu Hongxiang Deng | 2021 | Communications in Theoretical Physics2021，73，5： | 0 |
| 7 | Hyaluronic acid injection in the auricular base for the aesthetic correction of lying ears:A retrospective study显示文摘Background Ears play an important role in facial profiles.Lying ears are not perceived favorably in Asian cultures;therefore,surgical procedures are implemented to adjust this defect.However,surgery has complications and requires recovery time.We introduced a hyaluronic acid(HA)injection technique to aesthetically improve ear prominence.Methods This retrospective study examined 25 Chinese patients aged 20-47 years with congenital lying ears who received HA injections in the auricular base at Shanghai Ninth People’s Hospital and Hangzhou Yijie Medical Cosmetology Clinic between November 2019 and December 2022.The average injection volume was 6.32±1.22 mL in the auricular base unilaterally,and the follow-up time ranged from 6 to 24 months.Morphological measurement data were recorded.Two-dimensional(2D)and three-dimensional(3D)images were obtained to evaluate the effects.Results All patients showed improvements in ear prominence.The cranioauricular angle(CAA)increased from 22.24°±4.53°to 65.90°±5.38°immediately post-injection and was maintained at 49.18°±4.74°6 months later.The ear projection(EP)increased from 14.75±2.72 mm to 26.26±2.94 mm immediately post-injection and was 22.51±2.68 mm after 6 months.No serious complications were noted.Conclusion HA injection in the auricular base effectively corrected the lying ears and aesthetically optimized the facial profile.It also had a face-lift effect that made the face look younger and more compact.The injection procedure was minimally invasive and required no recovery period.The effect was maintained for a long time and was satisfactory. | Zhezhen Xiong Zhengzheng Jiang Yaping Bai Minxue Liang Weitai Jiang Kai Liu | 2023 | Chinese Journal Of Plastic and Reconstructive Surgery2023，5，1： | 0 |
| 8 | Clinical effects of injectable collagen in lower-lid pretarsal fullness rejuvenation显示文摘Background: Lower-lid pretarsal fullness rejuvenation is a popular surgery for Asian women. However, the current procedures have clinical complications and are not stable in the long-term. Here, we analyzed the effect of injectable collagen on lower-lid pretarsal fullness rejuvenation.Methods: To investigate the clinical effect of injectable collagen in lower-lid pretarsal fullness rejuvenation, we observed 32 Chinese Han female patients aged 18–55 years with non-distinctive lower-lid pretarsal fullness and no history of lower eyelid surgery or trauma. The injectable collagen products were used for local filling correction. After surgery, the patients were followed up for 12 months. A correction effect was evaluated through an analysis of volume changes using a visual analog scale. Adverse reactions were also recorded.Results: All patients achieved good aesthetic outcomes and strong stereoscopic impressions of lower-lid pretarsal fullness. Complications, such as edema and bruising, were not observed after the injection. Immediately after the operation, the average visual analog score was 2.65 ± 0.56. Six months after the operation, the average visual analog score was 2.96 ± 0.41. The patients reported high satisfaction levels. Immediately after the operation, the average lower-lid pretarsal fullness volume increase was 0.19 ± 0.04 m L on the left side and 0.21 ± 0.03 m L on the right side. After a 12-month follow-up, the average residual volume was 0.17 ± 0.06 m L on the left side and 0.19 ± 0.04 m L on the right side, suggesting that the injected collagen impact was stable.Conclusion: Injectable collagen promotes a vivid, natural appearance and is highly effective in rejuvenating lowerlid pretarsal fullness with low absorption rates in later stages. Therefore, injectable collagen should be considered in correcting congenital, non-distinctive, lower-lid pretarsal fullness in clinical practice. | Junjie Li Zhengzheng Jiang Zhezhen Xiong Minxue Liang Yaping Bai Weitai Jiang Kai Liu | 2022 | Chinese Journal Of Plastic and Reconstructive Surgery2022，4，3： | 0 |
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